Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18555-18564

  Boitz, Jan M ^a   Ullman, Buddy ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL STUDIES; IN-VITRO; IN-VIVO; KNOCK OUTS; LEISHMANIA; OVER-EXPRESSION; PARASITE-; PHOSPHORIBOSYLTRANSFERASE; RESTRICTIVE CONDITIONS; WILD TYPES;

MOLECULAR VIBRATIONS; NUCLEIC ACIDS; POSITIVE IONS;

AMPLIFICATION;

6 OXYPURINE DERIVATIVE; ADENINE PHOSPHORIBOSYLTRANSFERASE; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PHOSPHORIBOSYLTRANSFERASE; PURINE DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE PHOSPHORIBOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; FEMALE; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GROWTH INHIBITION; LEISHMANIA DONOVANI; LEISHMANIASIS; MICROBIAL ACTIVITY; MICROBIAL GROWTH; MOUSE; NONHUMAN; PARASITE VIRULENCE; PHENOTYPE; PRIORITY JOURNAL; PURINE METABOLISM;

ADENINE PHOSPHORIBOSYLTRANSFERASE; ANIMALS; ESCHERICHIA COLI; FEMALE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; LEISHMANIA DONOVANI; MACROPHAGES; MICE; MICE, INBRED BALB C; MODELS, GENETIC; MUTATION; PENTOSYLTRANSFERASES; PHENOTYPE; VIRULENCE;

LEISHMANIA DONOVANI; MUS;

EID: 77953305886     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.125393     Document Type: Article

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