IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice

Molecular and Biochemical Parasitology

Volumn 180, Issue 2, 2011, Pages 123-126

  Fulwiler, Audrey L ^a   Boitz, Jan M ^a   Gilroy, Caslin ^a   Yates, Phillip A ^a   Jardim, Armando ^b   Ullman, Buddy ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Gene targeting; Guanylate nucleotides; Inosine 5 monophosphate dehydrogenase; Leishmania donovani; Purine salvage

Indexed keywords

GUANINE; GUANINE DEAMINASE; GUANOSINE PHOSPHATE; INOSINATE DEHYDROGENASE; XANTHINE;

AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEAMINATION; HOST PARASITE INTERACTION; IMMUNOBLOTTING; INHIBITION KINETICS; LEISHMANIA DONOVANI; LEISHMANIASIS; MACROPHAGE; MICROBIAL GROWTH; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PARASITEMIA; PHENOTYPE; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION;

5'-GUANYLIC ACID; ANIMALS; HUMANS; IMP DEHYDROGENASE; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; MICE; MICE, INBRED BALB C; PHENOTYPE; PROTOZOAN PROTEINS; RIBONUCLEOTIDES;

LEISHMANIA DONOVANI; MUS;

EID: 80054715559     PISSN: 01666851     EISSN: 18729428     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2011.08.006     Document Type: Article

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