The interface of receptor trafficking and signalling

Journal of Cell Science

Volumn 114, Issue 17, 2001, Pages 3075-3081

  Clague, M J ^a   Urbe S ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cbl; EGF receptor; Endocytosis; Hgs; Hrs; Rab5; Tyrosine kinase receptor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; RAB PROTEIN; SCATTER FACTOR; TYROSINE KINASE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CELL MEMBRANE; DROSOPHILA PROTEINS; ENDOCYTOSIS; ENDOSOMES; GTP PHOSPHOHYDROLASES; MODELS, BIOLOGICAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; RAB5 GTP-BINDING PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 0034794184     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Hrs is associated with STAM, a signal-transducing adaptor molecule
2. Isolation of yeast mutants defective in protein targeting to the vacuole
3. Protein kinase B/akt and rab5 mediate ras activation of endocytosis
4. Epidermal growth factor and membrane trafficking: EGF receptor activation of endocytosis requires rab5a
5. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
6. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
7. Regulation of epidermal growth factor signaling by endocytosis and intracellular trafficking
8. The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:rab5 complex
9. Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor
10. Phosphatidylinositol-3-OH kinases are rab5 effectors
11. Membrane transport: Take your fusion partners
12. c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route
13. Endocytosis and mitogenic signalling
14. Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma
15. STAM2, a new member of the STAM family, binding to Janus kinases
16. Tyrosine phosphorylation of c-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of v-Abl-transfomed NIH3T3 fibroblasts
17. Ubiquitination: RING for destruction
18. The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: A role for the adaptor protein Crk
19. Rab5 controls early endosome fusion in vitro
20. Direct visualisation of the binding and internalisation of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431
21. Formation of c-cbl-phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
22. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems
23. A de-ubiquitinating enzyme UBPY interacts with the SH3 domain of Hrs binding protein via a novel binding motif Px(V/I)(D/N)RxxKP
24. Hrs and Hbp: Possible regulators of endocytosis and exocytosis
25. Enhanced degradation of EGF receptors by a sorting nexin, SNX1
26. Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalization
27. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5
28. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation
29. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
30. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
31. The evolutionary conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor
32. The Cbl protooncoprotein: A negative regulator of immune receptor signal transduction
33. β-arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes
34. RN-tre specifically binds to the SH3 domain of eps8 with high affinity and confers growth advantage to NIH3T3 cells upon carboxyterminal truncation
35. RN-tre identifies a family of tre-related proteins displaying a novel potential protein binding domain
36. A novel role for rab5-GDI in ligand sequestration into clathrin coated pits
37. Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes
38. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α
39. Rab5 regulates motility of early endosomes on microtubules
40. Immunocytochemical localization of Shc and activated EGF receptor in early endosomes after EGF stimulation of HeLa cells
41. Morphological classification of the yeast vacuolar protein sorting mutants: Evidence for a prevacuolar compartment in class E vps mutants
42. EPS8 and E3B1 transduce signals from Ras to Rac
43. EEA1 links PI(3)K function to rab5 regulation of endosome fusion
44. Endocytosis and intracellular sorting of receptor tyrosine kinases
45. Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation
46. Phosphorylation of GDI and the membrane cycling of rab proteins
47. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis
48. A Hrs protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors
49. Cbl:Many adaptions to regulate protein tyrosine kinases
50. Ring finger mutations that abolish c-Cbl directed polyubiquitination and down-regulation of the EGF receptor are insufficient for cell transformation
51. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
52. Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins
53. Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate
54. Control of EGF receptor signaling by clathrin-mediated endocytosis
55. Phoxy lipids: Revealing PX domains as phosphoinositide binding modules
56. Evidence for direct interaction between Sprouty and Cbl
57. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-Cbl