-
1
-
-
84859088981
-
A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation
-
P. Dalle Pezze, A. G. Sonntag, A. Thien, M. T. Prentzell, M. Gödel, S. Fischer, E. Neumann-Haefelin, T. B. Huber, R. Baumeister, D. P. Shanley, K. Thedieck, A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation. Sci. Signal. 5, ra25 (2012).
-
(2012)
Sci. Signal.
, vol.5
-
-
Dalle Pezze, P.1
Sonntag, A.G.2
Thien, A.3
Prentzell, M.T.4
Gödel, M.5
Fischer, S.6
Neumann-Haefelin, E.7
Huber, T.B.8
Baumeister, R.9
Shanley, D.P.10
Thedieck, K.11
-
2
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
D. D. Sarbassov, D. A. Guertin, S. M. Ali, D. M. Sabatini, Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
3
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
J. Huang, C. C. Dibble, M. Matsuzaki, B. D. Manning, The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol. Cell. Biol. 28, 4104-4115 (2008).
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
Manning, B.D.4
-
4
-
-
68049126433
-
Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors
-
J. Huang, S. Wu, C. L. Wu, B. D. Manning, Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res. 69, 6107-6114 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 6107-6114
-
-
Huang, J.1
Wu, S.2
Wu, C.L.3
Manning, B.D.4
-
5
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
L. S. Harrington, G. M. Findlay, A. Gray, T. Tolkacheva, S. Wigfield, H. Rebholz, J. Barnett, N. R. Leslie, S. Cheng, P. R. Shepherd, I. Gout, C. P. Downes, R. F. Lamb, The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166, 213-223 (2004).
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
Findlay, G.M.2
Gray, A.3
Tolkacheva, T.4
Wigfield, S.5
Rebholz, H.6
Barnett, J.7
Leslie, N.R.8
Cheng, S.9
Shepherd, P.R.10
Gout, I.11
Downes, C.P.12
Lamb, R.F.13
-
6
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
O. J. Shah, Z. Wang, T. Hunter, Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14, 1650-1656 (2004).
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
7
-
-
70350545722
-
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
-
C. C. Dibble, J. M. Asara, B. D. Manning, Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol. Cell. Biol. 29, 5657-5670 (2009).
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 5657-5670
-
-
Dibble, C.C.1
Asara, J.M.2
Manning, B.D.3
-
8
-
-
75749105049
-
MTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
-
L. A. Julien, A. Carriere, J. Moreau, P. P. Roux, mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol. Cell. Biol. 30, 908-921 (2010).
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 908-921
-
-
Julien, L.A.1
Carriere, A.2
Moreau, J.3
Roux, P.P.4
-
9
-
-
79958696336
-
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
-
Y. Yu, S. O. Yoon, G. Poulogiannis, Q. Yang, X. M. Ma, J. Villén, N. Kubica, G. R. Hoffman, L. C. Cantley, S. P. Gygi, J. Blenis, Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-1326 (2011).
-
(2011)
Science
, vol.332
, pp. 1322-1326
-
-
Yu, Y.1
Yoon, S.O.2
Poulogiannis, G.3
Yang, Q.4
Ma, X.M.5
Villén, J.6
Kubica, N.7
Hoffman, G.R.8
Cantley, L.C.9
Gygi, S.P.10
Blenis, J.11
-
10
-
-
79958696694
-
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
-
P. P. Hsu, S. A. Kang, J. Rameseder, Y. Zhang, K. A. Ottina, D. Lim, T. R. Peterson, Y. Choi, N. S. Gray, M. B. Yaffe, J. A. Marto, D. M. Sabatini, The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-1322 (2011).
-
(2011)
Science
, vol.332
, pp. 1317-1322
-
-
Hsu, P.P.1
Kang, S.A.2
Rameseder, J.3
Zhang, Y.4
Ottina, K.A.5
Lim, D.6
Peterson, T.R.7
Choi, Y.8
Gray, N.S.9
Yaffe, M.B.10
Marto, J.A.11
Sabatini, D.M.12
-
11
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
J. Huang, B. D. Manning, A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 37, 217-222 (2009).
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
-
12
-
-
67651210833
-
Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth
-
H. A. Acosta-Jaquez, J. A. Keller, K. G. Foster, B. Ekim, G. A. Soliman, E. P. Feener, B. A. Ballif, D. C. Fingar, Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol. Cell. Biol. 29, 4308-4324 (2009).
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4308-4324
-
-
Acosta-Jaquez, H.A.1
Keller, J.A.2
Foster, K.G.3
Ekim, B.4
Soliman, G.A.5
Feener, E.P.6
Ballif, B.A.7
Fingar, D.C.8
-
13
-
-
77950900079
-
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
-
G. A. Soliman, H. A. Acosta-Jaquez, E. A. Dunlop, B. Ekim, N. E. Maj, A. R. Tee, D. C. Fingar, mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J. Biol. Chem. 285, 7866-7879 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7866-7879
-
-
Soliman, G.A.1
Acosta-Jaquez, H.A.2
Dunlop, E.A.3
Ekim, B.4
Maj, N.E.5
Tee, A.R.6
Fingar, D.C.7
-
14
-
-
84859778293
-
mTOR signaling in growth control and disease
-
M. Laplante, D. M. Sabatini, mTOR signaling in growth control and disease. Cell 149, 274-293 (2012).
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
|