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Volumn 5, Issue 232, 2012, Pages

Cell biology - Comment on "a dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation": Building a model of the mTOR signaling network with a potentially faulty tool

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

EID: 84863834758     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003250     Document Type: Article
Times cited : (8)

References (14)
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    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • D. D. Sarbassov, D. A. Guertin, S. M. Ali, D. M. Sabatini, Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 3
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • J. Huang, C. C. Dibble, M. Matsuzaki, B. D. Manning, The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol. Cell. Biol. 28, 4104-4115 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 4
    • 68049126433 scopus 로고    scopus 로고
    • Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors
    • J. Huang, S. Wu, C. L. Wu, B. D. Manning, Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. Cancer Res. 69, 6107-6114 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 6107-6114
    • Huang, J.1    Wu, S.2    Wu, C.L.3    Manning, B.D.4
  • 6
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • O. J. Shah, Z. Wang, T. Hunter, Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14, 1650-1656 (2004).
    • (2004) Curr. Biol. , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 7
    • 70350545722 scopus 로고    scopus 로고
    • Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
    • C. C. Dibble, J. M. Asara, B. D. Manning, Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol. Cell. Biol. 29, 5657-5670 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 5657-5670
    • Dibble, C.C.1    Asara, J.M.2    Manning, B.D.3
  • 8
    • 75749105049 scopus 로고    scopus 로고
    • MTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
    • L. A. Julien, A. Carriere, J. Moreau, P. P. Roux, mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Mol. Cell. Biol. 30, 908-921 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 908-921
    • Julien, L.A.1    Carriere, A.2    Moreau, J.3    Roux, P.P.4
  • 11
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    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • J. Huang, B. D. Manning, A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 37, 217-222 (2009).
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 13
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    • mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
    • G. A. Soliman, H. A. Acosta-Jaquez, E. A. Dunlop, B. Ekim, N. E. Maj, A. R. Tee, D. C. Fingar, mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J. Biol. Chem. 285, 7866-7879 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 7866-7879
    • Soliman, G.A.1    Acosta-Jaquez, H.A.2    Dunlop, E.A.3    Ekim, B.4    Maj, N.E.5    Tee, A.R.6    Fingar, D.C.7
  • 14
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    • mTOR signaling in growth control and disease
    • M. Laplante, D. M. Sabatini, mTOR signaling in growth control and disease. Cell 149, 274-293 (2012).
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.