The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis

American Journal of Physiology - Endocrinology and Metabolism

Volumn 288, Issue 5 51-5, 2005, Pages

  Gilbert, Linda C ^a   Rubin, Janet ^a   Nanes, Mark S ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bone; Osteoblast; Osteoporosis; p75; Tumor necrosis factor; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor 2

Indexed keywords

ASCORBIC ACID; CASPASE 3; CELL DNA; DACTINOMYCIN; LIPOCORTIN 5; PROTEIN P55; PROTEIN P75; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; ENZYME INHIBITION; MENOPAUSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; STROMA CELL; WILD TYPE;

3T3 CELLS; ANIMALS; APOPTOSIS; BONE MARROW CELLS; CELL DIFFERENTIATION; MICE; OSTEOBLASTS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 17444389237     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00534.2004     Document Type: Article

References (50)

1. Abbas S, Zhang YH, Clohisy JC, and Abu-Amer Y. Tumor necrosis factor-alpha inhibits pre-osteoblast differentiation through its type-1 receptor. Cytokine 22: 33-41, 2003.
2. Abu-Amer Y, Erdmann J, Alexopoulou L, Kollias G, Ross FP, and Teitelbaum SL. Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis. J Biol Chem 275: 27307-27310, 2000.
3. Abu-Amer Y, Ross FP, Edwards J, and Teitelbaum SL. Lipopolysaccharide- stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor. J Clin Invest 100: 1557-1565, 1997.
4. Azuma Y, Kaji K, Katogi R, Takeshita S, and Kudo A. Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. J Biol Chem 275: 4858-4864, 2000.
5. Bellido T, Huening M, Raval-Pandya M, Manolagas SC, and Christakos S. Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. J Biol Chem 275: 26328-26332, 2000.
6. Bills CE, Eisenberg H, and Pallante SL. Complexes of organic acids with calcium phosphate: the Von Kossa stain as a clue to the composition of bone mineral. Johns Hopkins Med J 128: 194-207, 1974.
7. Bodine PV, Trailsmith M, and Komm BS. Development and characterization of a conditionally transformed adult human osteoblastic cell line. J Bone Miner Res 11: 806-819, 1996.
8. Cenci S, Weitzmann MN, Roggia C, Namba N, Novack D, Woodring J, and Pacifici R. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest 106: 1229-1237, 2000.
9. Chen G and Goeddel DV. TNF-R1 signaling: a beautiful pathway. Science 296: 1634-1635, 2002.
10. Chen S, Guttridge DC, Tang E, Shi S, Guan K, and Wang CY. Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling. J Biol Chem 276: 39259-39263, 2001.
11. Gilbert L, He X, Farmer P, Boden S, Kozlowski M, Rubin J, and Nanes MS. Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology 141: 3956-3964, 2000.
12. Gilbert L, He X, Farmer P, Rubin J, Drissi H, van Wijnen AJ, Lian JB, Stein GS, and Nanes MS. Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem 277: 2695-2701, 2002.
13. Gilbert LC, He X, Kauppi A, Rubin J, and Nanes MS. Inhibition of osteoblast differentiation by TNF-alpha is associated with suppression of osterix expression (Abstract). J Bone Miner Res 18: SU177, 2003.
14. Gravestein LA and Borst J. Tumor necrosis factor receptor family members in the immune system. Semin Immunol 10: 423-434, 1998.
15. Hay E, Lemonnier J, Fromigue O, Guenou H, and Marie PJ. Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells. J Biol Chem 279: 1650-1658, 2004.
16. Hill PA, Tumber A, and Meikle MC. Multiple extracellular signals promote osteoblast survival and apoptosis. Endocrinology 138: 3849-3858, 1997.
17. Hock JM, Krishnan V, Onyia JE, Bidwell JP, Milas J, and Stanislaus D. Osteoblast apoptosis and bone turnover. J Bone Miner Res 16: 975-984, 2001.
18. Horowitz MC, Xi Y, Wilson K, and Kacena MA. Control of osteoclastogenesis and bone resorption by members of the TNF family of receptors and ligands. Cytokine Growth Factor Rev 12: 9-18, 2001.
19. Jilka RL, Weinstein RS, Bellido T, Parfitt AM, and Manolagas SC. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res 13: 793-802, 1998.
20. Kagi D, Ho A, Odermatt B, Zakarian A, Ohashi PS, and Mak TW. TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes. J Immunol 162: 4598-4605, 1999.
21. Kitajima I, Soejima Y, Takasaki I, Beppu H, Tokioka T, and Maruyama I. Ceramide-induced nuclear translocation of NF-kappa B is a potential mediator of the apoptotic response to TNF-alpha in murine clonal osteoblasts. Bone 19: 263-270, 1996.
22. Komori T. Requisite roles of Runx2 and Cbfb in skeletal development. J Bone Miner Metab 21: 193-197, 2003.
23. Kon T, Cho TJ, Aizawa T, Yamazaki M, Nooh N, Graves D, Gerstenfeld LC, and Einhorn TA. Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res 16: 1004-1014, 2001.
24. Lewis M, Tartaglia LA, Lee A, Bennett GL, Rice GC, Wong GH, Chen EY, and Goeddel DV. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci USA 88: 2830-2834, 1991.
25. Lian JB, Javed A, Zaidi SK, Lengner C, Montecino M, van Wijnen AJ, Stein JL, and Stein GS. Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit Rev Eukaryot Gene Expr 14: 1-41, 2004.
26. Lian JB and Stein GS. Osteoblast Biology. In: Osteoporosis (2nd ed.), edited by Marcus R, Feldman D, and Kelsey J. San Diego, CA: Academic, 2001, p. 21-72.
27. Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, and Green DR. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Ab1. J Exp Med 182: 1545-1556, 1995.
28. Mogi M and Togari A. Activation of caspases is required for osteoblastic differentiation. J Biol Chem 278: 47477-47482, 2003.
29. Nakashima K and de Crombrugghe B. Transcriptional mechanisms in osteoblast differentiation and bone formation. Trends Genet 19: 458-466, 2003.
30. Nanes MS. Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology. Gene 321: 1-15, 2003.
31. Owen-Schaub LB, De Mars M, Murphy EC Jr, and Grimm EA. TNF-beta (lymphotoxin) strongly upregulates TNF-alpha gene expression in human peripheral blood lymphocytes. Lymphokine Res 9: 491-497, 1990.
32. Pacifici R. Aging and cytokine production. Calcif Tissue Int 65: 345-351, 1999.
33. Pasparakis M, Kousteni S, Peschon J, and Kollias G. Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles. Cell Immunol 201: 33-41, 2000.
34. Pavalko FM, Gerard RL, Ponik SM, Gallagher PJ, Jin Y, and Norvell SM. Fluid shear stress inhibits TNF-alpha-induced apoptosis in osteoblasts: a role for fluid shear stress-induced activation of PI3-kinase and inhibition of caspase-3. J Cell Physiol 194: 194-205, 2003.
35. Peschon JJ, Torrance DS, Stocking KL, Glaccum MB, Otten C, Willis CR, Charrier K, Morrissey PJ, Ware CB, and Mohler KM. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160: 943-952, 1998.
36. Reddy J, Chastagner P, Fiette L, Liu X, and Theze J. IL-2-induced tumor necrosis factor (TNF)-beta expression: further analysis in the IL-2 knockout model, and comparison with TNF-alpha, lymphotoxin-beta, TNFR1 and TNFR2 modulation. Int Immunol 13: 135-147, 2001.
37. Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, and Pacifici R. Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci USA 98: 13960-13965, 2001.
38. Schreyer SA, Peschon JJ, and LeBoeuf RC. Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55. J Biol Chem 271: 26174-26178, 1996.
39. Sheehan KC, Pinckard JK, Arthur CD, Dehner LP, Goeddel DV, and Schreiber RD. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med 181: 607-617, 1995.
40. Smith JR, Hart PH, Coster DJ, and Williams KA. Mice deficient in tumor necrosis factor receptors p55 and p75, interleukin-4, or inducible nitric oxide synthase are susceptible to endotoxin-induced uveitis. Invest Ophthalmol Vis Sci 39: 658-661, 1998.
41. Tanaka S, Nakamura I, Inoue J, Oda H, and Nakamura K. Signal transduction pathways regulating osteoclast differentiation and function. J Bone Miner Metab 21: 123-133, 2003.
42. Tartaglia LA, Goeddel DV, Reynolds C, Figari IS, Weber RF, Fendly BM, and Palladino MA Jr. Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor. J Immunol 151: 4637-4641, 1993.
43. Tartaglia LA, Pennica D, and Goeddel DV. Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J Biol Chem 268: 18542-18548, 1993.
44. Tartaglia LA, Rothe M, Hu YF, and Goeddel DV. Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor. Cell 73: 213-216, 1993.
45. Tartaglia LA, Weber RF, Figari IS, Reynolds C, Palladino MA Jr, and Goeddel DV. The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc Natl Acad Sci USA 88: 9292-9296, 1991.
46. Tamber A, Meikle MC, and Hill PA. Autocrine signals promote osteoblast survival in culture. J Endocrinol 167: 383-390, 2000.
47. Weiss T, Grell M, Hessabi B, Bourteele S, Muller G, Scheurich P, and Wajant H. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site. J Immunol 158: 2398-2404, 1997.
48. Yamada Y, Kirillova I, Peschon JJ, and Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 94: 1441-1446, 1997.
49. Zhang YH, Heulsmann A, Tondravi MM, Mukherjee A, and Abu-Amer Y. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem 276: 563-568, 2001.
50. Zheng L, Fisher G, Miller RE, Peschon J, Lynch DH, and Lenardo MJ. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377: 348-351, 1995.