Glutamate receptors in tendinopathic patients

Journal of Orthopaedic Research

Volumn 30, Issue 9, 2012, Pages 1447-1452

  Schizas, Nikos ^a   Weiss, Rudiger ^a   Lian, Oystein ^b,c   Frihagen, Frede ^d   Bahr, Roald ^b   Ackermann, Paul W ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NORWEGIAN SCHOOL OF SPORT SCIENCES   (Norway)

^c Kristiansund Hospital   (Norway)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

NMDAR1; pain; phospho NMDAR1; substance P; tendinopathy

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMATE RECEPTOR 7; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; SUBSTANCE P;

ADULT; ARTICLE; BIOPSY; BLOOD VESSEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MALE; NERVE FIBER; PATELLA TENDON; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; TENDINITIS; TISSUE DISTRIBUTION;

ADULT; FEMALE; HUMANS; MALE; NERVE TISSUE PROTEINS; PATELLAR LIGAMENT; PHOSPHORYLATION; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SUBSTANCE P; TENDINOPATHY; YOUNG ADULT;

EID: 84863816034     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22094     Document Type: Article

References (34)

1. Rees JD, Maffulli N, Cook J., 2009. Management of tendinopathy. Am J Sports Med 37: 1855-1867.
2. Ackermann PW, Renström P., 2001. Sensory neuropeptides in Achilles tendinosis: transactions of the Third Biennial Congress of the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine. Arthroscopy 17: 516.
3. Ackermann PW, Salo PT, Hart DA., 2009. Neuronal pathways in tendon healing. Front Biosci 14: 5165-5187. Review.
4. Ackermann PW, Ahmed M, Kreicbergs A., 2002. Early nerve regeneration after Achilles tendon rupture: a prerequisite for healing? A study in the rat. J Orthop Res 20: 849-856. (Pubitemid 34823008)
5. Ackermann PW, Li J, Lundeberg T, et al. 2003. Neuronal plasticity in relation to nociception and healing of rat Achilles tendon. J Orthop Res 21: 432-441. (Pubitemid 36546809)
6. Schizas N, Lian O, Frihagen F, et al. 2010. Coexistence of up-regulated NMDA receptor 1 and glutamate on nerves, vessels and transformed tenocytes in tendinopathy. Scand J Med Sci Sports 20: 208-215.
7. Madden DR., 2002. The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 3: 91-101. (Pubitemid 135706578)
8. Besson JM., 1999. The neurobiology of pain. Lancet 353: 1610-1615. (Pubitemid 29219221)
9. Lian O, Dahl J, Ackermann PW, et al. 2006. Pronociceptive and antinociceptive neuromediators in patellar tendinopathy. Am J Sports Med 34: 1801-1808. (Pubitemid 44735520)
10. Aniksztejn L, Otani S, Ben-Ari Y., 1992. Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term potentiation through protein kinase C. Eur J Neurosci 4: 500-505.
11. Bruno V, Copani A, Knöpfel T, et al. 1995. Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells. Neuropharmacology 34: 1089-1098.
12. Fitzjohn SM, Irving AJ, Palmer MJ, et al. 1996. Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices. Neurosci Lett 203: 211-213. (Pubitemid 26040212)
13. Schrader LA, Tasker JG., 1997. Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons. J Neurophysiol 77: 527-536. (Pubitemid 27087756)
14. Blazina ME, Kerlan RK, Jobe FW, et al. 1973. Jumper's knee. Orthop Clin North Am 4: 665-673.
15. Roels J, Martens M, Mulier JC, et al. 1978. Patellar tendinitis (jumper's knee). Am J Sports Med 6: 362-368. (Pubitemid 9073752)
16. Visentini PJ, Khan KM, Cook JL, et al. 1998. The VISA score: an index of severity of symptoms in patients with jumper's knee (patellar tendinosis). J Sci Med Sport 1: 22-28. (Pubitemid 28255464)
17. Marc RE, Liu WL, Kalloniatis M, et al. 1990. Patterns of glutamate immunoreactivity in the goldfish retina. J Neurosci 10: 4006-4034.
18. Siegel SJ, Brose N, Janssen WG, et al. 1994. Regional, cellular, and ultrastructural distribution of N-methyl- D -aspartate receptor subunit 1 in monkey hippocampus. Proc Natl Acad Sci USA 91: 564-568.
19. Billig I, Card JP, Yates BJ., 2003. Neurochemical phenotypes of MRF neurons influencing diaphragm and rectus abdominis activity. J Appl Physiol 94: 390.
20. Hinoi E, Yoneda Y., 2011. Possible involvement of glutamatergic signaling machineries in pathophysiology of rheumatoid arthritis. J Pharmacol Sci 116: 248-256. Review.
21. Skerry TM., 2008. The role of glutamate in the regulation of bone mass and architecture. J Musculoskelet Neuronal Interact 8: 166-173. Review.
22. Ayesh E, Jensen T, Svensson P., 2008. Effects of intra-articular ketamine on pain and somatosensory function in temporomandibular joint arthralgia patients. Pain 137: 286-294. (Pubitemid 351858605)
23. Nakanishi S., 1992. Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603. Review.
24. Ascher P, Bregestovski P, Nowak L., 1988. N-methyl- D -aspartate-activated channels of mouse central neurones in magnesium-free solutions. J Physiol 399: 207-226.
25. Liu H, Mantyh PW, Basbaum AI., 1997. NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature 386: 721-724. (Pubitemid 27193493)
26. McRoberts JA, Coutinho SV, Marvizõn JC, et al. 2001. Role of peripheral N-methyl- D -aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 120: 1737-1748. (Pubitemid 32523492)
27. Nazarian A, Gu G, Gracias NG, et al. 2008. Spinal N-methyl- D -aspartate receptors and nociception-evoked release of primary afferent substance P. Neuroscience 152: 119-127.
28. Burssens P, Steyaert A, Forsyth R, et al. 2005. Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing. Foot Ankle Int 26: 832-839. (Pubitemid 41428819)
29. Backman LJ, Fong G, Andersson G, et al. 2011. Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation. PLoS One 6: e27209.
30. Schubert TE, Weidler C, Lerch K, et al. 2005. Achilles tendinosis is associated with sprouting of substance P positive nerve fibres. Ann Rheum Dis 64: 1083-1086. (Pubitemid 40909529)
31. Andersson G, Backman LJ, Scott A, et al. 2011. Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model. Br J Sports Med 45: 1017-1022.
32. Alfredson H, Forsgren S, Thorsen K, et al. 2001. In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper's knee. J Orthop Res 19: 881-886. (Pubitemid 32799078)
33. Scott A, Alfredson H, Forsgren S., 2008. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. J Orthop Res 26: 685-692.
34. Alfredson H, Lorentzon R., 2003. Intratendinous glutamate levels and eccentric training in chronic Achilles tendinosis: a prospective study using microdialysis technique. Knee Surg Sports Traumatol Arthrosc 11: 196-199. (Pubitemid 38249647)