Possible involvement of glutamatergic signaling machineries in pathophysiology of rheumatoid arthritis

Journal of Pharmacological Sciences

Volumn 116, Issue 3, 2011, Pages 248-256

  Hinoi, Eiichi ^a   Yoneda, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Glutamate; Glutamate receptor; Glutamate transporter; Rheumatoid arthritis; Synovial fibroblast

Indexed keywords

COLLAGEN; EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; EXCITATORY AMINO ACID TRANSPORTER 4; EXCITATORY AMINO ACID TRANSPORTER 5; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; VESICULAR GLUTAMATE TRANSPORTER 1; VESICULAR GLUTAMATE TRANSPORTER 2; VESICULAR GLUTAMATE TRANSPORTER 3;

AUTOCRINE EFFECT; BONE DESTRUCTION; BONE TISSUE; CARTILAGE CELL; CELL FUNCTION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CHONDROGENESIS; EXOCYTOSIS; EXPERIMENTAL STUDY; FIBROBLAST; HUMAN; HYPERALGESIA; INTRACELLULAR SIGNALING; JOINT DESTRUCTION; MACROPHAGE ACTIVATION; MOLECULAR DYNAMICS; NEUROTRANSMISSION; NONHUMAN; OSSIFICATION; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID LEVEL;

EID: 79960407981     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11R03CR     Document Type: Review

References (67)

1. Hollmann M, O'Shea-Greenfield A, Rogers SW, Heinemann S. Cloning by functional expression of a member of the glutamate receptor family. Nature. 1989;342:643-648. (Pubitemid 20001579)
2. Nakanishi N, Shneider NA, Axel R. A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron. 1990;5:569-581.
3. Yoneda Y, Kuramoto N, Kitayama T, Hinoi E. Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain. Prog Neurobiol. 2001;63:697-719. (Pubitemid 32119424)
4. Scheetz AJ, Constantine-Paton M. Modulation of NMDA receptor function: implications for vertebrate neural development. FASEB J. 1994;8:745-752. (Pubitemid 24229769)
5. Riedel G, Platt B, Micheau J. Glutamate receptor function in learning and memory. Behav Brain Res. 2003;140:1-47. (Pubitemid 36313239)
6. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1988;1:623-634.
7. Goff DC, Wine L. Glutamate in schizophrenia: clinical and research implications. Schizophr Res. 1997;27:157-168. (Pubitemid 27512852)
8. Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol. 2001; 11:327-335. (Pubitemid 32524098)
9. Wisden W, Seeburg PH. Mammalian ionotropic glutamate receptors. Curr Opin Neurobiol. 1993;3:291-298. (Pubitemid 23210937)
10. Hollmann M, Heinemann S. Cloned glutamate receptors. Ann Rev Neurosci. 1994;17:31-108. (Pubitemid 24117025)
11. Reynolds IJ, Miller RJ. Multiple sites for the regulation of the N-methyl-D-aspartate receptor. Mol Pharmacol. 1988;33:581-584.
12. MacDonald JF, Nowak LM. Mechanisms of blockade of excitatory amino acid receptor channels. Trends Pharmacol Sci. 1990;11:167-172. (Pubitemid 20118011)
13. Masu M, Tanabe Y, Tsutida K, Shigemoto R, Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature. 1991;349:760-765. (Pubitemid 21912156)
14. Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 1992;8:169-179.
15. +-dependent glutamate/ aspartate transporter from rat brain. Proc Natl Acad Sci U S A. 1992;89:10955-10959.
16. Tanaka K. Cloning and expression of a glutamate transporter from mouse brain. Neurosci Lett. 1993;159:183-186. (Pubitemid 23283269)
17. Pines G, Danbolt NC, Bjoras M, Zhang Y, Bendahan A, Eide L, et al. Cloning and expression of a rat brain L-glutamate transporter. Nature. 1992;360:464-467.
18. Kanai Y, Hediger MA. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 1992; 360:467-471.
19. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 1995;375:599-603.
20. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci U S A. 1997;94: 4155-4160. (Pubitemid 27180515)
21. Lehre KP, Levy LM, Ottersen OP, Storm-Mathisen J, Danbolt NC. Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J Neurosci. 1995;15:1835-1853.
22. Kanai Y, Bhide PG, DiFiglia M, Hediger MA. Neuronal highaffinity glutamate transport in the rat central nervous system. Neuroreport. 1995;6:2357-2362. (Pubitemid 26013125)
23. Pow DV, Barnett NL. Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina. Neurosci Lett. 2000;280:21-24. (Pubitemid 30069564)
24. Sato H, Tamba M, Ishii T, Bannai S. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem. 1999;274:11455-11458.
25. Kato S, Negishi K, Mawatari K, Kuo CH. A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion. Neuroscience. 1992;48:903-914.
26. Sato H, Fujiwara K, Sagara J, Bannai S. Induction of cystine transport activity in mouse peritoneal macrophages by bacterial lipopolysaccharide. Biochem J. 1995;310:547-551.
27. Kaneko T, Fujiyama F. Complementary distribution of vesicular glutamate transporters in the central nervous system. Neurosci Res. 2002;42:243-250. (Pubitemid 34414984)
28. Fremeau RT Jr, Burman J, Qureshi T, Tran CH, Proctor J, Johnson J, et al. The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate. Proc Natl Acad Sci U S A. 2002;99:14488-14493. (Pubitemid 35257698)
29. Ducy P, Schinke T, Karsenty G. The osteoblast: a sophisticated fibroblast under central surveillance. Science. 2000;289:1501-1504.
30. Teitelbaum SL. Bone resorption by osteoclasts. Science. 2000; 289:1504-1508.
31. Karsenty G, Kronenberg HM, Settembre C. Genetic control of bone formation. Annu Rev Dev Biol. 2009;25:629-648.
32. Hinoi E, Fujimori S, Takemori A, Kurabayashi H, Nakamura Y, Yoneda Y. Demonstration of expression of mRNA for particular AMPA and kainate receptor subunits in immature and mature cultured rat calvarial osteoblasts. Brain Res. 2002;943:112-116. (Pubitemid 34671179)
33. Genever PG, Skerry TM. Regulation of spontaneous glutamate release activity in osteoblastic cells and its role in differentiation and survival: evidence for intrinsic glutamatergic signaling in bone. FASEB J. 2001;15:1586-1588.
34. Hinoi E, Fujimori S, Takarada T, Taniura H, Yoneda Y. Facilitation of glutamate release by ionotropic glutamate receptors in osteoblasts. Biochem Biophys Res Commun. 2002;297:452-458.
35. Chenu C, Serre CM, Raynal C, Burt-Pichat B, Delmas PD. Glutamate receptors are expressed by bone cells and are involved in bone resorption. Bone. 1998;22:295-299. (Pubitemid 28177180)
36. Peet NM, Grabowski PS, Laketic-Ljubojevic I, Skerry TM. The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation. FASEB J. 1999;13:2179-2185.
37. Laketic-Ljubojevic I, Suva LJ, Maathuis FJ, Sanders D, Skerry TM. Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells. Bone. 1999;25:631-637. (Pubitemid 29525428)
38. Hinoi E, Fujimori S, Yoneda Y. Modulation of cellular differentiation by N-methyl-D-aspartate receptors in osteoblasts. FASEB J. 2003;17:1532-1534.
39. Hinoi E, Fujimori S, Nakamura Y, Yoneda Y. Group III metabotropic glutamate receptors in rat cultured calvarial osteoblasts. Biochem Biophys Res Commun. 2001;281:341-346. (Pubitemid 32928160)
40. Gray C, Marie H, Arora M, Tanaka K, Boyde A, Jones S, et al. Glutamate does not play a major role in controlling bone growth. J Bone Miner Res. 2001;16:742-749. (Pubitemid 32230603)
41. Mason DJ, Suva LJ, Genever PG, Patton AJ, Steuckle S, Hillam RA, et al. Mechanically regulated expression of a neural glutamate transporter in bone: a role for excitatory amino acids as osteotropic agents? Bone. 1997;20:199-205.
42. Hinoi E, Takarada T, Uno K, Inoue M, Murafuji Y, Yoneda Y. Glutamate suppresses osteoclastogenesis through the cystine/ glutamate antiporter. Am J Pathol. 2007;170:1277-1290. (Pubitemid 47339335)
43. Uno K, Takarada T, Nakamura Y, Fujita H, Hinoi E, Yoneda Y. A negative correlation between expression profiles of runt-related transcription factor-2 and cystine/glutamate antiporter xCT subunit in ovariectomized mouse bone. J Pharmacol Sci. 2011;115:309-319.
44. Karsenty G. The complexities of skeletal biology. Nature. 2003; 423:316-318. (Pubitemid 40852704)
45. Kronenberg HM. Developmental regulation of the growth plate. Nature. 2003;423:332-336. (Pubitemid 40852707)
46. Wang L, Hinoi E, Takemori A, Takarada T, Yoneda Y. Abolition of chondral mineralization by group III metabotropic glutamate receptors expressed in rodent cartilage. Br J Pharmacol. 2005; 146:732-743. (Pubitemid 41573624)
47. Wang L, Hinoi E, Takemori A, Yoneda Y. Release of endogenous glutamate by AMPA receptors expressed in cultured rat costal chondrocytes. Biol Pharm Bull. 2005;28:990-993. (Pubitemid 40880302)
48. Hinoi E, Wang L, Takemori A, Yoneda Y. Functional expression of particular isoforms of excitatory amino acid transporters by rodent cartilage. Biochem Pharmacol. 2005;70:70-81. (Pubitemid 40797872)
49. Wang L, Hinoi E, Takemori A, Nakamichi N, Yoneda Y. Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter. J Biol Chem. 2006;281:24553- 24565. (Pubitemid 44274230)
50. Cerhan JR, Saag KG, Merlino LA, Kikuls TR, Criwell LA. Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol. 2003;157:345-354. (Pubitemid 36193937)
51. Hagfors L, Leanderson P, Sköldstam L, Andersson J, Johansson G. Antioxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis. Nutr J. 2003;2:5.
52. Feldmann M. Pathogenesis of arthritis: recent research progress. Nat Immunol. 2001;2:771-773.
53. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423:356-361. (Pubitemid 40852711)
54. Wooley PH, Luthra HS, Stuart JM, David CS. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J Exp Med. 1981; 154:688-700.
55. Sasakawa T, Sasakawa Y, Ohkubo Y, Mutoh S. FK506 ameliorates spontaneous locomotor activity in collagen-induced arthritis: implication of distinct effect from suppression of inflammation. Int Immunopharmacol. 2005;5:503-510. (Pubitemid 40430758)
56. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977; 146:857-868. (Pubitemid 8175993)
57. Hinoi E, Ohashi R, Miyata S, Kato Y, Iemata M, Hojo H, et al. Excitatory amino acid transporters expressed by synovial fibroblasts in rats with collagen-induced arthritis. Biochem Pharmacol. 2005;70:1744-1755. (Pubitemid 41612005)
58. Zimmermann T, Kunisch E, Pfeiffer R, Hirth A, Stahl HD, Sack U, et al. Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture - primary culture cells markedly differ from fourth-passage cells. Arthritis Res. 2001; 3:72-76. (Pubitemid 32223808)
59. Seto H, Kamekura S, Miura T, Yamamoto A, Chikuda H, Ogata T, et al. Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts. J Clin Invest. 2004;113:718-726. (Pubitemid 38544165)
60. Burmester GR, Dimitriu-Bona A, Waters SJ, Winchester RJ. Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts. Scand J Immunol. 1983;17:69-82. (Pubitemid 13177793)
61. Takayanagi H, Oda H, Yamamoto S, Kawaguchi H, Tanaka S, Nishikawa T, et al. A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis. Biochem Biophys Res Commun. 1997;240:279-286. (Pubitemid 27523651)
62. McNearney T, Speegle D, Lawand N, Lisse J, Westlund KN. Excitatory amino acid profiles of synovial fluid from patients with arthritis. J Rheumatol. 2000;27:739-745. (Pubitemid 30151357)
63. Lawand NB, McNearney T, Westlund KN. Amino acid release into the knee joint: key role in nociception and inflammation. Pain. 2000;86:69-74. (Pubitemid 30211704)
64. McNearney T, Baethge BA, Cao S, Alam R, Lisse JR, Westlund KN. Excitatory amino acids, TNF-alpha, and chemokine levels in synovial fluids of patients with active arthropathies. Clin Exp Immunol. 2004;137:621-627.
65. Tak PP, Bresnihan B. The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis. Arthritis Rheum. 2000;43:2619-2633. (Pubitemid 32001727)
66. Hofbauer LC, Heufelder AE. The role of osteoprotegerin and receptor activator of nuclear factor kappaB ligand in the pathogenesis and treatment of rheumatoid arthritis. Arthritis Rheum. 2001;44:253-259. (Pubitemid 32207017)
67. Kaneko M, Tomita T, Nakase T, Ohsawa Y, Seki H, Takeuchi E, et al. Expression of proteinases and inflammatory cytokines in subchondral bone regions in the destructive joint of rheumatoid arthritis. Rheumatology (Oxford). 2001;40:247-255.