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Volumn 6, Issue 11, 2011, Pages

Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROKININ 1 RECEPTOR; SUBSTANCE P; TENOMODULIN; UNCLASSIFIED DRUG; VIMENTIN;

EID: 80055121883     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027209     Document Type: Article
Times cited : (71)

References (49)
  • 1
    • 0032785647 scopus 로고    scopus 로고
    • Histopathology of common tendinopathies. Update and implications for clinical management
    • Khan KM, Cook JL, Bonar F, Harcourt P, Astrom M, (1999) Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med 27: 393-408.
    • (1999) Sports Med , vol.27 , pp. 393-408
    • Khan, K.M.1    Cook, J.L.2    Bonar, F.3    Harcourt, P.4    Astrom, M.5
  • 2
    • 65349179541 scopus 로고    scopus 로고
    • Reviving the "biochemical" hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances
    • Danielson P, (2009) Reviving the "biochemical" hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances. Br J Sports Med 43: 265-268.
    • (2009) Br J Sports Med , vol.43 , pp. 265-268
    • Danielson, P.1
  • 3
    • 0034065956 scopus 로고    scopus 로고
    • Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin
    • Khan KM, Cook JL, Maffulli N, Kannus P, (2000) Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin. Br J Sports Med 34: 81-83.
    • (2000) Br J Sports Med , vol.34 , pp. 81-83
    • Khan, K.M.1    Cook, J.L.2    Maffulli, N.3    Kannus, P.4
  • 4
    • 38348999392 scopus 로고    scopus 로고
    • Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy)
    • Bjur D, Danielson P, Alfredson H, Forsgren S, (2008) Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). Cell Tissue Res 331: 385-400.
    • (2008) Cell Tissue Res , vol.331 , pp. 385-400
    • Bjur, D.1    Danielson, P.2    Alfredson, H.3    Forsgren, S.4
  • 5
    • 33750009187 scopus 로고    scopus 로고
    • Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis
    • Danielson P, Alfredson H, Forsgren S, (2006) Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc Res Tech 69: 808-819.
    • (2006) Microsc Res Tech , vol.69 , pp. 808-819
    • Danielson, P.1    Alfredson, H.2    Forsgren, S.3
  • 6
    • 34249279453 scopus 로고    scopus 로고
    • Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis-a pilot study
    • Danielson P, Andersson G, Alfredson H, Forsgren S, (2007) Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis-a pilot study. Life Sci 80: 2235-2238.
    • (2007) Life Sci , vol.80 , pp. 2235-2238
    • Danielson, P.1    Andersson, G.2    Alfredson, H.3    Forsgren, S.4
  • 7
    • 38449112301 scopus 로고    scopus 로고
    • Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon
    • Bjur D, Danielson P, Alfredson H, Forsgren S, (2008) Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon. Histol Histopathol 23: 197-208.
    • (2008) Histol Histopathol , vol.23 , pp. 197-208
    • Bjur, D.1    Danielson, P.2    Alfredson, H.3    Forsgren, S.4
  • 8
    • 34147194902 scopus 로고    scopus 로고
    • Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man
    • Danielson P, Alfredson H, Forsgren S, (2007) Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. Microsc Res Tech 70: 310-324.
    • (2007) Microsc Res Tech , vol.70 , pp. 310-324
    • Danielson, P.1    Alfredson, H.2    Forsgren, S.3
  • 9
    • 35148823531 scopus 로고    scopus 로고
    • In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis
    • Danielson P, Alfredson H, Forsgren S, (2007) In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis. Microsc Res Tech 70: 908-911.
    • (2007) Microsc Res Tech , vol.70 , pp. 908-911
    • Danielson, P.1    Alfredson, H.2    Forsgren, S.3
  • 10
    • 43649100743 scopus 로고    scopus 로고
    • VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes
    • Scott A, Alfredson H, Forsgren S, (2008) VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes. J Orthop Res 26: 685-692.
    • (2008) J Orthop Res , vol.26 , pp. 685-692
    • Scott, A.1    Alfredson, H.2    Forsgren, S.3
  • 11
    • 51249116922 scopus 로고    scopus 로고
    • Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon
    • Andersson G, Danielson P, Alfredson H, Forsgren S, (2008) Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regul Pept 150: 81-87.
    • (2008) Regul Pept , vol.150 , pp. 81-87
    • Andersson, G.1    Danielson, P.2    Alfredson, H.3    Forsgren, S.4
  • 12
    • 0027281553 scopus 로고
    • Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists
    • Fan TP, Hu DE, Guard S, Gresham GA, Watling KJ, (1993) Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol 110: 43-49.
    • (1993) Br J Pharmacol , vol.110 , pp. 43-49
    • Fan, T.P.1    Hu, D.E.2    Guard, S.3    Gresham, G.A.4    Watling, K.J.5
  • 13
    • 26444483368 scopus 로고    scopus 로고
    • Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing
    • Burssens P, Steyaert A, Forsyth R, van Ovost EJ, Depaepe Y, et al. (2005) Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing. Foot Ankle Int 26: 832-839.
    • (2005) Foot Ankle Int , vol.26 , pp. 832-839
    • Burssens, P.1    Steyaert, A.2    Forsyth, R.3    van Ovost, E.J.4    Depaepe, Y.5
  • 14
    • 79960213474 scopus 로고    scopus 로고
    • Substance P injections enhance tissue proliferation and regulate sensory nerve ingrowth in rat tendon repair
    • Carlsson O, Schizas N, Li J, Ackermann PW, (2011) Substance P injections enhance tissue proliferation and regulate sensory nerve ingrowth in rat tendon repair. Scand J Med Sci Sports 21: 562-569.
    • (2011) Scand J Med Sci Sports , vol.21 , pp. 562-569
    • Carlsson, O.1    Schizas, N.2    Li, J.3    Ackermann, P.W.4
  • 16
    • 21344457464 scopus 로고    scopus 로고
    • Achilles tendinosis is associated with sprouting of substance P positive nerve fibres
    • Schubert TE, Weidler C, Lerch K, Hofstadter F, Straub RH, (2005) Achilles tendinosis is associated with sprouting of substance P positive nerve fibres. Ann Rheum Dis 64: 1083-1086.
    • (2005) Ann Rheum Dis , vol.64 , pp. 1083-1086
    • Schubert, T.E.1    Weidler, C.2    Lerch, K.3    Hofstadter, F.4    Straub, R.H.5
  • 17
    • 12344283092 scopus 로고    scopus 로고
    • Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens
    • Forsgren S, Danielson P, Alfredson H, (2005) Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens. Regul Pept 126: 173-181.
    • (2005) Regul Pept , vol.126 , pp. 173-181
    • Forsgren, S.1    Danielson, P.2    Alfredson, H.3
  • 18
    • 0029057535 scopus 로고
    • The mammalian tachykinin receptors
    • Maggi CA, (1995) The mammalian tachykinin receptors. General pharmacology 26: 911-944.
    • (1995) General Pharmacology , vol.26 , pp. 911-944
    • Maggi, C.A.1
  • 19
    • 34250814224 scopus 로고    scopus 로고
    • Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression
    • New DC, Wong YH, (2007) Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression. J Mol Signal 2: 2.
    • (2007) J Mol Signal , vol.2 , pp. 2
    • New, D.C.1    Wong, Y.H.2
  • 20
    • 8544273762 scopus 로고    scopus 로고
    • Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes
    • Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C, (2004) Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem 279: 45519-45527.
    • (2004) J Biol Chem , vol.279 , pp. 45519-45527
    • Koon, H.W.1    Zhao, D.2    Na, X.3    Moyer, M.P.4    Pothoulakis, C.5
  • 21
    • 26444540799 scopus 로고    scopus 로고
    • Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta
    • Yamaguchi K, Richardson MD, Bigner DD, Kwatra MM, (2005) Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta. Cancer Chemother Pharmacol 56: 585-593.
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 585-593
    • Yamaguchi, K.1    Richardson, M.D.2    Bigner, D.D.3    Kwatra, M.M.4
  • 22
    • 16644377247 scopus 로고    scopus 로고
    • Tenocyte response to cyclical strain and transforming growth factor beta is dependent upon age and site of origin
    • Goodman SA, May SA, Heinegard D, Smith RK, (2004) Tenocyte response to cyclical strain and transforming growth factor beta is dependent upon age and site of origin. Biorheology 41: 613-628.
    • (2004) Biorheology , vol.41 , pp. 613-628
    • Goodman, S.A.1    May, S.A.2    Heinegard, D.3    Smith, R.K.4
  • 23
    • 2942624012 scopus 로고    scopus 로고
    • Integrin-dependent signal cascades in chondrocyte mechanotransduction
    • Millward-Sadler SJ, Salter DM, (2004) Integrin-dependent signal cascades in chondrocyte mechanotransduction. Ann Biomed Eng 32: 435-446.
    • (2004) Ann Biomed Eng , vol.32 , pp. 435-446
    • Millward-Sadler, S.J.1    Salter, D.M.2
  • 24
    • 79952508776 scopus 로고    scopus 로고
    • Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms
    • Andersson G, Forsgren S, Scott A, Gaida JE, Stjernfeldt JE, et al. (2011) Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms. Br J Sports Med 45: 399-406.
    • (2011) Br J Sports Med , vol.45 , pp. 399-406
    • Andersson, G.1    Forsgren, S.2    Scott, A.3    Gaida, J.E.4    Stjernfeldt, J.E.5
  • 25
    • 0025455630 scopus 로고
    • Chronic achilles paratenonitis with tendinosis: an experimental model in the rabbit
    • Backman C, Boquist L, Friden J, Lorentzon R, Toolanen G, (1990) Chronic achilles paratenonitis with tendinosis: an experimental model in the rabbit. J Orthop Res 8: 541-547.
    • (1990) J Orthop Res , vol.8 , pp. 541-547
    • Backman, C.1    Boquist, L.2    Friden, J.3    Lorentzon, R.4    Toolanen, G.5
  • 26
    • 79958044926 scopus 로고    scopus 로고
    • Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes
    • Backman LJ, Andersson G, Wennstig G, Forsgren S, Danielson P, (2011) Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy-peptidergic elevation preceding tendinosis-like tissue changes. J Musculoskelet Neuronal Interact 11: 133-140.
    • (2011) J Musculoskelet Neuronal Interact , vol.11 , pp. 133-140
    • Backman, L.J.1    Andersson, G.2    Wennstig, G.3    Forsgren, S.4    Danielson, P.5
  • 27
    • 80052965845 scopus 로고    scopus 로고
    • Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model
    • Andersson G, Backman LJ, Scott A, Lorentzon R, Forsgren S, et al. (2011) Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model. Br J Sports Med 45: 1017-1022.
    • (2011) Br J Sports Med , vol.45 , pp. 1017-1022
    • Andersson, G.1    Backman, L.J.2    Scott, A.3    Lorentzon, R.4    Forsgren, S.5
  • 29
    • 33846932726 scopus 로고    scopus 로고
    • Substance P mediates antiapoptotic responses in human colonocytes by Akt activation
    • Koon HW, Zhao D, Zhan Y, Moyer MP, Pothoulakis C, (2007) Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proc Natl Acad Sci U S A 104: 2013-2018.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2013-2018
    • Koon, H.W.1    Zhao, D.2    Zhan, Y.3    Moyer, M.P.4    Pothoulakis, C.5
  • 30
    • 45049088695 scopus 로고    scopus 로고
    • The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells
    • Corps AN, Jones GC, Harrall RL, Curry VA, Hazleman BL, et al. (2008) The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells. Matrix Biol 27: 393-401.
    • (2008) Matrix Biol , vol.27 , pp. 393-401
    • Corps, A.N.1    Jones, G.C.2    Harrall, R.L.3    Curry, V.A.4    Hazleman, B.L.5
  • 32
    • 67649515664 scopus 로고    scopus 로고
    • In vitro model to study chondrogenic differentiation in tendinopathy
    • de Mos M, Koevoet W, van Schie HT, Kops N, Jahr H, et al. (2009) In vitro model to study chondrogenic differentiation in tendinopathy. Am J Sports Med 37: 1214-1222.
    • (2009) Am J Sports Med , vol.37 , pp. 1214-1222
    • de Mos, M.1    Koevoet, W.2    van Schie, H.T.3    Kops, N.4    Jahr, H.5
  • 33
    • 0004208569 scopus 로고    scopus 로고
    • Human tendons: Anatomy, physiology, and pathology
    • Champaign, IL, USA, Human Kinetics
    • Józsa L, Kannus P, (1997) Human tendons: Anatomy, physiology, and pathology. Champaign, IL, USA Human Kinetics.
    • (1997)
    • Józsa, L.1    Kannus, P.2
  • 34
    • 0023111250 scopus 로고
    • Chronic Achilles paratenonitis in athletes: a histological and histochemical study
    • Kvist M, Jozsa L, Jarvinen MJ, Kvist H, (1987) Chronic Achilles paratenonitis in athletes: a histological and histochemical study. Pathology 19: 1-11.
    • (1987) Pathology , vol.19 , pp. 1-11
    • Kvist, M.1    Jozsa, L.2    Jarvinen, M.J.3    Kvist, H.4
  • 35
    • 77149147093 scopus 로고    scopus 로고
    • Characterization of differential properties of rabbit tendon stem cells and tenocytes
    • Zhang J, Wang JH, (2010) Characterization of differential properties of rabbit tendon stem cells and tenocytes. BMC Musculoskelet Disord 11: 10.
    • (2010) BMC Musculoskelet Disord , vol.11 , pp. 10
    • Zhang, J.1    Wang, J.H.2
  • 36
    • 0027049229 scopus 로고
    • Development and ageing of phenotypically distinct fibrocartilages associated with the rat Achilles tendon
    • Rufai A, Benjamin M, Ralphs JR, (1992) Development and ageing of phenotypically distinct fibrocartilages associated with the rat Achilles tendon. Anat Embryol (Berl) 186: 611-618.
    • (1992) Anat Embryol (Berl) , vol.186 , pp. 611-618
    • Rufai, A.1    Benjamin, M.2    Ralphs, J.R.3
  • 37
    • 11844286305 scopus 로고    scopus 로고
    • Tenomodulin is necessary for tenocyte proliferation and tendon maturation
    • Docheva D, Hunziker EB, Fassler R, Brandau O, (2005) Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol 25: 699-705.
    • (2005) Mol Cell Biol , vol.25 , pp. 699-705
    • Docheva, D.1    Hunziker, E.B.2    Fassler, R.3    Brandau, O.4
  • 38
    • 73949130816 scopus 로고    scopus 로고
    • Tendon-selective genes identified from rat and human musculoskeletal tissues
    • Jelinsky SA, Archambault J, Li L, Seeherman H, (2010) Tendon-selective genes identified from rat and human musculoskeletal tissues. J Orthop Res 28: 289-297.
    • (2010) J Orthop Res , vol.28 , pp. 289-297
    • Jelinsky, S.A.1    Archambault, J.2    Li, L.3    Seeherman, H.4
  • 39
    • 33748765254 scopus 로고    scopus 로고
    • Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes
    • Shukunami C, Takimoto A, Oro M, Hiraki Y, (2006) Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes. Dev Biol 298: 234-247.
    • (2006) Dev Biol , vol.298 , pp. 234-247
    • Shukunami, C.1    Takimoto, A.2    Oro, M.3    Hiraki, Y.4
  • 40
    • 0036995410 scopus 로고    scopus 로고
    • Expression of substance P and its neurokinin-1 receptor on thymocytes: functional relevance in the regulation of thymocyte apoptosis and proliferation
    • Santoni G, Amantini C, Lucciarini R, Pompei P, Perfumi M, et al. (2002) Expression of substance P and its neurokinin-1 receptor on thymocytes: functional relevance in the regulation of thymocyte apoptosis and proliferation. Neuroimmunomodulation 10: 232-246.
    • (2002) Neuroimmunomodulation , vol.10 , pp. 232-246
    • Santoni, G.1    Amantini, C.2    Lucciarini, R.3    Pompei, P.4    Perfumi, M.5
  • 41
    • 73949113573 scopus 로고    scopus 로고
    • Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury
    • Fedorczyk JM, Barr AE, Rani S, Gao HG, Amin M, et al. (2010) Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. J Orthop Res 28: 298-307.
    • (2010) J Orthop Res , vol.28 , pp. 298-307
    • Fedorczyk, J.M.1    Barr, A.E.2    Rani, S.3    Gao, H.G.4    Amin, M.5
  • 42
    • 50449086944 scopus 로고    scopus 로고
    • Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor
    • Lai JP, Lai S, Tuluc F, Tansky MF, Kilpatrick LE, et al. (2008) Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. Proc Natl Acad Sci U S A 105: 12605-12610.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 12605-12610
    • Lai, J.P.1    Lai, S.2    Tuluc, F.3    Tansky, M.F.4    Kilpatrick, L.E.5
  • 43
    • 34547547971 scopus 로고    scopus 로고
    • Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor
    • Tansky MF, Pothoulakis C, Leeman SE, (2007) Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci U S A 104: 10691-10696.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10691-10696
    • Tansky, M.F.1    Pothoulakis, C.2    Leeman, S.E.3
  • 44
    • 0030047123 scopus 로고    scopus 로고
    • Different levels of sensory neuropeptides (calcitonin gene-related peptide and substance P) during and after exercise in man
    • Lind H, Brudin L, Lindholm L, Edvinsson L, (1996) Different levels of sensory neuropeptides (calcitonin gene-related peptide and substance P) during and after exercise in man. Clin Physiol 16: 73-82.
    • (1996) Clin Physiol , vol.16 , pp. 73-82
    • Lind, H.1    Brudin, L.2    Lindholm, L.3    Edvinsson, L.4
  • 46
    • 0036894881 scopus 로고    scopus 로고
    • A novel mechanism of neurokinin-1 receptor resensitization
    • Bennett VJ, Perrine SA, Simmons MA, (2002) A novel mechanism of neurokinin-1 receptor resensitization. J Pharmacol Exp Ther 303: 1155-1162.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 1155-1162
    • Bennett, V.J.1    Perrine, S.A.2    Simmons, M.A.3
  • 47
    • 0029978313 scopus 로고    scopus 로고
    • Interaction of substance P with epidermal growth factor and fibroblast growth factor in cyclooxygenase-dependent proliferation of human skin fibroblasts
    • Kahler CM, Herold M, Reinisch N, Wiedermann CJ, (1996) Interaction of substance P with epidermal growth factor and fibroblast growth factor in cyclooxygenase-dependent proliferation of human skin fibroblasts. J Cell Physiol 166: 601-608.
    • (1996) J Cell Physiol , vol.166 , pp. 601-608
    • Kahler, C.M.1    Herold, M.2    Reinisch, N.3    Wiedermann, C.J.4
  • 48
    • 0027261157 scopus 로고
    • Substance P: a competence factor for human fibroblast proliferation that induces the release of growth-regulatory arachidonic acid metabolites
    • Kahler CM, Herold M, Wiedermann CJ, (1993) Substance P: a competence factor for human fibroblast proliferation that induces the release of growth-regulatory arachidonic acid metabolites. J Cell Physiol 156: 579-587.
    • (1993) J Cell Physiol , vol.156 , pp. 579-587
    • Kahler, C.M.1    Herold, M.2    Wiedermann, C.J.3
  • 49
    • 77954569119 scopus 로고    scopus 로고
    • Qualitative analysis of substance P, NK1-receptor and nerve ingrowth in substance P-treated ruptured rat Achilles tendon
    • Steyaert A, Burssens P, Forsyth R, Vanderstraeten G, (2010) Qualitative analysis of substance P, NK1-receptor and nerve ingrowth in substance P-treated ruptured rat Achilles tendon. Acta Orthop Belg 76: 387-395.
    • (2010) Acta Orthop Belg , vol.76 , pp. 387-395
    • Steyaert, A.1    Burssens, P.2    Forsyth, R.3    Vanderstraeten, G.4


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