Pronociceptive and antinociceptive neuromediators in patellar tendinopathy

American Journal of Sports Medicine

Volumn 34, Issue 11, 2006, Pages 1801-1808

  Lian, Øystein ^a,b   Dahl, Johan ^c   Ackermann, Paul W ^c   Frihagen, Frede ^d   Engebretsen, Lars ^a,d   Bahr, Roald ^a  

^a NORWEGIAN SCHOOL OF SPORT SCIENCES   (Norway)

^b Kristiansund Hospital   (Norway)

^c KAROLINSKA INSTITUTE   (Sweden)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Jumper's knee; Noradrenaline; Pain; Substance P (SP); Tendon

Indexed keywords

NORADRENALIN; OXYGENASE; THYROXINE;

ADULT; ARTICLE; AUTONOMIC NERVE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; MALE; NERVE FIBER; NERVE GROWTH; PATELLA TENDON; PRIORITY JOURNAL; SENSORY SYSTEM; SYMPATHETIC NERVE; TENDON DISEASE; TENDON RUPTURE;

EID: 33750931432     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546506289169     Document Type: Article

References (38)

1. Ackermann PW, Ahmed M, Kreicbergs A. Early nerve regeneration after Achilles tendon rupture: a prerequisite for healing? A study in the rat. J Orthop Res. 2002;20:849-856.
2. Ackermann PW, Finn A, Ahmed M. Sensory neuropeptidergic pattern in tendon, ligament and joint capsule: a study in the rat. Neuroreport. 1999;13;2055-2060.
3. Ackermann PW, Li J, Finn A, Ahmed M, Kreicbergs A. Autonomic innervation of tendons, ligaments and joint capsules: a morphologic and quantitative study in the rat. J Orthop Res. 2001;19:372-378.
4. Ackermann PW, Li J, Lundeberg T, Kreicbergs A. Neuronal plasticity in relation to nociception and healing of rat Achilles tendon. J Orthop Res. 2003;21:432-441.
5. Ackermann PW, Renström P. Sensory neuropeptides in Achilles tendinosis: transactions of the Third Biennial Congress of the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine. Arthroscopy. 2001;17(suppl):516.
6. Alfredsson H, Lorentzon M, Bäckman S, Bäckman A, Lerner U. cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. J Orthop Res. 2003;21:970-975.
7. Astrom M, Westlin N. Blood flow in the human Achilles tendon assessed by laser Doppler flowmetry. J Orthop Res. 1994;12:246-252.
8. Bahr R, Fossan B, Løken S, Engebretsen L. Surgical treatment versus eccentric training for patellar tendinopathy (jumper's knee): a randomized controlled trial. J Bone Joint Surg Am. In press.
9. Barnard P. Musculoskeletal Disorders and Workplace Factors: A Critical Review of Epidemiologic Evidence For Work-Related Musculoskeletal Disorders Of The Neck, Upper Extremity, And Low Back. Cincinnati, Ohio: US Department of Health and Human Services, National Institute of Occupational Safety and Health; 1997.
10. Bjur D, Alfredson H, Forsgren S. The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation. Cell Tissue Res. 2005;320:201-206.
11. Blazina ME, Kerlan RK, Jobe FW, Carter VS, Carlson GJ. Jumper's knee. Orthop Clin North Am. 1973;4:665-673.
12. Brain SD. Sensory neuropeptides: their role in inflammation and wound healing. Immunopharmacology. 1997;37:133-150.
13. Bring DK, Heidgren ML, Kreicbergs A, Ackermann PW. Increase in sensory neuropeptides surrounding the Achilles tendon in rats with adjuvant arthritis. J Orthop Res. 2005;23:294-301.
14. Burssens P, Steyaert A, Forsyth R, van Ovost EJ, De Paepe Y, Verdonk R. Exogenously administered substance P and neutral endopeptidase inhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing. Foot Ankle Int. 2005;26:832-839.
15. Cook JL, Feller JA, Bonar SF, Khan KM. Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons. J Orthop Res. 2004;22:334-338.
16. Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O'Brien J, Jayson MI. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet. 1997;19:178-181.
17. Gulbenkian S, Wharton J, Polak JM. The visualization of cardiovascular innervation in the guinea pig using a antiserum to protein gene product 9.5 (PGP 9.5). J Auton Nerv Syst. 1987;18:235-247.
18. Hart DA, Kydd A, Reno C. Gender and pregnancy affect neuropeptide responses of the rabbit Achilles tendon. Clin Orthop Relat Res. 1999;365:237-246.
19. Khan KM, Cook JL, Maffulli N, Kannus P. Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin. Br J Sports Med. 2000;34:81-83.
20. Lai XN, Wang ZG, Zhu JM, Wang LL. Effect of substance P on gene expression of transforming growth factor beta-1 and its receptors in rat's fibroblasts. Chin J Traumatol. 2003;6:350-354.
21. Lian Ø, Engebretsen L, Bahr R. Prevalence of jumper's knee among elite athletes from different sports: a cross-sectional study. Am J Sports Med. 2005;33:561-567.
22. Lian Ø, Holen K, Engebretsen L, Bahr R. Relationship between symptoms of jumper's knee and the ultrasound characteristics of the patellar tendon among high level male volleyball players. Scand J Med Sci Sports. 1996;6:291-296.
23. Ljung BO, Alfredson H, Forsgren S. Neurokinin 1-receptors and sensory neuropeptides in tendon insertions at the medial and lateral epicondyles of the humerus: studies on tennis elbow and medial epicondylalgia. J Orthop Res. 2004;22:321-327.
24. Lundberg JM, Alm P, Wharton J, Polak JM. Protein gene product 9.5 (PGP 9.5). Histochemistry. 1988;90:9-17.
25. Maffulli N, Testa V, Capasso G, et al. Similar histopathological picture in males with Achilles and patellar tendinopathy. Med Sci Sports Exerc. 2004;36:1470-1475.
26. Movin T, Gad A, Reinholt FP, Rolf C. Tendon pathology in long-standing achillodynia: biopsy findings in 40 patients. Acta Orthop Scand. 1997;68:170-175.
27. Nilsson J, von Euler AM, Dalsgaard CJ. Stimulation of connective tissue cell growth by substance P and substance K. Nature. 1985;315:61-63.
28. Öhberg L, Lorentzon R, Alfredson H. Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc. 2001;9:233-238.
29. Renstrom P, Johnson RJ. Overuse injuries in sports: a review. Sports Med. 1985;2:316-333.
30. Rittner HL. Leukocytes in the regulation of pain and analgesia. J Leukoc Biol. 2005;78:1215-1222.
31. Roberts WJ, Kramis RC. Sympathetic nervous system influence on acute and chronic pain. In: Fields HL, ed. Pain Syndromes in Neurology. Essex, England: Butterworth; 1990:85-106.
32. Roels J, Martens M, Mulier JC, Burssens A. Patellar tendinitis (jumper's knee). Am J Sports Med. 1978;6:362-368.
33. Schubert TE, Weidler C, Lerch K, Hofstadter F, Straub RH. Achilles tendinosis is associated with sprouting of substance P positive nerve fibres. Ann Rheum Dis. 2005;64:1083-1086.
34. Straub RH, Gunzler C, Miller LE, Cutolo M, Scholmerich J, Schill S. Anti-inflammatory cooperativity of corticosteroids and norepinephrine in rheumatoid arthritis synovial tissue in vivo and in vitro. FASEB J. 2002;16:993-1000.
35. Ueda H. In vivo molecular signal transduction of peripheral mechanisms of pain. Jpn J Pharmacol. 1999;79:263-268.
36. Visentini PJ, Khan K, Cook J, Kiss ZS, Harcourt PR, Wark JD. The VISA score: an index of severity of symptoms in patients with jumper's knee (patellar tendinosis). Victorian Institute of Sport Tendon Study Group. J Sci Med Sport. 1998;1:22-28.
37. Wilkinson KD, Lee KM, Desphande S, Duerksen-Hughes P, Boss JM, Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science. 1989;246:670-673.
38. Zamboni L, De Martino C. Buffered picric acid-formaldehyde: a new, rapid fixative for electron microscopy. J Cell Biol. 1967;35:148.