Intratendinous glutamate levels and eccentric training in chronic Achilles tendinosis: A prospective study using microdialysis technique

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 11, Issue 3, 2003, Pages 196-199

  Alfredson, Håkan ^a   Lorentzon, Ronny ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Achilles tendinosis; Eccentric training; Glutamate; Microdialysis; Pain

Indexed keywords

GLUTAMIC ACID;

ACHILLES TENDON; ADULT; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOOT PAIN; GASTROCNEMIUS MUSCLE; HUMAN; MALE; MICRODIALYSIS; MUSCLE TRAINING; PROSPECTIVE STUDY; TENDON DISEASE; TISSUE LEVEL; TREATMENT OUTCOME; VISUAL ANALOG SCALE; WEIGHT BEARING; METABOLISM; MIDDLE AGED; PAIN ASSESSMENT; PHYSICAL EDUCATION; TENDINITIS;

ACHILLES TENDON; CHRONIC DISEASE; FEMALE; GLUTAMIC ACID; HUMANS; MALE; MICRODIALYSIS; MIDDLE AGED; PAIN MEASUREMENT; PHYSICAL EDUCATION AND TRAINING; PROSPECTIVE STUDIES; TENDINOPATHY; TREATMENT OUTCOME; WEIGHT-BEARING;

EID: 0141430894     PISSN: 09422056     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00167-003-0360-0     Document Type: Article

References (15)

1. Alfredson H, Pietilä T, Jonsson P, Lorentzon R (1998) Heavy-load eccentric calf muscle training for the treatment of chronic Achilles tendinosis. Am J Sports Med 26:360-366
2. 2 in chronic Achilles tendon pain. Knee Surg Sports Traumatol Arthrosc 7:378-381
3. Alfredson H, Forsgren S, Thorsen K, et al (2001) Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment? Knee Surg Sports Traumatol Arthrosc 9:123-126
4. Alfredson H, Lorentzon M, Bäckman S, Bäckman A, Lerner UH (2003) cDNA-arrays and real-time quantitative PCR techniques in the investigation of chronic Achilles tendinosis. J Orthop Res (in press)
5. Åström M, Rausing A (1995) Chronic Achilles tendinopathy. A survey of surgical and histopathologic findings. Clin Orthop 316:151-164
6. Chenu C, Serre CM, Raynal C, Burt-Pichat B, Delmas PD (1998) Glutamate receptors are expressed by bone cells and are involved in bone resorption. Bone 22:295-299
7. Coggeshall RE, Carlton SM (1998) Ultrastructural analysis of NMDA, AMPA and kainate receptors on unmyelinated and myelinated axons in the perifery. J Comp Neurol 391:78-86
8. Davidson EM, Coggeshall RE, Carlton SM (1997) Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test. Neuroreport 8:941-946
9. Dickenson AH, Chapman V, Green GM (1997) The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. A review. Gen Pharmacol 28:633-638
10. Khan KM, Cook JL, Bonar F, Harcourt P, Åström M (1999) Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med 27:393-408
11. Mafi N, Lorentzon R, Alfredson H (2001) Superior results with eccentric calf-muscle training compared to concentric training in a randomized prospective multi-center study on patients with chronic Achilles tendinosis. Knee Surg Sports Traumatol Arthrosc 9:42-47
12. Maffulli N, Khan KM, Puddu G (1998) Overuse tendon conditions: time to change a confusing terminology. Arthroscopy 14:840-843
13. Movin T, Gad A, Reinholt FP (1997) Tendon pathology in long-standing Achillodynia. Biopsy findings in 40 patients. Acta Orthop Scand 68:170-175
14. Öhberg L, Alfredson H (2002) Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med 36:173-177
15. Öhberg L, Lorentzon R, Alfredson H (2001) Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc 9:233-238