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Volumn , Issue 64, 2012, Pages 1-

Assessing replication and beta cell function in adenovirally-transduced isolated rodent islets

Author keywords

Adenovirus; Beta cell; Diabetes; Gene expression; Insulin secretion; Islet; Issue 64; Medicine; Physiology; Proliferation; Rat

Indexed keywords


EID: 84863799440     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/4080     Document Type: Article
Times cited : (10)

References (19)
  • 1
    • 12244299450 scopus 로고    scopus 로고
    • Beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: A new analysis
    • Ferrannini, E., et al. Beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J. Clin. Endocrinol. Metab. 90, 493-500 (2005).
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 493-500
    • Ferrannini, E.1
  • 2
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • Weyer, C., Bogardus, C., Mott, D.M., & Pratley, R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J. Clin. Invest. 104, 787-794 (1999).
    • (1999) J. Clin. Invest , vol.104 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 3
    • 78049320362 scopus 로고    scopus 로고
    • Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study
    • Keenan, H.A., et al. Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 59, 2846-2853 (2010).
    • (2010) Diabetes , vol.59 , pp. 2846-2853
    • Keenan, H.A.1
  • 4
    • 4344608398 scopus 로고    scopus 로고
    • An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans
    • Bain, J.R., Schisler, J.C., Takeuchi, K., Newgard, C.B., & Becker, T.C. An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. Diabetes. 53, 2190-2194 (2004).
    • (2004) Diabetes , vol.53 , pp. 2190-2194
    • Bain, J.R.1    Schisler, J.C.2    Takeuchi, K.3    Newgard, C.B.4    Becker, T.C.5
  • 5
    • 43049101101 scopus 로고    scopus 로고
    • Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function
    • Fueger, P.T., et al. Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. Mol. Endocrinol. 22, 1251-1259, (2008).
    • (2008) Mol. Endocrinol , vol.22 , pp. 1251-1259
    • Fueger, P.T.1
  • 6
    • 43249122991 scopus 로고    scopus 로고
    • Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeo domain transcription factor Nkx6.1
    • Schisler, J.C., et al. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeo domain transcription factor Nkx6.1. Mol. Cell Biol. 28, 3465-3476 (2008).
    • (2008) Mol. Cell Biol , vol.28 , pp. 3465-3476
    • Schisler, J.C.1
  • 7
    • 0032991716 scopus 로고    scopus 로고
    • Over expression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
    • Chan, C.B., et al. Over expression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes. 48, 1482-1486 (1999).
    • (1999) Diabetes , vol.48 , pp. 1482-1486
    • Chan, C.B.1
  • 8
    • 0347990598 scopus 로고    scopus 로고
    • Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1
    • Cozar-Castellano, I., Takane, K.K., Bottino, R., Balamurugan, A.N., & Stewart, A.F. Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes. 53, 149-159 (2004).
    • (2004) Diabetes , vol.53 , pp. 149-159
    • Cozar-Castellano, I.1    Takane, K.K.2    Bottino, R.3    Balamurugan, A.N.4    Stewart, A.F.5
  • 9
    • 65549104628 scopus 로고    scopus 로고
    • Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1
    • Icyuz, M., et al. Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1. Transplantation. 87, 821-824 (2009).
    • (2009) Transplantation , vol.87 , pp. 821-824
    • Icyuz, M.1
  • 10
    • 0035903192 scopus 로고    scopus 로고
    • Activation of the hexo samine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
    • Kaneto, H., et al. Activation of the hexo samine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J. Biol. Chem. 276, 31099-31104 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 31099-31104
    • Kaneto, H.1
  • 13
    • 0027994097 scopus 로고
    • Over expression of hexokinase I in isolated islets of Langer hans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
    • Becker, T.C., BeltrandelRio, H., Noel, R.J., Johnson, J.H., & Newgard, C.B. Over expression of hexokinase I in isolated islets of Langer hans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. J. Biol. Chem. 269, 21234-21238 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 21234-21238
    • Becker, T.C.1    Beltrandelrio, H.2    Noel, R.J.3    Johnson, J.H.4    Newgard, C.B.5
  • 14
    • 0028293708 scopus 로고
    • Adenoviral-mediated gene transfer to pancreatic islets does not alter islet function
    • Csete, M.E., et al. Adenoviral-mediated gene transfer to pancreatic islets does not alter islet function. Transplant Proc. 26, 756-757 (1994).
    • (1994) Transplant Proc , vol.26 , pp. 756-757
    • Csete, M.E.1
  • 15
    • 0028859143 scopus 로고
    • Efficient gene transfer to pancreatic islets mediated by adenoviral vectors
    • Csete, M.E., et al. Efficient gene transfer to pancreatic islets mediated by adenoviral vectors. Transplantation. 59, 263-268 (1995).
    • (1995) Transplantation , vol.59 , pp. 263-268
    • Csete, M.E.1
  • 16
    • 57249094223 scopus 로고    scopus 로고
    • Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest
    • Meng, Z.X., et al. Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 52, 125-135 (2009).
    • (2009) Diabetologia , vol.52 , pp. 125-135
    • Meng, Z.X.1
  • 17
    • 33750053271 scopus 로고    scopus 로고
    • A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
    • Ronnebaum, S.M., et al. A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J. Biol. Chem., (2006).
    • (2006) J. Biol. Chem
    • Ronnebaum, S.M.1
  • 18
    • 0028985060 scopus 로고
    • Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids
    • Milburn, J.L., Jr., et al. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J. Biol. Chem. 270, 1295-1299 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 1295-1299
    • Milburn Jr., J.L.1
  • 19
    • 80055106193 scopus 로고    scopus 로고
    • Murine Pancreatic Islet Isolation
    • DOI: 10.3791/255
    • Szot, G., Koudria, P., & Bluestone, J. Murine Pancreatic Islet Isolation. J. Vis. Exp. (7), e255, DOI: 10.3791/255 (2007).
    • (2007) J. Vis. Exp , vol.7
    • Szot, G.1    Koudria, P.2    Bluestone, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.