Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1

Transplantation

Volumn 87, Issue 6, 2009, Pages 821-824

  Icyuz, Mert ^a   Bryant, Stacie M J ^b   Fortinberry, Henry K ^b   Molakandov, Kfir ^a,c   Siegal, Gene P ^d,e   Contreras, Juan L ^b   Wu, Hongju ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Kentucky   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

^d University of Alabama at Birmingham   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Cell proliferation; Adenovirus; Akt1; Diabetes

Indexed keywords

ADENOVIRUS VECTOR; AKT1 PROTEIN; BROXURIDINE; GREEN FLUORESCENT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; INSULIN;

ADENOVIRUS 5; ARTICLE; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN TISSUE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTION; WESTERN BLOTTING; ADENOVIRUS; ADENOVIRUS INFECTION; ANIMAL; CELL DIVISION; GENETICS; METABOLISM; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; RAT; SWINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ADENOVIRUS INFECTIONS, HUMAN; ANIMALS; CELL DIVISION; CELL SURVIVAL; ENZYME ACTIVATION; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; SWINE;

EID: 65549104628     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318199c686     Document Type: Article

References (23)

1. Dor Y, Brown J, Martinez OI, et al. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004; 429: 41.
2. Meier JJ, Lin JC, Butler AE, et al. Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 2006; 49: 1838.
3. Hardikar AA. Generating new pancreas from old. Trends Endocrinol Metab 2004; 15: 198.
4. Cozar-Castellano I, Takane KK, Bottino R, et al. Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1. Diabetes 2004; 53: 149.
5. Rao P, Roccisana J, Takane KK, et al. Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes 2005; 54: 1664.
6. Contreras JL, Bilbao G, Smyth C, et al. Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement. Surgery 2001; 130: 166.
7. Emamaullee JA, Rajotte RV, Liston P, et al. XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes. Diabetes 2005; 54: 2541.
8. Fenjves ES, Ochoa MS, Gay-Rabinstein C, et al. Adenoviral gene transfer of erythropoietin confers cytoprotection to isolated pancreatic islets. Transplantation 2004; 77: 13.
9. Heimberg H, Heremans Y, Jobin C, et al. Inhibition of cytokineinduced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes 2001; 50: 2219.
10. Fiaschi-Taesch NM, Berman DM, Sicari BM, et al. Hepatocyte growth factor enhances engraftment and function of nonhuman primate islets. Diabetes 2008; 57: 2745.
11. Plesner A, Liston P, Tan R, et al. The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts. Diabetes 2005; 54: 2533.
12. Noguchi H, Xu G, Matsumoto S, et al. Induction of pancreatic stem/ progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant 2006; 15: 929.
13. Schisler JC, Fueger PT, Babu DA, et al. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Mol Cell Biol 2008; 28: 3465.
14. Le LP, Le HN, Dmitriev IP, et al. Dynamic monitoring of oncolytic adenovirus in vivo by genetic capsid labeling. J Natl Cancer Inst 2006; 98: 203.
15. Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim Biophys Acta 2004; 1697: 3.
16. Besson A, Dowdy SF, Roberts JM. CDK inhibitors: Cell cycle regulators and beyond. Dev Cell 2008; 14: 159.
17. Heron-Milhavet L, Franckhauser C, Rana V, et al. Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol 2006; 26: 8267.
18. Manning BD, Cantley LC. AKT/PKB signaling: Navigating downstream. Cell 2007; 129: 1261.
19. Fatrai S, Elghazi L, Balcazar N, et al. Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 2006; 55: 318.
20. Jetton TL, Lausier J, LaRock K, et al. Mechanisms of compensatory beta-cell growth in insulin-resistant rats: Roles of Akt kinase. Diabetes 2005; 54: 2294.
21. Tuttle RL, Gill NS, Pugh W, et al. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med 2001; 7: 1133.
22. Bernal-Mizrachi E, Wen W, Stahlhut S, et al. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 2001; 108: 1631.
23. Contreras JL, Smyth CA, Bilbao G, et al. Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation 2002; 74: 1063.