Improved fluoroquinolone detection in ELISA through engineering of a broad-specific single-chain variable fragment binding simultaneously to 20 fluoroquinolones

Analytical and Bioanalytical Chemistry

Volumn 403, Issue 9, 2012, Pages 2771-2783

  Wen, Kai ^a   Nölke, Greta ^b   Schillberg, Stefan ^b   Wang, Zhanhui ^a   Zhang, Suxia ^a   Wu, Congming ^a   Jiang, Haiyang ^a   Meng, Hui ^a   Shen, Jianzhong ^a  

^a NONE   (China)

^b NONE   (Germany)

Author keywords

Fluoroquinolones; Molecular modeling; Phage display; ScFv; Site directed mutagenesis

Indexed keywords

ANTIBIOTICS; ANTIGEN-ANTIBODY REACTIONS; BINDING ENERGY; MOLECULAR MODELING; MONOCLONAL ANTIBODIES; MUTAGENESIS; SYNTHETIC APERTURE RADAR;

COMPLEMENTARITY-DETERMINING REGIONS; FLUOROQUINOLONES; INDIRECT COMPETITIVE ENZYME- LINKED IMMUNOSORBENT ASSAYS; PHAGE DISPLAY LIBRARIES; PROTEIN HOMOLOGY MODELS; SCFV; SINGLE CHAIN VARIABLE FRAGMENTS; SITE DIRECTED MUTAGENESIS;

PHAGE DISPLAY;

ANIMALIA; BACTERIA (MICROORGANISMS); MURINAE;

EID: 84863781096     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6062-z     Document Type: Article

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