Anchoring a Cationic Ligand: The Structure of the Fab Fragment of the Anti-morphine Antibody 9B1 and its Complex with Morphine

Journal of Molecular Biology

Volumn 337, Issue 3, 2004, Pages 691-697

  Pozharski, Edwin ^a   Wilson, Mark A ^a   Hewagama, Anura ^b,c   Shanafelt, Armen B ^b,d   Petsko, Gregory ^a   Ringe, Dagmar ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b Roche Diagnostics Corporation   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

Cation interaction; CDR, complementarity determining region; Domain motion; Electrostatics; Hapten; Protein ligand interaction

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; MORPHINE; MORPHINE ANTIBODY 9B1; MORPHINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY STRUCTURE; ARTICLE; BINDING SITE; COMPLEMENTARITY DETERMINING REGION; CRYSTAL STRUCTURE; ELECTRICITY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 1542411577     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.12.084     Document Type: Article

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