Genome-wide association with C-reactive protein levels in CLHNS: Evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment

Inflammation

Volumn 35, Issue 2, 2012, Pages 574-583

  Wu, Ying ^a   McDade, Thomas W ^b   Kuzawa, Christopher W ^b   Borja, Judith ^c   Li, Yun ^a,d   Adair, Linda S ^d   Mohlke, Karen L ^a   Lange, Leslie A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF SAN CARLOS   (Philippines)

^d IL   (United States)

Author keywords

C reactive protein; Filipino women; Gene environment interaction; Genome wide association

Indexed keywords

APOLIPOPROTEIN E4; C REACTIVE PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; LEPTIN RECEPTOR;

ARTICLE; CHROMOSOME 6Q; COHORT ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMALE; FILIPINO; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HEALTH SURVEY; HUMAN; LONGITUDINAL STUDY; MOTHER; NUTRITION; PHILIPPINES; POPULATION RESEARCH; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM;

APOLIPOPROTEIN E4; C-REACTIVE PROTEIN; CHROMOSOMES, HUMAN, PAIR 6; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; INFLAMMATION; PHILIPPINES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEPTIN;

EID: 84863775148     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9348-y     Document Type: Article

References (29)

1. Hage, F.G., and A.J. Szalai. 2007. C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. Journal of the American College of Cardiology 50: 1115-1122. (Pubitemid 47375011)
2. Pankow, J.S., A.R. Folsom, M. Cushman, I.B. Borecki, P.N. Hopkins, J.H. Eckfeldt, and R.P. Tracy. 2001. Familial and genetic determinants of systemic markers of inflammation: the NHLBI Family Heart study. Atherosclerosis 154: 681-689. (Pubitemid 32232166)
3. Ridker, P.M., G. Pare, A. Parker, R.Y. Zee, J.S. Danik, J.E. Buring, D. Kwiatkowski, N.R. Cook, J.P. Miletich, and D.I. Chasman. 2008. Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. American Journal of Human Genetics 82: 1185-1192.
4. Reiner, A.P., M.J. Barber, Y. Guan, P.M. Ridker, L.A. Lange, D.I. Chasman, J.D. Walston, G.M. Cooper, N.S. Jenny, M.J. Rieder, J.P. Durda, J.D. Smith, J. Novembre, R.P. Tracy, J.I. Rotter, M. Stephens, D.A. Nickerson, and R.M. Krauss. 2008. Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein. American Journal of Human Genetics 82: 1193-1201.
5. Cordell, H.J. 2009. Genome-wide association studies: detecting gene-gene interactions that underlie human diseases. Nature Reviews. Genetics 10: 392-404.
6. Moore, J.H., and S.M. Williams. 2009. Epistasis and its implications for personal genetics. American Journal of Human Genetics 85: 309-320.
7. WHO. 2004. The World Health Report 2004 - changing history. Geneva: World Health Organization.
8. WHO. 2006. Mortality country fact sheet 2006. Geneva: World Health Orgnization.
9. McDade, T.W., J.N. Rutherford, L. Adair, and C. Kuzawa. 2008. Adiposity and pathogen exposure to a pathogenic environment predict C-reactive protein in Filipino women. The Journal of Nutrition 138: 2442-2447.
10. McDade, T.W., J.N. Rutherford, L. Adair, and C. Kuzawa. 2009. Population differences in associations between C-reactive protein concentration and adiposity: comparison of young adults in the Philippines and the United States. The American Journal of Clinical Nutrition 89: 1237-1245.
11. Adair, L. S., B. M. Popkin, J. S. Akin, D. K. Guilkey, S. Gultiano, J. Borja, L. Perez, C. W. Kuzawa, T. McDade, and M. J. Hindin (2011) Cohort profile: the Cebu Longitudinal Health and Nutrition Survey. Int J Epidemiol (in press).
12. Lange, L.A., D.C. Croteau-Chonka, A.F. Marvelle, L. Qin, K.J. Gaulton, C.W. Kuzawa, T.W. McDade, Y. Wang, Y. Li, S. Levy, J.B. Borja, E.M. Lange, L.S. Adair, and K.L. Mohlke. 2010. Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults. Human Molecular Genetics 19: 2050-2058.
13. Li, Y., C.J. Willer, J. Ding, P. Scheet, and G.R. Abecasis. 2010. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genetic Epidemiology 34: 816-834.
14. Pruim, R.J., R.P. Welch, S. Sanna, T.M. Teslovich, P.S. Chines, T.P. Gliedt, M. Boehnke, G.R. Abecasis, and C.J. Willer. 2010. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26: 2336-2337.
15. Morita, A., T. Nakayama, N. Doba, S. Hinohara, T. Mizutani, and M. Soma. 2007. Genotyping of triallelic SNPs using TaqMan PCR. Molecular and Cellular Probes 21: 171-176. (Pubitemid 46412694)
16. Szalai, A.J., J. Wu, E.M. Lange, M.A. McCrory, C.D. Langefeld, A. Williams, S.O. Zakharkin, V. George, D.B. Allison, G.S. Cooper, F. Xie, Z. Fan, J.C. Edberg, and R.P. Kimberly. 2005. Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. Journal of Molecular Medicine 83: 440-447. (Pubitemid 40922166)
17. Kathiresan, S., M.G. Larson, R.S. Vasan, C.Y. Guo, P. Gona, J.F. Keaney Jr., P.W. Wilson, C. Newton-Cheh, S.L. Musone, A.L. Camargo, J.A. Drake, D. Levy, C.J. O'Donnell, J.N. Hirschhorn, and E.J. Benjamin. 2006. Contribution of clinical correlates and C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation 113: 1415-1423.
18. Judson, R., C. Brain, B. Dain, A. Windemuth, G. Ruano, and C. Reed. 2004. New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals. Atherosclerosis 177: 345-351. (Pubitemid 39505267)
19. Suk, H.J., P.M. Ridker, N.R. Cook, and R.Y. Zee. 2005. Relation of polymorphism within the C-reactive protein gene and plasma CRP levels. Atherosclerosis 178: 139-145. (Pubitemid 39600826)
20. Kovacs, A., F. Green, L.O. Hansson, P. Lundman, A. Samnegard, S. Boquist, C.G. Ericsson, H. Watkins, A. Hamsten, and P. Tornvall. 2005. A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. Atherosclerosis 178: 193-198. (Pubitemid 39600833)
21. Brull, D. J., N. Serrano, F. Zito, L. Jones, H. E. Montgomery, A. Rumley, P. Sharma, G. D. Lowe, M. J. World, S. E. Humphries, and A. D. Hingorani. 2003. Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology 23: 2063-2069. (Pubitemid 37433201)
22. Miller, D.T., R.Y. Zee, J. Suk Danik, P. Kozlowski, D.I. Chasman, R. Lazarus, N.R. Cook, P.M. Ridker, and D.J. Kwiatkowski. 2005. Association of common CRP gene variants with CRP levels and cardiovascular events. Annals of Human Genetics 69: 623-638. (Pubitemid 41556317)
23. Lange, L.A., C.S. Carlson, L.A. Hindorff, E.M. Lange, J.Walston, J.P. Durda, M. Cushman, J.C. Bis, D. Zeng, D. Lin, L.H. Kuller, D.A. Nickerson, B.M. Psaty, R.P. Tracy, and A.P. Reiner. 2006. Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA 296: 2703-2711. (Pubitemid 44917547)
24. Nishikawa, T., K. Hagihara, S. Serada, T. Isobe, A. Matsumura, J. Song, T. Tanaka, I. Kawase, T. Naka, and K. Yoshizaki. 2008. Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression. Journal of Immunology 180: 3492-3501.
25. Reiner, A.P., M.D. Gross, C.S. Carlson, S.J. Bielinski, L.A. Lange, M. Fornage, N.S. Jenny, J. Walston, R.P. Tracy, O.D. Williams, D. R. Jacobs Jr., and D.A. Nickerson. 2009. Common coding variants of the HNF1A gene are associated with multiple cardiovascular risk phenotypes in community-based samples of younger and older European-American adults: the Coronary Artery Risk Development in Young Adults Study and The Cardiovascular Health Study. Circ Cardiovasc Genet 2: 244-254.
26. Lohmueller, K.E., C.L. Pearce, M. Pike, E.S. Lander, and J.N. Hirschhorn. 2003. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nature Genetics 33: 177-182. (Pubitemid 36177070)
27. Thomas, D. 2010. Gene-environment-wide association studies: emerging approaches. Nature Reviews. Genetics 11: 259-272.
28. Black, S., I. Kushner, and D. Samols. 2004. C-reactive protein. The Journal of Biological Chemistry 279: 48487-48490. (Pubitemid 39625721)
29. McDade, T.W., J. Rutherford, L. Adair, and C.W. Kuzawa. 2010. Early origins of inflammation: microbial exposures in infancy predict lower levels of C-reactive protein in adulthood. Proc Biol Sci 277: 1129-1137.