Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level

Journal of Molecular Medicine

Volumn 83, Issue 6, 2005, Pages 440-447

  Szalai, A J ^a   Wu, J ^a   Lange, E M ^b   McCrory, M A ^a   Langefeld, C D ^b   Williams, A ^b   Zakharkin, S O ^c   George, V ^c   Allison, D B ^c   Cooper, G S ^d   Xie, F ^a   Fan, Z ^a   Edberg, J C ^a   Kimberly, R P ^a,e  

^a The University of Alabama at Birmingham   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e Department of Medicine and Microbiology ^*

Author keywords

Acute phase reactants; Gene regulation; Inflammation

Indexed keywords

C REACTIVE PROTEIN; TRANSCRIPTION FACTOR;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; E BOX ELEMENT; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE SEQUENCE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN BINDING; PROTEIN BLOOD LEVEL; REPORTER GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFRICAN AMERICANS; ALLELES; C-REACTIVE PROTEIN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); PROSPECTIVE STUDIES; SERUM; TRANSCRIPTION FACTORS;

EID: 21544446404     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-005-0658-0     Document Type: Article

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