Atrazine effects on antioxidant status and xenobiotic metabolizing enzymes after oral administration in peripubertal male rat

Environmental Toxicology and Pharmacology

Volumn 34, Issue 2, 2012, Pages 495-501

  Pogrmic Majkic, Kristina ^a   Kaisarevic, Sonja ^a   Fa, Svetlana ^a   Dakic, Vanja ^a   Glisic, Branka ^a   Hrubik, Jelena ^a   Kovacevic, Radmila ^a  

^a UNIVERSITY OF NOVI SAD   (Serbia)

Author keywords

Antioxidant enzymes; Atrazine; CYP enzymes; Testicular steroidogenesis

Indexed keywords

ATRAZINE; CATALASE; CYTOCHROME P450 1A; CYTOCHROME P450 2B; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; SUPEROXIDE DISMUTASE; CYTOCHROME; CYTOCHROME P-448; CYTOCHROME P448; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; HERBICIDE; TESTOSTERONE; XENOBIOTIC AGENT; ANDROGEN; CHORIONIC GONADOTROPIN; CYTOCHROME P450 1A2;

ANDROGEN SYNTHESIS; ANDROGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EX VIVO STUDY; LEYDIG CELL; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PREPUBERTY; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; STEROIDOGENESIS; TOXICITY TESTING; XENOBIOTIC METABOLISM; ANIMAL; DRUG EFFECT; LIVER MICROSOME; METABOLISM; ORAL DRUG ADMINISTRATION; PUBERTY; WISTAR RAT; ANTIOXIDANT ACTIVITY; CELL STIMULATION; DISORDERS OF HORMONE METABOLISM; INTERSTITIUM; LIVER; OXIDATION; TESTIS; TESTOSTERONE SYNTHESIS;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; ATRAZINE; CATALASE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROMES; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HERBICIDES; LEYDIG CELLS; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; PUBERTY; RATS; RATS, WISTAR; TESTOSTERONE; XENOBIOTICS;

EID: 84863764938     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2012.06.004     Document Type: Article

References (44)

1. Abarikwu, S.O., Adesiyan, A.C., Oyeloja, T.O., Oyeyemi, M.O., Farombi, E.O., 2010. Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazine. Arch. Environ. Contam. Toxicol. 58, 874-882.
2. Abel, E.L., Opp, S.M., Verlinde, C.L.M.J., Bammler, T.K., Eaton, D.L., 2004. Characterization of atrazine biotransformation by human and murine glutathione S-transferases. Toxicol. Sci. 80, 230-238.
3. Adesiyan, A.C., Oyeloja, T.O., Abarikwu, S.O., Oyeyemi, M.O., Farombi, E.O., 2011. Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity. Exp. Toxicol. Pathol. 63, 201-207.
4. Andric, N.L., Andric, S.A., Zoric, S.N., Kostic, T., Stojilkovic, S.S., Kovacevic, R.Z., 2003. Parallelism and dissociation in the action of an Aroclor 1260-based transformer fluid on testicular steroidogenesis and antioxidant enzymes. Toxicology 194, 65-75.
5. Andric, N.L., Kostic, T.S., Zoric, S.N., Stanic, B.D., Andric, S.A., Kovacevic, R.Z., 2006. Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes. Reprod. Toxicol. 22, 102-110.
6. Andric, N., Kostic, T., Kaisarevic, S., Fa, S., Pogrmic, K., Kovacevic, R., 2008. In vivo and in vitro effects of PCB126 and PCB153 on rat testicular androgenesis. Environ. Toxicol. Pharmacol. 25, 222-226.
7. Bradford, M.M., 1976. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
8. Burke, M.D., Thompson, S., Elcombe, C.R., Halpert, J., Haaparanta, T., Mayer, R.T., 1985. Ethoxy, pentoxy, and benzyloxyphenoxazones and homologues: a series ofsubstrate to distinguish between different induced cytochromes P450. Biochem. Pharmacol. 48, 923-936.
9. Claiborne, A., 1984. Catalase activity. In: Greenwald, R.A. (Ed.), Handbook of Methods for Oxygen Radical Research. CRC Press, Boca Raton, Florida, pp. 283-284.
10. Cooper, R.L., Laws, S.C., Das, P.C., Norotsky, M.G., Goldman, J.M., Tyrey, E.L., Stoker, T.E., 2007. Atrazine and reproductive function: mode and mechanism of action studies. Birth Defects Res. B: Dev. Reprod. Toxicol. 80, 98-112.
11. Cragin, L.A., Kesner, J.S., Bachand, A.M., Barr, D.B., Meadows, J.W., Krieg, E.F., Reif, J.S., 2011. Menstrual cycle characteristics and reproductive hormone levels in women exposed to atrazine in drinking water. Environ. Res. 111, 1293-1301.
12. Crain, D.A., Guillette Jr., L.J., Rooney, A.A., Pickford, D.B., 1997. Alterations in steroidogenesis in alligators (Alligator mississippiensis) exposed naturally and experimentally to environmental contaminants. Environ. Health Perspect. 105, 528-533.
13. Friedmann, A.S., 2002. Atrazine inhibition of testosterone production in rat males following peripubertal exposure. Reprod. Toxicol. 16, 275-279.
14. Fujii, J., Iuchi, Y., Matsuki, S., Ishii, T., 2003. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian J. Androl. 5, 231-242.
15. Habig, W.H., Pabst, M.J., Jakoby, W.B., 1974. Glutathione-S-transferases. J. Biol. Chem. 249, 7130-7139.
16. Hayes, T., Haston, K., Tsui, M., Hoang, A., Haeffele, C., Vonk, A., 2003. Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. Environ. Health Perspect. 111, 568-575.
17. Hayes, T.B., Khoury, V., Narayan, A., Nazir, M., Park, A., Brown, T., Adame, L., Chan, E., Buchholz, D., Stueve, T., et al., 2010. Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis). Proc. Natl. Acad. Sci. U.S.A. 107, 4612-4617.
18. Islam, M.O., Hara, M., Miyake, J., 2002. Induction of P-glycoprotein, glutathione-S-transferase and cytochrome P450 in rat liver by atrazine. Environ. Toxicol. Pharmacol. 12, 1-6.
19. Jin, Y., Zhang, X., Shu, L., Chen, L., Sun, L., Qian, H., Liu, W., Fu, Z., 2010. Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere 78, 846-852.
20. Kostic, T.S., Andric, S.A., Maric, D., Kovacevic, R.Z., 2000. Inhibitory effects of stress-activated nitric oxide on antioxidant enzymes and testicular steroidogenesis. J. Steroid Biochem. Mol. Biol. 75, 299-306.
21. Leckie, C.M.,Welberg, L.A.M., Seckl, J.R., 1998. 11β-Hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells. J. Endocrinol. 159, 233-238.
22. Misra, H.P., Fridovich, I., 1972. The generation of superoxide radicals during autooxidation of hemoglobin. J. Biol. Chem. 247, 69600-69620.
23. Muralidhara, T.R.K., 2002. Oxidative stress response of rat testis to model prooxidants in vitro and its modulation. Toxicol. In Vitro 16, 675-682.
24. Murugesan, P., Kanagaraj, P., Yuvaraj, S., Balasubramanian, K., Aruldhas, M.M., Arunakaran, J., 2005. The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats. Reprod. Toxicol. 20, 117-126.
25. Nwani, C.D., Lakra, W.S., Nagpure, N.S., Kumar, R., Kushwaha, B., Srivastava, S.K., 2010. Toxicity of the herbicide atrazine: effects on lipid peroxidation and activities of antioxidant enzymes in the freshwater fish Channa Punctatus (Bloch). Int. J. Environ. Res. Public Health 7, 3298-3312.
26. Paglia, D.E., Valentine, N.W., 1967. Studies on qualitative and quantitative characterization of erythrocyte glutathione peroxidases. J. Lab. Clin. Med. 70, 74-77.
27. Payne, A.H., Downing, J., Wongi, K.L., 1980. Luteinizing hormone receptors and testosterone synthesis in two distinct populations of Leydig cells. Endocrinology 106, 1424-1429.
28. Peltola, V., Huhtaniemi, I., Ahotupa, M., 1992. Antioxidant enzyme activity in the maturing rat testes. J. Androl. 13, 450-455.
29. Peltola, V., Huhtaniemi, I., Metsa-Ketela, T., Ahotupa, M., 1996. Induction of lipid peroxidation during steroidogenesis in the rat testis. Endocrinology 137, 105-112.
30. Pogrmic, K., Fa, S., Dakic, V., Kaisarevic, S., Kovacevic, R., 2009. Atrazine oral exposure of peripubertal male rats down-regulates steroidogenesis gene expression in Leydig cells. Toxicol. Sci. 111, 189-197.
31. Pogrmic-Majkic, K., Fa, S., Dakic, V., Kaisarevic, S., Kovacevic, R., 2010. Up-regulation of peripubertal rat Leydig cell steroidogenesis following 24 hour in vitro and in vivo exposure to atrazine. Toxicol. Sci. 118, 52-60.
32. Pucarević, M., šovljanski, R., Lazić, S., Marjanović, N., 2002. Atrazine in groundwater of Vojvodina Province. Water Res. 36, 5120-5126.
33. Sass, J.B., Colangelo, A., 2006. European Union bans atrazine, while the United States negotiates continued use. Int. J. Occup. Environ. Health 12, 260-267.
34. Sharma, R.K., Chauhan, P.K., Fulia, A., 2001. Atrazine induced morphological alterations in spermatocytes of goat in vitro. J. Med. Sci. 11, 177-184.
35. Singh, M., Sandhir, R., Kiran, R., 2011. Effects on antioxidant status of liver following atrazine exposure and its attenuation by vitamin E. Exp. Toxicol. Pathol. 63, 269-276.
36. Slater, T.F., 1984. Overview of methods for detecting lipid peroxidation. Modification of methods for detecting lipid peroxidation. Methods Enzymol. 105, 283-293.
37. Solomon, K.R., Carr, J.A., Preez, L.H.D., Giesy, J.P., Kendall, R.J., Smith, E.E., Van Der Kraak, G.J., 2008. Effects of atrazine on fish, amphibians, and aquatic reptiles: a critical review. Crit. Rev. Toxicol. 38, 721-772.
38. Spano, L., Tyler, C.R., van Aerle, R., Devos, P., Mandiki, S.N., 2004. Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus). Aquat. Toxicol. 66, 369-379.
39. Stoker, T.E., Laws, S.C., Guidici, D.L., Cooper, R.L., 2000. The effects of atrazine on puberty in male Wistar rats: an evaluation in the protocol for the assessment of pubertal development and thyroid function. Toxicol. Sci. 58, 50-59.
40. Sujatha, R., Chitra, K.C., Latchomycandane, C., Mathur, P.P., 2001. Effects of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats. Asian J. Androl. 3, 135-138.
41. Trentacoste, S.V., Friedmann, A.S., Youker, R.T., Breckenridge, C.B., Zirkin, B.R., 2001. Atrazine effects on testosterone levels and androgen-dependent reproductive organs in peripubertal male rats. J. Androl. 22, 142-148.
42. Twaroski, T.P., O'Brien, M.L., Robertson, L.W., 2001. Effects of selected polychlorinated biphenyl (PCB) congener on hepatic glutathione, glutathione-related enzymes, and selenium status: implications for oxidative stress. Biochem. Pharmacol. 62, 273-281.
43. Van den Berg, M., Sanderson, T., Kurihara, N., Katayama, A., 2003. Role of metabolism in the endocrine-disrupting effects of chemicals in aquatic and terrestrial systems. Pure Appl. Chem. 75, 1917-1932.
44. Wilhelms, K.W., Cutler, S.A., Proudman, J.A., Anderson, L.L., Scanes, C.G., 2005. Atrazine and the hypothalamo-pituitary-gonadal axis in sexually maturing precocial birds: studies in male Japanese quail. Toxicol. Sci. 86, 152-160.