In vivo and in vitro effects of PCB126 and PCB153 on rat testicular androgenesis

Environmental Toxicology and Pharmacology

Volumn 25, Issue 2, 2008, Pages 222-226

  Andric, N ^a   Kostic, T ^a   Kaisarevic, S ^a   Fa, S ^a   Pogrmic, K ^a   Kovacevic, R ^a  

^a UNIVERSITY OF NOVI SAD   (Serbia)

Author keywords

Androgenesis; PCB126; PCB153; Rat Leydig cells

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; ANDROSTENEDIONE; ANTIOXIDANT; POLYCHLORINATED BIPHENYL 153; POLYCHLORINATED BIPHENYL DERIVATIVE; PROGESTERONE; STEROID; TESTOSTERONE; UNCLASSIFIED DRUG;

ANDROGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; IN VITRO STUDY; IN VIVO STUDY; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TESTIS;

RATTUS;

EID: 38649141866     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2007.10.002     Document Type: Article

References (24)

1. Andric N.L., Andric S.A., Zoric S.N., Kostic T.S., Stojilkovic S.S., and Kovacevic R.Z. Parallelism and dissociation in the action of an Aroclor 1260-based transformer fluid on testicular steroidogenesis and antioxidant enzymes. Toxicology 194 (2003) 65
2. Andric S.A., Kostic, Zoric S.N., Stanic B.D., Andric S.A., and Kovacevic R.Z. Effect of PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes. Reprod. Toxicol. 22 (2006) 102
3. Andric S.A., Kostic T.S., Dragisic S., Andric N.L., Stojilkovic S.S., and Kovacevic R.Z. Acute in vivo and in vitro effects of Aroclors on rat testicular steroidogenesis. In: Robertson L.W., and Hansen PCBs L.G. (Eds). Recent Advances in the Environmental Toxicology and Health Effects (2001), The University Press of Kentucky, Kentucky 303
4. Andric S.A., Kostic T.S., Dragisic S., Andric N.L., Stojilkovic S.S., and Kovacevic R.Z. Acute effects of polychlorinated biphenyl-containing and -free transformer fluids on rat testicular steroidogenesis. Environ. Health Perspect. 108 (2000) 959
5. Andric S.A., Kostic T.S., Stojilkovic S.S., and Kovacevic R.Z. Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture Aroclor 1248. Biol. Reprod. 62 (2000) 1882
6. Cooke P.S., Sato T., and Buchanan D.L. Disruption of steroid hormone signalling by PCBs. In: Robertson L.W., and Hansen PCBs L.G. (Eds). Recent Advances in the Environmental Toxicology and Health Effects (2001), The University Press of Kentucky, Kentucky 257
7. Fukazawa N.H., Ohsako S., Nagano R., Sakaue M., Baba T., Aoki Y., and Tohyama C. Effects of 3,3′,4,4′-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Toxicol. in Vitro 17 (2003) 1
8. Hansen L.G. Metabolism and metabolites. The ortho side of PCBs. Occurrence and Disposition (1999), Kluwer Academic Publisher, London p. 81
9. Korkalainen M., Tuomisto J., and Pohjanvirta R. Primary structure and inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDD-resistent rat strain. Biochem. Bioph. Res. Comm. 315 (2004) 123
10. Kostic T.S., Andric S.A., Maric D., and Kovacevic R.Z. Inhibitory effects of stress-activated nitric oxide on antioxidant enzymes and testicular steroidogenesis. J. Steroid. Biochem. Molec. Biol. 75 (2000) 299
11. Leckie C.M., Welberg L.A.M., and Seckl J.R. 11β-Hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells. J. Endocrinol. 159 (1998) 233
12. Li L.A., and Wang P.W. PCB 126 induces differential changes in androgen, cortisol, and aldosterone biosynthesis in human adrenocortical H295R cells. Toxicol. Sci. 85 (2005) 530
13. Murugesan P., Balaganesh M., Balasubramanian K., and Arunakaran J. Effects of polychlorinated biphenyl (Aroclor 1254) on steroidogenesis and antioxidant system in cultured adult rat Leydig cells. J. Endocrinol. 192 (2007) 325
14. Murugesan P., Kanagaraj P., Yuvaraj S., Balasubramanian K., Aruldhas M.M., and Arunakaran J. The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats. Reprod. Toxicol. 20 (2005) 117
15. Payne A.H., Downing J., and Wongi K.L. Luteinizing hormone receptors and testosterone synthesis in two distinct population of Leydig cells. Endocrinology 106 (1980) 1424
16. Peltola V., Mantyla E., Huhtaniemi I., and Ahotupa M. Lipid peroxidation and antioxidant enzymes activities in the rat testes after cigarette smoke inhalation or administration of polychlorinated biphenyls or polychlorinated naphthalene's. J. Androl. 15 (1994) 353
17. Safe S. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses and implications for risk assessment. Crit. Rev. Toxicol. 24 (1994) 87
18. Schlezinger J.J., Struntz W.D.J., Goldstone J.V., and Stegeman J.J. Uncoupling of cytochrome P4501A and stimulation of reactive oxygen species by co-planar polyhlorinated biphenyl congeners. Aquat. Toxicol. 77 (2006) 422
19. Schlezinger J.J., White R.D., and Stegeman J.J. oxidative inactivation of cytochrome P-450 1A (CYP 1A) stimulated by 3,3′,4,4′-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Molec. Pharmacol. 56 (1999) 588
20. Soontornchat S., Li M.H., Cooke P.S., and Hansen L.G. Toxicokinetic and toxicodynamic influences on endocrine disruption by polychlorinated biphenyls. Environ. Health Perspect. 102 (1994) 568
21. Twarowski T.P., O'Brien M.L., and Robertson L.W. Effects of selected polychlorinated biphenyl (PCB) congener on hepatic glutathione, glutathione-related enzymes, and selenium status: implications for oxidative stress. Biochem. Pharmacol. 62 (2001) 273
22. Wojtowicz A.K., Goch M., and Gregoraszczuk E.L. Polychlorinated Biphenyls (PCB153 and PCB126) action on conversion of 20-hydroxylated cholesterol to progesterone, androstenedione to testosterone and testosterone to estradiol 17β. Exp. Clin. Endocrinol. Diabetes 113 (2005) 1
23. Wojtowicz A.K., Ropstad E., and Gregoraszczuk E.L. Time dependent and cell-specific action of polychlorinated biphenyls (PCB153 and PCB126) on steroid secretion by porcine theca and granulose cells in mono- and co-culture. J. Physiol. Pharmacol. 51 (2000) 555
24. 2- PCBs on adrenocortical steroidogenesis in H295R human adrenocortical carcinoma cells. Chemosphere 63 (2006) 772