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Volumn 49, Issue 1, 2012, Pages 8-15

Clinical implication of targeting of cancer stem cells

Author keywords

Cancer stem cells; Molecular markers; Resistance; Signaling pathway; Target therapy

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; BCR ABL PROTEIN; BETA CATENIN; BREAST CANCER RESISTANCE PROTEIN; CARBOPLATIN; CATHEPSIN B; CATHEPSIN L; CYSTEINE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; GLYCOPROTEIN P; IMATINIB; IRINOTECAN; MICRORNA 124; MICRORNA 200; MULTIDRUG RESISTANCE PROTEIN 1; NOTCH RECEPTOR; OXALIPLATIN; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SONIC HEDGEHOG PROTEIN; TEMOZOLOMIDE; VASCULOTROPIN; WNT PROTEIN;

EID: 84863755025     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000339610     Document Type: Review
Times cited : (6)

References (78)
  • 1
    • 72449210651 scopus 로고    scopus 로고
    • Cancer stem cells: Cell culture, markers, and targets for new therapies
    • Gilbert CA, Ross AH: Cancer stem cells: cell culture, markers, and targets for new therapies. J Cell Biochem 2009; 108: 1031-1038.
    • (2009) J Cell Biochem , vol.108 , pp. 1031-1038
    • Gilbert, C.A.1    Ross, A.H.2
  • 2
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: Cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler CE, Rich JN: Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 2008; 26: 2839-2845.
    • (2008) J Clin Oncol , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 3
    • 84863183398 scopus 로고    scopus 로고
    • Cancer stem cells: Relevance to clinical transpla ntation
    • Ghiaur G, et al: Cancer stem cells: relevance to clinical transpla ntation. Curr Opin Oncol 2012; 24: 170-175.
    • (2012) Curr Opin Oncol , vol.24 , pp. 170-175
    • Ghiaur, G.1
  • 4
    • 77954646313 scopus 로고    scopus 로고
    • Emerging strategies for the identification and targeting of cancer stem cells
    • Dou J, Gu N: Emerging strategies for the identification and targeting of cancer stem cells. Tumour Biol 2010; 31: 243-253.
    • (2010) Tumour Biol , vol.31 , pp. 243-253
    • Dou, J.1    Gu, N.2
  • 5
    • 84856501335 scopus 로고    scopus 로고
    • The developing cancer stem-cell model: Clinical challenges and opportunities
    • Vermeulen L, et al: The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol 2012; 13:e83-e89.
    • (2012) Lancet Oncol , vol.13
    • Vermeulen, L.1
  • 6
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, et al: Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1
  • 7
    • 79955947379 scopus 로고    scopus 로고
    • The renaissance of interferon therapy for the treatment of myeloid malignancies
    • Kiladjian JJ, Mesa RA, Hoffman R: The renaissance of interferon therapy for the treatment of myeloid malignancies. Blood 2011; 117: 4706-4715.
    • (2011) Blood , vol.117 , pp. 4706-4715
    • Kiladjian, J.J.1    Mesa, R.A.2    Hoffman, R.3
  • 8
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, et al: Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009; 23: 1054-1061.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1
  • 9
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response
    • Cortes J, O'Brien S, Kantarjian H: Discontinuation of imatinib therapy after achieving a molecular response. Blood 2004; 104: 2204-2205.
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 10
    • 1342343034 scopus 로고    scopus 로고
    • Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission
    • Mauro MJ, Druker BJ, Maziarz RT: Divergent clinical outcome in two CML patients who discontinued imatinib therapy after achieving a molecular remission. Leuk Res 2004; 28(suppl 1):S71-S73.
    • (2004) Leuk Res , vol.28 , Issue.SUPPL. 1
    • Mauro, M.J.1    Druker, B.J.2    Maziarz, R.T.3
  • 11
    • 22544459376 scopus 로고    scopus 로고
    • Outcome of four patients with chronic myeloid leukemia after ima-tinib mesylate discontinuation
    • Merante S, et al: Outcome of four patients with chronic myeloid leukemia after ima-tinib mesylate discontinuation. Haemato-logica 2005; 90: 979-981.
    • (2005) Haemato-logica , vol.90 , pp. 979-981
    • Merante, S.1
  • 12
    • 33845996567 scopus 로고    scopus 로고
    • Cancer stem cells: From bench to bedside
    • Jones RJ, Matsui W: Cancer stem cells: from bench to bedside. Biol Blood Marrow Transplant 2007; 13(suppl 1):47-52.
    • (2007) Biol Blood Marrow Transplant , vol.3 , Issue.SUPPL. 1 , pp. 47-52
    • Jones, R.J.1    Matsui, W.2
  • 14
    • 30444446406 scopus 로고    scopus 로고
    • The paradox of response and survival in cancer therapeutics
    • Huff CA, et al: The paradox of response and survival in cancer therapeutics. Blood 2006; 107: 431-434.
    • (2006) Blood , vol.107 , pp. 431-434
    • Huff, C.A.1
  • 15
    • 70449529780 scopus 로고    scopus 로고
    • Cancer stem cells-clinical relevance
    • Jones RJ: Cancer stem cells-clinical relevance. J Mol Med (Berl) 2009; 87: 1105-1110.
    • (2009) J Mol Med (Berl) , vol.87 , pp. 1105-1110
    • Jones, R.J.1
  • 16
    • 79957622341 scopus 로고    scopus 로고
    • Concise review: Emerging concepts in clinical targeting of cancer stem cells
    • Rasheed ZA, et al: Concise review: emerging concepts in clinical targeting of cancer stem cells. Stem Cells 2011; 29: 883-887.
    • (2011) Stem Cells , vol.29 , pp. 883-887
    • Rasheed, Z.A.1
  • 17
    • 79951681568 scopus 로고    scopus 로고
    • Cancer stem cells: A new framework for the design of tumor therapies
    • Garvalov BK, Acker T: Cancer stem cells: a new framework for the design of tumor therapies. J Mol Med (Berl) 2011; 89: 95-107.
    • (2011) J Mol Med (Berl) , vol.89 , pp. 95-107
    • Garvalov, B.K.1    Acker, T.2
  • 18
    • 63649119820 scopus 로고    scopus 로고
    • Cancer stem cell-directed therapies: Recent data from the laboratory and clinic
    • Park CY, Tseng D, Weissman IL: Cancer stem cell-directed therapies: recent data from the laboratory and clinic. Mol Ther 2009; 17: 219-230.
    • (2009) Mol Ther , vol.17 , pp. 219-230
    • Park, C.Y.1    Tseng, D.2    Weissman, I.L.3
  • 19
    • 0032865742 scopus 로고    scopus 로고
    • The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0): Reduced immunogenicity and high frequency of CD34+/CD38-leuke-mic progenitors
    • Costello R, et al: The immunophenotype of minimally differentiated acute myeloid leukemia (AML-M0): reduced immunogenicity and high frequency of CD34+/CD38-leuke-mic progenitors. Leukemia 1999; 13: 1513-1518.
    • (1999) Leukemia , vol.13 , pp. 1513-1518
    • Costello, R.1
  • 20
    • 0037440158 scopus 로고    scopus 로고
    • Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: Results of a multiparameter analysis from the German AML Cooperative Group studies
    • Haferlach T, et al: Morphologic dysplasia in de novo acute myeloid leukemia (AML) is related to unfavorable cytogenetics but has no independent prognostic relevance under the conditions of intensive induction therapy: results of a multiparameter analysis from the German AML Cooperative Group studies. J Clin Oncol 2003; 21: 256-265.
    • (2003) J Clin Oncol , vol.21 , pp. 256-265
    • Haferlach, T.1
  • 21
    • 34447625239 scopus 로고    scopus 로고
    • Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: Correlation of nestin with prognosis of patient survival
    • discussion 143-144
    • Strojnik T, et al: Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival. Surg Neurol 2007; 68: 133-143, discussion 143-144.
    • (2007) Surg Neurol , vol.68 , pp. 133-143
    • Strojnik, T.1
  • 22
    • 66949150208 scopus 로고    scopus 로고
    • Targeting stem cells-clinical implications for cancer therapy
    • Tu LC, et al: Targeting stem cells-clinical implications for cancer therapy. Curr Stem Cell Res Ther 2009; 4: 147-153.
    • (2009) Curr Stem Cell Res Ther , vol.4 , pp. 147-153
    • Tu, L.C.1
  • 23
    • 53149105484 scopus 로고    scopus 로고
    • Cancer stem cell markers in common cancers-therapeutic implications
    • Klonisch T, et al: Cancer stem cell markers in common cancers-therapeutic implications. Trends Mol Med 2008; 14: 450-460.
    • (2008) Trends Mol Med , vol.14 , pp. 450-460
    • Klonisch, T.1
  • 24
    • 33846425793 scopus 로고    scopus 로고
    • The prognostic role of a gene signature from tumorigenic breast-cancer cells
    • Liu R, et al: The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med 2007; 356: 217-226.
    • (2007) N Engl J Med , vol.356 , pp. 217-226
    • Liu, R.1
  • 25
    • 36849083949 scopus 로고    scopus 로고
    • Cancer stem cell: Target for anti-cancer therapy
    • Tang C, Ang BT, Pervaiz S: Cancer stem cell: target for anti-cancer therapy. FASEB J 2007; 21: 3777-3785.
    • (2007) FASEB J , vol.21 , pp. 3777-3785
    • Tang, C.1    Ang, B.T.2    Pervaiz, S.3
  • 26
    • 33845671339 scopus 로고    scopus 로고
    • Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    • Liu G, et al: Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006; 5: 67.
    • (2006) Mol Cancer , vol.5 , pp. 67
    • Liu, G.1
  • 27
    • 42549142322 scopus 로고    scopus 로고
    • Brca1 breast tumors contain distinct CD44+/CD24-and CD133+ cells with cancer stem cell characteristics
    • Wright MH, et al: Brca1 breast tumors contain distinct CD44+/CD24-and CD133+ cells with cancer stem cell characteristics. Breast Cancer Res 2008; 10:R10.
    • (2008) Breast Cancer Res , vol.10
    • Wright, M.H.1
  • 28
    • 4444262529 scopus 로고    scopus 로고
    • CD133, a novel marker for human prostatic epithelial stem cells
    • Richardson GD, et al: CD133, a novel marker for human prostatic epithelial stem cells. J Cell Sci 2004; 117: 3539-3545.
    • (2004) J Cell Sci , vol.117 , pp. 3539-3545
    • Richardson, G.D.1
  • 29
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins AT, et al: Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005; 65: 10946-10951.
    • (2005) Cancer Res , vol.65 , pp. 10946-10951
    • Collins, A.T.1
  • 30
    • 80051609605 scopus 로고    scopus 로고
    • Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells
    • Tang M, et al: Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells. Blood 2011; 118: 1622-1631.
    • (2011) Blood , vol.118 , pp. 1622-1631
    • Tang, M.1
  • 31
    • 33749524667 scopus 로고    scopus 로고
    • Dynamic modeling of ima-tinib-treated chronic myeloid leukemia: Functional insights and clinical implications
    • Roeder I, et al: Dynamic modeling of ima-tinib-treated chronic myeloid leukemia: functional insights and clinical implications. Nat Med 2006; 12: 1181-1184.
    • (2006) Nat Med , vol.12 , pp. 1181-1184
    • Roeder, I.1
  • 32
    • 77956146147 scopus 로고    scopus 로고
    • Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors
    • Bardsley MR, et al: Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology 2010; 139: 942-952.
    • (2010) Gastroenterology , vol.139 , pp. 942-952
    • Bardsley, M.R.1
  • 33
    • 49149107236 scopus 로고    scopus 로고
    • Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy
    • Dylla SJ, et al: Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One 2008; 3:e2428.
    • (2008) PLoS One , vol.3
    • Dylla, S.J.1
  • 34
    • 34848866647 scopus 로고    scopus 로고
    • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    • Todaro M, et al: Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007; 1: 389-402.
    • (2007) Cell Stem Cell , vol.1 , pp. 389-402
    • Todaro, M.1
  • 35
    • 79960933733 scopus 로고    scopus 로고
    • ABCB5 identifies a therapy-refractory tumor cell population in colorec-tal cancer patients
    • Wilson BJ, et al: ABCB5 identifies a therapy-refractory tumor cell population in colorec-tal cancer patients. Cancer Res 2011; 71: 5307-5316.
    • (2011) Cancer Res , vol.71 , pp. 5307-5316
    • Wilson, B.J.1
  • 36
    • 33746625091 scopus 로고    scopus 로고
    • Ovarian cancer side population defines cells with stem cell-like characteristics and mullerian inhibiting substance responsiveness
    • Szotek PP, et al: Ovarian cancer side population defines cells with stem cell-like characteristics and mullerian inhibiting substance responsiveness. Proc Natl Acad Sci USA 2006; 103: 11154-11159.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11154-11159
    • Szotek, P.P.1
  • 37
    • 73649139235 scopus 로고    scopus 로고
    • Side population and cancer stem cells: Therapeutic implications
    • Moserle L, et al: Side population and cancer stem cells: therapeutic implications. Cancer Lett 2010; 288: 1-9.
    • (2010) Cancer Lett , vol.288 , pp. 1-9
    • Moserle, L.1
  • 38
    • 77957751477 scopus 로고    scopus 로고
    • Identification of multi-drug resistance associated proteins MRP1 (ABCC1) and MRP3 (ABCC3) from rainbow trout (Oncorhynchus mykiss)
    • Fischer S, et al: Identification of multi-drug resistance associated proteins MRP1 (ABCC1) and MRP3 (ABCC3) from rainbow trout (Oncorhynchus mykiss). Mar Environ Res 2010; 69(suppl):S7-S10.
    • (2010) Mar Environ Res , vol.69 , Issue.SUPPL.
    • Fischer, S.1
  • 39
    • 0033107768 scopus 로고    scopus 로고
    • In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice
    • Bruns CJ, et al: In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1999; 1: 50-62.
    • (1999) Neoplasia , vol.1 , pp. 50-62
    • Bruns, C.J.1
  • 40
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radio-resistance by preferential activation of the DNA damage response
    • Bao S, et al: Glioma stem cells promote radio-resistance by preferential activation of the DNA damage response. Nature 2006; 444: 756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1
  • 41
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    • Phillips TM, McBride WH, Pajonk F: The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006; 98: 1777-1785.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 42
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M, et al: Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009; 458: 780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1
  • 43
    • 33847369455 scopus 로고    scopus 로고
    • Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
    • Chen MS, et al: Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci 2007; 120: 468-477.
    • (2007) J Cell Sci , vol.120 , pp. 468-477
    • Chen, M.S.1
  • 44
    • 33845621982 scopus 로고    scopus 로고
    • Daoy medul-loblastoma cells that express CD133 are ra-dioresista nt relative to CD133-cells, and t he CD133+ sector is enlarged by hypoxia
    • Blazek ER, Foutch JL, Maki G: Daoy medul-loblastoma cells that express CD133 are ra-dioresista nt relative to CD133-cells, and t he CD133+ sector is enlarged by hypoxia. Int J Radiat Oncol Biol Phys 2007; 67: 1-5.
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 1-5
    • Blazek, E.R.1    Foutch, J.L.2    Maki, G.3
  • 45
    • 36148995870 scopus 로고    scopus 로고
    • Inf luence of oxygen tension on CD133 phenotype in human glioma cell cultures
    • Platet N, et al: Inf luence of oxygen tension on CD133 phenotype in human glioma cell cultures. Cancer Lett 2007; 258: 286-290.
    • (2007) Cancer Lett , vol.258 , pp. 286-290
    • Platet, N.1
  • 46
    • 13344277921 scopus 로고    scopus 로고
    • Theragnostic imaging for radiation oncology: Dose-painting by numbers
    • Bentzen SM: Theragnostic imaging for radiation oncology: dose-painting by numbers. Lancet Oncol 2005; 6: 112-117.
    • (2005) Lancet Oncol , vol.6 , pp. 112-117
    • Bentzen, S.M.1
  • 47
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, et al: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009; 10: 459-466.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1
  • 48
    • 35648999534 scopus 로고    scopus 로고
    • Recent advances in cancer stem/progenitor cell research: Therapeutic implications for overcoming resistance to the most aggressive cancers
    • Mimeault M, et al: Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. J Cell Mol Med 2007; 11: 981-1011.
    • (2007) J Cell Mol Med , vol.11 , pp. 981-1011
    • Mimeault, M.1
  • 49
    • 34547415968 scopus 로고    scopus 로고
    • CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia
    • Hosen N, et al: CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci USA 2007; 104: 11008-11013.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11008-11013
    • Hosen, N.1
  • 50
    • 0032936135 scopus 로고    scopus 로고
    • A signal sequence trap based on a constitutively active cytokine receptor
    • Kojima T, Kitamura T: A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol 1999; 17: 487-490.
    • (1999) Nat Biotechnol , vol.17 , pp. 487-490
    • Kojima, T.1    Kitamura, T.2
  • 51
    • 80755141299 scopus 로고    scopus 로고
    • Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy
    • Lonardo E, et al: Nodal/activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. Cell Stem Cell 2011; 9: 433-446.
    • (2011) Cell Stem Cell , vol.9 , pp. 433-446
    • Lonardo, E.1
  • 52
    • 70349638289 scopus 로고    scopus 로고
    • Tumour-initiating cells: Challenges and opportunities for anticancer drug discovery
    • Zhou BB, et al: Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov 2009; 8: 806-823.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 806-823
    • Zhou, B.B.1
  • 53
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, et al: Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-111.
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1
  • 54
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H: Wnt signalling in stem cells and cancer. Nature 2005; 434: 843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 55
    • 34247555482 scopus 로고    scopus 로고
    • Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies
    • Jiang X, et al: Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Leukemia 2007; 21: 926-935.
    • (2007) Leukemia , vol.21 , pp. 926-935
    • Jiang, X.1
  • 56
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C, et al: Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009; 458: 776-779.
    • (2009) Nature , vol.458 , pp. 776-779
    • Zhao, C.1
  • 57
    • 33847666952 scopus 로고    scopus 로고
    • Contribution of Notch signaling activation to human glioblastoma multiforme
    • Kanamori M, et al: Contribution of Notch signaling activation to human glioblastoma multiforme. J Neurosurg 2007; 106: 417-427.
    • (2007) J Neurosurg , vol.106 , pp. 417-427
    • Kanamori, M.1
  • 58
    • 84861960819 scopus 로고    scopus 로고
    • Management of glioblastoma multiforme in pregnancy
    • E-pub ahead of print
    • Jayasekera BA, Bacon AD, Whitfield PC: Management of glioblastoma multiforme in pregnancy. J Neurosurg 2012, E-pub ahead of print.
    • (2012) J Neurosurg
    • Jayasekera, B.A.1    Bacon, A.D.2    Whitfield, P.C.3
  • 59
    • 33744535197 scopus 로고    scopus 로고
    • Telomeres and telomerase in cancer stem cells
    • Ju Z, Rudolph KL: Telomeres and telomerase in cancer stem cells. Eur J Cancer 2006; 42: 1197-1203.
    • (2006) Eur J Cancer , vol.42 , pp. 1197-1203
    • Ju, Z.1    Rudolph, K.L.2
  • 60
    • 80455140226 scopus 로고    scopus 로고
    • Telomerase peptide vaccination in NSCLC: A phase II trial in stage 111 patients vaccinated after chemoradio-therapy and an 8-year update on a phase I/II trial
    • Brunsvig PF, et al: Telomerase peptide vaccination in NSCLC: a phase II trial in stage 111 patients vaccinated after chemoradio-therapy and an 8-year update on a phase I/II trial. Clin Cancer Res 2011; 17: 6847-6857.
    • (2011) Clin Cancer Res , vol.17 , pp. 6847-6857
    • Brunsvig, P.F.1
  • 61
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1
  • 63
    • 77950838848 scopus 로고    scopus 로고
    • A hypoxic niche regulates glio-blastoma stem cells through hypoxia induc-ible factor 2 alpha
    • Seidel S, et al: A hypoxic niche regulates glio-blastoma stem cells through hypoxia induc-ible factor 2 alpha. Brain 2010; 133: 983-995.
    • (2010) Brain , vol.133 , pp. 983-995
    • Seidel, S.1
  • 64
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, et al: The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008. 283: 14910-14914.
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1
  • 65
  • 66
    • 33947180884 scopus 로고    scopus 로고
    • A functional study of miR-124 in the developing neural tube
    • Cao X, Pfaff SL, Gage FH: A functional study of miR-124 in the developing neural tube. Genes Dev 2007; 21: 531-536.
    • (2007) Genes Dev , vol.21 , pp. 531-536
    • Cao, X.1    Pfaff, S.L.2    Gage, F.H.3
  • 67
    • 2942534403 scopus 로고    scopus 로고
    • Human embryonic stem cells express a unique set of microRNAs
    • Suh MR, et al: Human embryonic stem cells express a unique set of microRNAs. Dev Biol 2004; 270: 488-498.
    • (2004) Dev Biol , vol.270 , pp. 488-498
    • Suh, M.R.1
  • 68
    • 67349149082 scopus 로고    scopus 로고
    • MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    • Xu N, et al: MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009; 137: 647-658.
    • (2009) Cell , vol.137 , pp. 647-658
    • Xu, N.1
  • 69
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: An emerging axis of evil in the war on cancer
    • Singh A, Settleman J: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010; 29: 4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 70
    • 77956610796 scopus 로고    scopus 로고
    • Targeting breast cancer stem cells
    • McDermott SP, Wicha MS: Targeting breast cancer stem cells. Mol Oncol 2010; 4: 404-419.
    • (2010) Mol Oncol , vol.4 , pp. 404-419
    • McDermott, S.P.1    Wicha, M.S.2
  • 71
    • 46049106797 scopus 로고    scopus 로고
    • Completion of premainte-nance phases in total therapies 2 and 3 improves clinical outcomes in multiple myeloma: An important variable to be considered in clinical trial designs
    • Barlogie B, et al: Completion of premainte-nance phases in total therapies 2 and 3 improves clinical outcomes in multiple myeloma: an important variable to be considered in clinical trial designs. Cancer 2008; 112: 2720-2725.
    • (2008) Cancer , vol.112 , pp. 2720-2725
    • Barlogie, B.1
  • 72
    • 33847052127 scopus 로고    scopus 로고
    • Identif icat ion of pa ncreatic cancer stem cells
    • Li C, et al: Identif icat ion of pa ncreatic cancer stem cells. Cancer Res 2007; 67: 1030-1037.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1
  • 73
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj M, et al: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100: 3983-3988.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1
  • 74
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P, et al: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 2007; 104: 10158-10163.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10158-10163
    • Dalerba, P.1
  • 75
    • 79953113373 scopus 로고    scopus 로고
    • Therapeutics formulated to target cancer stem cells: Is it in our future?
    • Clayton S, Mousa SA: Therapeutics formulated to target cancer stem cells: is it in our future? Cancer Cell Int 2011; 11: 7.
    • (2011) Cancer Cell Int , vol.11 , pp. 7
    • Clayton, S.1    Mousa, S.A.2
  • 76
    • 33644825465 scopus 로고    scopus 로고
    • Stem-like cells in bone sarcomas: Implications for tumorigenesis
    • Gibbs CP, et al: Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia 2005; 7: 967-976.
    • (2005) Neoplasia , vol.7 , pp. 967-976
    • Gibbs, C.P.1
  • 77
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F, et al: let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007; 131: 1109-1123.
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1
  • 78
    • 43449100341 scopus 로고    scopus 로고
    • REST maintains self-renewal and pluripotency of embryonic stem cells
    • Singh SK, et al: REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 2008; 453: 223-227.
    • (2008) Nature , vol.453 , pp. 223-227
    • Singh, S.K.1


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