Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing

Current Medicinal Chemistry

Volumn 19, Issue 21, 2012, Pages 3641-3650

  Zhu, J ^a   Declercq, J ^a   Creemers, J W M ^a   Chen, C ^b   Cui, Y ^b   Van De Ven, W J M ^a   Vermorken, A J M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b NORTHWEST UNIVERSITY   (China)

Author keywords

( ) EGCG; Diphtheria toxin; Furin mediated substrate processing; Gamma globulin; IGF 1R mediated signaling; Polyphenols; Pro GPC3; Pro IGF 1R; Proprotein convertase; Pyr RTKR AMC; Tumorigenesis; Tyrosine kinase receptors

Indexed keywords

BAICALEIN; BIOCHANIN A; CASEIN; CHRYSIN; DIPHTHERIA TOXIN; DODECYL GALLATE; EPICATECHIN GALLATE; EPIGALLOCATECHIN GALLATE; FISETIN; FURIN; GALLIC ACID; GALLIC ACID ETHYL ESTER; GALLIC ACID METHYL ESTER; GALLIC ACID OCTYL ESTER; GALLIC ACID PROPYL ESTER; GENISTEIN; IMMUNOGLOBULIN; KAEMPFEROL; MORIN; MYRICETIN; POLYPHENOL DERIVATIVE; QUERCETIN; RUTOSIDE; SERINE PROTEINASE; SOMATOMEDIN C RECEPTOR; TAXIFOLIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84863751873     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712801323162     Document Type: Article

References (32)

1. Yang, C.S.; Maliakal, P.; Meng, X. Inhibition of carcinogenesis by tea. Annu Rev Pharmacol Toxicol., 2002, 42, 25-54
2. Yang, C.S.; Wang, X.; Lu, G.; Picinich, S.C. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer., 2009, 9(6), 429-439
3. Lambert, J.D.; Hong, J.; Kim, D.H.; Mishin, V.M.; Yang, C.S. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3- gallate in mice. J Nutr., 2004, 134(8), 1948-1952
4. Kim, J.; Zhang, X.; Rieger-Christ, K.M.; Summerhayes, I.C.; Wazer, D.E.; Paulson, K.E.; Yee, A.S. Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1. J Biol Chem., 2006, 281(16), 10865-10875
5. Li, W.; Zhu, S.; Li, J.; Assa, A.; Jundoria, A.; Xu, J.; Fan, S.; Eissa, N.T.; Tracey, K.J.; Sama, A.E.; Wang, H. EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochem Pharmacol., 2011, 81(9), 1152-1163
6. Majumdar, S.; Mohanta, B.C.; Chowdhury, D.R.; Banik, R.; Dinda, B.; Basak, A. Proprotein convertase inhibitory activities of flavonoids isolated from Oroxylum indicum. Curr Med Chem., 2010, 17(19), 2049-2058
7. Van Dyck, F.; Declercq, J.; Braem, C.V.; Van de Ven, W.J. PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review). Int J Oncol., 2007, 30(4), 765-774
8. Lopez, T.; Hanahan, D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell., 2002, 1(4), 339-353
9. De Vos, L.; Declercq, J.; Rosas, G.G.; Van Damme, B.; Roebroek, A.; Vermorken, F.; Ceuppens, J.; Van de Ven, W.; Creemers, J. MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice. Int J Oncol., 2008, 32(5), 1073-1083
10. Van de Ven, W.J.; Voorberg, J.; Fontijn, R.; Pannekoek, H.; van den Ouweland, A.M.; van Duijnhoven, H.L.; Roebroek, A.J.; Siezen, R.J. Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes. Mol Biol Rep., 1990, 14(4), 265-275
11. Seidah, N.G.; Chretien, M.; Day, R. The family of subtilisin/kexin like pro protein and pro-hormone convertases: divergent or shared functions. Biochimie., 1994, 76(3-4), 197-209
12. Van de Ven, W.J.; Creemers, J.W.; Roebroek, A.J. Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway. Enzyme., 1991, 45(5-6), 257-270
13. Khatib, A.M.; Siegfried, G.; Chretien, M.; Metrakos, P.; Seidah, N.G. Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. Am J Pathol., 2002, 160(6), 1921-1935
14. Taylor, N.A.; Van De Ven, W.J.; Creemers, J.W. Curbing activation: proprotein convertases in homeostasis and pathology. FASEB J., 2003, 17(10), 1215-1227
15. Thomas, G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol., 2002, 3(10), 753-766
16. Khatib, A.M.; Siegfried, G.; Prat, A.; Luis, J.; Chretien, M.; Metrakos, P.; Seidah, N.G. Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions. J Biol Chem., 2001, 276(33), 30686-30693
17. Declercq, J.; Van Dyck, F.; Braem, C.V.; Van Valckenborgh, I.C.; Voz, M.; Wassef, M.; Schoonjans, L.; Van Damme, B.; Fiette, L.; Van de Ven, W.J. Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression. Cancer Res., 2005, 65(11), 4544-4553
18. Veugelers, M.; Cat, B.D.; Muyldermans, S.Y.; Reekmans, G.; Delande, N.; Frints, S.; Legius, E.; Fryns, J.P.; Schrander-Stumpel, C.; Weidle, B.; Magdalena, N.; David, G. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. Hum Mol Genet., 2000, 9(9), 1321-1328
19. Anderson, E.D.; Thomas, L.; Hayflick, J.S.; Thomas, G. Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant. J Biol Chem., 1993, 268(33), 24887-24891
20. Jean, F.; Stella, K.; Thomas, L.; Liu, G.; Xiang, Y.; Reason, A.J.; Thomas, G. Alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent. Proc Natl Acad Sci U S A., 1998, 95(13), 7293-7298
21. Benjannet, S.; Savaria, D.; Laslop, A.; Munzer, J.S.; Chretien, M.; Marcinkiewicz, M.; Seidah, N.G. Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway. J Biol Chem., 1997, 272(42), 26210-26218
22. Ishii, T.; Mori, T.; Tanaka, T.; Mizuno, D.; Yamaji, R.; Kumazawa, S.; Nakayama, T.; Akagawa, M. Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation. Free Radic Biol Med., 2008, 45(10), 1384-1394
23. Kacprzak, M.M.; Peinado, J.R.; Than, M.E.; Appel, J.; Henrich, S.; Lipkind, G.; Houghten, R.A.; Bode, W.; Lindberg, I. Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine. J Biol Chem., 2004, 279(35), 36788-36794
24. Creemers, J.W.; Siezen, R.J.; Roebroek, A.J.; Ayoubi, T.A.; Huylebroeck, D.; Van de Ven, W.J. Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis. J Biol Chem., 1993, 268(29), 21826-21834
25. Cameron, A.; Appel, J.; Houghten, R.A.; Lindberg, I. Polyarginines are potent furin inhibitors. J Biol Chem., 2000, 275(47), 36741-36749
26. Tsuneoka, M.; Nakayama, K.; Hatsuzawa, K.; Komada, M.; Kitamura, N.; Mekada, E. Evidence for involvement of furin in cleavage and activation of diphtheria toxin. J Biol Chem., 1993, 268(35), 26461-26465
27. Cao, D.; Zhang, Y.; Zhang, H.; Zhong, L.; Qian, X. Systematic characterization of the covalent interactions between (-)-epigallocatechin gallate and peptides under physiological conditions by mass spectrometry. Rapid Commun Mass Spectrom., 2009, 23(8), 1147-1157
28. Vaidyanathan, J.B.; Walle, T. Cellular uptake and efflux of the tea flavonoid (-)epicatechin-3-gallate in the human intestinal cell line Caco-2. J Pharmacol Exp Ther., 2003, 307(2), 745-752
29. Wang, P.; Heber, D.; Henning, S.M. Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo. Food Funct., 2012, Mar 22. [Epub ahead of print] PMID: 22438067
30. Ahn, H.Y.; Hadizadeh, K.R.; Seul, C.; Yun, Y.P.; Vetter, H.; Sachinidis, A. Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172). Mol Biol Cell., 1999, 10(4), 1093-1104
31. Lamy, S.; Gingras, D.; Beliveau, R. Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res., 2002, 62(2), 381-385
32. Liang, Y.C.; Lin-shiau, S.Y.; Chen, C.F.; Lin, J.K. Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells. J Cell Biochem., 1997, 67(1), 55-65.