Physical activity is related to insulin sensitivity in children and adolescents, independent of adiposity: A review of the literature

Diabetes/Metabolism Research and Reviews

Volumn 28, Issue 5, 2012, Pages 395-408

  Berman, Laura J ^a   Weigensberg, Marc J ^a   Spruijt Metz, Donna ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adiposity; Adolescents; Children; Diabetes; Insulin sensitivity; Physical activity

Indexed keywords

INSULIN;

BODY WEIGHT; CARDIOPULMONARY FUNCTION; CROSS-SECTIONAL STUDY; ETHNICITY; FITNESS; GENDER; GROUPS BY AGE; HUMAN; INSULIN SENSITIVITY; INTERVENTION STUDY; LONGITUDINAL STUDY; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PUBERTY; REVIEW; STRENGTH;

ADIPOSITY; ADOLESCENT; ADULT; CHILD; CROSS-SECTIONAL STUDIES; EXERCISE; FEMALE; HUMANS; INSULIN RESISTANCE; LONGITUDINAL STUDIES; MALE;

EID: 84863745583     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.2292     Document Type: Review

References (108)

1. Goran MI, Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes 2001; 50(11): 2444-2450.
2. Rizzo NS, Ruiz JR, Oja L, Veidebaum T, Sjostrom M. Associations between physical activity, body fat, and insulin resistance (homeostasis model assessment) in adolescents: the European Youth Heart Study. Am J Clin Nutr 2008; 87(3): 586-592.
3. Belcher BR, Berrigan D, Dodd KW, Emken BA, Chou CP, Spuijt-Metz D. Physical Activity in US Youth: Impact of Race/Ethnicity, Age, Gender, & Weight Status. Med Sci Sports Exerc 2010; 42(12): 2211-2221.
4. Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993; 44: 121-131.
5. Goran MI, Bergman RN, Cruz ML, Watanabe R. Insulin resistance and associated compensatory responses in african-american and Hispanic children. Diabetes Care 2002; 25(12): 2184-2190.
6. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 2003; 107(10): 1448-1453.
7. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of High Body Mass Index in US Children and Adolescents, 2007-2008. JAMA 2010: 242-249.
8. DiPietro L. Physical activity, body weight, and adiposity: an epidemiologic perspective. Exerc Sport Sci Rev 1995; 23: 275-303.
9. Casazza K, Gower BA, Willig AL, Hunter GR, Fernandez JR. Physical fitness, activity, and insulin dynamics in early pubertal children. Pediatr Exerc Sci 2009; 21(1): 63-76.
10. Jago R, Wedderkopp N, Kristensen PL, et al. Six-year change in youth physical activity and effect on fasting insulin and HOMA-IR. Am J Prev Med 2008; 35(6): 554-560.
11. Manson JE, Rimm EB, Stampfer MJ, et al. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 1991; 338(8770): 774-778.
12. Hawley JA. Exercise as a therapeutic intervention for the prevention and treatment of insulin resistance. Diabetes Metab Res Rev 2004; 20(5): 383-393.
13. Irwin ML, Mayer-Davis EJ, Addy CL, et al. Moderate-intensity physical activity and fasting insulin levels in women: the Cross-Cultural Activity Participation Study. Diabetes Care 2000; 23(4): 449-454.
14. Kriska AM, Pereira MA, Hanson RL, et al. Association of physical activity and serum insulin concentrations in two populations at high risk for type 2 diabetes but differing by BMI. Diabetes Care 2001; 24(7): 1175-1180.
15. Kelley DE, Goodpaster BH. Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc 1999; 31(11 SUPPL): S619-S623.
16. Lynch J, Helmrich SP, Lakka TA, et al. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men. Arch Intern Med 1996; 156(12): 1307-1314.
17. Poehlman ET, Dvorak RV, DeNino WF, Brochu M, Ades PA. Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: a controlled randomized trial. J Clin Endocrinol Metab 2000; 85(7): 2463-2468.
18. Bell LM, Watts K, Siafarikas A, et al. Exercise alone reduces insulin resistance in obese children independently of changes in body composition. J Clin Endocrinol Metab 2007; 92(11): 4230-4235.
19. Cruz ML, Shaibi GQ, Weigensberg MJ, Spruijt-Metz D, Ball GD, Goran MI. Pediatric obesity and insulin resistance: chronic disease risk and implications for treatment and prevention beyond body weight modification. Annu Rev Nutr 2005; 25: 435-468.
20. Shaibi GQ, Roberts CK, Goran MI. Exercise and insulin resistance in youth. Exerc Sport Sci Rev 2008; 36(1): 5-11.
21. LaMonte MJ, Blair SN, Church TS. Physical activity and diabetes prevention. J Appl Physiol 2005; 99(3): 1205.
22. Thompson PD, Crouse SF, Goodpaster B, Kelley D, Moyna N, Pescatello L. The acute versus the chronic response to exercise. Med Sci Sports Exerc 2001; 33(6 SUPPL): S438-S445; discussion S52-3.
23. Mikines KJ, Sonne B, Tronier B, Galbo H. Effects of acute exercise and detraining on insulin action in trained men. J Appl Physiol 1989; 66(2): 704-711.
24. Borghouts LB, Keizer HA. Exercise and insulin sensitivity: a review. Int J Sports Med 2000; 21(1): 1-12.
25. Foricher JM, Ville N, Gratas-Delamarche A, Delamarche P. Effects of submaximal intensity cycle ergometry for one hour on substrate utilisation in trained prepubertal boys versus trained adults. J Sports Med Phys Fitness 2003; 43(1): 36-43.
26. Martinez LR, Haymes EM. Substrate utilization during treadmill running in prepubertal girls and women. Med Sci Sports Exerc 1992; 24(9): 975-983.
27. Timmons BW, Bar-Or O, Riddell MC. Oxidation rate of exogenous carbohydrate during exercise is higher in boys than in men. J Appl Physiol 2003; 94(1): 278-284.
28. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 1985; 100(2): 126-131.
29. Corbin CB. Concepts in physical education with laboratories and experiments, 1977.
30. Strong WB, Malina RM, Blimkie CJ, et al. Evidence based physical activity for school-age youth. J Pediatr 2005; 146(6): 732-737.
31. Morrow JR, Freedson PS. Relationship Between-Habitual Physical Activity and Aerobic Fitness in Adolescents. Pediatr Exerc Sci 1994; 6: 315.
32. Ekelund U, Anderssen SA, Froberg K, Sardinha LB, Andersen LB, Brage S. Independent associations of physical activity and cardiorespiratory fitness with metabolic risk factors in children: the European youth heart study. Diabetologia 2007; 50(9): 1832-1840.
33. DeFronzo RA, Ferrannini E, Sato Y, Felig P, Wahren J. Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest 1981; 68(6): 1468-1474.
34. Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci 2007; 4(1): 19-27.
35. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237(3): E214-E223.
36. Radziuk J. Insulin sensitivity and its measurement: structural commonalities among the methods. J Clin Endocrinol Metab 2000; 85(12): 4426-4433.
37. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22(9): 1462-1470.
38. Weigensberg MJ, Cruz ML, Goran MI. Association between insulin sensitivity and post-glucose challenge plasma insulin values in overweight Latino youth. Diabetes Care 2003; 26(7): 2094-2099.
39. McAuley KA, Williams SM, Mann JI, et al. Diagnosing insulin resistance in the general population. Diabetes Care 2001; 24(3): 460-464.
40. Cutfield WS, Jefferies CA, Jackson WE, Robinson EM, Hofman PL. Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children. Pediatr Diabetes 2003; 4(3): 119-125.
41. Rossner SM, Neovius M, Montgomery SM, Marcus C, Norgren S. Alternative methods of insulin sensitivity assessment in obese children and adolescents. Diabetes Care 2008; 31(4): 802-804.
42. de Vries SI, Bakker I, Hopman-Rock M, Hirasing RA, van Mechelen W. Clinimetric review of motion sensors in children and adolescents. J Clin Epidemiol 2006; 59(7): 670-680.
43. Rowlands AV, Eston RG. The measurement and interpretation of children's physical activity. J Sports Sci Med 2007; 6: 270-276.
44. Bunt JC, Salbe AD, Harper IT, Hanson RL, Tataranni PA. Weight, adiposity, and physical activity as determinants of an insulin sensitivity index in pima Indian children. Diabetes Care 2003; 26(9): 2524-2530.
45. Pate RR, Long BJ, Heath G. Descriptive epidemiology of physical activity in adolescents. Pediatr Exerc Sci 1994; 6: 434.
46. Kelly AS, Wetzsteon RJ, Kaiser DR, Steinberger J, Bank AJ, Dengel DR. Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise. J Pediatr 2004; 145(6): 731-736.
47. McMurray RG, Bauman MJ, Harrell JS, Brown S, Bangdiwala SI. Effects of improvement in aerobic power on resting insulin and glucose concentrations in children. Eur J Appl Physiol 2000; 81(1-2): 132-139.
48. Nassis GP, Papantakou K, Skenderi K, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 2005; 54(11): 1472-1479.
49. Carrel AL, Clark RR, Peterson SE, Nemeth BA, Sullivan J, Allen DB. Improvement of fitness, body composition, and insulin sensitivity in overweight children in a school-based exercise program: a randomized, controlled study. Arch Pediatr Adolesc Med 2005; 159(10): 963-968.
50. Davis JN, Kelly LA, Lane CJ, et al. Randomized control trial to improve adiposity and insulin resistance in overweight Latino adolescents. Obesity (Silver Spring) 2009; 17(8): 1542-1548.
51. Macias-Cervantes MH, Malacara JM, Garay-Sevilla ME, Diaz-Cisneros FJ. Effect of recreational physical activity on insulin levels in Mexican/Hispanic children. Eur J Pediatr 2009; 168(10): 1195-1202.
52. van der Heijden GJ, Toffolo G, Manesso E, Sauer PJ, Sunehag AL. Aerobic exercise increases peripheral and hepatic insulin sensitivity in sedentary adolescents. J Clin Endocrinol Metab 2009; 94(11): 4292-4299.
53. Whipp B. The peak versus maximum oxygen uptake issue.
54. Strath SJ, Swartz AM, Bassett DR, O'Brien WL, King GA, Ainsworth BE. Evaluation of heart rate as a method for assessing moderate intensity physical activity. Med Sci Sports Exerc 2000; 32(9): S465.
55. Riddoch C, Edwards D, Page A, et al. The European Youth Heart Study-cardiovascular disease risk factors in children: rationale, aims, study design, and validation of methods. J Phys Act Health 2005; 2: 115-129.
56. Ball GD, Shaibi GQ, Cruz ML, Watkins MP, Weigensberg MJ, Goran MI. Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth. Obes Res 2004; 12(1): 77-85.
57. Telford RD, Cunningham RB, Shaw JE, et al. Contrasting longitudinal and cross-sectional relationships between insulin resistance and percentage of body fat, fitness, and physical activity in children-the LOOK study. Pediatr Diabetes 2009; 10(8): 500-507.
58. Tomkinson GR, Leger LA, Olds TS, Cazorla G. Secular trends in the performance of children and adolescents (1980-2000): an analysis of 55 studies of the 20m shuttle run test in 11 countries. Sports Med 2003; 33(4): 285-300.
59. Chaffin DB, Andersson G, Martin BJ. Occupational biomechanics. Wiley: New York, 1991.
60. Malina RM. Weight training in youth-growth, maturation, and safety: an evidence-based review. Clin J Sport Med 2006; 16(6): 478-487.
61. van der Heijden GJ, Wang ZJ, Chu Z, et al. Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth. Med Sci Sports Exerc 2010; 42(11): 1973-1980.
62. Faigenbaum AD, Milliken LA, Westcott WL. Maximal strength testing in healthy children. J Strength Cond Res 2003; 17(1): 162-166.
63. Lindsay RS, Hanson RL, Roumain J, Ravussin E, Knowler WC, Tataranni PA. Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy x-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab 2001; 86(9): 4061-4067.
64. Pietrobelli A, Faith M, Allison D, Gallagher D, Chiumello G, Heymsfield S. Body mass index as a measure of adiposity among children and adolescents: a validation study. J Pediatr 1998; 132: 204-210.
65. Sun G, French CR, Martin GR, et al. Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population. Am J Clin Nutr 2005; 81(1): 74.
66. Metcalf BS, Jeffery AN, Hosking J, Voss LD, Sattar N, Wilkin TJ. Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (EarlyBird 38). Diabetes Care 2009; 32(3): 468-473.
67. Imperatore G, Cheng YJ, Williams DE, Fulton J, Gregg EW. Physical activity, cardiovascular fitness, and insulin sensitivity among U.S. adolescents: the National Health and Nutrition Examination Survey, 1999-2002. Diabetes Care 2006; 29(7): 1567-1572.
68. Brage S, Wedderkopp N, Ekelund U, et al. Objectively measured physical activity correlates with indices of insulin resistance in Danish children. The European Youth Heart Study (EYHS). Int J Obes Relat Metab Disord 2004; 28(11): 1503-1508.
69. Owen CG, Nightingale CM, Rudnicka AR, et al. Physical activity, obesity and cardiometabolic risk factors in 9- to 10-year-old UK children of white European, South Asian and black African-Caribbean origin: the Child Heart And health Study in England (CHASE). Diabetologia 2010; 53(8): 1620-1630.
70. Kasa-Vubu JZ, Lee CC, Rosenthal A, Singer K, Halter JB. Cardiovascular fitness and exercise as determinants of insulin resistance in postpubertal adolescent females. J Clin Endocrinol Metab 2005; 90(2): 849-854.
71. Schmitz KH, Jacobs DR Jr, Hong CP, Steinberger J, Moran A, Sinaiko AR. Association of physical activity with insulin sensitivity in children. Int J Obes Relat Metab Disord 2002; 26(10): 1310-1316.
72. Ku CY, Gower BA, Hunter GR, Goran MI. Racial differences in insulin secretion and sensitivity in prepubertal children: role of physical fitness and physical activity. Obes Res 2000; 8(7): 506-515.
73. Allen DB, Nemeth BA, Clark RR, Peterson SE, Eickhoff J, Carrel AL. Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children. J Pediatr 2007; 150(4): 383-387.
74. Gutin B, Yin Z, Humphries MC, Hoffman WH, Gower B, Barbeau P. Relations of fatness and fitness to fasting insulin in black and white adolescents. J Pediatr 2004; 145(6): 737-743.
75. Cummings D, DuBose K. Imai S. Collier D: Fitness versus Fatness and Insulin Resistance in US Adolescents, 2010.
76. Bougle D, Zunquin G, Sesboue B, Sabatier JP. Relationships of cardiorespiratory fitness with metabolic risk factors, inflammation, and liver transaminases in overweight youths. Int J Pediatr 2010; 2010: 580897.
77. Ruiz JR, Rizzo NS, Ortega FB, Loit HM, Veidebaum T, Sjostrom M. Markers of insulin resistance are associated with fatness and fitness in school-aged children: the European Youth Heart Study. Diabetologia 2007; 50(7): 1401-1408.
78. Rubin DA, McMurray RG, Harrell JS. Insulin and weight status in adolescents: independent effects of intensity of physical activity and peak aerobic power. Pediatr Exerc Sci 2008; 20(1): 29-39.
79. Sardinha LB, Andersen LB, Anderssen SA, et al. Objectively measured time spent sedentary is associated with insulin resistance independent of overall and central body fat in 9- to 10-year-old Portuguese children. Diabetes Care 2008; 31(3): 569-575.
80. Snitker S, Le KY, Hager E, Caballero B, Black MM. Association of physical activity and body composition with insulin sensitivity in a community sample of adolescents. Arch Pediatr Adolesc Med 2007; 161(7): 677-683.
81. Mitchell MS, Gaul CA, Naylor PJ, Panagiotopoulos C. Habitual moderate-to-vigorous physical activity is inversely associated with insulin resistance in Canadian first nations youth. Pediatr Exerc Sci 2010; 22(2): 254-265.
82. Shaibi GQ, Cruz ML, Ball GD, et al. Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc 2006; 38(7): 1208-1215.
83. Steele RM, Brage S, Corder K, Wareham NJ, Ekelund U. Physical activity, cardiorespiratory fitness, and the metabolic syndrome in youth. J Appl Physiol 2008; 105(1): 342-351.
84. Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG. Prevalence and determinants of insulin resistance among US adolescents. Diabetes Care 2006; 29(11): 2427.
85. Eisenmann JC, Bartee RT, Wang MQ. Physical activity, TV viewing, and weight in US youth: 1999 Youth Risk Behavior Survey. Obesity 2002; 10(5): 379-385.
86. Murphy MJ, Metcalf BS, Voss LD, et al. Girls at five are intrinsically more insulin resistant than boys: The Programming Hypotheses Revisited--The EarlyBird Study (EarlyBird 6). Pediatrics 2004; 113(1 Pt 1): 82-86.
87. Travers SH, Jeffers BW, Bloch CA, Hill JO, Eckel RH. Gender and Tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab 1995; 80(1): 172-178.
88. Goran MI, Gower BA, Nagy TR, Johnson RK. Developmental changes in energy expenditure and physical activity in children: evidence for a decline in physical activity in girls before puberty. Pediatrics 1998; 101(5): 887-891.
89. Trost SG, Pate RR, Sallis JF, et al. Age and gender differences in objectively measured physical activity in youth. Med Sci Sports Exerc 2002; 34(2): 350-355.
90. Daniels SR, Khoury PR, Morrison JA. The utility of body mass index as a measure of body fatness in children and adolescents: differences by race and gender. Pediatrics 1997; 99(6): 804-807.
91. Trowbridge CA, Gower BA, Nagy TR, Hunter GR, Treuth MS, Goran MI. Maximal aerobic capacity in African-American and Caucasian prepubertal children. Am J Physiol 1997; 273(4 PART 1): E809-E814.
92. Ortega FB, Ruiz JR, Hurtig-Wennlof A, et al. Cardiovascular fitness modifies the associations between physical activity and abdominal adiposity in children and adolescents: the European Youth Heart Study. Br J Sports Med 2008; 44(4): 256-262.
93. Brufani C, Grossi A, Fintini D, et al. Cardiovascular fitness, insulin resistance and metabolic syndrome in severely obese prepubertal Italian children. Horm Res 2008; 70(6): 349-356.
94. Shaibi GQ, Cruz ML, Ball GD, et al. Cardiovascular fitness and the metabolic syndrome in overweight latino youths. Med Sci Sports Exerc 2005; 37(6): 922-928.
95. Morinder G, Larsson UE, Norgren S, Marcus C. Insulin sensitivity, VO2max and body composition in severely obese Swedish children and adolescents. Acta Paediatr 2009; 98(1): 132-138.
96. Ferguson MA, Gutin B, Le NA, et al. Effects of exercise training and its cessation on components of the insulin resistance syndrome in obese children. Int J Obes Relat Metab Disord 1999; 23(8): 889-895.
97. Burstein R, Polychronakos C, Toews CJ, MacDougall JD, Guyda HJ, Posner BI. Acute reversal of the enhanced insulin action in trained athletes. Association with insulin receptor changes. Diabetes 1985; 34(8): 756-760.
98. Heath GW, Gavin JR 3rd, Hinderliter JM, Hagberg JM, Bloomfield SA, Holloszy JO. Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. J Appl Physiol 1983; 55(2): 512-517.
99. Froberg K, Andersen LB. Mini review: physical activity and fitness and its relations to cardiovascular disease risk factors in children. Int J Obes (Lond) 2005; 29(SUPPL 2): S34-S39.
100. Dwyer T, Magnussen CG, Schmidt MD, et al. Decline in physical fitness from childhood to adulthood associated with increased obesity and insulin resistance in adults. Diabetes Care 2009; 32(4): 683-687.
101. Goran MI, Reynolds KD, Lindquist CH. Role of physical activity in the prevention of obesity in children. Int J Obes Relat Metab Disord 1999; 23(SUPPL 3): S18-S33.
102. Davis JN, Tung A, Chak SS, et al. Aerobic and strength training reduces adiposity in overweight Latina adolescents. Med Sci Sports Exerc 2009; 41(7): 1494-1503.
103. Krekoukia M, Nassis GP, Psarra G, Skenderi K, Chrousos GP, Sidossis LS. Elevated total and central adiposity and low physical activity are associated with insulin resistance in children. Metabolism 2007; 56(2): 206-213.
104. Eisenmann JC, DuBose KD, Donnelly JE. Fatness, fitness, and insulin sensitivity among 7- to 9-year-old children. Obesity (Silver Spring) 2007; 15(8): 2135-2144.
105. Jago R, Drews KL, McMurray RG, et al. Fatness, Fitness, and Cardiometabolic Risk Factors among Sixth-Grade Youth. Med Sci Sports Exerc 2010; 42(8): 1502.
106. Lee S, Bacha F, Gungor N, Arslanian SA. Cardiorespiratory fitness in youth: relationship to insulin sensitivity and beta-cell function. Obesity (Silver Spring) 2006; 14(9): 1579-1585.
107. Nadeau KJ, Regensteiner JG, Bauer TA, et al. Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab 2009; 95(2): 513-521.
108. Suriano K, Curran J, Byrne SM, Jones TW, Davis EA. Fatness, fitness, and increased cardiovascular risk in young children. J Pediatr 2010; 157(4): 552-558.