Cardiovascular fitness, insulin resistance and metabolic syndrome in severely obese prepubertal Italian children

Hormone Research

Volumn 70, Issue 6, 2008, Pages 349-356

  Brufani, Claudia ^a   Grossi, Armando ^a   Fintini, Danilo ^a   Fiori, Rossana ^a   Ubertini, Graziamaria ^a   Colabianchi, Diego ^a   Ciampalini, Paolo ^a   Tozzi, Alberto ^a   Barbetti, Fabrizio ^a,b   Cappa, Marco ^a  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Cardiovascular fitness; Children; Insulin resistance; Metabolic syndrome; Obesity

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

AGE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CARDIOVASCULAR SYSTEM; CHILD; CHOLESTEROL BLOOD LEVEL; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE ASSAY; HUMAN; HYPERTENSION; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; ITALY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MULTIVARIATE ANALYSIS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREPUBERTY; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; TREADMILL; TRIACYLGLYCEROL BLOOD LEVEL;

AGE FACTORS; BODY COMPOSITION; CARDIOVASCULAR SYSTEM; CHILD; CHOLESTEROL, HDL; EXERCISE TEST; FEMALE; HUMANS; ITALY; MALE; METABOLIC SYNDROME X; OBESITY, MORBID; PHYSICAL FITNESS; SEX FACTORS; TRIGLYCERIDES;

EID: 54449091720     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000161865     Document Type: Article

References (42)

1. Bao W, Srinivasan SR, Wattigney WA, Berenson GS: Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood: the Bogalusa Heart Study. Arch Intern Med 1994;154:1842-1847.
2. Johnson MS, Figueroa-Colon R, Herd SL, Fields DA, Sun M, Hunter GR, Goran MI: Aerobic fitness, not energy expenditure, influences subsequent increase in adiposity in black and white children. Pediatrics 2000;106:E50.
3. Wei M, Kampert JB, Barlow CE, Nichaman MZ, Gibbons LW, Paffenbarger RS, Blair SN: Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 1999;282:1547-1553.
4. Kullo IJ, Hensrud DD, Allison TG: Relation of low cardiorespiratory fitness to the metabolic syndrome in middle-aged men. Am J Cardiol 2002;90:795-797.
5. Lakka TA, Laaksonen DE, Lakka HM: Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome. Med Sci Sports Exerc 2003;35:1279-1286.
6. Katzmarzyk PT, Leon AS, Wilmore JH: Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study. Med Sci Sports Exerc 2003;35:1703-1709.
7. Laaksonen DE, Lakka HM, Salonen JT, Niskanen LK, Rauramaa R, Lakka TA: Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care 2002;25:1612-1618.
8. Shaibi GQ, Cruz ML, Ball GD, Weigensberg MJ, Kobaissi HA, Salem GJ, Goran MI: Cardiovascular fitness and the metabolic syndrome in overweight Latino youths. Med Sci Sports Exerc 2005;37:922-928.
9. Ball GDC, Shaibi GQ, Cruz ML, Watkins MP, Weigensberg MJ, Goran MI: Insulin sensitivity, cardiorespiratory fitness and physical activity in overweight Hispanic youth. Obes Res 2004;12:77-85.
10. Brage S, Wedderkopp N, Ekelund U, Franks PW, Wareham NJ, Andersen LB, Froberg K: Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children. Diabetes Care 2004;27:2141-2148.
11. Török K, Szelényi Z, Pórszász J, Molnár D: Low physical performance in obese adolescent boys with metabolic syndrome. Int J Obes 2001;25:966-970.
12. Andersen LB, Harro M, Sardinha LB, Froberg K, Ekelund U, Brage S, Anderssen SA: Physical activity and clustered cardiovascular risk in children: a cross-sectional study (The European Youth Heart Study). Lancet 2006;368:299-304.
13. Gutin B, Zenong Y, Matthew C, Hoffman WH, Gower B, Barbeau P: Relations of fatness and fitness to fasting insulin in black and white adolescents. J Pediatr 2004;145:737-743.
14. Molnár D, Pórszász J: The effect of fasting hyperinsulinaemia on physical fitness in obese children. Eur J Pediatr 1990;149:570-573.
15. Luciano A, Bressan F, Zoppi G: Body mass index reference curves for children aged 3-19 years from Verona, Italy. Eur J Clin Nutr 1997;51:6-10.
16. Tanner JM: Growth and maturation during adolescence. Nutr Rev 1981;39:43-55.
17. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
18. WHO Consultation on Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. Geneva, World Health Organization, 1999, pp 1-49.
19. Matthews DR, Hosker JP, Rudenski AS: Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
20. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ: Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000;85:2402-2410.
21. Matsuda M, De Fronzo RA: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470.
22. Gutin B, Barbeau P, Owens S, Lemmon CR, Bauman M, Allison J, Kang HS, Litaker M: Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents. Am J Clin Nutr 2002;75:818-826.
23. Bruce R: Exercise testing for ventricular function. N Engl J Med 1977;296:671-675.
24. Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, Froelicher VF, Leon AS, Pina IL, Rodney R, Simons-Morton DA, Williams MA, Bazzarre T: Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation 2001;104:1694-1740.
25. Weiss R, Dziura J, Burget TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S: Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362-2374.
26. Italian Society of Pediatrics: Obesitàdel bambino e dell'adolescente: Consensus su prevenzione, diagnosi e terapia. 2006, www.scottibassani.it.
27. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents: The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-576.
28. American College of Sports Medicine Position Stand: The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. Med Sci Sports Exerc 1998;30:975-991.
29. Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S: Validation of insulin sensitivity indices from oral glucose tolerance test parameters in obese children and adolescents. J Clin Endocrinol Metab 2004;89:1096-1101.
30. Conwell LS, Trost SG, Brown WJ, Batch JA: Indexes of insulin resistance and secretion in obese children and adolescents. Diabetes Care 2004;27:314-319.
31. McMurray RG, Bauman MJ, Harrel JS, Brown S, Bangdiwala SI: Effects of improvement in aerobic power on resting insulin and glucose concentration in children. Eur J Appl Physiol 2000;81:132-139.
32. Carrel AL, Clark RR, Peterson SE, Nemeth BA, Sullivan J, Allen DB: Improvement of fitness, body composition, and insulin sensitivity in overweight children in a school-based exercise program. Arch Pediatr Adolesc Med 2005;159:963-968.
33. Ku CY, Gower BA, Hunter GR, Goran MI: Racial differences in insulin secretion and sensitivity in prepubertal children: role of physical fitness and physical activity. Obes Res 2000;8:506-515.
34. Shaibi GQ, Ball GDC, Goran MI: Aerobic fitness among Caucasian, African-American, and Latino youth. Ethn Dis 2006;16:120-125.
35. Goran MI, Ball GDC, Cruz ML: Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. J Clin Endocrinol Metab 2003;88:1417-1427.
36. Invitti C, Maffeis C, Gilardini R, Pontiggia B, Mazzilli G, Girola A, Sartorio A, Morabito F, Viberti GC: Metabolic syndrome in obese Caucasian children: prevalence using WHO-derived criteria and association with non traditional cardiovascular risk factors. Int J Obesity 2006;30:627-633.
37. Csabi G, Torok K, Jeges S, Molnar D: Presence of metabolic cardiovascular syndrome in obese children. Eur J Pediatr 2000;159:91-94.
38. Borghouts LB, Keizer HA: Exercise and insulin sensitivity: a review: Int J Sports Med 2000;21:1-12.
39. Kelley DE, Goodpaster BH: Effects of physical activity on insulin action and glucose tolerance in obesity. Med Sci Sports Exerc 1999;31:619-623.
40. Zierath JR: Exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol 2002;93:773-781.
41. Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI, Caprio S: Assessment of skeletal muscle triglyceride content by 1H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 2002;51:1022-1027.
42. Eliakim A, Scheet TP, Newcomb R, Cooper DM: Fitness training and the growth hormone/IGF-1 axis in prepubertal girls. J Clin Endocrinol Metab 2001;86:2797-2802.