Insulin sensitivity, VO2max and body composition in severely obese Swedish children and adolescents

Acta Paediatrica, International Journal of Paediatrics

Volumn 98, Issue 1, 2009, Pages 132-138

  Morinder, Gunilla ^a,b   Larsson, Ulla Evers ^a   Norgren, Svante ^b   Marcus, Claude ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Body composition; Cardiorespiratory fitness; Children; Insulin sensitivity

Indexed keywords

ADOLESCENT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BICYCLE ERGOMETRY; BODY COMPOSITION; BODY FAT; BODY MASS; CHILD; CONTROLLED STUDY; DISEASE SEVERITY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FITNESS; HUMAN; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SCHOOL CHILD; ADIPOSE TISSUE; ANTHROPOMETRY; EXERCISE TEST; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; METABOLIC SYNDROME X; METABOLISM; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; STATISTICAL MODEL; SWEDEN;

ABSORPTIOMETRY, PHOTON; ADIPOSE TISSUE; ADOLESCENT; ANTHROPOMETRY; BODY COMPOSITION; BODY MASS INDEX; CHILD; EXERCISE TEST; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; LINEAR MODELS; MALE; METABOLIC SYNDROME X; OBESITY; OXYGEN CONSUMPTION; PHYSICAL FITNESS; SWEDEN;

EID: 57449089146     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2008.01030.x     Document Type: Article

References (45)

1. Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005 116 : 473 80.
2. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 2003 107 : 1448 53.
3. Fagot-Campagna A. Emergence of type 2 diabetes mellitus in children: epidemiological evidence. J Pediatr Endocrinol Metab 2000 13 : 1395 402.
4. Malecka-Tendera E, Erhardt E, Molnar D. Type 2 diabetes mellitus in European children and adolescents. Acta Paediatr 2005 94 : 543 6.
5. Wabitsch M, Hauner H, Hertrampf M, Muche R, Hay B, Mayer H, et al. Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany. Int J Obes Relat Metab Disord 2004 28 : 307 13.
6. Goodpaster BH, Katsiaras A, Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 2003 52 : 2191 7.
7. Ortega FB, Ruiz JR, Castillo MJ, Sjostrom M. Physical fitness in childhood and adolescence: a powerful marker of health. Int J Obes (Lond) 2008 32 : 1 11.
8. Allen DB, Nemeth BA, Clark RR, Peterson SE, Eickhoff J, Carrel AL. Fitness is a stronger predictor of fasting insulin levels than fatness in overweight male middle-school children. J Pediatr 2007 150 : 383 7.
9. Ball GD, Shaibi GQ, Cruz ML, Watkins MP, Weigensberg MJ, Goran MI. Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth. Obes Res 2004 12 : 77 85.
10. Bunt JC, Salbe AD, Harper IT, Hanson RL, Tataranni PA. Weight, adiposity, and physical activity as determinants of an insulin sensitivity index in pima Indian children. Diabetes Care 2003 26 : 2524 30.
11. Eisenmann JC, DuBose KD, Donnelly JE. Fatness, fitness, and insulin sensitivity among 7- to 9-year-old children. Obesity (Silver Spring) 2007 15 : 2135 44.
12. Rossner SM, Neovius M, Montgomery SM, Marcus C, Norgren S. Alternative methods of insulin sensitivity assessment in obese children and adolescents. Diabetes Care 2008 31 : 802 4.
13. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000 320 : 1240 3.
14. Bergman RN. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 1989 38 : 1512 27.
15. Bachrach LK. Dual energy X-ray absorptiometry (DEXA) measurements of bone density and body composition: promise and pitfalls. J Pediatr Endocrinol Metab 2000 13 : 983 8.
16. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969 44 : 291 303.
17. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970 45 : 13 23.
18. Karlberg J, Luo ZC, Albertsson-Wikland K. Body mass index reference values (mean and SD) for Swedish children. Acta Paediatr 2001 90 : 1427 34.
19. Kooij PRF, Zillikens M, Sluimer J, Krenning E, Pols H. Comparison of BMD and%fat in adults and children with the DPX-L and prodigy bone densitometers. Departments of Internal Medicine and Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands. Presented at the American Society for Bone and Mineral Research Annual Meeting, October 1-5, 2004, Seattle, WA, USA.
20. Astrand PO, Ryhming I. A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during sub-maximal work. J Appl Physiol 1954 7 : 218 21.
21. 2max in epidemiologic studies: modification of the Astrand-Rhyming test. Med Sci Sports Exerc 1982 14 : 335 8.
22. Ekblom O, Oddsson K, Ekblom B. Physical performance and body mass index in Swedish children and adolescents. Scand J Nutr 2005 49 : 172 9.
23. Kamel A, Norgren S, Elimam A, Danielsson P, Marcus C. Effects of growth hormone treatment in obese prepubertal boys. J Clin Endocrinol Metab 2000 85 : 1412 9.
24. Brandou F, Brun JF, Mercier J. Limited accuracy of surrogates of insulin resistance during puberty in obese and lean children at risk for altered glucoregulation. J Clin Endocrinol Metab 2005 90 : 761 7.
25. Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, et al. The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 2001 134 : 663 94.
26. Eisenmann JC. Aerobic fitness, fatness and the metabolic syndrome in children and adolescents. Acta Paediatr 2007 96 : 1723 9.
27. Gutin B, Yin Z, Humphries MC, Hoffman WH, Gower B, Barbeau P. Relations of fatness and fitness to fasting insulin in black and white adolescents. J Pediatr 2004 145 : 737 43.
28. Wilmore JH CD. Physiology of sport and exercise. Champaign, IL : Human Kinetics, 1994.
29. 2max in Swedish obese children and adolescents. Acta Paediatr 2007 96 : 567 71.
30. Lopes VP, Vasques CM, Maia JA, Ferreira JC. Habitual physical activity levels in childhood and adolescence assessed with accelerometry. J Sports Med Phys Fitness 2007 47 : 217 22.
31. Santos P, Guerra S, Ribeiro JC, Duarte JA, Mota J. Age and gender-related physical activity. A descriptive study in children using accelerometry. J Sports Med Phys Fitness 2003 43 : 85 9.
32. Stratton G, Ridgers ND, Fairclough SJ, Richardson DJ. Physical activity levels of normal-weight and overweight girls and boys during primary school recess. Obesity 2007 15 : 1513 9.
33. Goran M, Fields DA, Hunter GR, Herd SL, Weinsier RL. Total body fat does not influence maximal aerobic capacity. Int J Obes Relat Metab Disord 2000 24 : 841 8.
34. 2max in the sedentary state: the HERITAGE family study. Med Sci Sports Exerc 1998 30 : 252 8.
35. Bell LM, Watts K, Siafarikas A, Thompson A, Ratnam N, Bulsara M, et al. Exercise alone reduces insulin resistance in obese children independently of changes in body composition. J Clin Endocrinol Metab 2007 92 : 4230 5.
36. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism 2005 54 : 1472 9.
37. Marcovecchio M, Mohn A, Chiarelli F. Type 2 diabetes mellitus in children and adolescents. J Endocrinol Invest 2005 28 : 853 63.
38. Druet C, Baltakse V, Chevenne D, Dorgeret S, Zaccaria I, Wang Y, et al. Independent Effect of Visceral Adipose Tissue on Metabolic Syndrome in Obese Adolescents. Horm Res 2008 70 : 22 8.
39. Chan DC, Watts GF, Sussekov AV, Barrett PH, Yang Z, Hua J, et al. Adipose tissue compartments and insulin resistance in overweight-obese Caucasian men. Diabetes Res Clin Pract 2004 63 : 77 85.
40. Despres JP. Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 1993 9 : 452 9.
41. Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, et al. Central adiposity and its metabolic correlates in obese adolescent girls. Am J Physiol 1995 269 : 118 26.
42. Glickman SG, Marn CS, Supiano MA, Dengel DR. Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity. J Appl Physiol 2004 97 : 509 14.
43. Mocellin R, Lindemann H, Rutenfranz J, Sbresny W. Determination of W 170 and maximal oxygen uptake in children by different methods. Acta Paediatr Scand 1971 217 : 13 7.
44. Docherty D. Measurement in Pediatric Exercise Science, Champaign, IL : Human Kinetics, 1996.
45. Woynarowska B. The validity of indirect estimations of maximal oxygen uptake in children 11-12 years of age. Eur J Appl Physiol Occup Physiol 1980 43 : 19 23.