Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein

Journal of Pharmacy and Pharmacology

Volumn 64, Issue 8, 2012, Pages 1138-1145

  Cong, Xiao Dong ^a   Wu, You ^a   Dai, De Zai ^b   Ding, Ming Jian ^a   Zhang, Yun ^a   Dai, Yin ^b  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

AQP4; Argirein; ER stress; Inflammation; P66Shc

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ADAPTOR PROTEIN; AQUAPORIN 4; ARGININE; ARGIREIN; CARRAGEENAN; GELATINASE A; INDOMETACIN; PLANT MEDICINAL PRODUCT; PROTEIN P22PHOX; PROTEIN P66SHC; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; RHEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FEMALE; MALE; NONHUMAN; PAW EDEMA; RAT;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS; AQUAPORIN 4; ARGININE; BIOLOGICAL MARKERS; CARRAGEENAN; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; EDEMA; ENDOPLASMIC RETICULUM STRESS; FEMALE; INDOMETHACIN; INFLAMMATION; MALE; MATRIX METALLOPROTEINASE 2; NADPH OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SHC SIGNALING ADAPTOR PROTEINS;

EID: 84863715589     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01507.x     Document Type: Article

References (46)

1. Towne JE, et al,. Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after acute viral infection. Am J Respir Cell Mol Biol 2000; 22: 34-44. (Pubitemid 30342957)
2. Adamzik M, et al,. Aquaporin 5 gene promoter-1364A/C polymorphism associated with 30-day survival in severe sepsis. Anesthesiology 2011; 114: 912-917.
3. Shen Y, et al,. Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice. J Cell Mol Med 2011; 15: 1355-1363.
4. Li L, et al,. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J 2011; 25: 1556-1566.
5. Wang P, et al,. Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation. Genet Mol Res 2011; 10: 2165-2171.
6. Liu LZ, et al,. Role and mechanism of arsenic in regulating angiogenesis. PLoS ONE 2011; 6: e20858.
7. Ziskoven C, et al,. Oxidative stress in secondary osteoarthritis: from cartilage destruction to clinical presentation? Orthop Rev (Pavia) 2010; 2: e23.
8. Pinton P, Rizzuto R,. p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria. Cell Cycle 2008; 7: 304-308. (Pubitemid 351366492)
9. Schmidt M, et al,. Non-steroidal anti-inflammatory drug use and risk of atrial fibrillation or flutter: population based case-control study. BMJ 2011; 343: d3450.
10. Peterson K, et al,. Drug class review: nonsteroidal antiinflammatory drugs (NSAIDs): final update 4 report [Internet]. 2010.
11. Dias RG, et al,. Nitric oxide and the cardiovascular system: cell activation, vascular reactivity and genetic variant. Arq Bras Cardiol 2011; 96: 68-75.
12. Zhang Z, et al,. Asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury? World J Gastroenterol 2011; 17: 2178-2180.
13. Brzozowski T, et al,. Lipoxins, the novel mediators of gastroprotection and gastric adaptation to ulcerogenic action of aspirin. Curr Pharm Des 2011; 17: 1541-1551.
14. Nemmani KV, et al,. NO-NSAIDs: gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs. Bioorg Med Chem Lett 2009; 19: 5297-5301.
15. Ma BL, et al,. Effective constituents in Xiexin Decoction for anti-inflammation. J Ethnopharmacol 2009; 125: 151-156.
16. Boileau C, et al,. Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling. Arthritis Res Ther 2008; 10: R71.
17. Yu DQ, et al,. Effects of Rhein on the hypertrophy of renal proximal tubular epithelial cells induced by high glucose and angiotensin II in rats. Zhong Yao Cai 2010; 33: 570-574.
18. Peng Y, et al,. Pharmacokinetic study of rhein and its carboxyl-esterification derivatives in rats. Chin J Nat Med 2009; 7: 228-233.
19. Yetik-Anacak G, Catravas JD,. Nitric oxide and the endothelium: history and impact on cardiovascular disease. Vascul Pharmacol 2006; 45: 268-276. (Pubitemid 44765289)
20. Kraaij MD, et al,. Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species. Proc Natl Acad Sci U S A 2010; 107: 17686-17691.
21. Seyhun E, et al,. Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 2011; 301: G773-G782.
22. Hu C, et al,. Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue. Naunyn Schmiedebergs Arch Pharmacol 2011; 383: 309-319.
23. Peng HJ, et al,. The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. Eur J Pharmacol 2010; 634: 101-106.
24. Wu H, et al,. Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. Neurochem Int 2010; 57: 248-253.
25. Thrane AS, et al,. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci USA 2011; 108: 846-851.
26. Cheng YS, et al,. AQP4 knockout mice manifest abnormal expressions of calcium handling proteins possibly due to exacerbating pro-inflammatory factors in the heart. Biochem Pharmacol 2012; 83: 97-105.
27. Tang XY, et al,. CPU0213, a novel endothelin receptor antagonist, suppresses the upregulation of matrix metalloproteinases and connexin 43 in hyperthyroid myocardium. Pharmacol Rep 2008; 60: 524-531.
28. Qi W, et al,. Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. Metabolism 2011; 60: 594-603.
29. Zhang Q, et al,. Strontium fructose 1,6-diphosphate alleviates early diabetic testopathy by suppressing abnormal testicular matrix metalloproteinase system in streptozocin-treated rats. J Pharm Pharmacol 2009; 61: 229-236.
30. Kushner I, et al,. A unifying biologic explanation for 'high-sensitivity' C-reactive protein and 'low-grade' inflammation. Arthritis Care Res (Hoboken) 2010; 62: 442-446.
31. Skurlova M, et al,. Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1beta, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats. Neurosci Lett 2011; 487: 250-254.
32. Cong XD, et al,. ER stress, p66Shc and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein a supermolecule and rhein in rats. Inflammation 2011 (in press).
33. Yin W, et al,. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J Biol Chem 2009; 284: 31972-31981.
34. Chang HR, et al,. Formation of 8-nitroguanine in blood of patients with inflammatory gouty arthritis. Clin Chim Acta 2005; 362: 170-175.
35. Campo GM, et al,. Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation. Exp Biol Med (Maywood) 2008; 233: 741-752.
36. Konda VR, et al,. META060 inhibits osteoclastogenesis and matrix metalloproteinases in vitro and reduces bone and cartilage degradation in a mouse model of rheumatoid arthritis. Arthritis Rheum 2010; 62: 1683-1692.
37. Koskinen A, et al,. Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients. Clin Exp Rheumatol 2011; 29: 57-64.
38. Pakozdi A, et al,. Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. Arthritis Res Ther 2006; 8: R132.
39. Zhang K,. Integration of ER stress, oxidative stress and the inflammatory response in health and disease. Int J Clin Exp Med 2010; 3: 33-40.
40. McGuckin MA, et al,. ER stress and the unfolded protein response in intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 2010; 298: G820-G832.
41. Sukumaran V, et al,. Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by experimental autoimmune myocarditis. Int J Biol Sci 2011; 7: 154-167.
42. Giorgio M, et al,. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005; 122: 221-233. (Pubitemid 41032986)
43. Khanday FA, et al,. Sos-mediated activation of rac1 by p66shc. J Cell Biol 2006; 172: 817-822.
44. Zanetti M, et al,. Hemodialysis induces p66(shc) gene expression in nondiabetic humans: correlations with oxidative stress and systemic inflammation. J Ren Nutr 2011; 21: 401-409.
45. Bosutti A, et al,. Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66ShcA in pacemaker-implanted patients. Clin Exp Med 2007; 7: 16-23. (Pubitemid 46475004)
46. Tomilov AA, et al,. Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem 2010; 285: 1153-1165.