A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men

PLoS Genetics

Volumn 8, Issue 5, 2012, Pages

  Lacaria, Melanie ^a   Saha, Pradip ^a   Potocki, Lorraine ^a,b   Bi, Weimin ^a   Yan, Jiong ^a   Girirajan, Santhosh ^c   Burns, Brooke ^d   Elsea, Sarah ^c,d   Walz, Katherina ^e   Chan, Lawrence ^a   Lupski, James R ^a,b   Gu, Wenli ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RAI1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CONTROLLED STUDY; COPY NUMBER VARIATION; ENERGY METABOLISM; FAT CONTENT; FOOD INTAKE; GENE DELETION; GENE DUPLICATION; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; INSULIN RESISTANCE; INSULIN SENSITIVITY; METABOLIC REGULATION; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT GAIN; ANIMAL; C57BL MOUSE; CHROMOSOME DELETION; CHROMOSOME DUPLICATION; DISEASE MODEL; GENETICS; HAPLOINSUFFICIENCY; LIPID DIET; METABOLISM; PATHOLOGY; SMITH MAGENIS SYNDROME; TRANSGENIC MOUSE;

ANIMALIA; MUS;

ANIMALS; BODY WEIGHT; CHROMOSOME DELETION; CHROMOSOME DUPLICATION; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DNA COPY NUMBER VARIATIONS; HAPLOINSUFFICIENCY; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY; SMITH-MAGENIS SYNDROME; TRANS-ACTIVATORS;

EID: 84863685348     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002713     Document Type: Article

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