Systemic administration of a novel human umbilical cord mesenchymal stem cells population accelerates the resolution of acute liver injury

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Burra, Patrizia ^a   Arcidiacono, Diletta ^a   Bizzaro, Debora ^a   Chioato, Tatiana ^b   Di Liddo, Rosa ^b   Banerjee, Antara ^a   Cappon, Andrea ^a   Bo, Patrizio ^c   Conconi, Maria T ^b   Parnigotto, Pier P ^c   Mirandola, Silvia ^d   Gringeri, Enrico ^a   Carraro, Amedeo ^a   Cillo, Umberto ^a   Russo, Francesco P ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c Cittadella Hospital   (Italy)

^d VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

Acute liver injury; Cell transplantation; Hepatocyte like cells; Mesenchymal stem cells; Regenerative medicine; Umbilical cord

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; CATALASE; CELL MARKER; CYTOKINE; GLYCOGEN; MATRIGEL; SCHIFF BASE; SUPEROXIDE DISMUTASE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL HOMING; CELL ISOLATION; CELL MATURATION; CELL POPULATION; CELL STRUCTURE; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HEPATITIS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KUPFFER CELL; LIVER CELL; LIVER INJURY; LIVER REGENERATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; MYOFIBROBLAST; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; STELLATE CELL; UMBILICAL CORD BLOOD; UPREGULATION;

ACUTE LUNG INJURY; ALBUMINS; ALPHA-FETOPROTEINS; ANIMALS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; CATALASE; CELL DIFFERENTIATION; CELL SEPARATION; CELLS, CULTURED; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOKINES; GLYCOGEN; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER REGENERATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; TRANSCRIPTOME; TRANSPLANTATION, HETEROLOGOUS; UREA;

EID: 84863683024     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-88     Document Type: Article

References (46)

1. Keeffe EB. Liver transplantation: current status and novel approaches to liver replacement. Gastroenterology 2001, 120:749-762. 10.1053/gast.2001.22583, 11179248.
2. Burra P, Tomat S, Bizzaro D, Pellicanò D, Masier A, Conconi MT, Russo F, Bo P, Parnigotto PP. Stem cells in hepatology. Organs Tissues Cells 2008, 1:15-22.
3. van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology 2008, 47:1634-1643. 10.1002/hep.22236, 18395843.
4. Burra P, Tomat S, Villa E, Gasbarrini A, Costa AN, Conconi MT, Forbes SJ, Farinati F, Cozzi E, Alison MR, Russo FP. Experimental hepatology applied to stem cells. Dig Liver Dis 2008, 40:54-61. 10.1016/j.dld.2007.08.012, 17997371.
5. Denker HW. Potentiality of embryonic stem cells: an ethical problem even with alternative stem cell sources. J Med Ethics 2006, 32:665-671. 10.1136/jme.2005.014738, 2563291, 17074826.
6. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006, 24:1294-1301. 10.1634/stemcells.2005-0342, 16410387.
7. Campard D, Lysy PA, Najimi M, Sokal EM. Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells. Gastroenterology 2008, 134:833-848. 10.1053/j.gastro.2007.12.024, 18243183.
8. Lee KD, Kuo TK, Whang-Peng J, Chung YF, Lin CT, Chou SH, Chen JR, Chen YP, Lee OK. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 2004, 40:1275-1284. 10.1002/hep.20469, 15562440.
9. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005, 105:1815-1822. 10.1182/blood-2004-04-1559, 15494428.
10. Kuo TK, Ho JH, Lee OK. Mesenchymal stem cell therapy for nonmusculoskeletal diseases: emerging applications. Cell Transplant 2009, 18:1013-1028. 10.3727/096368909X471206, 19523328.
11. Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal cells: biology and potential application. Stem Cells 2001, 19:180-192. 10.1634/stemcells.19-3-180, 11359943.
12. Mareschi K, Ferrero I, Rustichelli D, Aschero S, Gammaitoni L, Aglietta M, Madon E, Fagioli F. Expansion of mesenchymal stem cells isolated from pediatric and adult donor bone marrow. J Cell Biochem 2006, 97:744-754. 10.1002/jcb.20681, 16229018.
13. Mendes SC, Tibbe JM, Veenhof M, Bakker K, Both S, Platenburg PP, Oner FC, de Bruijn JD, van Blitterswijk CA. Bone tissue-engineered implants using human bone marrow stromal cells: effect of culture conditions and donor age. Tissue Eng 2002, 8:911-920. 10.1089/107632702320934010, 12542937.
14. Rodriguez AM, Elabd C, Amri EZ, Ailhaud G, Dani C. The human adipose tissue is a source of multipotent stem cells. Biochimie 2005, 87:125-128. 10.1016/j.biochi.2004.11.007, 15733747.
15. Miao Z, Jin J, Chen L, Zhu J, Huang W, Zhao J, Qian H, Zhang X. Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells. Cell Biol Int 2006, 30:681-687. 10.1016/j.cellbi.2006.03.009, 16870478.
16. Yu SJ, Soncini M, Kaneko Y, Hess D, Parolini O, Borlongan C. Amnion: A potent graft source for cell therapy in stroke. Cell Transplant 2009, 18:111-118. 10.3727/096368909788341243, 19499700.
17. Lee OK, Kuo TK, Chen WM, Lee KD, Hsieh SL, Chen TH. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 2004, 103:1669-1675. 10.1182/blood-2003-05-1670, 14576065.
18. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC, Chen CC. Mesenchymal stem cells in the Wharton's jelly of the human umbilical cord. Stem Cells 2004, 22:1330-1337. 10.1634/stemcells.2004-0013, 15579650.
19. Covas DT, Siufi JL, Silva AR, Orellana MD. Isolation and culture of umbilical vein mesenchymal stem cells. Braz J Med Biol Res 2003, 36:1179-1183. 10.1590/S0100-879X2003000900006, 12937783.
20. Romanov YA, Svintsitskaya VA, Smirnov VN. Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 2003, 21:105-110. 10.1634/stemcells.21-1-105, 12529557.
21. Conconi MT, Burra P, Di Liddo R, Calore C, Turetta M, Bellini S, Bo P, Nussdorfer GG, Parnigotto PP. CD105(+) cells from Wharton's jelly show in vitro and in vivo myogenic differentiative potential. Int J Mol Med 2006, 18:1089-1096.
22. Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003, 100:8407-8411. 10.1073/pnas.1432929100, 166242, 12815096.
23. Yokokawa M, Ohnishi S, Ishibashi-Ueda H, Obata H, Otani K, Miyahara Y, Tanaka K, Shimizu W, Nakazawa K, Kangawa K, Kamakura S, Kitamura S, Nagaya N. Transplantation of mesenchymal stem cells improves atrioventricular conduction in a rat model of complete atrioventricular block. Cell Transplant 2008, 17:1145-1155. 10.3727/096368908787236594, 19181209.
24. Kunter U, Rong S, Djuric Z, Boor P, Muller-Newen G, Yu D, Floege J. Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis. J Am Soc Nephrol 2006, 17:2202-2212. 10.1681/ASN.2005080815, 16790513.
25. Tanaka K, Soto-Gutierrez A, Navarro-Alvarez N, Rivas-Carrillo JD, Jun HS, Kobayashi N. Functional hepatocyte culture and its application to cell therapies. Cell Transplant 2006, 15:855-864. 10.3727/000000006783981332, 17299989.
26. Burra P, Tomat S, Conconi MT, Macchi C, Russo FP, Parnigotto PP, Naccarato R, Nussdorfer GG. Acellular liver matrix improves the survival and functions of isolated rat hepatocytes cultured in vitro. Int J Mol Med 2004, 14:511-515.
27. Tomat S, Burra P, Gringeri E, Cillo U, Calabrese F, Giacometti C, Carraro P, Macchi C, Nussdorfer GG, Parnigotto PP. Metabolic activity of rat hepatocytes cultured on homologous acellular matrix and transplanted into Gunn rats. Int J Mol Med 2006, 18:837-842.
28. Richert L, Binda D, Hamilton G, Viollon-Abadie C, Alexandre E, Bigot-Lasserre D, Bars R, Coassolo P, LeCluyse E. Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes. Toxicol In Vitro 2002, 16:89-99. 10.1016/S0887-2333(01)00099-6, 11812644.
29. Friedman SL. Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver. Physiol Rev 2008, 88:125-172. 10.1152/physrev.00013.2007, 2888531, 18195085.
30. Niki T, Pekny M, Hellemans K, Bleser PD, Berg KV, Vaeyens F, Quartier E, Schuit F, Geerts A. Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Hepatology 1999, 29:520-527. 10.1002/hep.510290232, 9918930.
31. Stocum DL. Stem cells in regenerative biology and medicine. Wound Repair Regen 2001, 9:429-442. 10.1046/j.1524-475x.2001.00429.x, 11896986.
32. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105-111. 10.1038/35102167, 11689955.
33. Mirandola S, Realdon S, Iqbal J, Gerotto M, Dal Pero F, Bortoletto G, Marcolongo M, Vario A, Datz C, Hussain MM, Alberti A. Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Gastroenterology 2006, 130:1661-1669. 10.1053/j.gastro.2006.02.035, 16697730.
34. Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003, 75:389-397. 10.1097/01.TP.0000045055.63901.A9, 12589164.
35. Kuo TK, Hung SP, Chuang CH, Chen CT, Shih YR, Fang SC, Yang VW, Lee OK. Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 2008, 134:2111-2121. 10.1053/j.gastro.2008.03.015, 3086672, 18455168.
36. Lam SP, Luk JM, Man K, Ng KT, Cheung CK, Rose-John S, Lo CM. Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration. Liver Transpl 2010, 16:1195-1206. 10.1002/lt.22136, 20879018.
37. Zagoura DS, Roubelakis MG, Bitsika V, Trohatou O, Pappa KI, Kapelouzou A, Antsaklis A, Anagnou NP. Therapeutic potential of a distinct population of human amniotic fluid mesenchymal stem cells and their secreted molecules in mice with acute hepatic failure. Gut 2012, 61:894-906. 10.1136/gutjnl-2011-300908, 21997562.
38. Shi LL, Liu FP, Wang DW. Transplantation of human umbilical cord blood mesenchymal stem cells improves survival rates in a rat model of acute hepatic necrosis. Am J Med Sci 2011, 342:212-217. 10.1097/MAJ.0b013e3182112b90, 21642820.
39. Jung KH, Uhm YK, Lim YJ, Yim SV. Human umbilical cord blood-derived mesenchymal stem cells improve glucose homeostasis in rats with liver cirrhosis. Int J Oncol 2011, 39:137-143.
40. Tsai PC, Fu TW, Chen YM, Ko TL, Chen TH, Shih YH, Hung SC, Fu YS. The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis. Liver Transpl 2009, 15:484-495. 10.1002/lt.21715, 19399744.
41. Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, Zhou H, Mao F. Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int 2009, 29:356-365. 10.1111/j.1478-3231.2008.01855.x, 19141029.
42. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006, 98:1076-1084. 10.1002/jcb.20886, 16619257.
43. Togel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation independent mechanisms. Am J Physiol Renal Physiol 2005, 289:F31-F42. 10.1152/ajprenal.00007.2005, 15713913.
44. Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008, 132:344-362. 10.1016/j.cell.2008.01.020, 18267068.
45. Meezan E, Hyelle JT, Brendel K. A simple versatile, non-disruptive method for the isolation of morphologically and chemically pure basement membranes from several tissues. Life Sci 1975, 17:1721-1732. 10.1016/0024-3205(75)90119-8, 1207385.
46. Aebi H. Catalase in vitro. Methods Enzymol 1984, 105:121-126.