Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin α-sarcin

Protein Engineering, Design and Selection

Volumn 25, Issue 8, 2012, Pages 425-435

  Carreras Sangrà, Nelson ^a,c   Tomé Amat, Jaime ^a   García Ortega, Lucía ^a   Batt, Carl A ^b   Oñaderra, Mercedes ^a   Martínez Del Pozo, Álvaro ^a   Gavilanes, José G ^a   Lacadena, Javier ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b Department of Obstetrics Gynecology   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

sarcin; colon cancer; GPA33; immunotoxin; ribonuclease

Indexed keywords

CHIMERIC PROTEINS; COLON CANCER; CYTOLYTIC ACTIVITIES; FUSION PROTEINS; GPA33; HIGH YIELD; HUMANIZED ANTIBODY; IMMUNOTOXINS; PICHIA PASTORIS; RIBONUCLEASE; SCIENTIFIC EVIDENCE; SINGLE CHAIN VARIABLE FRAGMENTS; TUMOR ANTIGEN; TUMORAL CELLS;

CELL CULTURE; FUNGI; MONOCLONAL ANTIBODIES; RECOMBINANT PROTEINS;

DISEASES;

ALPHA SARCIN; CHIMERIC PROTEIN; GLYCOPROTEIN A 33; HYBRID PROTEIN; IMMUNOTOXIN; MYCOTOXIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TUMOR ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TARGETING; RIBOSOME;

CELL LINE, TUMOR; COLONIC NEOPLASMS; ENDORIBONUCLEASES; FLOW CYTOMETRY; FUNGAL PROTEINS; HUMANS; IMMUNOTOXINS; MEMBRANE GLYCOPROTEINS; MICROSCOPY, FLUORESCENCE; PICHIA; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES;

PICHIA PASTORIS;

EID: 84863655391     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzs032     Document Type: Article

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