Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp. novicida

Journal of Proteome Research

Volumn 11, Issue 7, 2012, Pages 3690-3703

  Varnum, Susan M ^a   Webb Robertson, Bobbie Jo M ^a   Pounds, Joel G ^a   Moore, Ronald J ^a   Smith, Richard D ^a   Frevert, Charles W ^b   Skerrett, Shawn J ^b   Wunschel, David ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

bronchoalveolar lavage fluid; Francisella tularensis; innate immunity; proteomics

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1A7; BRONCHOALVEOLAR LAVAGE FLUID PROTEIN; CALGRANULIN A; CALGRANULIN B; CATHEPSIN G; CHITINASE; CHITINASE 3 LIKE 1; COPPER ZINC SUPEROXIDE DISMUTASE; FIBRINOGEN; GALECTIN 3; GLUTATHIONE TRANSFERASE A3; GLUTATHIONE TRANSFERASE A4; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M2; GLUTATHIONE TRANSFERASE P1; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ISOENZYME 1; LACTATE DEHYDROGENASE ISOENZYME 5; LEUKOCYTE ELASTASE; LYSOZYME; MACROGLOBULIN; MYELOBLASTIN; MYELOPEROXIDASE; PEROXIREDOXIN 1; PEROXIREDOXIN 5; PEROXIREDOXIN 6; PROTEIN; RETINAL DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BACTERIUM MUTANT; COMPLEMENT SYSTEM; CONTROLLED STUDY; FRANCISELLA; FRANCISELLA NOVICIDA; FRANCISELLA NOVICIDA INFECTION; FRANCISELLA TULARENSIS; GRAM NEGATIVE INFECTION; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LUNG LAVAGE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; TULAREMIA; UPREGULATION;

ACUTE-PHASE PROTEINS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; COMPLEMENT SYSTEM PROTEINS; FRANCISELLA TULARENSIS; IMMUNITY, INNATE; MALE; MICE; MICE, INBRED C57BL; NEUTROPHILS; OXIDATIVE STRESS; PROTEOME; PROTEOMICS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TULAREMIA;

ANIMALIA; BACTERIA (MICROORGANISMS); FRANCISELLA TULARENSIS; MUS; PSEUDOMONAS AERUGINOSA;

EID: 84863617796     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3001767     Document Type: Article

References (76)

1. McCrumb, F. R. Aerosol infection of man with Pasteurella tularensis Bacteriol. Rev. 1961, 25, 262-267
2. Malik, M.; Bakshi, C. S.; McCabe, K.; Catlett, S. V.; Shah, A.; Singh, R.; Jackson, P. L.; Gaggar, A.; Metzger, D. W.; Melendez, J. A.; Blalock, J. E.; Sellati, T. J. Matrix metalloproteinase 9 activity enhances host susceptibility to pulmonary infection with type A and B strains of Francisella tularensis J. Immunol. 2007, 178, 1013-1020 (Pubitemid 46095174)
3. Hollis, D. G.; Weaver, R. E.; Steigerwalt, A. G.; Wenger, J. D.; Moss, C. W.; Brenner, D. J. Francisella philomiragia comb. nov. (formerly Yersinia philomiragia) and Francisella tularensis biogroup novicida (formerly Francisella novicida) associated with human disease J. Clin. Microbiol. 1989, 27, 1601-1608 (Pubitemid 19170170)
4. Anthony, L. D.; Burke, R. D.; Nano, F. E. Growth of Francisella spp. in rodent macrophages Infect. Immun. 1991, 59, 3291-3296
5. Hajjar, A. M.; Harvey, M. D.; Shaffer, S. A.; Goodlett, D. R.; Sjostedt, A.; Edebro, H.; Forsman, M.; Bystrom, M.; Pelletier, M.; Wilson, C. B.; Miller, S. I.; Skerrett, S. J.; Ernst, R. K. Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors Infect. Immun. 2006, 74, 6730-6738 (Pubitemid 44913147)
6. Wunschel, D.; Webb-Robertson, B.-J.; Frevert, C. W.; Skerrett, S.; Beagley, N.; Willse, A.; Colburn, H.; Antolick, K. Differentiation of gram-negative bacterial aerosol exposure using detected markers in bronchial-alveolar lavage fluid PLoS One 2009, 4, e7047
7. Duenas, A. I.; Aceves, M.; Orduna, A.; Diaz, R.; Sanchez Crespo, M.; Garcia-Rodriguez, C. Francisella tularensis LPS induces the production of cytokines in human monocytes and signals via Toll-like receptor 4 with much lower potency than E. coli LPS Int. Immunol. 2006, 18, 785-795 (Pubitemid 43779068)
8. Fortier, A. H.; Slayter, M. V.; Ziemba, R.; Meltzer, M. S.; Nacy, C. A. Live vaccine strain of Francisella tularensis: infection and immunity in mice Infect. Immun. 1991, 59, 2922-2928
9. Bosio, C. M.; Dow, S. W. Francisella tularensis induces aberrant activation of pulmonary dendritic cells J. Immunol. 2005, 175, 6792-6801 (Pubitemid 41598924)
10. Telepnev, M.; Golovliov, I.; Grundstrom, T.; Tarnvik, A.; Sjostedt, A. Francisella tularensis inhibits Toll-like receptor-mediated activation of intracellular signalling and secretion of TNF-alpha and IL-1 from murine macrophages Cell. Microbiol. 2003, 5, 41-51 (Pubitemid 36395119)
11. Bosio, C. M.; Bielefeldt-Ohmann, H.; Belisle, J. T. Active suppression of the pulmonary immune response by Francisella tularensis Schu4 J. Immunol. 2007, 178, 4538-4547 (Pubitemid 46492406)
12. Chase, J. C.; Celli, J.; Bosio, C. M. Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4 Infect. Immun. 2009, 77, 180-195
13. Clemens, D. L.; Lee, B. Y.; Horwitz, M. A. Francisella tularensis enters macrophages via a novel process involving pseudopod loops Infect. Immun. 2005, 73, 5892-5902 (Pubitemid 41193026)
14. Balagopal, A.; MacFarlane, A. S.; Mohapatra, N.; Soni, S.; Gunn, J. S.; Schlesinger, L. S. Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages Infect. Immun. 2006, 74, 5114-5125 (Pubitemid 44300429)
15. Fortier, A. H.; Leiby, D. A.; Narayanan, R. B.; Asafoadjei, E.; Crawford, R. M.; Nacy, C. A.; Meltzer, M. S. Growth of Francisella tularensis LVS in macrophages: the acidic intracellular compartment provides essential iron required for growth Infect. Immun. 1995, 63, 1478-1483
16. Baron, G. S.; Nano, F. E. MglA and MglB are required for the intramacrophage growth of Francisella novicida Mol. Microbiol. 1998, 29, 247-259 (Pubitemid 28318578)
17. Lauriano, C. M.; Barker, J. R.; Yoon, S. S.; Nano, F. E.; Arulanandam, B. P.; Hassett, D. J.; Klose, K. E. MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 4246-4249 (Pubitemid 38405914)
18. West, T. E.; Pelletier, M. R.; Majure, M. C.; Lembo, A.; Hajjar, A. M.; Skerrett, S. J. Inhalation of Francisella novicida Delta mglA causes replicative infection that elicits innate and adaptive responses but is not protective against invasive pneumonic tularemia Microbes Infect. 2008, 10, 773-780
19. Guina, T.; Radulovic, D.; Bahrami, A. J.; Bolton, D. L.; Rohmer, L.; Jones-Isaac, K. A.; Chen, J.; Gallagher, L. A.; Gallis, B.; Ryu, S.; Taylor, G. K.; Brittnacher, M. J.; Manoil, C.; Goodlett, D. R. MglA regulates Francisella tularensis subsp. novicida (Francisella novicida) response to starvation and oxidative stress J. Bacteriol. 2007, 189, 6580-6586 (Pubitemid 47397363)
20. Skerrett, S. J.; Wilson, C. B.; Liggitt, H. D.; Hajjar, A. M. Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa Am. J. Physiol.: Lung Cell Mol. Physiol. 2007, 292, L312-322
21. Livesay, E. A.; Tang, K.; Taylor, B. K.; Buschbach, M. A.; Hopkins, D. F.; LaMarche, B. L.; Zhao, R.; Shen, Y.; Orton, D. J.; Moore, R. J.; Kelly, R. T.; Udseth, H. R.; Smith, R. D. Fully automated four-column capillary LC-MS system for maximizing throughput in proteomic analyses Anal. Chem. 2008, 80, 294-302 (Pubitemid 351448434)
22. Smith, R. D.; Anderson, G. A.; Lipton, M. S.; Pasa-Tolic, L.; Shen, Y.; Conrads, T. P.; Veenstra, T. D.; Udseth, H. R. An accurate mass tag strategy for quantitative and high-throughput proteome measurements Proteomics 2002, 2, 513-523 (Pubitemid 34507341)
23. Eng, J. K.; Mccormack, A. L.; Yates, J. R. An approach to correlate tandem mass-spectral data of peptides with amino-acid-sequences in a protein database J. Am. Soc. Mass Spectrom. 1994, 5, 976-989
24. Washburn, M. P.; Wolters, D.; Yates, J. R. Large-scale analysis of the yeast proteome by multidimensional protein identification technology Nat. Biotechnol. 2001, 19, 242-247 (Pubitemid 32220565)
25. Kiebel, G. R.; Auberry, K. J.; Jaitly, N.; Clark, D. A.; Monroe, M. E.; Peterson, E. S.; Tolic, N.; Anderson, G. A.; Smith, R. D. PRISM: a data management system for high-throughput proteomics Proteomics 2006, 6, 1783-1790
26. Zimmer, J. S. D.; Monroe, M. E.; Qian, W.-J.; Smith, R. D. Advances in proteomics data analysis and display using an accurate mass and time tag approach Mass Spectrom. Rev. 2006, 25, 450-482
27. Pounds, J. G.; Flora, J. W.; Adkins, J. N.; Lee, K. M.; Rana, G. S. J. B.; Sengupta, T.; Smith, R. D.; McKinney, W. J. Characterization of the mouse bronchoalveolar lavage proteome by micro-capillary LC-FTICR mass spectrometry J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2008, 864, 95-101
28. Jin, S.; Daly, D. S.; Springer, D. L.; Miller, J. H. The effects of shared peptides on protein quantitation in label-free proteomics by LC/MS/MS J. Proteome Res. 2008, 7, 164-169 (Pubitemid 351171128)
29. Qian, W.-J.; Liu, T.; Monroe, M. E.; Strittmatter, E. F.; Jacobs, J. M.; Kangas, L. J.; Petritis, K.; Camp, D. G.; Smith, R. D. Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: the human proteome J. Proteome Res. 2005, 4, 53-62 (Pubitemid 40352578)
30. Jaitly, N.; Mayampurath, A.; Littlefield, K.; Adkins, J. N.; Anderson, G. A.; Smith, R. D. Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data BMC Bioinf. 2009, 10, 87
31. Monroe, M. E.; Tolic, N.; Jaitly, N.; Shaw, J. L.; Adkins, J. N.; Smith, R. D. VIPER: An advanced software package to support high-throughput LC-MS peptide identification Bioinformatics 2007, 23, 2021-2023 (Pubitemid 47299846)
32. Anderson, K. K.; Monroe, M. E.; Daly, D. S. Estimating probabilities of peptide database identifications to LC-FTICR-MS observations Proteome Sci. 2006, 4, 1
33. Webb-Robertson, B. J.; McCue, L. A.; Waters, K. M.; Matzke, M. M.; Jacobs, J. M.; Metz, T. O.; Varnum, S. M.; Pounds, J. G. Combined statistical analyses of peptide intensities and peptide occurrences improves identification of significant peptides from MS-based proteomics data J. Proteome Res. 2010, 9, 5748-5756
34. Polpitiya, A. D.; Qian, W.-J.; Jaitly, N.; Petyuk, V. A.; Adkins, J. N.; Camp, D. G.; Anderson, G. A.; Smith, R. D. DAnTE: a statistical tool for quantitative analysis of -omics data Bioinformatics 2008, 24, 1556-1558 (Pubitemid 351911716)
35. Nesvizhskii, A. I.; Keller, A.; Kolker, E.; Aebersold, R. A statistical model for identifying proteins by tandem mass spectrometry Anal. Chem. 2003, 75, 4646-4658 (Pubitemid 37082259)
36. Ventura, C. L.; Higdon, R.; Hohmann, L.; Martin, D.; Kolker, E.; Liggitt, H. D.; Skerrett, S. J.; Rubens, C. E. Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia Infect. Immun. 2008, 76, 5862-5872
37. Gharib, S. A.; Nguyen, E.; Altemeier, W. A.; Shaffer, S. A.; Doneanu, C. E.; Goodlett, D. R.; Schnapp, L. M. Of mice and men: comparative proteomics of bronchoalveolar fluid Eur. Respir. J. 2010, 35, 1388-1395
38. Schnapp, L. M.; Donohoe, S.; Chen, J.; Sunde, D. A.; Kelly, P. M.; Ruzinski, J.; Martin, T.; Goodlett, D. R. Mining the acute respiratory distress syndrome proteome: Identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury Am. J. Pathol. 2006, 169, 86-95
39. Gabay, C.; Kushner, I. Acute-phase proteins and other systemic responses to inflammation N. Engl. J. Med. 1999, 340, 448-454 (Pubitemid 29084777)
40. Umans, L.; Serneels, L.; Overbergh, L.; Stas, L.; Van Leuven, F. Alpha2-macroglobulin- and murinoglobulin-1-deficient mice. A mouse model for acute pancreatitis Am. J. Pathol. 1999, 155, 983-993 (Pubitemid 29426845)
41. Correia Soeiro, M. N.; Paiva, M. M.; Waghabi, M.; Meirelles, M. N.; Lorent, K.; Araujo-Jorge, T. C.; Van Leuven, F. Differential expression of mRNA coding for the alpha-2-macroglobulin family and the LRP receptor system in C57BL/6J and C3H/HeJ male mice Cell Struct. Funct. 2001, 26, 161-167 (Pubitemid 32894082)
42. Nagase, H.; Itoh, Y.; Binner, S. Interaction of alpha 2-macroglobulin with matrix metalloproteinases and its use for identification of their active forms Ann. N.Y. Acad. Sci. 1994, 732, 294-302
43. Ward, P. P.; Mendoza-Meneses, M.; Park, P. W.; Conneely, O. M. Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice Am. J. Pathol. 2008, 172, 1019-1029 (Pubitemid 351519998)
44. Actor, J. K.; Hwang, S. A.; Kruzel, M. L. Lactoferrin as a natural immune modulator Curr. Pharm. Des. 2009, 15, 1956-1973
45. Legrand, D.; Elass, E.; Carpentier, M.; Mazurier, J. Lactoferrin: a modulator of immune and inflammatory responses Cell. Mol. Life Sci. 2005, 62, 2549-2559 (Pubitemid 41722207)
46. van der Veen, B. S.; de Winther, M. P.; Heeringa, P. Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease Antioxid. Redox Signaling 2009, 11, 2899-2937
47. Fitch, P. M.; Roghanian, A.; Howie, S. E.; Sallenave, J. M. Human neutrophil elastase inhibitors in innate and adaptive immunity Biochem. Soc. Trans. 2006, 34, 279-282
48. Chase, J. C.; Bosio, C. M. The presence of CD14 overcomes evasion of innate immune responses by virulent Francisella tularensis in human dendritic cells in vitro and pulmonary cells in vivo Infect. Immun. 2010, 78, 154-167
49. Lin, S. M.; Frevert, C. W.; Kajikawa, O.; Wurfel, M. M.; Ballman, K.; Mongovin, S.; Wong, V. A.; Selk, A.; Martin, T. R. Differential regulation of membrane CD14 expression and endotoxin-tolerance in alveolar macrophages Am. J. Respir. Cell Mol. Biol. 2004, 31, 162-170 (Pubitemid 39095446)
50. Senft, A. P.; Korfhagen, T. R.; Whitsett, J. A.; Shapiro, S. D.; LeVine, A. M. Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12 J. Immunol. 2005, 174, 4953-4959 (Pubitemid 40514461)
51. Butchar, J. P.; Cremer, T. J.; Clay, C. D.; Gavrilin, M. A.; Wewers, M. D.; Marsh, C. B.; Schlesinger, L. S.; Tridandapani, S. Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion PLoS One 2008, 3, e2924
52. Kuroki, Y.; Takahashi, M.; Nishitani, C. Pulmonary collectins in innate immunity of the lung Cell. Microbiol. 2007, 9, 1871-1879 (Pubitemid 47087079)
53. Pastva, A. M.; Wright, J. R.; Williams, K. L. Immunomodulatory roles of surfactant proteins A and D: implications in lung disease Proc. Am. Thorac. Soc. 2007, 4, 252-257 (Pubitemid 47036444)
54. Beatty, A. L.; Malloy, J. L.; Wright, J. R. Pseudomonas aeruginosa degrades pulmonary surfactant and increases conversion in vitro Am. J. Respir. Cell Mol. Biol. 2005, 32, 128-134 (Pubitemid 40189694)
55. Sato, S.; Hughes, R. C. Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages J. Biol. Chem. 1994, 269, 4424-4430
56. Henderson, N. C.; Sethi, T. The regulation of inflammation by galectin-3 Immunol. Rev. 2009, 230, 160-171
57. Sato, S.; Ouellet, N.; Pelletier, I.; Simard, M.; Rancourt, A.; Bergeron, M. G. Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia J. Immunol. 2002, 168, 1813-1822 (Pubitemid 34135781)
58. Foell, D.; Wittkowski, H.; Vogl, T.; Roth, J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules J. Leukocyte Biol. 2007, 81, 28-37 (Pubitemid 46021248)
59. Hessian, P. A.; Edgeworth, J.; Hogg, N. MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes J. Leukocyte Biol. 1993, 53, 197-204
60. Nacken, W.; Roth, J.; Sorg, C.; Kerkhoff, C. S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity Microsc. Res. Tech. 2003, 60, 569-580
61. Ryckman, C.; Vandal, K.; Rouleau, P.; Talbot, M.; Tessier, P. A. Proinflammatory activities of S100: Proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion J. Immunol. 2003, 170, 3233-3242 (Pubitemid 36302201)
62. Andersson, H.; Hartmanova, B.; Kuolee, R.; Ryden, P.; Conlan, W.; Chen, W.; Sjostedt, A. Transcriptional profiling of host responses in mouse lungs following aerosol infection with type A Francisella tularensis J. Med. Microbiol. 2006, 55, 263-271
63. Mares, C. A.; Ojeda, S. S.; Morris, E. G.; Li, Q.; Teale, J. M. Initial delay in the immune response to Francisella tularensis is followed by hypercytokinemia characteristic of severe sepsis and correlating with upregulation and release of damage-associated molecular patterns Infect. Immun. 2008, 76, 3001-3010
64. Sharma, J.; Li, Q.; Mishra, B. B.; Pena, C.; Teale, J. M. Lethal pulmonary infection with Francisella novicida is associated with severe sepsis J. Leukocyte Biol. 2009, 86, 491-504
65. Andersson, H.; Hartmanova, B.; Back, E.; Eliasson, H.; Landfors, M.; Naslund, L.; Ryden, P.; Sjostedt, A. Transcriptional profiling of the peripheral blood response during tularemia Genes Immun. 2006, 7, 503-513 (Pubitemid 44323684)
66. Raes, G.; Noel, W.; Beschin, A.; Brys, L.; de Baetselier, P.; Hassanzadeh, G. H. FIZZ1 and Ym as tools to discriminate between differentially activated macrophages Dev. Immunol. 2002, 9, 151-159 (Pubitemid 36898373)
67. Sharma, J.; Mares, C. A.; Li, Q.; Morris, E. G.; Teale, J. M. Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain Microb. Pathog. 2011, 51, 39-47
68. Twenhafel, N. A.; Alves, D. A.; Purcell, B. K. Pathology of inhalational Francisella tularensis spp. tularensis SCHU S4 infection in African green monkeys (Chlorocebus aethiops) Vet. Pathol. 2009, 46, 698-706
69. Mosser, D. M.; Edwards, J. P. Exploring the full spectrum of macrophage activation Nat. Rev. Immunol. 2008, 8, 958-969
70. Mares, C. A.; Sharma, J.; Li, Q.; Rangel, E. L.; Morris, E. G.; Enriquez, M. I.; Teale, J. M. Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections Immunol. Cell Biol. 2011, 89, 167-172
71. Shirey, K. A.; Cole, L. E.; Keegan, A. D.; Vogel, S. N. Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism J. Immunol. 2008, 181, 4159-4167
72. Lee, C. G.; Da Silva, C.; Dela Cruz, C. S.; Ahangari, F.; Ma, B.; Kang, M. J.; He, C. H.; Takyar, S.; Elias, J. A. Role of chitin, chitinase/chitinase- like proteins in inflammation, tissue remodeling, and injury Annu. Rev. Physiol. 2011, 73, 479-501
73. Ober, C.; Tan, Z.; Sun, Y.; Possick, J. D.; Pan, L.; Nicolae, R.; Radford, S.; Parry, R. R.; Heinzmann, A.; Deichmann, K. A.; Lester, L. A.; Gern, J. E.; Lemanske, R. F., Jr.; Nicolae, D. L.; Elias, J. A.; Chupp, G. L. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function N. Engl. J. Med. 2008, 358, 1682-1691 (Pubitemid 351549915)
74. Wu, J.; Kobayashi, M.; Sousa, E. A.; Liu, W.; Cai, J.; Goldman, S. J.; Dorner, A. J.; Projan, S. J.; Kavuru, M. S.; Qiu, Y.; Thomassen, M. J. Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmental antigen challenge Mol. Cell. Proteomics 2005, 4, 1251-1264 (Pubitemid 41448713)
75. Wood, Z. A.; Schroder, E.; Robin Harris, J.; Poole, L. B. Structure, mechanism and regulation of peroxiredoxins Trends Biochem. Sci. 2003, 28, 32-40 (Pubitemid 36051004)
76. Riddell, J. R.; Wang, X. Y.; Minderman, H.; Gollnick, S. O. Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4 J. Immunol. 2010, 184, 1022-1030