Heparan sulfate enhances invasion by human colon carcinoma cell lines through expression of CD44 variant exon 3

Clinical Cancer Research

Volumn 7, Issue 12, 2001, Pages 4067-4072

  Kuniyasu, Hiroki ^a   Tsutsumi, Masahiro ^a   Oue, Naohide ^b   Yasui, Wataru ^b   Tahara, Eiichi ^c  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c Hiroshima Cancer Seminar Foundation   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARAN SULFATE; HERMES ANTIGEN; MESSENGER RNA; TRITON X 100;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; COLON CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; METASTASIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIGENS, CD; ANTIGENS, CD44; BASE SEQUENCE; CELL DIVISION; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS; CYTOSKELETON; EXONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPARITIN SULFATE; HUMANS; KINETICS; NEOPLASM INVASIVENESS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL RATE; THIONUCLEOTIDES; TIME FACTORS; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

EID: 0035674835     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. CD44: A molecule involved in leukocyte adherence and T-cell activation
2. Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons
3. Human lymphocyte and lymphoma homing receptors
4. Monoclonal antibodies to Pgp-1/CD44 block lymphohemopoiesis in long-term bone marrow cultures
5. Dual role of the CD44 molecule in T cell adhesion and activation
6. The normal structure and function of CD44 and its role in neoplasia
7. CD44 and the adhesion of neoplastic cells
8. CD44: Structure, function, and association with the malignant process
9. CD44 in colon cancer
10. Are CD44 variant isoforms involved in human tumour progression?
11. To metastasize or not? Selection of CD44 splice sites
12. CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor
13. 121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells
14. CD44 isoforms, including the CD44 V3 variant, are expressed on endothelium, suggesting a role for CD44 in the immobilization of growth factors and the regulation of the local immune response
15. Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met
16. Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor
17. A serine protease-inhibitory benzamidine derivative inhibits the growth of human colon carcinoma cells
18. Structural requirements for heparan sulphate self-association
19. Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer
20. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons
21. Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge, but how is synthesis regulated?
22. Regulated diversity of heparan sulfate
23. Growth factors in the extracellular matrix
24. Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8
25. Expression of keratinocyte growth factor and its receptor in colorectal cancer
26. Establishment of a quantitative mouse dorsal air sac model and its application to evaluate a new angiogenesis inhibitor
27. Signal transduction via CD44: Role of plasma membrane microdomains
28. Signaling complex formation of CD44 with src-related kinases
29. Tyrosine kinase activity is associated with CD44 in human neutrophils
30. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
31. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
32. A new CD44V3-containing isoform is involved in tumor cell growth and migration during human breast carcinoma progression
33. Prognostic value of CD44 standard, variant isoforms 3 and 6 and -catenin expression in local prostate cancer treated by radical prostatectomy
34. CD44v3 and v6 variant isoform expression correlates with poor prognosis in early-stage vulvar cancer
35. Expression of CD44 and its variant isoform v3 has no prognostic value in gastric cancer