The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Volumn 114, Issue 2, 2012, Pages 240-250

  Mashhadiabbas, Fatemeh ^a   Mahjour, Faranak ^a   Mahjour, Seyyed Babak ^b   Fereidooni, Forouzandeh ^c   Hosseini, Fatemeh Sadat ^d  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Stevens Institute of Technology   (United States)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; PDPN PROTEIN, HUMAN; STROMELYSIN 2; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADULT; AGE; AGED; ARTICLE; BIOSYNTHESIS; CANCER INVASION; CHEMISTRY; FEMALE; HUMAN; IRAN; LYMPH NODE METASTASIS; LYMPH VESSEL; MALE; METABOLISM; MIDDLE AGED; MOUTH TUMOR; NONPARAMETRIC TEST; PATHOLOGY; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; SEX DIFFERENCE; SQUAMOUS CELL CARCINOMA;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; IRAN; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MATRIX METALLOPROTEINASE 10; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SEX FACTORS; STATISTICS, NONPARAMETRIC; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 84863601493     PISSN: 22124403     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oooo.2012.04.009     Document Type: Article

References (59)

1. D.M. Parkin, F. Bray, J. Ferlay, P. Pisani Estimating the world cancer burden: Globocan 2000 Int J Cancer 94 2001 153 156
2. H.K. Williams Molecular pathogenesis of oral squamous carcinoma Mol Pathol 53 2000 165 172
3. J. Bernier, C. Domenge, M. Ozsahin, K. Matuszewska, J.L. Lefèbvre, R.H. Greiner Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer N Engl J Med 350 2004 1945 1952
4. H.T. Eich, M. Löschcke, M. Scheer, M. Kocher, R. Bongartz, S. Wacker Neoadjuvant radiochemotherapy and radical resection for advanced squamous cell carcinoma of the oral cavity Outcome of 134 patients Strahlenther Onkol 184 2008 23 29
5. C. Klug, A. Wutzl, C. Kermer, O. Ploder, I. Sulzbacher, E. Selzer Preoperative radiochemotherapy and radical resection for stages II to IV oral and oropharyngeal cancer: grade of regression as crucial prognostic factor Int J Oral Maxillofac Surg 34 2005 262 267
6. H. Myoung, M.J. Kim, S.D. Hong, J.I. Lee, C.Y. Lim, S.P. Hong Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma Cancer Lett 185 2002 201 209
7. N.F. Abbas, S. Labib El-Sharkawy, E.A. Abbas, M. Abdel Monem El-Shaer Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 2007 385 390
8. M.J. Duffy The role of proteolytic enzymes in cancer invasion and metastasis Clin Exp Metastasis 10 1992 145 155
9. L.M. Coussens, B. Fingleton, L.M. Matrisian Matrix metalloproteinase inhibitors and cancer: trials and tribulations Science 295 2002 2387 2392
10. R.C. Jordan, M. Macabeo-Ong, C.H. Shiboski, N. Dekker, D.G. Ginzinger, D.T. Wong, B.L. Schmidt Overexpression of matrix metalloproteinase-1 and -9 mRNA is associated with progression of oral dysplasia to cancer Clin Cancer Res 10 2004 6460 6465
11. Z.S. Zeng, A.M. Cohen, J.G. Guillem Loss of basement membrane type IV collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis Carcinogenesis 20 1999 749 755
12. D. Muller, C. Wolf, J. Abecassis, R. Millon, A. Engelmann, G. Bronner Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas Cancer Res 53 1993 165 169
13. G.T. Thomas, M.P. Lewis, P.M. Speight Matrix metalloproteinases and oral cancer Oral Oncol 35 1999 227 233
14. M. Murashige, M. Miyahara, N. Shiraishi, T. Saito, K. Kohno, M. Kobayashi Enhanced expression of tissue inhibitors of metalloproteinases in human colorectal tumors Jpn J Clin Oncol 26 1996 303 309
15. A.H. Ree, V.A. Florenes, J.P. Berg, G.M. Maelandsmo, J.M. Nesland, O. Fodstad High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases Clin Cancer Res 3 1997 1623 1628
16. J.S. Greenberg, A.K. El Naggar, V. Mo, D. Roberts, J.N. Myers Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma Implication for therapeutic decision making Cancer 98 2003 508 515
17. R.J. Shaw, D. Lowe, J.A. Woolgar, J.S. Brown, E.D. Vaughan, C. Evans Extracapsular spread in oral squamous cell carcinoma Head Neck 32 2010 714 722
18. M. Kreppel, M. Scheer, U. Drebber, L. Ritter, J.E. Zöller Impact of podoplanin expression in oral squamous cell carcinoma: clinical and histopathologic correlations Virchows Arch 456 2010 473 482
19. S. Breiteneder-Geleff, A. Soleiman, H. Kowalski, R. Horvat, G. Amann, E. Kriehuber Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium Am J Pathol 154 1999 385 394
20. M. Durchdewald, J. Guinea-Viniegra, D. Haag, A. Riehl, P. Lichter, M. Hahn Podoplanin is a novel fos target gene in skin carcinogenesis Cancer Res 68 2008 6877 6883
21. Y. Shimada, G. Ishii, K. Nagai, N. Atsumi, S. Fujii, A. Yamada Expression of podoplanin, CD44, and p63 in squamous cell carcinoma of the lung Cancer Sci 100 2009 2054 2059
22. P. Liang, J.W. Hong, H. Ubukata, H.R. Liu, Y. Watanabe, M. Katano Increased density and diameter of lymphatic microvessels correlate with lymph node metastasis in early stage invasive colorectal carcinoma Virchows Arch 448 2006 470 475
23. S.M. Mousavi, M.M. Gouya, R. Ramazani, M. Davanlou, N. Hajsadeghi, Z. Seddighi Cancer incidence and mortality in Iran Ann Oncol 20 2009 556 563
24. A.C. Fracalossi, S.R. Miranda, C.T. Oshima, M. Franco, D.A. Ribeiro The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide J Mol Histol 41 2010 19 25
25. A. Katayama, N. Bandoh, K. Kishibe, M. Takahara, T. Ogino, S. Nonaka, Y. Harabuchi Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis Clin Cancer Res 10 2004 634 640
26. J.I. Lee, B.H. Jin, M.A. Kim, H.J. Yoon, S.P. Hong, S.D. Hong Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107 2009 678 684
27. L. Barnes, J.W. Eveson, P. Reichart, D. Sidransky World Health Organization classification of tumours Pathology and genetics of head and neck tumours 2005 IARC Lyon, France 168 175
28. V. Souza Freitas, P.P. de Andrade Santos, R. de Almeida Freitas, L. Pereira Pinto, L.B. de Souza Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112 2011 342 348
29. J.C. de Vicente, M.F. Fresno, L. Villalain, J.A. Vega, J.S. López Arranz Immunoexpression and prognostic significance of TIMP-1 and -2 in oral squamous cell carcinoma Oral Oncol 41 2005 568 579
30. S. Kurahara, M. Shinohara, T. Ikebe, S. Nakamura, M. Beppu, A. Hiraki Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis Head Neck 21 1999 627 638
31. P. Yuan, S. Temam, A. El-Naggar, X. Zhou, D.D. Liu, J.J. Lee, L. Mao Overexpression of podoplanin in oral cancer and its association with poor clinical outcome Cancer 107 2006 563 569
32. W.Y. Chuang, C.J. Yeh, Y.C. Wu, Y.K. Chao, Y.H. Liu, C.K. Tseng Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma Histol Histopathol 24 2009 1021 1027
33. P.A. Jakobsson, C.M. Eneroth, D. Killander, G. Moberger, B. Mårtensson Histologic classification and grading of malignancy in carcinoma of the larynx Acta Radiol Ther Phys Biol 12 1973 1 8
34. N. Weidner, J.P. Semple, W.R. Welch, J. Folkman Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma N Engl J Med 324 1991 1 8
35. Z.B. Gao, Y.Q. Duan, L. Zhang, D.W. Chen, P.T. Ding Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma Int J Mol Med 16 2005 599 603
36. C.H. Tsai, Y.S. Hsieh, S.F. Yang, M.Y. Chou, Y.C. Chang Matrix metalloproteinase 2 and matrix metalloproteinase 9 expression in human oral squamous cell carcinoma and the effect of protein kinase C inhibitors: preliminary observations Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95 2003 710 716
37. M. Sutinen, T. Kainulainen, T. Hurskainen, E. Vesterlund, J.P. Alexander, C.M. Overall Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis Br J Cancer 77 1998 2239 2245
38. T. Shimada, H. Nakamura, K. Yamashita, R. Kawata, Y. Murakami, N. Fujimoto Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis Clin Exp Metastasis 18 2000 179 188
39. K. Kato, A. Hara, T. Kuno, N. Kitaori, Z. Huilan, H. Mori Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity J Cancer Res Clin Oncol 131 2005 340 346
40. S.D. Hong, S.P. Hong, J.I. Lee, C.Y. Lim Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential Oral Oncol 36 2000 207 213
41. Á.C. Henriques, M.G. Vasconcelos, H.C. Galvão, L.B. de Souza, R. de Almeida Freitas Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112 2011 468 475
42. T. Görögh, U.H. Beier, J. Bäumken, J.E. Meyer, M. Hoffmann, S. Gottschlich, S. Maune Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck squamous cell carcinomas Head Neck 28 2006 31 39
43. T.J. Kim, S.B. Rho, Y.L. Choi, C.H. Choi, J.W. Lee, D.S. Bae High expression of tissue inhibitor of metalloproteinase-2 in serous ovarian carcinomas and the role of this expression in ovarian tumorigenesis Hum Pathol 37 2006 906 913
44. P. O-Charoenrat, P.H. Rhys-Evans, S.A. Eccles Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck Arch Otolaryngol Head Neck Surg 127 2001 813 820
45. O.S. Bindhu, K. Ramadas, P. Sebastian, M.R. Pillai High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma Head Neck 28 2006 916 925
46. T. Yoshizaki, Y. Maruyama, H. Sato, M. Furukawa Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma Int J Cancer 95 2001 44 50
47. T. Ikebe, M. Shinohara, H. Takeuchi, M. Beppu, S. Kurahara, S. Nakamura, K. Shirasuna Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer Clin Exp Metastasis 17 1999 315 323
48. K.D. Nanda, K. Ranganathan, U. Devi, E. Joshua Increased expression of CK8 and CK18 in leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma: an immunohistochemistry study Oral Surg Oral Med Oral Pathol Oral Radiol Endod 113 2012 245 253
49. H. Kawaguchi, A.K. El-Naggar, V. Papadimitrakopoulou, H. Ren, Y.H. Fan, L. Feng Podoplanin: a novel marker for oral cancer risk in patients with oral premalignancy J Clin Oncol 26 2008 354 360
50. X. Wang, J. Zhang, M. Fan, Q. Zhou, H. Deng, M.J. Aisharif, X. Chen The expression of E-cadherin at the invasive tumor front of oral squamous cell carcinoma: immunohistochemical and RT-PCR analysis with clinicopathological correlation Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107 2009 547 554
51. C. Ondruschka, P. Buhtz, C. Motsch, B. Freigang, R. Schneider-Stock, A. Roessner, C. Boltze Prognostic value of MMP-2, -9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas Pathol Res Pract 198 2002 509 515
52. H. Sato, T. Takino, T. Kinoshita, K. Imai, Y. Okada, W.G. Stetler Stevenson, M. Seiki Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP) FEBS Lett 385 1996 238 240
53. K. Imai, E. Ohuchi, T. Aoki, H. Nomura, Y. Fujii, H. Sato Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2 Cancer Res 56 1996 2707 2710
54. A. Wicki, F. Lehembre, N. Wick, B. Hantusch, D. Kerjaschki, G. Christofori Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton Cancer Cell 9 2006 261 272
55. F. Renyi-Vamos, J. Tovari, J. Fillinger, J. Timar, S. Paku, I. Kenessey Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer Clin Cancer Res 11 2005 7344 7353
56. F. Ohno, H. Nakanishi, A. Abe, Y. Seki, A. Kinoshita, Y. Hasegawa Regional difference in intratumoral lymphangiogenesis of oral squamous cell carcinomas evaluated by immunohistochemistry using D2-40 and podoplanin antibody: an analysis in comparison with angiogenesis J Oral Pathol Med 36 2007 281 289
57. R. Sedivy, J. Beck-Mannagetta, C. Haverkampf, W. Battistutti, S. Hönigschnabl Expression of vascular endothelial growth factor-C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer J Oral Pathol Med 32 2003 455 460
58. A. Bolzoni Villaret, A. Schreiber, F. Facchetti, S. Fisogni, S. Lonardi, D. Lombardi Immunostaining patterns of CD31 and podoplanin in previously untreated advanced oral/oropharyngeal cancer: prognostic implications Head Neck 32 2010 786 792
59. G. Zhang, Z.L. Guo, Y. Gao [Podoplanin expression in oral squamous cell carcinoma and leukoplakia and its correlation with lymph vessels density] Zhonghua Kou Qiang Yi Xue Za Zhi 44 2009 488 489