Increased expression of CK8 and CK18 in leukoplakia, oral submucous fibrosis, and oral squamous cell carcinoma: An immunohistochemistry study

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Volumn 113, Issue 2, 2012, Pages 245-253

  Nanda, Kanwar Deep Singh ^a   Ranganathan, Kanan ^b   Devi, Uma ^b   Joshua, Elizabeth ^b  

^a SGT UNIVERSITY   (India)

^b RAGAS DENTAL COLLEGE AND HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84862537093     PISSN: 22124403     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2011.05.034     Document Type: Article

References (36)

1. Peterson PE. Strengthening the prevention of oral cancer: the WHO perspective. Community Dent Oral Epidemiol 2005; 33:397-9.
2. Gupta PC, Nandakumar A. Oral cancer scene in India. Oral Dis 1999;5:1-2. (Pubitemid 29061459)
3. Warnakulasuriya S, Johnson NW, van der Waal I, Nomenclature. and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med 2007;36:575-80. (Pubitemid 47609807)
4. Morgan PR, Shirlaw PJ, Johnson NW, Leigh IM, Lane EB. Potential application of anti-keratin antibodies in oral diagnosis. J Oral Pathol 1987;16:212-22.
5. Moll R, Franke W, Schiller D. The catalog of human cytokeratin pattern in normal epithelia, tumors and cultered cells. J Cell Biol 1990;111:567-80.
6. Vaidya MM, Sawant SS, Borges AM, Ogale SB, Bhisey AN. Cytokeratin expression in precancerous lesions of human oral cavity. Oral Oncol 1998;34:261-4. (Pubitemid 28318251)
7. Ranganathan K, Kavitha R, Sawant SS, Vaidya MM. Cytokeratin expression in oral submucous fibrosis-an immunohistochemistry study. J Oral Pathol Med 2006;35:25-32.
8. National Cancer Control Programmes 2002. Policies and managerial guidelines: cancer prevention and control (58th World Health Assembly, provisional agenda item 13.12). Geneva: World Health Organization.
9. Jussawalla DJ, Yeole BB, Natekar MV. An epidemiological study of cancer incidence in greater Bombay (by religion and sex) 1973-78. Mumbai: Indian Cancer Society; 1985. p. 49.
10. Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79:321-9.
11. Schulz J, Ermich T, Kasper M, Raabe G, Schumann D. Cytokeratin pattern of clinically intact and pathologically changed oral mucosa. Int J Oral Maxillofac Surg 1992;21:35-9.
12. Vigneswaran N, Peter KP, Hornstein OP, Haneke E. Comparison of cytokeratin, filaggrin and involucrin profiles in oral leukoplakia and squamous cell carcinomas. J Oral Pathol Med 1989;18:377-90. (Pubitemid 20001922)
13. Woelfle U, Sauter G, Santjer S, Brakenhoff R, Pantel K. Downregulation expression of cytokeratin 18 promotes progression of human breast cancer. Clin Cancer Res 2004;10:2670-4. (Pubitemid 38509140)
14. Kumar S, Fogarasi M, Canova A, Mota A, Ciesielski T. Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br J Cancer 2002;86:1884-7.
15. Skerrow D, Hunter I. Protein modifications during thekeratinisation of normal and psoriatic human epidermis. Biochim Biophys Acta 1978;537:474-84. (Pubitemid 9062218)
16. Ogden GR, Chisholm DM, Leigh IM, Lane EB. Cytokeratin profiles in dyskeratosis congenita: an immunocytochemical investigation of lingual hyperkeratosis. J Oral Pathol Med 1992;21:353-7.
17. Oshima RG, Baribault H, Caulín C. Oncogenic regulation and function of keratin 8 and keratin 18. Cancer Metastasis Rev 1996;15:445-71.
18. Balm AJ, Hageman PC, van Doornewaard MH, Groeneveld EM, Ivanyi D. Cytokeratin 18 expression in squamous cell carcinoma of the head and neck. Eur Arch Otorhinolaryngol 1996; 253:227-33. (Pubitemid 26164429)
19. Vaidya MM, Sawant SS, Borges AM, Naresh NK, Purandare MC, Bhisey AN. Cytokeratin expression in human fetal tongue and buccal mucosa. J Biosci 2000;25:235-42.
20. Gires O, Mack B, Rauch J. CK8 correlates with malignancy in leukoplakia and carcinomas of the head and neck. Biochim Biophys Res 2006;343:252-59.
21. Vaidya MM, Borges AM, Pradhan SA, Haneke E. Altered keratin expression in buccal mucosal squamous cell carcinomas. J Oral Pathol Med 1989;18:377-90.
22. Vaidya MM, Sawant SS, Borges AM, Ogale SB, Bhisey AN. Cytokeratin expression in precancerous lesions of the human oral cavity. Eur J Cancer B Oral Oncol 1998;34:261-4. (Pubitemid 28318251)
23. Vaidya MM, Borges AM, Pradhan SA, Bhisey AN. Cytokeratin expression in squamous cell carcinomas of the tongue and alveolar mucosa. Eur J Cancer B Oral Oncol 1996;32B:333-6.
24. Ogden GR, Chisholm DM, Adi M, Lane EB. Cytokeratin expression in oral cancer and its relationship to tumor differentiation. J Oral Pathol Med 1993;22:82-6. (Pubitemid 23121628)
25. Kannan S, Balaram P, Chandran GJ, et al. Differential expression of cytokeratin proteins during tumor progression in oral mucosa. Epithelial Cell Biol 1994;3:61-9. (Pubitemid 24283741)
26. Morgan PR, Su L. Intermediate filaments in oral neoplasia. I. Oral cancer and epithelial dysplasia. Eur J Cancer B Oral Oncol 1994;30:160-6. (Pubitemid 24219271)
27. Raul U, Sawant S, Dange P, Kalraiya R, Ingle A, Vaidya M. Implications of cytokeratin 8/18 filament formation in stratified epithelial cells: induction of transformed phenotype. Int J Cancer 2004;20:662-8. (Pubitemid 39062887)
28. Hansson A, Bloor BK, Sarang Z, Haig Y, Morgan PR, Stark HJ, et al. Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes. Eur J Oral Sci 2003;111:34-41. (Pubitemid 37465296)
29. Pankov R, Umezawa A, Maki R, Der CJ, Hauser CA, Oshima RG. Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway. Proc Natl Acad Sci U S A 1994;91:873-7. (Pubitemid 24048469)
30. Gilbert S, Loranger A, Daigle N, Marceau N. Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol 2001;154:763-73. (Pubitemid 34292958)
31. Casanova ML, Bravo A, Martínez-Palacio J, Fernández- Aceñero MJ, Villanueva C, Larcher F, et al. Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice. FASEB J 2004;18:1556-8. (Pubitemid 39561631)
32. Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, et al. An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J Oral Pathol Med 2008;37:211-20. (Pubitemid 351347605)
33. Lane EB, Alexander CM. Use of keratin antibodies in tumor diagnosis. Semin Cancer Biol 1990;1:165-79.
34. Ogden GR, Lunny D, Lane EB. Keratin antigen retrieval in oral mucosal biopsies using microwave processing. Histochem J 1996;28:875-82. (Pubitemid 27055266)
35. Upasani OS, Vaidya MM, Bhisey AN. Database on monoclonal antibodies to cytokeratins. Oral Oncol 2004;40:236-56. (Pubitemid 38121561)
36. Mackenzie IC, Hill MW. Maintenance of regionally specific patterns of cell proliferation and differentiation in transplanted skin and oral mucosa. Cell Tissue Res 1981; 219:597-607. (Pubitemid 11029122)