Expression of vascular endothelial growth factor-C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer

Journal of Oral Pathology and Medicine

Volumn 32, Issue 8, 2003, Pages 455-460

  Sedivy, Roland ^a   Beck Mannagetta, Johann ^b   Haverkampf, C ^a   Battistutti, Walter ^a   Hönigschnabl, Selma ^c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Landeskliniken Salzburg ^*  (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Blood microvessel density; Lymphatic microvessel density; Oral squamous cell carcinoma; Podoplanin; VEGF C

Indexed keywords

CD34 ANTIGEN; CELL PROTEIN; PODOPLANIN; UNCLASSIFIED DRUG; VASCULOTROPIN C;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH FLOW; MALE; MICROVASCULATURE; MOUTH CARCINOMA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR BLOOD FLOW; TUMOR VASCULARIZATION;

ADULT; AGED; ANTIGENS, CD34; BIOLOGICAL MARKERS; CARCINOMA, SQUAMOUS CELL; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; LONGITUDINAL STUDIES; LYMPH NODES; LYMPHATIC METASTASIS; LYMPHATIC SYSTEM; MALE; MEMBRANE GLYCOPROTEINS; MICROCIRCULATION; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; SURVIVAL RATE; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 0042427799     PISSN: 09042512     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0714.2003.00168.x     Document Type: Article

References (10)

1. Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990; 82: 4-6.
2. Weidner N. Intratumoral microvessel density as a prognostic factor in cancer. Am J Pathol 1995; 147: 9-19.
3. Clarijs R, Ruiter D, De Waal R. Lymphangiogenesis in malignant tumours: does it occur? J Pathol 2001; 193: 143-6.
4. Folkman J, Klagsbrun M. Angiogenic factors. Science 1987; 235: 442-7.
5. Polverini P, Leibovich S. Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages. Lab Invest 1984; 51: 635-42.
6. Nakayama A, Ogawa A, Fukuta Y, Kudo K. Relation between lymphatic vessel diameter and clinicopathologic parameters in squamous cell carcinomas of the oral region. Cancer 1999; 86: 200-6.
7. Beasley N, Prevo R, Banerji S, et al. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 2002; 62: 1315-20.
8. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries - podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999; 154: 385-94.
9. Weidner N, Semple J, Welch W, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast cancer. N Engl J Med 1991; 324: 1-8.
10. O-Charoenrat P, Rhys-Evans P, Eccles S. Expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis. Cancer 2001; 92: 556-68.