Suppression of antigen-specific T cell responses by the Kaposi's sarcoma-associated herpesvirus viral OX2 protein and its cellular orthologue, CD200

Journal of Virology

Volumn 86, Issue 11, 2012, Pages 6246-6257

  Misstear, Karen ^a   Chanas, Simon A ^a   Rezaee, S A Rahim ^b   Colman, Rachel ^a   Quinn, Laura L ^a   Long, Heather M ^a   Goodyear, Oliver ^a   Lord, Janet M ^a   Hislop, Andrew D ^a   Blackbourn, David J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

CD200 ANTIGEN; CD200 RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN OX2; UNCLASSIFIED DRUG; VIRUS PROTEIN; ANTIGENS, CD200; G PROTEIN COUPLED RECEPTOR; LEUKOCYTE ANTIGEN; NEUROPEPTIDE RECEPTOR; OREXIN RECEPTORS; VIRULENCE FACTOR;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL KILLING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPRESSION VECTOR; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; VIRUS ATTENUATION; VIRUS IMMUNITY; ANTIGEN PRESENTING CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; PATHOGENICITY; SECRETION; T LYMPHOCYTE; VIROLOGY;

HARNESS; HUMAN HERPESVIRUS 8;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; HERPESVIRUS 8, HUMAN; HUMANS; IMMUNE TOLERANCE; INTERFERON-GAMMA; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; T-LYMPHOCYTES; VIRAL PROTEINS; VIRULENCE FACTORS;

EID: 84863578843     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.07168-11     Document Type: Article

References (54)

1. Alberola-Ila J, Hernandez-Hoyos G. 2003. The Ras/MAPK cascade and the control of positive selection. Immunol. Rev. 191:79-96.
2. Alegre ML, Frauwirth KA, Thompson CB. 2001. T-cell regulation by CD28 and CTLA-4. Nat. Rev. Immunol. 1:220-228.
3. Aresté C, Blackbourn DJ. 2009. Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus. Trends Microbiol. 17:119-129.
4. Au-Yeung BB, et al. 2009. The structure, regulation, and function of ZAP-70. Immunol. Rev. 228:41-57.
5. + cells from HIV-2-infected baboons control HIV replication. AIDS 11:737-746.
6. Bouvard V, et al. 2009. A review of human carcinogens-part B: biological agents. Lancet Oncol. 10:321-322.
7. Broderick C, et al. 2002. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am. J. Pathol. 161:1669-1677.
8. Brown KW, Gallimore PH. 1987. Malignant progression of an SV40-transformed human epidermal keratinocyte cell line. Br. J. Cancer 56:545-554.
9. Cameron CM, Barrett JW, Liu L, Lucas AR, McFadden G. 2005. Myxoma virus M141R expresses a viral CD200 (vOX-2) that is responsible for down-regulation of macrophage and T-cell activation in vivo. J. Virol. 79:6052-6067.
10. Chang Y, et al. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 266:1865-1869.
11. Chung YH, Means RE, Choi JK, Lee BS, Jung JU. 2002. Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein activates myeloidlineage cells to induce inflammatory cytokine production. J. Virol. 76: 4688-4698.
12. Coscoy L, Ganem D. 2000. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display ofMHCclass I chains by enhancing their endocytosis. Proc. Natl. Acad. Sci. U. S. A. 97:8051-8056.
13. Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN. 2004. Human herpesvirus 8 K14 protein mimics CD200 in downregulating macrophage activation through CD200 receptor. J. Virol. 78: 7667-7676.
14. Francisco LM, Sage PT, Sharpe AH. 2010. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236:219-242.
15. Gorczynski RM, et al. 1999. An immunoadhesin incorporating the molecule OX-2 is a potent immunosuppressant that prolongs allo- and xenograft survival. J. Immunol. 163:1654-1660.
16. Gorczynski RM, Chen Z, Yu K, Hu J. 2001. CD200 immunoadhesin suppresses collagen-induced arthritis in mice. Clin. Immunol. 101:328-334.
17. Grundhoff A, Ganem D. 2004. Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J. Clin. Invest. 113:124-136.
18. + T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates. J. Exp. Med. 204:1863-1873.
19. Hoek RM, et al. 2000. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290:1768-1771.
20. Ishido S, Wang C, Lee BS, Cohen GB, Jung JU. 2000. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcomaassociated herpesvirus K3 and K5 proteins. J. Virol. 74:5300-5309.
21. Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. 2001. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat. Immunol. 2:37-44.
22. Kawasaki BT, Farrar WL. 2008. Cancer stem cells, CD200 and immunoevasion. Trends Immunol. 29:464-468.
23. Koning N, Swaab DF, Hoek RM, Huitinga I. 2009. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. J. Neuropathol. Exp. Neurol. 68:159-167.
24. Kretz-Rommel A, et al. 2007. CD200 expression on tumor cells suppresses antitumor immunity: new approaches to cancer immunotherapy. J. Immunol. 178:5595-5605.
25. Li-Weber M, et al. 2005. Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-kappa B signaling pathways. J. Immunol. 175:2132-2143.
26. Mihrshahi R, Brown MH. 2010. Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling. J. Immunol. 185:7216-7222.
27. Milligan S, Robinson M, O'Donnell E, Blackbourn DJ. 2004. Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells. J. Virol. 78:2591-2596.
28. Moreaux J, et al. 2006. CD200 is a new prognostic factor in multiple myeloma. Blood 108:4194-4197.
29. Paz PE, et al. 2001. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Biochem. J. 356:461-471.
30. Qureshi OS, et al. 2011. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332:600-603.
31. Renne R, et al. 1996. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 2:342-346.
32. Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ. 2006. Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. J. Gen. Virol. 87:1781-1804.
33. Rezaee SR, Gracie JA, McInnes IB, Blackbourn DJ. 2005. Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein. AIDS 19:1907-1910.
34. Rosenblum MD, et al. 2004. Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance? J. Invest. Dermatol. 123:880-887.
35. Rubio V, et al. 2003. Ex vivo identification, isolation and analysis of tumor-cytolytic T cells. Nat. Med. 9:1377-1382.
36. Rudd CE. 2008. The reverse stop-signal model for CTLA4 function. Nat. Rev. Immunol. 8:153-160.
37. Salata C, et al. 2009. vOX2 glycoprotein of human herpesvirus 8 modulates human primary macrophages activity. J. Cell. Physiol. 219: 698-706.
38. Santos LL, Dacumos A, Yamana J, Sharma L, Morand EF. 2008. Reduced arthritis in MIF deficient mice is associated with reduced T cell activation: down-regulation of ERK MAP kinase phosphorylation. Clin. Exp. Immunol. 152:372-380.
39. Schneider H, et al. 2006. Reversal of the TCR stop signal by CTLA-4. Science 313:1972-1975.
40. Shiratori I, et al. 2005. Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J. Immunol. 175:4441-4449.
41. Snelgrove RJ, et al. 2008. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat. Immunol. 9:1074-1083.
42. Steven NM, Leese AM, Annels NE, Lee SP, Rickinson AB. 1996. Epitope focusing in the primary cytotoxic T cell response to Epstein-Barr virus and its relationship to T cell memory. J. Exp. Med. 184:1801-1813.
43. Stevenson PG, Efstathiou S, Doherty PC, Lehner PJ. 2000. Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses. Proc. Natl. Acad. Sci. U. S. A. 97:8455-8460.
44. Sun J, Madan R, Karp CL, Braciale TJ. 2009. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat. Med. 15:277-284.
45. Tivol EA, et al. 1995. Loss of CTLA-4 leads to massive lymphoprolifera-tion and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541-547.
46. Tomescu C, Law WK, Kedes DH. 2003. Surface downregulation of major histocompatibility complex class I, PE-CAM, and ICAM-1 following de novo infection of endothelial cells with Kaposi's sarcoma-associated herpesvirus. J. Virol. 77:9669-9684.
47. Tonks A, et al. 2007. CD200 as a prognostic factor in acute myeloid leukaemia. Leukemia 21:566-568.
48. Waterhouse P, et al. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270:985-988.
49. Wright GJ, et al. 2003. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171: 3034-3046.
50. Wright GJ, Jones M, Puklavec MJ, Brown MH, Barclay AN. 2001. The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. Immunology 102:173-179.
51. Xiao Z, Mescher MF, Jameson SC. 2007. Detuning CD8 T cells: downregulation of CD8 expression, tetramer binding, and response during CTL activation. J. Exp. Med. 204:2667-2677.
52. Zelinskyy G, et al. 2009. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood 114:3199-3207.
53. Zhang S, Cherwinski H, Sedgwick JD, Phillips JH. 2004. Molecular mechanisms of CD200 inhibition of mast cell activation. J. Immunol. 173:6786-6793.
54. Zuo J, et al. 2009. The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation. PLoS Pathog. 5:e1000255.