CD8+ cells from HIV-2-infected baboons control HIV replication

AIDS

Volumn 11, Issue 6, 1997, Pages 737-746

  Blackbourn, David J ^a   Locher, Christopher P ^a   Ramachandran, Bineetha ^a   Barnett, Susan W ^b   Murthy, Krishna K ^c   Carey, Kenneth D ^c   Brasky, Kathleen M ^c   Levy, Jay A ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiviral; Baboons; CD8+ cells; HIV 2

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PHYTOHEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BABOON; CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MONONUCLEAR CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; VIRUS REPLICATION;

EID: 0030902149     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199706000-00006     Document Type: Article

References (36)

1. Townsend A, Bodmer H: Antigen recognition by class I-restricted T lymphocytes. Ann Rev Immunol 1989, 7:601 624.
2. Walker CM, Moody DJ, Stites DP, Levy JA: CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986, 234:1563-1566.
3. Blackbourn DJ, Mackewicz C, Barker E, Levy JA: Human CD8+ cell non-cytolytic anti-HIV activity mediated by a novel cytokine. Res. Immunol 1994, 145:653-658.
4. Levy JA, Mackewicz CE, Barker E: Controlling HIV pathogenesis: the role of noncytotoxic anti-HIV activity of CD8+ cells. Immunol Today 1996, 17:217-224.
5. Wiviott LD, Walker CM, Levy JA: CD8+ lymphocytes suppress HIV production by autologous CD4+ cells without eliminating the infected cells from culture. Cell Immunol 1990, 128:628-634.
6. Walker CM, Erikson AL, Hsueh FC, Levy JA: Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism. J Virol 1991, 65:5921-5927.
7. Mackewicz C, Levy JA: CD8+ cell anti-HIV activity: nonlytic suppression of virus replication. AIDS Res Hum Retrovirus 1992, 8:1039-1050.
8. Mackewicz CE, Ortega HW, Levy JA: CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual. J Clin Invest 1991, 87:1462 1466.
9. Walker CM, Levy JA: A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 1989, 66:628-630.
10. Brinchmann JE, Gaudernack G, Vartdal F: CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells.: evidence for a soluble inhibitor. J Immunol 1990, 144:2961-2966.
11. Brichmann JE, Gaudernack G, Vartdal F: In vitro replication of HIV-1 in naturally infected CD4+ cells is inhibited by rIFNα2 and by a soluble factor secreted by activated CD8+ T cells, but not by rIFNβ, rIFNγ, or recombinant tumor necrosis factor-α. J Acquir Immune Defic Syndr 1991, 4:480-488.
12. Mackewicz CE, Ortega H, Levy JA: Effect of cytokines on HIV replication in CD4+ lymphocytes: lack of identity with the CD8+ cell antiviral factor. Cell Immunol 1994, 153:329-343.
13. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995, 270:1811-1815.
14. Baier M, Werner A, Bannert N, Metzner K, Kurth R: HIV suppression by interleukin-16. Nature 1995, 378:563.
15. Mackewicz CE, Levy JA, Cruikshank WW, Kornfeld H, Center DM: Potential role of IL-16 in CD8+ cell mediated suppression of HIV replication in infected humans. Nature 1996, 383:488-489.
16. Mackewicz CE, Barker E, Levy JA: Role of β-chemokines in suppressing HIV replication. Science 1996, 274:1393 1395.
17. Landay AL, Mackewicz C, Levy JA: An activated CD8+ T cell phenotype correlates with anti-HIV activity and asymptomatic clinical status. Clin Immunol Immunopathol 1993, 69:106-116.
18. Kannagi M, Chalifoux LV, Lord CI, Letvin NL: Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes. J Immunol 1988, 140:2237-2242.
19. Powell JD, Yehuda-Cohen T, Villinger F, McClure HM, Sell KW, Ahmed-Ansari A: Inhibition of SIV/SMM replication in vitro by CD8+ cells from SIV/SIMM infected seropositive clinically asymptomatic sooty mangabeys. J Med Primatol 1990, 19:239-249.
20. Castro BA, Walker CM, Eichberg JW, Levy JA: Suppression of human immunodeficiency virus replication by CD8+ cells from infected and uninfected chimpanzees. Cell Immunol 1991, 132:246-255.
21. Ennen J, Findeklee H, Dittmar MT, Norley S, Ernst M, Kurth R: CD8+ T lymphocytes of African green monkeys secrete an immunodeficiency virus-suppressing lymphokine. Proc Natl Acad Sci USA 1994, 91:7207-7211.
22. Barnett SW, Murthy KK, Herndier BG, Levy JA: An AIDS-like condition induced in baboons by HIV-2. Science 1994, 266:642-646.
23. Evans LA, Moreau J, Odehouri K, et al.: Simultaneous isolation of HIV-1 and HIV-2 from an AIDS patient. Lancet 1988, ii:1389-1391.
24. UC2. Virology 1996, 221:257-261.
25. Castro BA, Nepomuceno M, Lerche NW, Eichberg JW, Levy JA: Persistent infection of baboon and rhesus monkeys with different strains of HIV-2. Virology 1991, 184:219-226.
26. Hoffman AD, Banapour B, Levy JA: Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions. Virology 1985, 147:326-335.
27. McDougal JS, Cort SP, Kennedy MS, et al.: Immunoassay for the detection and quantitation of infectious human retrovirus, lymphadenopathy-associated virus (LAV). J Immunol Methods 1985, 76:171-183.
28. Castro BA, Weiss CD, Wiviott LD, Levy JA: Optimal conditions for recovery of the human immunodeficiency virus from peripheral blood mononuclear cells. J Clin Microbiol 1988, 26:2371-2376.
29. Mackwicz CE, Blackbourn DJ, Levy JA: CD8+ cells suppress HIV replication by inhibiting viral transcription. Proc Natl Acad Sci USA 1995, 92:2308 2312.
30. Locher CT, Blackbourn DJ, Murthy KK et al.: Pathogenic and immunologic consequences of HIV-2 serial passage in baboons. Eighth Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS. 1996 [abstract p. 127].
31. Pantaleo G, Cohen RJ, Schwartzentuber DJ, Graziosi C, Vaccarezza M, Fauci AS: Pathogenic insights from studies of lymphoid tissue from HIV-infected individuals. J Acquir Immune Defic Syndr Hum Retrovirol 1995, 10 (suppl 1):S6-S14.
32. Blackbourn DJ, Mackwicz CE, Barker E, et al.: Suppression of HIV replication by lymphoid tissue CD8+ cells correlates with the clinical state of HIV-infected individuals. Proc Natl Acad Sci USA 1996, 93:13125-13130.
33. Folks TM, Justement J, Kinter A, Dinarello CA, Fauci AS: Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science 1987, 238:800-802.
34. Grant RF, Windsor SK, Malinak CJ, et al.: Characterization of infectious type D retrovirus from baboons. Virology 1995, 207:292-296.
35. van der Kuyl AC, Dekker JT, Goudsmit J: Full-length proviruses of baboon endogenous virus (BaEV) and dispersed BaEV reverse transcriptase retroelements in the genome of baboon species. J Virol 1995, 69:5917-5924.
36. Mackewicz CE, Yang LC, Lifson JD, Levy JA: Non-cytolytic CD8 T-cell anti-HIV responses in primary infection. Lancet 1994, 344:1671 1673.