메뉴 건너뛰기




Volumn 30, Issue 2, 2012, Pages 337-343

Genistein inhibits MDA-MB-231 triple-negative breast cancer cell growth by inhibiting NF-κB activity via the Notch-1 pathway

Author keywords

Genistein; Notch 1 signaling pathway; Nuclear factor B; Triple negative breast cancer

Indexed keywords

CYCLIN B1; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH1 RECEPTOR; PROTEIN BCL 2; PROTEIN BCL XL; SMALL INTERFERING RNA;

EID: 84863553441     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.990     Document Type: Article
Times cited : (143)

References (37)
  • 2
    • 79951834315 scopus 로고    scopus 로고
    • Cancer screening in the United States, 2011: A review of current American Cancer Society guidelines and issues in cancer screening
    • Smith RA, Cokkinides V, Brooks D, Saslow D, Shah M and Brawley OW: Cancer screening in the United States, 2011: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin 61: 8-30, 2011.
    • (2011) CA Cancer J Clin , vol.61 , pp. 8-30
    • Smith, R.A.1    Cokkinides, V.2    Brooks, D.3    Saslow, D.4    Shah, M.5    Brawley, O.W.6
  • 3
    • 80051518997 scopus 로고    scopus 로고
    • Triple negative breast cancer in Hispanic patients: High prevalence, poor prognosis, and association with menopausal status, body mass index, and parity
    • Lara-Medina F, Perez-Sanchez V, Saavedra-Perez D, et al: Triple negative breast cancer in Hispanic patients: high prevalence, poor prognosis, and association with menopausal status, body mass index, and parity. Cancer 117: 3658-3669, 2011.
    • (2011) Cancer , vol.117 , pp. 3658-3669
    • Lara-Medina, F.1    Perez-Sanchez, V.2    Saavedra-Perez, D.3
  • 4
    • 33744960226 scopus 로고    scopus 로고
    • Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    • Carey LA, Perou CM, Livasy CA, et al: Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295: 2492-2502, 2006.
    • (2006) JAMA , vol.295 , pp. 2492-2502
    • Carey, L.A.1    Perou, C.M.2    Livasy, C.A.3
  • 5
    • 34547661993 scopus 로고    scopus 로고
    • Triple-negative breast cancer: Clinical features and patterns of recurrence
    • Dent R, Trudeau M, Pritchard KI, et al: Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13: 4429-4434, 2007.
    • (2007) Clin Cancer Res , vol.13 , pp. 4429-4434
    • Dent, R.1    Trudeau, M.2    Pritchard, K.I.3
  • 6
    • 34247381115 scopus 로고    scopus 로고
    • Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    • Haffty BG, Yang Q, Reiss M, et al: Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 24: 5652-5657, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 5652-5657
    • Haffty, B.G.1    Yang, Q.2    Reiss, M.3
  • 8
    • 34547982817 scopus 로고    scopus 로고
    • Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
    • Tischkowitz M, Brunet JS, Begin LR, et al: Use of immunohistochemical markers can refine prognosis in triple negative breast cancer. BMC Cancer 7: 134, 2007.
    • (2007) BMC Cancer , vol.7 , pp. 134
    • Tischkowitz, M.1    Brunet, J.S.2    Begin, L.R.3
  • 9
    • 38049074972 scopus 로고    scopus 로고
    • Epidemiology of soy exposures and breast cancer risk
    • Wu AH, Yu MC, Tseng CC and Pike MC: Epidemiology of soy exposures and breast cancer risk. Br J Cancer 98: 9-14, 2008.
    • (2008) Br J Cancer , vol.98 , pp. 9-14
    • Wu, A.H.1    Yu, M.C.2    Tseng, C.C.3    Pike, M.C.4
  • 10
    • 46349109619 scopus 로고    scopus 로고
    • Soy intake and breast cancer risk in Singapore Chinese Health Study
    • Wu AH, Koh WP, Wang R, Lee HP and Yu MC: Soy intake and breast cancer risk in Singapore Chinese Health Study. Br J Cancer 99: 196-200, 2008.
    • (2008) Br J Cancer , vol.99 , pp. 196-200
    • Wu, A.H.1    Koh, W.P.2    Wang, R.3    Lee, H.P.4    Yu, M.C.5
  • 11
    • 66849115652 scopus 로고    scopus 로고
    • Adolescent and adult soy food intake and breast cancer risk: Results from the Shanghai Women's Health Study
    • Lee SA, Shu XO, Li H, et al: Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study. Am J Clin Nutr 89: 1920-1926, 2009.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1920-1926
    • Lee, S.A.1    Shu, X.O.2    Li, H.3
  • 13
    • 78650992290 scopus 로고    scopus 로고
    • Soy isoflavones consumption and risk of breast cancer incidence or recurrence: A meta-analysis of prospective studies
    • Dong JY and Qin LQ: Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 125: 315-323, 2011.
    • (2011) Breast Cancer Res Treat , vol.125 , pp. 315-323
    • Dong, J.Y.1    Qin, L.Q.2
  • 14
    • 51749113325 scopus 로고    scopus 로고
    • Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway
    • Li Z, Li J, Mo B, et al: Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway. Toxicol in Vitro 22: 1749-1753, 2008.
    • (2008) Toxicol in Vitro , vol.22 , pp. 1749-1753
    • Li, Z.1    Li, J.2    Mo, B.3
  • 15
    • 50249177143 scopus 로고    scopus 로고
    • Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells
    • Li Z, Li J, Mo B, et al: Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells. Cell Biol Toxicol 24: 401-409, 2008.
    • (2008) Cell Biol Toxicol , vol.24 , pp. 401-409
    • Li, Z.1    Li, J.2    Mo, B.3
  • 16
    • 84860175405 scopus 로고    scopus 로고
    • Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer
    • Nov 13, 2011 Epub ahead of print
    • Speiser J, Foreman K, Drinka E, et al: Notch-1 and Notch-4 biomarker expression in triple-negative breast cancer. Int J Surg Pathol: Nov 13, 2011 (Epub ahead of print).
    • Int J Surg Pathol
    • Speiser, J.1    Foreman, K.2    Drinka, E.3
  • 17
    • 33947214529 scopus 로고    scopus 로고
    • Notch signaling, gamma-secretase inhibitors, and cancer therapy
    • Shih IeM and Wang TL: Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res 67: 1879-1882, 2007.
    • (2007) Cancer Res , vol.67 , pp. 1879-1882
    • Shih, Ie.M.1    Wang, T.L.2
  • 18
    • 0031594575 scopus 로고    scopus 로고
    • NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
    • Oswald F, Liptay S, Adler G and Schmid RM: NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. Mol Cell Biol 18: 2077-2088, 1998.
    • (1998) Mol Cell Biol , vol.18 , pp. 2077-2088
    • Oswald, F.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 19
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation of notch signaling in human breast cancer
    • Stylianou S, Clarke RB and Brennan K: Aberrant activation of notch signaling in human breast cancer. Cancer Res 66: 1517-1525, 2006.
    • (2006) Cancer Res , vol.66 , pp. 1517-1525
    • Stylianou, S.1    Clarke, R.B.2    Brennan, K.3
  • 20
    • 0032996755 scopus 로고    scopus 로고
    • Human ligands of the Notch receptor
    • Gray GE, Mann RS, Mitsiadis E, et al: Human ligands of the Notch receptor. Am J Pathol 154: 785-794, 1999.
    • (1999) Am J Pathol , vol.154 , pp. 785-794
    • Gray, G.E.1    Mann, R.S.2    Mitsiadis, E.3
  • 21
    • 2142771662 scopus 로고    scopus 로고
    • Notch1 receptor: Structure and role during T-cell development
    • In Polish
    • Gidzinska B: Notch1 receptor: structure and role during T-cell development. Postepy Hig Med Dosw 57: 369-376, 2003 (In Polish).
    • (2003) Postepy Hig Med Dosw , vol.57 , pp. 369-376
    • Gidzinska, B.1
  • 22
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M, Odorcic S, Chang L, et al: High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 65: 8530-8537, 2005.
    • (2005) Cancer Res , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3
  • 23
    • 51649090695 scopus 로고    scopus 로고
    • JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer
    • Reedijk M, Pinnaduwage D, Dickson BC, et al: JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res Treat 111: 439-448, 2008.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 439-448
    • Reedijk, M.1    Pinnaduwage, D.2    Dickson, B.C.3
  • 25
    • 54549107725 scopus 로고    scopus 로고
    • Rational targeting of Notch signaling in breast cancer
    • Miele L: Rational targeting of Notch signaling in breast cancer. Expert Rev Anticancer Ther 8: 1197-1202, 2008.
    • (2008) Expert Rev Anticancer Ther , vol.8 , pp. 1197-1202
    • Miele, L.1
  • 26
    • 48549103124 scopus 로고    scopus 로고
    • Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
    • Rizzo P, Miao H, D'Souza G, et al: Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 68: 5226-5235, 2008.
    • (2008) Cancer Res , vol.68 , pp. 5226-5235
    • Rizzo, P.1    Miao, H.2    D'Souza, G.3
  • 27
    • 0034708132 scopus 로고    scopus 로고
    • Selective activation of NF-kappa B subunits in human breast cancer: Potential roles for NF-kappa B2/p52 and for Bcl-3
    • Cogswell PC, Guttridge DC, Funkhouser WK and Baldwin AS Jr: Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Oncogene 19: 1123-1131, 2000.
    • (2000) Oncogene , vol.19 , pp. 1123-1131
    • Cogswell, P.C.1    Guttridge, D.C.2    Funkhouser, W.K.3    Baldwin Jr., A.S.4
  • 28
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth
    • Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet RJ Jr and Sledge GW Jr: Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 17: 3629-3639, 1997.
    • (1997) Mol Cell Biol , vol.17 , pp. 3629-3639
    • Nakshatri, H.1    Bhat-Nakshatri, P.2    Martin, D.A.3    Goulet Jr., R.J.4    Sledge Jr., G.W.5
  • 29
    • 0031440245 scopus 로고    scopus 로고
    • Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer
    • Sovak MA, Bellas RE, Kim DW, et al: Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. J Clin Invest 100: 2952-2960, 1997.
    • (1997) J Clin Invest , vol.100 , pp. 2952-2960
    • Sovak, M.A.1    Bellas, R.E.2    Kim, D.W.3
  • 31
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-kappaB action regulated by reversible acetylation
    • Chen LF, Fischle W, Verdin E and Greene WC: Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 293: 1653-1657, 2001.
    • (2001) Science , vol.293 , pp. 1653-1657
    • Chen, L.F.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 32
    • 0031021648 scopus 로고    scopus 로고
    • Expression of the G2-M checkpoint regulators cyclin B1 and cdc2 in nonmalignant and malignant human breast lesions: Immunocytochemical and quantitative image analyses
    • Kawamoto H, Koizumi H and Uchikoshi T: Expression of the G2-M checkpoint regulators cyclin B1 and cdc2 in nonmalignant and malignant human breast lesions: immunocytochemical and quantitative image analyses. Am J Pathol 150: 15-23, 1997.
    • (1997) Am J Pathol , vol.150 , pp. 15-23
    • Kawamoto, H.1    Koizumi, H.2    Uchikoshi, T.3
  • 33
    • 4143080409 scopus 로고    scopus 로고
    • Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells
    • Yuan J, Yan R, Krämer A, Eckerdt F, Roller M, Kaufmann M and Strebhardt K: Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells. Oncogene 23: 5843-5852, 2004.
    • (2004) Oncogene , vol.23 , pp. 5843-5852
    • Yuan, J.1    Yan, R.2    Krämer, A.3    Eckerdt, F.4    Roller, M.5    Kaufmann, M.6    Strebhardt, K.7
  • 35
    • 0033968519 scopus 로고    scopus 로고
    • Importance of estrogen receptors for the behavior of invasive micropapillary carcinoma of the breast. Review of 68 cases with follow-up of 54
    • Luna-Moré S, Casquero S, Pérez-Mellado A, Rius F, Weill B and Gornemann I: Importance of estrogen receptors for the behavior of invasive micropapillary carcinoma of the breast. Review of 68 cases with follow-up of 54. Pathol Res Pract 196: 35-39, 2000.
    • (2000) Pathol Res Pract , vol.196 , pp. 35-39
    • Luna-Moré, S.1    Casquero, S.2    Pérez-Mellado, A.3    Rius, F.4    Weill, B.5    Gornemann, I.6
  • 36
    • 0242721548 scopus 로고    scopus 로고
    • Targeting Bcl-2 and Bcl-xL with nonpeptidic small-molecule antagonists
    • Wang S, Yang D and Lippman ME: Targeting Bcl-2 and Bcl-xL with nonpeptidic small-molecule antagonists. Semin Oncol 30: 133-142, 2003.
    • (2003) Semin Oncol , vol.30 , pp. 133-142
    • Wang, S.1    Yang, D.2    Lippman, M.E.3
  • 37
    • 0032763060 scopus 로고    scopus 로고
    • Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model
    • Liu R, Page C, Beidler DR, Wicha MS and Núñez G: Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model. Am J Pathol 155: 1861-1867, 1999.
    • (1999) Am J Pathol , vol.155 , pp. 1861-1867
    • Liu, R.1    Page, C.2    Beidler, D.R.3    Wicha, M.S.4    Núñez, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.