Expression of the G2-M checkpoint regulators cyclin B1 and cdc2 in nonmalignant and malignant human breast lesions: Immunocytochemical and quantitative image analyses

American Journal of Pathology

Volumn 150, Issue 1, 1997, Pages 15-23

  Kawamoto, Hisanori ^a   Koizumi, Hirotaka ^a   Uchikoshi, Toshiyuki ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN B;

ARTICLE; BREAST CARCINOMA; BREAST DISEASE; BREAST HYPERPLASIA; CARCINOMA IN SITU; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; METAPHASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

BREAST DISEASES; BREAST NEOPLASMS; CDC2 PROTEIN KINASE; CYCLIN B; CYCLINS; G2 PHASE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MITOSIS;

EID: 0031021648     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Nasmyth K, Hunt T: Dams and sluices. Nature 1993, 366:634-635
2. Reed SI: The role of p34 kinases in the G1 to S-phase transition. Annu Rev Cell Biol 1992, 8:529-561
3. Grana X, Reddy EP: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes, and cyclin-dependent kinase inhibitors (CKIs). Oncogene 1995, 11:211-219
4. Cordon-Cardo C: Mutation of cell cycle regulators. Am J Pathol 1995, 147:545-560
5. Hunter T, Pines J: Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age. Cell 1994, 79:573-582
6. Hartwell LH, Kastan MB: Cell cycle control and cancer. Science 1994, 266:1821-1828
7. Buckley MF, Sweeney KJ, Hamilton JA, Sini RL, Manning DL, Nicholson RI, deFazio A, Watts CK, Musgrove EA, Sutherland RL: Expression and amplification of cyclin genes in human breast cancer. Oncogene 1993, 8:2127-2133
8. Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D, Peters G: Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res 1994, 54:1812-1817
9. Zhang SY, Caamano J, Cooper F, Quo X, Klein SA: Immunohistochemistry of cyclin D1 in human breast cancer. Am J Clin Pathol 1994, 102:695-698
10. Dutta A, Chandra R, Leiter LM, Lester S: Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer. Proc Natl Acad Sci USA 1995, 92:5386-5390
11. McIntosh GG, Anderson JJ, Milton I, Steward M, Parr AH, Thomas MD, Henry JA, Angus B, Lennard TW, Horne CH: Determination of the prognostic value of cyclin D1 overexpression in breast cancer. Oncogene 1995, 11:885-891
12. Weinstat-Saslow D, Merino MJ, Manrow RE, Lawrence JA, Bluth RF, Wittenbel KD, Simpson JF, Page DL, Steeg PS: Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nature Med 1995, 1:1257-1260
13. Page DL, DuPont WD, Rogers LW, Rados MS: Atypical hyperplastic lesions of the female breast. A long-term follow-up study. Cancer 1985, 55:2698-2708
14. DuPont WD, Page DL: Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med 1985, 312:146-151
15. Rosai J: Borderline epithelial lesions of the breast. Am J Surg Pathol 1991, 15:209-221
16. Rosen PP: Proliferative breast "disease": an unsolved diagnostic dilemma. Cancer 1993, 71:3798-3807
17. Keyomarsi K, Pardee AB: Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci USA 1993, 90:1112-1116
18. Page DL, Rogers LW: Combined histologic and cyto- logic criteria for the diagnosis of mammary atypical ductal hyperplasia. Hum Pathol 1992, 23:1095-1097
19. Schnitt SJ, Connolly JL, Tavassoli FA, Fechner RE, Kempson RL, Gelman R, Page DL: Interobserver reproducibility in the diagnosis of ductal proliferative breast lesions using standardized criteria. Am J Surg Pathol 1992, 16:1133-1143
20. Shibayama E, Koizumi H: Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. Am J Pathol 1996, 148:1807-1818
21. Bacus SS, Goldschmidt R, Chin D, Moran G, Weinberg D, Bacus JW: Biological grading of breast cancer using antibodies of proliferating cells and other markers. Am J Pathol 1989, 135:783-792
22. Kerns B-JM, Jordan PA, Faerman LL, Berchuk A, Bast RC, Layfield LJ: Determination of proliferative index with MIB-1 in advanced ovarian cancer using quantitative image analysis. Am J Clin Pathol 1993, 101:192-197
23. Stein GH, Drullinger LF, Robetorye RS, Pereira SO, Smith JR: Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc Natl Acad Sci USA 1991, 88:11012-11016
24. Afshari CA, Barrett JC: Disruption of GO-G1 arrest in quiescent and senescent cells treated with phosphatase inhibitors. Cancer Res 1994, 54:2317-2321
25. cdc2 in the cells of normal, hyperplastic, and malignant epithelium and lymphoid tissues of the oral cavity. J Pathol 1996, 178:422-428
26. Pines J, Hunter T: Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol 1991, 115: 1-17
27. 2/M and enters vesicles at anaphase. EMBO J 1989; 8:3989-3995
28. cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes. EMBO J 1992, 11:1763-1772
29. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD: Cell growth and division. Molecular Biology of the Cell. Edited by R Adams, New York, Garland Publishing, 1989, pp 727-790
30. Maller JL: Mitotic control. Curr Opin Cell Biol 1991, 3:269-275
31. Murray AW, Solomon MJ, Kirschner MW: The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 1989, 339: 280-285
32. Crissman HA, Gadbois DM, Tobey RA, Bradbury EM: Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle. Proc Natl Acad Sci USA 1991, 88: 7580-7584
33. Guillouf C, Rosselli F, Krishnaraju K, Moustacchi E, Huffman B, Liebermann DA: p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis. Oncogene 1995, 10:2263-2270
34. McKinney CD, Fechner RE: Papilloma of the breast: a histologic spectrum including atypical hyperplasia and carcinoma in situ. Pathology Annual 1995, part 2. Edited by PP Rosen, RE Fechner. Stamford, CT, Appleton & Lange, 1996, pp 137-178
35. Ohuchi N, Thor A, Page DL, Hand PH, Halter SA, Schlom J: Expression of the 21,000 molecular weight Ras protein in a spectrum of benign and malignant human mammary tissues. Cancer Res 1986, 46:2511-2519
36. Kumar R, Sukumar S, Barbacid M: Activation of ras oncogenes preceding the onset of neoplasia. Science 1990, 248:1101-1104