A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin

Journal of Materials Science: Materials in Medicine

Volumn 23, Issue 2, 2012, Pages 399-407

  Fan, Junjun ^a   Bi, Long ^a   Wu, Tao ^b   Cao, Liangguo ^b   Wang, Dexin ^a   Nan, Kaihui ^c   Chen, Jingdi ^d   Jin, Dan ^b   Jiang, Shan ^b   Pei, Guoxian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FIRST MILITARY MEDICAL UNIVERSITY   (China)

^c WENZHOU MEDICAL UNIVERSITY   (China)

^d SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BONE MARROW; BONE REGENERATION; BONE REPAIRING; CHEMICAL CHANGE; CONTROLLED RELEASE; DELIVERY METHODS; DRUG RELEASE KINETICS; FLAVONOL GLYCOSIDES; HYDROLYTIC DEGRADATION; ICARIIN; IN-VITRO; IN-VITRO BIOACTIVITY; MECHANICAL TESTS; MINERALIZED NODULES; PHOSPHATE BUFFERED SALINE SOLUTIONS; RELEASE KINETICS; STROMA CELLS;

BONE; DEGRADATION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; KINETICS; PHOSPHATASES; SCANNING ELECTRON MICROSCOPY; SUGARS; X RAY DIFFRACTION;

HYDROXYAPATITE;

ALKALINE PHOSPHATASE; CHITOSAN; HYDROXYAPATITE; ICARIIN; PHOSPHATE BUFFERED SALINE;

ANIMAL CELL; ARTICLE; BIOMECHANICS; BONE MARROW; BONE MINERALIZATION; BONE REMODELING; CELL ADHESION; CELL PROLIFERATION; CHEMICAL ANALYSIS; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG STABILITY; ENZYME ACTIVITY; HYDROLYSIS; IN VITRO STUDY; INCUBATION TIME; INFRARED SPECTROSCOPY; KINETICS; MORPHOMETRICS; NONHUMAN; POROSITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STROMA CELL; TENSILE STRENGTH; X RAY DIFFRACTION;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; CHITOSAN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DURAPATITE; FLAVONOIDS; HYDROLYSIS; KINETICS; MICE; MICE, INBRED BALB C; NANOPARTICLES; NANOTECHNOLOGY; POROSITY; STRESS, MECHANICAL; STROMAL CELLS; TECHNOLOGY, PHARMACEUTICAL; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84863483217     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-011-4491-4     Document Type: Article

References (30)

1. Kretlow JD, Mikos AG. Review: mineralization of synthetic polymer scaffolds for bone tissue engineering. Tissue Eng. 2007; 13:927-38.
2. Lin ZY, Duan ZX, Guo XD, Li JF, Lu HW, Zheng QX, Quan DP, Yang SH. Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo. J Control Release. 2010;144:190-5.
3. Lee JY, Seol YJ, Kim KM, Lee YM, Park YJ, Rhyu IC, Chung CP, Lee SJ. Transforming growth factor (TGF)-beta1 releasing tricalcium phosphate/chitosan microgranules as bone substitutes. Pharm Res. 2004;21:1790-6.
4. Bi L, Cheng W, Fan H, Pei G Reconstruction of goat tibial defects using an injectable tricalcium phosphate/chitosan in combination with autologous platelet-rich plasma. Biomaterials. 2010;31:3201-11.
5. Okada M, Sangadala S, Liu Y, Yoshida M, Reddy BV, Titus L, Boden SD. Development and optimization of a cell-based assay for the selection of synthetic compounds that potentiate bone morpho-genetic protein-2 activity. Cell Biochem Funct. 2009;27:526-34.
6. Santin M, Morris C, Standen G, Nicolais L, Ambrosio L. A new class of bioactive and biodegradable soybean-based bone fillers. Biomacromolecules. 2007;8(9):2706-11.
7. Giavaresi G, Fini M, Salvage J, Nicoli Aldini N, Giardino R, Ambrosio L, Nicolais L, Santin M. Bone regeneration potential of a soybean-based filler: experimental study in a rabbit cancellous bone defect. J Mater Sci Mater Med. 2010;21(2):615-26.
8. Morris C, Thorpe J, Ambrosio L, Santin M. The soybean iso-flavone genistein induces differentiation of MG63 human osteo-sarcoma osteoblasts. J Nutr. 2006;136:1166-70.
9. Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T. Icariin: a potential osteoinductive compound for bone tissue engineering. Tissue Eng Part A. 2010;16:233-43.
10. Nian H, Ma MH, Nian SS, Xu LL. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine. 2009;16:320-6.
11. Qin L, Han T, Zhang Q, Cao D, Nian H, Rahman K, Zheng H. Antiosteoporotic chemical constituents from Er-Xian decoction, a traditional Chinese herbal formula. J Ethnopharmacol. 2008;118: 271-9.
12. Zhao J, Ohba S, Shinkai M, Chung UI, Nangamue T. Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun. 2008;369: 444-8.
13. De la Riva B, Sánchez E, Hernández A, Reyes R, Tamimi F, López-Cabarcos E, Delgado A, Evora C. Local controlled release of VEGF and PDGF from a combined brushite-chitosan system enhances bone regeneration. J Control Release. 2010;143:45-52.
14. Venugopal J, Prabhakaran MP, Zhang Y, Low S, Choon AT, Ramakrishna S. Biomimetic hydroxyapatite-containing compos-ite nanofibrous substrates for bone tissue engineering. Philos Transact A Math Phys Eng Sci. 2010;368:2065-81.
15. Liuyun J, Yubao L, Chengdong X. Preparation and biological properties of a novel composite scaffold of nano-hydroxyapatite chitosan carboxymethyl cellulose for bone tissue engineering. J Biomed Sci. 2009;14:65.
16. Hu Q, Li B, Wang M, Shen J. Preparation and characterization of nano-sized hydroxyapatite particles and hydroxyapatitechitosan nano-composite for use in biomedical materials. Biomaterials. 2004;25:779-85.
17. Han J, Zhou Z, Yin R, Yang D, Nie J. Alginate-chitosan hydroxyapatite polyelectrolyte complex porous scaffolds: prepa-ration and characterization. Int J Biol Macromol. 2010;46: 199-205.
18. Yamaguchi I, Tokuchi K, Fukuzaki H, Koyama Y, Takakuda K, Monma H, Tanaka J. Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites. J Biomed Mater Res. 2000;55(1):20-7.
19. Yoshida A, Miyazaki T, Ishida E, Ashizuka M. Preparation of bioactive chitosan-hydroxyapatite nanocomposites for bone repair through mechanochemical reaction. Mater Trans. 2004;45: 994-8.
20. Kong LJ, Gao Y, Cao WL, Gong YD, Zhao NM, Zhang XF. Preparation and characterization of nano-hydroxyapatite/chitosan composite scaffolds. J Biomed Mater Res A. 2005;75(2):275-82.
21. Oliveira JM, Rodrigues MT, Silva SS, Malafaya PB, Gomes ME, Viegas CA, Dias IR, Azevedo JT, Mano JF, Reis RL. Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials. 2006; 27:6123-37.
22. Kong LJ, Gao Y, Lu GY, Gong YD, Zhao NM, Zhang XF. A study on the bioactivity of chitosan/nano-hydroxyapatite com-posite scaffolds for bone tissue engineering. Eur Polym J. 2006;42:3171-9.
23. Zhang R, Ma PX. Poly (alpha-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res. 1999;44:446-55.
24. Zheng J, Liang L. Intra-portal transplantation of bone marrow stromal cells ameliorates liver fibrosis in mice. Hepatobiliary Pancreat Dis Int. 2008;7(3):264-70.
25. Zhang Y, Venugopal JR, El-Turki A, Ramakrishna S, Su B, Lim CT. Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering. Biomateri-als. 2008;29:4314-22.
26. Niu X, Feng Q, Wang M, Guo X, Zheng Q. Porous nano-HA collagen PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2. J Control Release. 2009;134:111-7.
27. Gong YH, Zhou QL, Gao CY, Shen JC. In vitro and in vivo degradability and cytocompatibility of poly(L-lactic acid) scaffold fabricated by a gelatin particle leaching method. Acta Biomater. 2007;3:531-40.
28. Wei GB, Jin QM, Giannobile WV, Ma PX. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rh BMP-7 nanospheres. Biomaterials. 2007;28:2087-96.
29. Kim SE, Park JH, Cho YW, Chung H, Jeong SY, Lee EB, Kwon IC. Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta 1: implications for cartilage tis-sue engineering. J Control Release. 2003;91:365-74.
30. Lee J, Kim KE, Kwon IC, Ahn HJ, Lee SH, Cho HC, Kim HJ, Seong SC, Lee MC. Effects of the controlled-released TGF-beta 1 from chitosan microspheres on chondrocytes cultured in a collagen/chit-osan/glycosaminoglycan scaffold. Biomaterials. 2004;25:4163-73.