Local controlled release of VEGF and PDGF from a combined brushite-chitosan system enhances bone regeneration

Journal of Controlled Release

Volumn 143, Issue 1, 2010, Pages 45-52

  De la Riva, Beatriz ^a   Sánchez, Esther ^a   Hernández, Antonio ^b   Reyes, Ricardo ^a   Tamimi, Faleh ^c   López Cabarcos, Enrique ^c   Delgado, Araceli ^a   vora, Carmen ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

^b Traumatology Service   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Bone regeneration; Brushite; Chitosan; Platelet derived growth factor (PDGF); Vascular endothelial growth factor (VEGF)

Indexed keywords

BONE DEFECT; BONE FORMATION; BONE HEALING; BONE REGENERATION; BRUSHITE; CHITOSAN SCAFFOLD; CONTROLLED RELEASE; GROWTH FACTOR; IMPLANTATION SITES; IN-VIVO; LIQUID PHASE; PEAK CONCENTRATIONS; PLATELET-DERIVED GROWTH FACTORS; RELEASE KINETICS; RELEASE RATE; TISSUE DISTRIBUTIONS; VASCULAR ENDOTHELIAL GROWTH FACTOR;

BIOACTIVITY; BLOOD SUBSTITUTES; CHITIN; CHITOSAN; CONCENTRATION (PROCESS); CYTOTOXICITY; PEPTIDES; PLATELETS; SCAFFOLDS; SELF ASSEMBLY;

BONE;

ALGINIC ACID; CALCIUM PHOSPHATE DIBASIC; CHITOSAN; IODINE 125; MICROSPHERE; PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE REGENERATION; BONE REMODELING; BONE TRANSPLANTATION; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENCAPSULATION; FRACTURE HEALING; HISTOPATHOLOGY; IN VIVO STUDY; MALE; NONHUMAN; OSSIFICATION; POROSITY; PRIORITY JOURNAL; RABBIT; TISSUE DISTRIBUTION; TISSUE REGENERATION;

ALGINATES; ANIMALS; BONE REGENERATION; CALCIUM PHOSPHATES; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; FEMUR; GLUCURONIC ACID; HEXURONIC ACIDS; PLATELET-DERIVED GROWTH FACTOR; POROSITY; RABBITS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TISSUE DISTRIBUTION; TISSUE SCAFFOLDS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77950534950     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.11.026     Document Type: Article

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