Role of Vitamin B12 on methylmalonyl-CoA mutase activity

Journal of Zhejiang University: Science B

Volumn 13, Issue 6, 2012, Pages 423-437

  Takahashi Iñiguez, Tóshiko ^a   García Hernandez, Enrique ^a   Arreguín Espinosa, Roberto ^a   Flores, María Elena ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

MeaB; Methylmalonic academia (MMA); Methylmalonyl CoA mutase (MCM); MMAA; Protectase; Reactivase; Vitamin B12

Indexed keywords

BACTERIAL PROTEIN; CHAPERONE; COBAMAMIDE; CYANOCOBALAMIN; ISOMERASE; LIGAND; METHYLMALONYL COENZYME A MUTASE; SUCCINYL COENZYME A; MUTANT PROTEIN;

COENZYME; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; ISOMERIZATION; METABOLISM; METHYLMALONIC ACIDEMIA; METHYLOBACTERIUM EXTORQUENS; MUTATION; PRIORITY JOURNAL; PROPIONIBACTERIUM FREUDENREICHII SHERMANII; REGENERATION; REVIEW; SACCHAROPOLYSPORA; ANIMAL; CHEMISTRY; DISORDERS OF AMINO ACID AND PROTEIN METABOLISM; ENZYMOLOGY; GENETICS; MAMMAL; PROPIONIBACTERIUM;

BACTERIA (MICROORGANISMS); PROPIONIBACTERIUM FREUDENREICHII;

AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; BACTERIAL PROTEINS; COBAMIDES; HUMANS; MAMMALS; METHYLMALONYL-COA MUTASE; MUTANT PROTEINS; MUTATION; PROPIONIBACTERIUM; VITAMIN B 12;

EID: 84863434741     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1100329     Document Type: Review

References (73)

1. 12. Arch. Biochem. Biophys., 370(1):138-141. [doi:10.1006/abbi.1999. 1382] (Pubitemid 29476960)
2. Andrews, E., Jansen, R., Crane, M., Cholin, S., McDonell, D., Ledley, F., 1993. Expression of recombinant human methylmalonyl CoA mutase: in primary mut fibroblast and Saccharomyces cerevisiae. Biochem. Med. Metab. Biol., 50(2):135-144. [doi:10.1006/bmmb.1993.1055] (Pubitemid 23295780)
3. 12. eLS, John Wiley & Sons, Ltd. [doi:10.1038/npg.els. 0000666]
4. 12 dependent methylmalonyl CoA mutase. Biochem. Soc. Transact., 30(4):621-624. [doi:10.1042/bst0300621] (Pubitemid 35001611)
5. 12. PNAS, 44(11):1093-1097. [doi:10.1073/pnas.44.11. 1093]
6. Berkovitch, F., Besad, E., Tang, K., Enns, E., Frey, P., Drenan C., 2004. A locking mechanism preventing radical damage in the absence of substrate, as revealed by the X-ray structure of lysine 5, 6-aminomutase. PNAS, 101(45):15870-15875. [doi:10.1073/pnas.0407074101] (Pubitemid 39507894)
7. Bobik, T. A., Rasche, M. E., 2001. Identification of the human methylmalonyl CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome. J. Biol. Chem., 276(40):37194-37198. [doi:10.1074/jbc. M107232200]
8. 12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction. Biochemistry, 33(42):12676-12685. [doi:10.1021/bi00208a019] (Pubitemid 24345900)
9. Bradbeer, C., 1965. The clostridial fermentations of choline and ethanolamine. J. Biol. Chem., 240(12):4669-4674.
10. 3+ ground state. J. Am. Chem. Soc., 126(26):8167-8180. [doi:10.1021/ja039114b] (Pubitemid 38878962)
11. Brooks, A., Vlasie, M., Banerjee, R., Brunold, T., 2005. Co-C bond activation in methylmalonyl-CoA mutase by estabilization of the post-homolysis product Co2+cobalamin. J. Am. Chem. Soc., 127(47):16522-16528. [doi:10.1021/ja0503736] (Pubitemid 41740403)
12. 12-dependent enzymes. Chem. Soc. Rev., 5(25):329-337. [doi:10.1039/CS9962 500329] (Pubitemid 126664395)
13. Cannata, J. B., Focesi, A., Mazumder, R., Warner, R., Ochoa, S., 1965. Metabolism of propionic acid in animal tissues: properties of mammalian methylmalonyl coenzyme A mutase. J. Biol. Chem., 240(8):3249-3257.
14. 12 dependent methylmalonyl-CoA mutase. Biochemistry, 38(46):15287-15294. [doi:10.1021/ bi9914762] (Pubitemid 129520362)
15. 12-dependent intercorversion of isovaleryl-CoA and pivalyl-CoA. J. Biol. Chem., 287(6):3723-3732. [doi:10.1074/jbc. M111.320051]
16. 12 enzyme isobutyryl-CoA mutase and its G-protein chaperone. J. Biol. Chem., 285(1):655-666. [doi:10.1074/jbc. M109.062182]
17. 12 responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements. PNAS, 99(24):15554-15559. [doi:10.1073/pnas.242614 799] (Pubitemid 35403972)
18. 12-dependent acyl-CoA mutases. J. Biol. Chem., 283(47):32283-32293. [doi:10. 1074/jbc. M805527200]
19. Erfle, D., Clark, M., Nystrom, R., Johnson, C., 1964. Direct hydrogen transfer by methylmalonyl coenzyme A mutase. J. Biol. Chem., 239(6):1920-1924.
20. Faust, L., Babior, B., 1992. Overexpression, purification and some properties of the AdoCbl-dependent ethanolamine ammonia-lyase from Salmonella typhimurium. Arch. Biochem. Biophys., 294(1):50-54. [doi:10.1016/0003-9861 (92) 90135-J]
21. Fenton, W., Hack, A., Willard, H., Gertler, A., Rosenberg, E., 1982. Purification and properties of methylmalonyl coenzyme A mutase from human liver. Arch. Biochem. Biophys., 214(2):815-823. [doi:10.1016/0003-9861 (82) 90088-1] (Pubitemid 13137196)
22. Fenton, W., Hack, A., Helfgott, D., Rosenberg, E., 1984. Biogenesis of the mitochondrial enzyme methylmalonyl CoA mutase. Synthesis and processing of a precursor in a cell system and in cultures cells. J. Biol. Chem., 259(10):6616-6621. (Pubitemid 14108218)
23. Flavin, M., Ortiz, P. J., Ochoa, S., 1955. Metabolism of propionic acid in animal tissues. Nature, 176(4487):823-826. [doi:10.1038/176823a0]
24. 12-independent dehydratases of Klebsiella sp. and Citrobacter freundii. Biochim. Biophys. Acta Enzymol., 569(2):249-258. [doi:10.1016/0005- 2744 (79) 90060-3] (Pubitemid 9237882)
25. Froese, D., Dobson, M., White, P., Wu, X., Padovani, D., Banerjee, R., Haller, T., Gerlt, A., Surette, G., Gravel, R., 2009. Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli. Microbiol. Res., 164(1):1-8. [doi:10.1016/j.micres.2008.08.006]
26. 12-dependent methylmalonyl-CoA mutase and insight into their complex formation. J. Biol. Chem., 285(49):38204-38213. [doi:10.1074/jbc. M110. 177717]
27. Guest, J., Friedman, S., Woods, D., Smith, E., 1962. A methyl analogue of cobamide coenzyme in relation to methionine synthesis by bacteria. Nature, 195(4839):340-342. [doi:10.1038/195340a0]
28. 12. Nature, 178(4524):64-66. [doi:10.1038/178064a0]
29. Hubbard, P. A., Padovani, D., Labunska, T., Mahlstedt, S. A., Banerjee, R., Drennan, C. L., 2007. Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. J. Biol. Chem., 282(43):31308-31316. [doi:10.1074/jbc. M704850200] (Pubitemid 350044861)
30. Janata, J., Kogekar, N., Fenton, W., 1997. Expression and kinetic characterization of methylmalonyl CoA mutase from patients with the mut-phenotype: evidence for naturally occuring interallelic complementation. Hum. Mol. Genet., 6(9):1457-1464. [doi:10.1093/hmg/6.9.1457] (Pubitemid 27397021)
31. Jansen, R., Kalousek, F., Fenton, W., Rosenberg, E., Ledley, F., 1989. Cloning of full-length methylmalonyl CoA mutase from cDNA library using the polymerase chain reaction. Genomics, 4(2):198-205. [doi:10.1016/0888-7543 (89) 90300-5]
32. Kambo, A., Sharma, V., Casteel, D., Woods, V., Pilz, R., Boss, G., 2005. Nitric oxide inhibits mammalian methylmalonyl CoA mutase. J. Biol. Chem., 280(11):10073-10082. [doi:10.1074/jbc. M411842200] (Pubitemid 40395859)
33. Katz, J., Chaikoff, I. L., 1955. The metabolism of propionate by rat liver slices and the formation of isosuccinic acid. J. Am. Chem. Soc., 77(9):2659-2660. [doi:10.1021/ja01614a105]
34. Korotkova, N., Lidstrom, M., 2004. MeaB is a component of the methylmalonyl CoA mutase complex required for protection of the enzyme from inactivation. J. Biol. Chem., 279(14):13652-13658. [doi:10.1074/jbc. M312852200] (Pubitemid 38468893)
35. Korotkova, N., Chistoserdova, L., Kuksa, V., Lidstrom, M., 2002. Glyoxalate regeneration pathway in the methylotroph Methylobacterium extorquens AM1. J. Bacteriol., 184(6):1750-1758. [doi:10.1128/JB.184.6.1750-1758. 2002] (Pubitemid 34188227)
36. 12: chemistry and biochemistry. Biochem. Soc. Trans., 33(Pt.4):806-810. (Pubitemid 41160868)
37. 12. New type of a natural corrinoid. Helv. Chim. Acta, 86(11):3698-3716. [doi:10.1002/hlca.200390313] (Pubitemid 37541585)
38. Ledley, F., Lumetta, M., Nguyen, N., Kolhouse, F., Allen, R., 1988. Molecular cloning of L-methylmalonyl-CoA mutase: gene transfer and analysis of mut cell lines. PNAS, 85(10):3518-3521. [doi:10.1073/pnas.85.10.3518]
39. Lee, A., Abeles, R., 1963. Purification and properties of diol dehydratase, an enzyme requiring a cobamide coenzyme. J. Biol. Chem., 238(7):2367-2373.
40. Lehninger, A., Nelson, D., Cox, M., 1993. Principles of Biochemistry. Worth Publishers, New York, p. 492-495, 533-535.
41. Lenhert, G., Hodgkin, D., 1961. Structure of the 5, 6- dimethylbenzimidazolylcobamide coenzyme. Nature, 192(4806):937-938. [doi:10.1038/192937a0]
42. Loferer, M., Webb, B., Grant, G., Liedl, K., 2003. Energetic and stereochemical effects of the protein environment on substrate: a theorical study of methylmalonyl CoA mutase. J. Am. Chem. Soc., 125(4):1072-1078. [doi:10.1021/ja028906n] (Pubitemid 36152659)
43. Mancia, F., Evans, P., 1998. Conformational changes on substrate binding to methylmalonyl CoA mutase and new insights into the free radical mechanism. Structure, 6(6):711-720. [doi:10.1016/S0969-2126 (98) 00073-2] (Pubitemid 28301205)
44. 12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 Å resolution. Structure, 4(3):339-350. [doi:10.1016/S0969-2126 (96) 00037-8]
45. Mancia, F., Smiths, G., Evans, P., 1999. Crystal structure of substrate complexes of methylmalonyl-CoA mutase. Biochemistry, 38(25):7999-8005. [doi:10.1021/bi9903852] (Pubitemid 29302371)
46. Minot, M., Murphy, W., 1926. Treatment of pernicious anemia by a special diet. JAMA, 87(7):470-476. [doi:10.1001/jama.1926.02680070016005]
47. 12 analog with an imidazole axial nucleoside. Dalton Trans., 21(4):782-787. [doi:10.1039/B414092C] (Pubitemid 40308531)
48. Nham, S., Wilkemeyer, M., Ledley, F., 1990. Structure of the human methylmalonyl CoA mutase (MUT) locus. Genomics, 8(4):710-716. [doi:10.1016/0888-7543 (90) 90259-W]
49. 12 dependent Methylmalonyl-CoA mutase. Biochemistry, 45(9):2951-2959. [doi:10.1021/bi051742d] (Pubitemid 43334543)
50. Padovani, D., Banerjee, R., 2006. Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone. Biochemistry, 45(30):9300-9306. [doi:10. 1021/bi0604532] (Pubitemid 44156393)
51. 12 loading and is corrupted in methylmalonic aciduria. PNAS, 106(51):21567-21572. [doi:10.1073/pnas.0908106106]
52. 12-dependent methylmalonyl-CoA mutase. J. Biol. Chem., 281(26):17838-17844. [doi:10.1074/jbc. M6000 47200] (Pubitemid 44537031)
53. Peters, H., Nefedov, M., Salsero, J., Pitt, J., Fowler, K., Gazeas, S., Kahler, S., Ioannou, P., 2003. A knock-out mouse model for methylmalonic aciduria resulting in neonatal lethality. J. Biol. Chem., 278(52):52909-52913. [doi:10. 1074/jbc. M310533200] (Pubitemid 38035891)
54. Reeves, A., Brikun, I., Cernota, W., Leach, B., Gonzalez, M., Weber, M., 2006. Effects of methylmalonyl-CoA mutasa gene knockouts on erythromycin production in carbohydrate-base and oil based fementations of Saccharopolyspora erythraea. J. Ind. Microbiol. Biotechnol., 33(7):600-609. [doi:10.1007/s10295- 006-0094-3] (Pubitemid 43876122)
55. 12-dependent enzyme provides new mechanistic insights. Structure, 7(8):891-902. [doi:10.1016/S0969-2126 (99) 80116-6] (Pubitemid 29372511)
56. 12. Science, 107(2781):396-397. [doi:10.1126/science.107.2781.396]
57. Rosenblatt, D., Fenton, W., 2001. Inherited Disorders of Folato and Cobalamin Transport Metabolism. In: Scriver, C., Beaudet, A. L., Sly, W., Valle, D. (Eds.), The Metabolic and Molecular Basis of Inherited Diseases. Mc Graw Hill, New York, p. 3897-3923.
58. Sintchak, D., Arjara, G., Kellogg, B., Stubbe, J., Drennan, C., 2002. The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimmer. Nat. Struct. Biol., 9(4):293-300. [doi:10.1038/nsb774] (Pubitemid 34289903)
59. Smith, E., Parker, L., 1948. Purification of anti-pernicious anaemia factor. Biochem. J., 43(1):viii-ix.
60. 12-dependent D-alpha-ornithine 5, 4-aminomutase. Biochemistry, 12(14):2597-2604. [doi:10.1021/bi00738a008]
61. Takahashi-Iñiguez, T., García-Arellano, H., Trujillo-Roldán, M., Flores, M. E., 2011. Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein. Biochem. Biophys. Res. Commun., 404(1):443-447. [doi:10.1016/j.bbrc.2010.11.141]
62. Thomä, N. H., Leadlay, P. F., 1996. Homology modeling of human methylmalonyl-CoA mutase: a structural basis for point mutations causing methylmalonic aciduria. Prot. Sci., 5(9):1922-1927. [doi:10.1002/pro.5560050919] (Pubitemid 26303497)
63. Thomä, N. H., Evans, P. R., Leadlay, P. F., 2000. Protection of radical intermediates at the active site of adenosylcobalamin dependent methymalonyl CoA mutase. Biochemistry, 39(31):9213-9221. [doi:10.1021/bi0004302] (Pubitemid 30626313)
64. Tobimatsu, T., Sakai, T., Hasida, Y., Mizoguchi, N., Miyoshi, S., Toraya, T., 1997. Heterologous expression, purification and properties of diol dehydratase, an adenosylcobalamin-dependent enzyme of Klebsiella oxytoca. Arch. Biochem. Biophys., 347(1):132-140. [doi:10.1006/abbi. 1997.0325] (Pubitemid 27484030)
65. 12 enzymes: structure, mechanism, inactivation and reactivation of diol and glycerol dehydratases. Cell. Mol. Life Sci., 57(1):106-127. [doi:10.1007/s000180050502] (Pubitemid 30105333)
66. 12-dependent diol dehydratase and glycerol dehydratase. Eur. J. Biochem., 76(1):285-289. [doi:10.1111/j.1432-1033.1977. tb11594.x] (Pubitemid 8117421)
67. 12-dependent diol dehydratase and glycerol dehydratase in selected genera of Enterobacteriaceae and Propionibacteriaceae. J. Bacteriol., 141(3):1439-1442. (Pubitemid 10074779)
68. Vlasie, M., Banerjee, R., 2003. Tyrosine 89 accelerates Co-carbon bond homolysis in methylmalonyl-CoA mutase. J. Am. Chem. Soc., 125(18):5431-5435. [doi:10. 1021/ja029420+] (Pubitemid 36582752)
69. Vlasie, M., Banerjee, R., 2004. When a spectator turns killer: suicidal electron transfer from cobalamin in methylmalonyl CoA mutase. Biochemistry, 43(26):8410-8417. [doi:10.1021/bi036299q] (Pubitemid 38902519)
70. 12 in the reaction catalyzed by methylmalonyl CoA mutase. J. Biol. Chem., 277(21):18523-18527. [doi:10.1074/jbc. M111809200] (Pubitemid 34952402)
71. Wilcken, B., Wiley, V., Hammond, J., Carpenter, K., 2003. Screening newborns for inborn errors of metabolism by tandem mass spectrometry. N. Engl. J. Med., 348(23):2304-2312. [doi:10.1056/NEJMoa025225] (Pubitemid 36638104)
72. 12-dependent glycerol dehydratase in complex with cobalamin and propane-1, 2-diol. Eur. J. Biochem., 269(18):4484-4494. [doi:10.1046/j.1432-1033.2002.03151.x]
73. 12-dependent isobutyryl-CoA mutase from Streptomyces cinnamonensis. J. Biol. Chem., 273(11):6508-6517. [doi:10.1074/jbc.273.11.6508] (Pubitemid 28144748)