Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38204-38213

  Froese, D Sean ^a,b   Kochan, Grazyna ^a   Muniz, João R C ^a   Wu, Xuchu ^b   Gileadi, Carina ^a   Ugochukwu, Emelie ^a   Krysztofinska, Ewelina ^a   Gravel, Roy A ^b   Oppermann, Udo ^a,c   Yue, Wyatt W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CALGARY   (Canada)

^c NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COFACTORS; COMPLEMENTATION; COMPLEX FORMATIONS; CYTOSOLS; DATA POINTS; DOMAIN ARCHITECTURES; GATEKEEPING; GTP-DEPENDENT MANNER; GTPASE ACTIVITY; HUMAN ENZYMES; IN-VITRO; LIGAND BINDING; METHIONINE SYNTHASE; METHYLMALONIC ACIDURIA; METHYLMALONYL-COA MUTASE; SUBSTRATE-BOUND; VITAMIN B;

AMINO ACIDS; MACHINERY; MITOCHONDRIA;

PROTEINS;

APOENZYME; COBAMAMIDE; CYANOCOBALAMIN; GUANOSINE TRIPHOSPHATASE; METHYLMALONIC ACIDURIA TYPE A PROTEIN; METHYLMALONYL COENZYME A MUTASE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLIZATION; DIMERIZATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

CHILD; CHILD, PRESCHOOL; COBAMIDES; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; MEMBRANE TRANSPORT PROTEINS; METABOLISM, INBORN ERRORS; METHYLMALONYL-COA MUTASE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MULTIPROTEIN COMPLEXES; MUTATION, MISSENSE; PROTEIN STRUCTURE, QUATERNARY;

BACTERIA (MICROORGANISMS);

EID: 78649674598     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.177717     Document Type: Article

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