Crystal structure and mutagenesis of the metallochaperone MeaB: Insight into the causes of methylmalonic aciduria

Journal of Biological Chemistry

Volumn 282, Issue 43, 2007, Pages 31308-31316

  Hubbard, Paul A ^a   Padovani, Dominique ^b   Labunska, Tetyana ^b   Mahlstedt, Sarah A ^a   Banerjee, Ruma ^a   Drennan, Catherine L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMODIMERS; METALLOENZYME CHAPERONE GTPASES; NUCLEOTIDE-FREE FORMS;

CRYSTAL STRUCTURE; DISEASES; ENZYMES; HYDROLYSIS; METABOLISM; PATHOLOGY;

MUTAGENESIS;

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; METALLOCHAPERONE MEAB; METALLOPROTEINASE; METHYLMALONYL COENZYME A MUTASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; GENE MAPPING; GENE MUTATION; HUMAN; HUMAN CELL; METHYLMALONIC ACIDURIA; MITOCHONDRION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION;

ACID-BASE IMBALANCE; AMINO ACID METABOLISM, INBORN ERRORS; AMINO ACID SEQUENCE; BINDING SITES; HUMANS; METHYLMALONIC ACID; METHYLMALONYL-COA MUTASE; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SPECTRUM ANALYSIS, RAMAN;

EID: 35748951636     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704850200     Document Type: Article

References (36)

1. Mulrooney, S. B., and Hausinger, R. P. (2003) FEMS Microbiol. Rev. 27, 239-261
2. Mulrooney, S. B., and Hausinger, R. P. (1990) J. Bacteriol. 172, 5837-5843
3. Zambelli, B., Stola, M., Musiani, F., De Vriendt, K., Samyn, B., Devreese, B., Van Beeumen, J., Turano, P., Dikiy, A., Bryant, D. A., and Ciurli, S. (2005) J. Biol. Chem. 280, 4684-4695
4. Fu, C., Olson, J. W., and Maier, R. J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2333-2337
5. Gasper, R., Scrima, A., and Wittinghofer, A. (2006) J. Biol. Chem. 281, 27492-27502
6. Jeon, W. B., Cheng, J., and Ludden, P. W. (2001) J. Biol. Chem. 276, 38602-38609
7. Korotkova, N., and Lidstrom, M. E. (2004) J. Biol. Chem. 279, 13652-13658
8. Leipe, D. D., Wolf, Y. I., Koonin, E. V., and Aravind, L. (2002) J. Mol. Biol. 317, 41-72
9. Padovani, D., Labunska, T., and Banerjee, R. (2006) J. Biol. Chem. 281, 17838-17844
10. Padovani, D., and Banerjee, R. (2006) Biochemistry 45, 9300-9306
11. Banerjee, R. (2003) Chem. Rev. 103, 2083-2094
12. Banerjee, R., and Ragsdale, S. W. (2003) Annu. Rev. Biochem. 72, 209-247
13. Dobson, C. M., Wai, T., Leclerc, D., Wilson, A., Wu, X., Dore, C., Hudson, T., Rosenblatt, D. S., and Gravel, R. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 15554-15559
14. Fujii, K., Galivan, J. H., and Huennekens, F. M. (1977) Arch. Biochem. Biophys. 178, 662-670
15. Toraya, T., and Mori, K. (1999) J. Biol. Chem. 274, 3372-3377
16. Mancia, F., and Evans, P. R. (1998) Structure 6, 711-720
17. Maier, T., Lottspeich, F., and Bock, A. (1995) Eur. J. Biochem. 230, 133-138
18. Soriano, A., and Hausinger, R. P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11140-11144
19. Mori, K., Tobimatsu, T., and Toraya, T. (1997) Biosci. Biotechnol. Biochem. 61, 1729-1733
20. Taoka, S., Padmakumar, R., Lai, M. T., Liu, H. W., and Banerjee, R. (1994) J. Biol. Chem. 269, 31630-31634
21. Gill, S. C., and von Hippel, P. H. (1989) Anal. Biochem. 182, 319-326
22. Otwinowski, Z., and Minor, W. (1997) Macromolecular Crystallogr., Pt A 276, 307-326
23. Howell, P. L., and Smith, G. D. (1992) J. Appl. Crystallogr. 25, 81-86
24. Collaborative Computational Project, Number 4. (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
25. Terwilliger, T. C., and Berendzen, J. (1999) Acta Crystallogr. D Biol. Crystallogr. 55, 849-861
26. delaFortelle, E., and Bricogne, G. (1997) Macromolecular Crystallogr., Pt A 276, 472-494
27. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
28. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. D Biol. Crystallogr. 54, 905-921
29. Read, R. J. (1986) Acta Crystallogr. Section A 42, 140-149
30. Morris, R. J., Perrakis, A., and Lamzin, V. S. (2003) Methods Enzymol. 374, 229-244
31. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. D Biol. Crystallogr. 53, 240-255
32. Read, R. J. (2001) Acta Crystallogr. D Biol. Crystallogr. 57, 1373-1382
33. Egea, P. F., Shan, S. O., Napetschnig, J., Savage, D. F., Walter, P., and Stroud, R. M. (2004) Nature 427, 215-221
34. Lerner-Ellis, J. P., Dobson, C. M., Wai, T., Watkins, D., Tirone, J. C., Leclerc, D., Dore, C., Lepage, P., Gravel, R. A., and Rosenblatt, D. S. (2004) Hum. Mutat. 24, 509-516
35. Banerjee, R., and Chowdhury S. (1999) in Chemistry and Biochemistry of B12 (Banerjee, R., ed) pp. 707-730, John Wiley & Sons, Inc., New York
36. Khil, P. P., Obmolova, G., Teplyakov, A., Howard, A. J., Gilliland, G. L., and Camerini-Otero, R. D. (2004) Proteins 54, 371-374