Respiratory epithelial cells require Toll-like receptor 4 for induction of human β-defensin 2 by lipopolysaccharide

Respiratory Research

Volumn 6, Issue , 2005, Pages

  MacRedmond, Ruth E ^a,b   Greene, Catherine M ^a   Taggart, Clifford T ^a   McElvaney, Noel G ^a   O'Neill, Shane ^a  

^a BEAUMONT HOSPITAL   (Ireland)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

Airway epithelium; Human defensin 2; Lipopolysaccharide; Toll like receptor 4

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BETA DEFENSIN 2; INTERLEUKIN 8; LUCIFERASE; MUTANT PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 4; BETA DEFENSIN; DEFB4A PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; TLR4 PROTEIN, HUMAN;

ARTICLE; CELL STIMULATION; CELL STRAIN; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; DATA ANALYSIS; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HOST RESISTANCE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ANALYSIS; REPORTER GENE; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; WILD TYPE; DRUG EFFECTS; LUNG; METABOLISM; RESPIRATORY TRACT MUCOSA;

BETA-DEFENSINS; EPITHELIAL CELLS; HUMANS; LIPOPOLYSACCHARIDES; LUNG; RESPIRATORY MUCOSA; TOLL-LIKE RECEPTOR 4;

EID: 27644445147     PISSN: 1465993X     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-6-116     Document Type: Article

References (48)

1. Bowie, A. and L.A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products. J Leukoc Biol, 2000. 67(4): p. 508-
2. May, M.J. and S. Ghosh, Signal transduction through NF-kappa B. Immunol Today, 1998. 19(2): p. 80-8.
3. Yamamoto, M., K. Takeda, and S. Akira, TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol, 2004. 40(12): p. 861-8.
4. Yang, D., et al., Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science, 1999. 286(5439): p. 525-8.
5. Ganz, T., Antimicrobial polypeptides in host defense of the respiratory tract. J Clin Invest, 2002. 109(6): p. 693-7.
6. Bals, R. and P.S. Hiemstra, Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J, 2004. 23(2): p. 327-33.
7. Ganz, T., Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol, 2003. 3(9): p. 710-20.
8. Raj, P.A. and A.R. Dentino, Current status of defensins and their role in innate and adaptive immunity. FEMS Microbiol Lett, 2002. 206(1): p. 9-18.
9. Schutte, B.C., et al., Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U. S. A., 2002. 99(4): p. 2129-33.
10. Harder, J., et al., Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia. Am J Respir Cell Mol Biol, 2000. 22(6): p. 714-21.
11. Singh, P.K., et al., Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U. S. A., 1998. 95(25): p. 14961-6.
12. Hertz, C.J., et al., Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol, 2003. 171(12): p. 6820-6.
13. Sethi, S. and T.F. Murphy, Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev, 2001. 14(2): p. 336-63.
14. Parad, R.B., et al., Pulmonary outcome in cystic fibrosis is influenced primarily by mucoid Pseudomonas aeruginosa infection and immune status and only modestly by genotype. Infect Immun, 1999. 67(9): p. 4744-50.
15. Vora, P., et al., Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J Immunol, 2004. 173(9): p. 5398-405.
16. Becker, M.N., et al., CD14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem, 2000. 275(38): p. 29731-6.
17. Monick, M.M., et al., Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem, 2003. 278(52): p. 53035-44.
18. Jia, H.P., et al., Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am J Physiol Lung Cell Mol Physiol, 2004. 287(2): p. L428-37.
19. Greene, C., et al., Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia. J Infect Dis, 2002. 186(12): p. 1790-6.
20. Griffin, S., et al., Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells. FEBS Lett, 2003. 546(2-3): p. 233-6.
21. Frantz, S., et al., Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest, 1999. 104(3): p. 271-80.
22. Re, F. and J.L. Strominger, Separate functional domains of human MD-2 mediate toll-like receptor 4-binding and lipopolysaccharide responsiveness. J Immunol, 2003. 171(10): p. 5272-6.
23. Guillot, L., et al., Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem, 2004. 279(4): p. 2712-8.
24. Devaney, J.M., et al., Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4. FEBS Lett, 2003. 544(1-3): p. 129-32.
25. Lee, J.H., et al., Intercellular adhesion molecule-1 mediates cellular cross-talk between parenchymal and immune cells after lipopolysaccharide neutralization. J Immunol, 2004. 172(1): p. 608-16.
26. Tsutsumi-Ishii, Y. and I. Nagaoka, Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J Immunol, 2003. 170(8): p. 4226-36.
27. Keicho, N., et al., Adenovirus EIA upregulates interleukin-8 expression induced by endotoxin in pulmonary epithelial cells. Am J Physiol, 1997. 272(6 Pt 1): p. L1046-52.
28. Krakauer, T., Stimulant-dependent modulation of cytokines and chemokines by airway epithelial cells: cross talk between pulmonary epithelial and peripheral blood mononuclear cells. Clin Diagn Lab Immunol, 2002. 9(1): p. 126-31.
29. Kaper, J.B., J.P. Nataro, and H.L. Mobley, Pathogenic Escherichia coli. Nat Rev Microbiol, 2004. 2(2): p. 123-40.
30. Schulz, C., et al., Differences in LPS-induced activation of bronchial epithelial cells (BEAS-2B) and type II-like pneumocytes (A-549). Scand J Immunol, 2002. 56(3): p. 294-302.
31. Erridge, C., E. Bennett-Guerrero, and I.R. Poxton, Structure and function of lipopolysaccharides. Microbes Infect, 2002. 4(8): p. 837-51.
32. Kulshin, V.A., et al., Structural characterization of the lipid A component of Pseudomonas aeruginosa wild-type and rough mutant lipopolysaccharides. Eur J Biochem, 1991. 198(3): p. 697-704.
33. Lyczak, J.B., C.L. Cannon, and G.B. Pier, Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect, 2000. 2(9): p. 1051-60.
34. Koyama, S., et al., The potential of various lipopolysaccharides to release IL-8 and G-CSF. Am J Physiol Lung Cell Mol Physiol, 2000. 278(4): p. L658-66.
35. Wurfel, M.M. and S.D. Wright, Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid. J Immunol, 1997. 158(8): p. 3925-34.
36. Viriyakosol, S., et al., MD-2 binds to bacterial lipopolysaccharide. J Biol Chem, 2001. 276(41): p. 38044-51.
37. Muir, A., et al., Toll like receptors in normal and cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol, 2003.
38. Azghani, A.O., E.J. Miller, and B.T. Peterson, Virulence factors from Pseudomonas aeruginosa increase lung epithelial permeability. Lung, 2000. 178(5): p. 261-9.
39. Diamond, G., J.P. Russell, and C.L. Bevins, Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc Natl Acad Sci U. S. A., 1996. 93(10): p. 5156-60.
40. Haziot, A., et al., The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. J Immunol, 1988. 141(2): p. 547-52.
41. Tsutsumi-Ishii, Y. and I. Nagaoka, NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation. J Leukoc Biol, 2002. 71(1): p. 154-62.
42. O'Neill, L.A., et al., Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors. J Endotoxin Res, 2003. 9(1): p. 55-9.
43. Takeda, K. and S. Akira, TLR signaling pathways. Semin Immunol, 2004. 16(1): p. 3-9.
44. Graham, N.M., The epidemiology of acute respiratory infections in children and adults: a global perspective. Epidemiol Rev, 1990. 12: p. 149-78.
45. Renshaw, M., et al., Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol, 2002. 169(9): p. 4697-701.
46. Ohta, T., et al., Cigarette smoking decreases interleukin-8 secretion by human alveolar macrophages. Respir Med, 1998. 92(7): p. 922-7.
47. Hasday, J.D., et al., Bacterial endotoxin is an active component of cigarette smoke. Chest, 1999. 115(3): p. 829-35.
48. Iwami, K.I, et al., Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling. J Immunol, 2000. 165(12): p. 6682-6.