메뉴 건너뛰기




Volumn 7, Issue 3, 2012, Pages

Amiloride enhances antigen specific CTL by faciliting HBV DNA vaccine entry into cells

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CD8 ANTIGEN; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; GRANZYME B; HEPATITIS B VACCINE; GRANZYME; GZMB PROTEIN, MOUSE; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN; SODIUM CHANNEL BLOCKING AGENT;

EID: 84863380419     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033015     Document Type: Article
Times cited : (13)

References (49)
  • 1
    • 0028135693 scopus 로고
    • Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo
    • Coney L, Wang B, Ugen KE, Boyer J, McCallus D, et al. (1994) Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo. Vaccine 12: 1545-1550.
    • (1994) Vaccine , vol.12 , pp. 1545-1550
    • Coney, L.1    Wang, B.2    Ugen, K.E.3    Boyer, J.4    McCallus, D.5
  • 3
    • 23244456102 scopus 로고    scopus 로고
    • DNA vaccines: progress and challenges
    • Donnelly JJ, Wahren B, Liu MA, (2005) DNA vaccines: progress and challenges. J Immunol 175: 633-639.
    • (2005) J Immunol , vol.175 , pp. 633-639
    • Donnelly, J.J.1    Wahren, B.2    Liu, M.A.3
  • 5
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: immunology, application, and optimization*
    • Gurunathan S, Klinman DM, Seder RA, (2000) DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol 18: 927-974.
    • (2000) Annu Rev Immunol , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 6
  • 7
    • 0036186083 scopus 로고    scopus 로고
    • Parenteral and oral immunization with a plasmid DNA expressing the human papillomavirus 16-L1 gene induces systemic and mucosal antibodies and cytotoxic T lymphocyte responses
    • Rocha-Zavaleta L, Alejandre JE, Garcia-Carranca A, (2002) Parenteral and oral immunization with a plasmid DNA expressing the human papillomavirus 16-L1 gene induces systemic and mucosal antibodies and cytotoxic T lymphocyte responses. J Med Virol 66: 86-95.
    • (2002) J Med Virol , vol.66 , pp. 86-95
    • Rocha-Zavaleta, L.1    Alejandre, J.E.2    Garcia-Carranca, A.3
  • 8
    • 0032834491 scopus 로고    scopus 로고
    • Immune responses induced by gene gun or intramuscular injection of DNA vaccines that express immunogenic regions of the serine repeat antigen from Plasmodium falciparum
    • Belperron AA, Feltquate D, Fox BA, Horii T, Bzik DJ, (1999) Immune responses induced by gene gun or intramuscular injection of DNA vaccines that express immunogenic regions of the serine repeat antigen from Plasmodium falciparum. Infect Immun 67: 5163-5169.
    • (1999) Infect Immun , vol.67 , pp. 5163-5169
    • Belperron, A.A.1    Feltquate, D.2    Fox, B.A.3    Horii, T.4    Bzik, D.J.5
  • 9
    • 59449091323 scopus 로고    scopus 로고
    • Enhancement of DNA tumor vaccine efficacy by gene gun-mediated codelivery of threshold amounts of plasmid-encoded helper antigen
    • Leitner WW, Baker MC, Berenberg TL, Lu MC, Yannie PJ, et al. (2009) Enhancement of DNA tumor vaccine efficacy by gene gun-mediated codelivery of threshold amounts of plasmid-encoded helper antigen. Blood 113: 37-45.
    • (2009) Blood , vol.113 , pp. 37-45
    • Leitner, W.W.1    Baker, M.C.2    Berenberg, T.L.3    Lu, M.C.4    Yannie, P.J.5
  • 10
    • 37549037877 scopus 로고    scopus 로고
    • Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques
    • Hirao LA, Wu L, Khan AS, Satishchandran A, Draghia-Akli R, et al. (2008) Intradermal/subcutaneous immunization by electroporation improves plasmid vaccine delivery and potency in pigs and rhesus macaques. Vaccine 26: 440-448.
    • (2008) Vaccine , vol.26 , pp. 440-448
    • Hirao, L.A.1    Wu, L.2    Khan, A.S.3    Satishchandran, A.4    Draghia-Akli, R.5
  • 11
    • 63449140410 scopus 로고    scopus 로고
    • Enhancing DNA vaccination by sequential injection of lymph nodes with plasmid vectors and peptides
    • Smith KA, Tam VL, Wong RM, Pagarigan RR, Meisenburg BL, et al. (2009) Enhancing DNA vaccination by sequential injection of lymph nodes with plasmid vectors and peptides. Vaccine 27: 2603-2615.
    • (2009) Vaccine , vol.27 , pp. 2603-2615
    • Smith, K.A.1    Tam, V.L.2    Wong, R.M.3    Pagarigan, R.R.4    Meisenburg, B.L.5
  • 12
    • 18144446323 scopus 로고    scopus 로고
    • Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
    • Widera G, Austin M, Rabussay D, Goldbeck C, Barnett SW, et al. (2000) Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol 164: 4635-4640.
    • (2000) J Immunol , vol.164 , pp. 4635-4640
    • Widera, G.1    Austin, M.2    Rabussay, D.3    Goldbeck, C.4    Barnett, S.W.5
  • 13
    • 0032736810 scopus 로고    scopus 로고
    • A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms
    • Aberle JH, Aberle SW, Allison SL, Stiasny K, Ecker M, et al. (1999) A DNA immunization model study with constructs expressing the tick-borne encephalitis virus envelope protein E in different physical forms. J Immunol 163: 6756-6761.
    • (1999) J Immunol , vol.163 , pp. 6756-6761
    • Aberle, J.H.1    Aberle, S.W.2    Allison, S.L.3    Stiasny, K.4    Ecker, M.5
  • 14
    • 0036001289 scopus 로고    scopus 로고
    • The assessment of local tolerance, acute toxicity, and DNA biodistribution following particle-mediated delivery of a DNA vaccine to minipigs
    • Pilling AM, Harman RM, Jones SA, McCormack NA, Lavender D, et al. (2002) The assessment of local tolerance, acute toxicity, and DNA biodistribution following particle-mediated delivery of a DNA vaccine to minipigs. Toxicol Pathol 30: 298-305.
    • (2002) Toxicol Pathol , vol.30 , pp. 298-305
    • Pilling, A.M.1    Harman, R.M.2    Jones, S.A.3    McCormack, N.A.4    Lavender, D.5
  • 15
    • 0027284896 scopus 로고
    • Gene inoculation generates immune responses against human immunodeficiency virus type 1
    • Wang B, Ugen KE, Srikantan V, Agadjanyan MG, Dang K, et al. (1993) Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc Natl Acad Sci U S A 90: 4156-4160.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4156-4160
    • Wang, B.1    Ugen, K.E.2    Srikantan, V.3    Agadjanyan, M.G.4    Dang, K.5
  • 16
    • 77149129342 scopus 로고    scopus 로고
    • Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling
    • Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, et al.Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol 188: 547-563.
    • J Cell Biol , vol.188 , pp. 547-563
    • Koivusalo, M.1    Welch, C.2    Hayashi, H.3    Scott, C.C.4    Kim, M.5
  • 17
    • 34250314960 scopus 로고    scopus 로고
    • Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling
    • Gong Q, Weide M, Huntsman C, Xu Z, Jan LY, et al. (2007) Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling. J Biol Chem 282: 13087-13097.
    • (2007) J Biol Chem , vol.282 , pp. 13087-13097
    • Gong, Q.1    Weide, M.2    Huntsman, C.3    Xu, Z.4    Jan, L.Y.5
  • 18
    • 34547559617 scopus 로고    scopus 로고
    • The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio
    • Hood SJ, Taylor KP, Ashby MJ, Brown MJ, (2007) The spironolactone, amiloride, losartan, and thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio. Circulation 116: 268-275.
    • (2007) Circulation , vol.116 , pp. 268-275
    • Hood, S.J.1    Taylor, K.P.2    Ashby, M.J.3    Brown, M.J.4
  • 19
    • 33748480430 scopus 로고    scopus 로고
    • Gene transfer by means of lipo- and polyplexes: role of clathrin and caveolae-mediated endocytosis
    • Rejman J, Conese M, Hoekstra D, (2006) Gene transfer by means of lipo- and polyplexes: role of clathrin and caveolae-mediated endocytosis. J Liposome Res 16: 237-247.
    • (2006) J Liposome Res , vol.16 , pp. 237-247
    • Rejman, J.1    Conese, M.2    Hoekstra, D.3
  • 20
    • 0142149065 scopus 로고    scopus 로고
    • Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways
    • Ignatovich IA, Dizhe EB, Pavlotskaya AV, Akifiev BN, Burov SV, et al. (2003) Complexes of plasmid DNA with basic domain 47-57 of the HIV-1 Tat protein are transferred to mammalian cells by endocytosis-mediated pathways. J Biol Chem 278: 42625-42636.
    • (2003) J Biol Chem , vol.278 , pp. 42625-42636
    • Ignatovich, I.A.1    Dizhe, E.B.2    Pavlotskaya, A.V.3    Akifiev, B.N.4    Burov, S.V.5
  • 21
    • 0036889760 scopus 로고    scopus 로고
    • Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
    • Qian ZM, Li H, Sun H, Ho K, (2002) Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol Rev 54: 561-587.
    • (2002) Pharmacol Rev , vol.54 , pp. 561-587
    • Qian, Z.M.1    Li, H.2    Sun, H.3    Ho, K.4
  • 22
    • 0028057270 scopus 로고
    • Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells
    • Di Fabio S, Mbawuike IN, Kiyono H, Fujihashi K, Couch RB, et al. (1994) Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells. Int Immunol 6: 11-19.
    • (1994) Int Immunol , vol.6 , pp. 11-19
    • Di Fabio, S.1    Mbawuike, I.N.2    Kiyono, H.3    Fujihashi, K.4    Couch, R.B.5
  • 23
    • 0035500636 scopus 로고    scopus 로고
    • Dendritic cell-derived IL-12 is not required for the generation of cytotoxic, IFN-gamma-secreting, CD8(+) CTL in vivo
    • Wan Y, Lu L, Bramson JL, Baral S, Zhu Q, et al. (2001) Dendritic cell-derived IL-12 is not required for the generation of cytotoxic, IFN-gamma-secreting, CD8(+) CTL in vivo. J Immunol 167: 5027-5033.
    • (2001) J Immunol , vol.167 , pp. 5027-5033
    • Wan, Y.1    Lu, L.2    Bramson, J.L.3    Baral, S.4    Zhu, Q.5
  • 24
    • 58149260267 scopus 로고    scopus 로고
    • The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression
    • Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, et al. (2009) The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. J Leukoc Biol 85: 88-97.
    • (2009) J Leukoc Biol , vol.85 , pp. 88-97
    • Chattopadhyay, P.K.1    Betts, M.R.2    Price, D.A.3    Gostick, E.4    Horton, H.5
  • 25
    • 0345269791 scopus 로고    scopus 로고
    • Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice
    • Johnson BJ, Costelloe EO, Fitzpatrick DR, Haanen JB, Schumacher TN, et al. (2003) Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice. Proc Natl Acad Sci U S A 100: 2657-2662.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2657-2662
    • Johnson, B.J.1    Costelloe, E.O.2    Fitzpatrick, D.R.3    Haanen, J.B.4    Schumacher, T.N.5
  • 26
    • 2942737129 scopus 로고    scopus 로고
    • Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection
    • Shacklett BL, Cox CA, Quigley MF, Kreis C, Stollman NH, et al. (2004) Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection. J Immunol 173: 641-648.
    • (2004) J Immunol , vol.173 , pp. 641-648
    • Shacklett, B.L.1    Cox, C.A.2    Quigley, M.F.3    Kreis, C.4    Stollman, N.H.5
  • 27
    • 77950422606 scopus 로고    scopus 로고
    • Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells
    • Makedonas G, Hutnick N, Haney D, Amick AC, Gardner J, et al. (2010) Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. PLoS Pathog 6: e1000798.
    • (2010) PLoS Pathog , vol.6
    • Makedonas, G.1    Hutnick, N.2    Haney, D.3    Amick, A.C.4    Gardner, J.5
  • 28
    • 66949149500 scopus 로고    scopus 로고
    • Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity
    • Makedonas G, Banerjee PP, Pandey R, Hersperger AR, Sanborn KB, et al. (2009) Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. J Immunol 182: 5560-5569.
    • (2009) J Immunol , vol.182 , pp. 5560-5569
    • Makedonas, G.1    Banerjee, P.P.2    Pandey, R.3    Hersperger, A.R.4    Sanborn, K.B.5
  • 29
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn SD, Shin H, Haining WN, Zou T, Workman CJ, et al. (2009) Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10: 29-37.
    • (2009) Nat Immunol , vol.10 , pp. 29-37
    • Blackburn, S.D.1    Shin, H.2    Haining, W.N.3    Zou, T.4    Workman, C.J.5
  • 30
    • 0035806991 scopus 로고    scopus 로고
    • Cytoskeleton: actin and endocytosis-no longer the weakest link
    • Jeng RL, Welch MD, (2001) Cytoskeleton: actin and endocytosis-no longer the weakest link. Curr Biol 11: R691-694.
    • (2001) Curr Biol , vol.11
    • Jeng, R.L.1    Welch, M.D.2
  • 31
    • 0036041079 scopus 로고    scopus 로고
    • Endocytosis and the cytoskeleton
    • Qualmann B, Kessels MM, (2002) Endocytosis and the cytoskeleton. Int Rev Cytol 220: 93-144.
    • (2002) Int Rev Cytol , vol.220 , pp. 93-144
    • Qualmann, B.1    Kessels, M.M.2
  • 32
    • 0035890047 scopus 로고    scopus 로고
    • Pathways linking endocytosis and actin cytoskeleton in mammalian cells
    • Lanzetti L, Di Fiore PP, Scita G, (2001) Pathways linking endocytosis and actin cytoskeleton in mammalian cells. Exp Cell Res 271: 45-56.
    • (2001) Exp Cell Res , vol.271 , pp. 45-56
    • Lanzetti, L.1    Di Fiore, P.P.2    Scita, G.3
  • 33
    • 35348888976 scopus 로고    scopus 로고
    • The role of actin and microtubule networks in plasmid DNA intracellular trafficking
    • Ondrej V, Lukasova E, Falk M, Kozubek S, (2007) The role of actin and microtubule networks in plasmid DNA intracellular trafficking. Acta Biochim Pol 54: 657-663.
    • (2007) Acta Biochim Pol , vol.54 , pp. 657-663
    • Ondrej, V.1    Lukasova, E.2    Falk, M.3    Kozubek, S.4
  • 34
    • 33645752511 scopus 로고    scopus 로고
    • Cyclic stretch-induced reorganization of the cytoskeleton and its role in enhanced gene transfer
    • Geiger RC, Taylor W, Glucksberg MR, Dean DA, (2006) Cyclic stretch-induced reorganization of the cytoskeleton and its role in enhanced gene transfer. Gene Ther 13: 725-731.
    • (2006) Gene Ther , vol.13 , pp. 725-731
    • Geiger, R.C.1    Taylor, W.2    Glucksberg, M.R.3    Dean, D.A.4
  • 35
    • 55249114136 scopus 로고    scopus 로고
    • Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA
    • Yang Z, Sahay G, Sriadibhatla S, Kabanov AV, (2008) Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. Bioconjug Chem 19: 1987-1994.
    • (2008) Bioconjug Chem , vol.19 , pp. 1987-1994
    • Yang, Z.1    Sahay, G.2    Sriadibhatla, S.3    Kabanov, A.V.4
  • 37
    • 77955660585 scopus 로고    scopus 로고
    • A liposome-based platform, VacciMax, and its modified water-free platform DepoVax enhance efficacy of in vivo nucleic acid delivery
    • Karkada M, Weir GM, Quinton T, Fuentes-Ortega A, Mansour M, (2010) A liposome-based platform, VacciMax, and its modified water-free platform DepoVax enhance efficacy of in vivo nucleic acid delivery. Vaccine 28: 6176-6182.
    • (2010) Vaccine , vol.28 , pp. 6176-6182
    • Karkada, M.1    Weir, G.M.2    Quinton, T.3    Fuentes-Ortega, A.4    Mansour, M.5
  • 38
    • 0030793192 scopus 로고    scopus 로고
    • Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer
    • Nomura T, Nakajima S, Kawabata K, Yamashita F, Takakura Y, et al. (1997) Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer. Cancer Res 57: 2681-2686.
    • (1997) Cancer Res , vol.57 , pp. 2681-2686
    • Nomura, T.1    Nakajima, S.2    Kawabata, K.3    Yamashita, F.4    Takakura, Y.5
  • 39
    • 0035870252 scopus 로고    scopus 로고
    • Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation
    • Lohr F, Lo DY, Zaharoff DA, Hu K, Zhang X, et al. (2001) Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. Cancer Res 61: 3281-3284.
    • (2001) Cancer Res , vol.61 , pp. 3281-3284
    • Lohr, F.1    Lo, D.Y.2    Zaharoff, D.A.3    Hu, K.4    Zhang, X.5
  • 40
    • 0034292354 scopus 로고    scopus 로고
    • Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including immature dendritic cells into injected muscles
    • Haddad D, Ramprakash J, Sedegah M, Charoenvit Y, Baumgartner R, et al. (2000) Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including immature dendritic cells into injected muscles. J Immunol 165: 3772-3781.
    • (2000) J Immunol , vol.165 , pp. 3772-3781
    • Haddad, D.1    Ramprakash, J.2    Sedegah, M.3    Charoenvit, Y.4    Baumgartner, R.5
  • 42
    • 0034475120 scopus 로고    scopus 로고
    • DNA-based vaccines: role of dendritic cells in antigen presentation
    • Paul L, Porgador A, (2000) DNA-based vaccines: role of dendritic cells in antigen presentation. Adv Exp Med Biol 479: 175-184.
    • (2000) Adv Exp Med Biol , vol.479 , pp. 175-184
    • Paul, L.1    Porgador, A.2
  • 43
    • 0033529518 scopus 로고    scopus 로고
    • Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines
    • Rice J, King CA, Spellerberg MB, Fairweather N, Stevenson FK, (1999) Manipulation of pathogen-derived genes to influence antigen presentation via DNA vaccines. Vaccine 17: 3030-3038.
    • (1999) Vaccine , vol.17 , pp. 3030-3038
    • Rice, J.1    King, C.A.2    Spellerberg, M.B.3    Fairweather, N.4    Stevenson, F.K.5
  • 44
    • 0032441270 scopus 로고    scopus 로고
    • DNA vaccines: vector design, delivery, and antigen presentation
    • Feltquate DM, (1998) DNA vaccines: vector design, delivery, and antigen presentation. J Cell Biochem (Suppl 30-31): 304-311.
    • (1998) J Cell Biochem Suppl , vol.30-31 , pp. 304-311
    • Feltquate, D.M.1
  • 45
    • 0034667917 scopus 로고    scopus 로고
    • HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response
    • Weissman D, Ni H, Scales D, Dude A, Capodici J, et al. (2000) HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response. J Immunol 165: 4710-4717.
    • (2000) J Immunol , vol.165 , pp. 4710-4717
    • Weissman, D.1    Ni, H.2    Scales, D.3    Dude, A.4    Capodici, J.5
  • 46
    • 0033664689 scopus 로고    scopus 로고
    • DNA vaccination: antigen presentation and the induction of immunity
    • Shedlock DJ, Weiner DB, (2000) DNA vaccination: antigen presentation and the induction of immunity. J Leukoc Biol 68: 793-806.
    • (2000) J Leukoc Biol , vol.68 , pp. 793-806
    • Shedlock, D.J.1    Weiner, D.B.2
  • 47
    • 33947413164 scopus 로고    scopus 로고
    • The adjuvant effects of co-stimulatory molecules on cellular and memory responses to HBsAg DNA vaccination
    • Du X, Zheng G, Jin H, Kang Y, Wang J, et al. (2007) The adjuvant effects of co-stimulatory molecules on cellular and memory responses to HBsAg DNA vaccination. J Gene Med 9: 136-146.
    • (2007) J Gene Med , vol.9 , pp. 136-146
    • Du, X.1    Zheng, G.2    Jin, H.3    Kang, Y.4    Wang, J.5
  • 48
    • 0034548376 scopus 로고    scopus 로고
    • Design of a flow cytometric assay for the determination of natural killer and cytotoxic T-lymphocyte activity in human and in different animal species
    • Piriou L, Chilmonczyk S, Genetet N, Albina E, (2000) Design of a flow cytometric assay for the determination of natural killer and cytotoxic T-lymphocyte activity in human and in different animal species. Cytometry 41: 289-297.
    • (2000) Cytometry , vol.41 , pp. 289-297
    • Piriou, L.1    Chilmonczyk, S.2    Genetet, N.3    Albina, E.4
  • 49
    • 0037096206 scopus 로고    scopus 로고
    • The immunodominant, Ld-restricted T cell response to hepatitis B surface antigen (HBsAg) efficiently suppresses T cell priming to multiple Dd-, Kd-, and Kb-restricted HBsAg epitopes
    • Schirmbeck R, Stober D, El-Kholy S, Riedl P, Reimann J, (2002) The immunodominant, Ld-restricted T cell response to hepatitis B surface antigen (HBsAg) efficiently suppresses T cell priming to multiple Dd-, Kd-, and Kb-restricted HBsAg epitopes. J Immunol 168: 6253-6262.
    • (2002) J Immunol , vol.168 , pp. 6253-6262
    • Schirmbeck, R.1    Stober, D.2    El-Kholy, S.3    Riedl, P.4    Reimann, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.