DNA-based vaccines: Role of dendritic cells in antigen presentation

Advances in Experimental Medicine and Biology

Volumn 479, Issue , 2000, Pages 175-184

  Paul, L ^a   Porgador, A ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; BONE MARROW; CELLULAR IMMUNITY; CHIMERA; CONFERENCE PAPER; DENDRITIC CELL; FEMALE; GENE GUN; GENETIC TRANSDUCTION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; HUMANS; MICE; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; VACCINES, SYNTHETIC;

ANIMALIA;

EID: 0034475120     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (24)

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2. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
3. Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope
4. Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes
5. DNA-based immunization by in vivo transfection of dendritic cells
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7. High expression of naked plasmid DNA in muscles of young rodents
8. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
9. Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes
10. Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases
11. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites
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13. Contribution of cell at the site of DNA vaccination to the generation of antigen-specific immunity and memory
14. A model for keratinocyte gene therapy: Preclinical and therapeutic considerations
15. + T cells after gene gun immunization
16. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
17. The dendritic cell system and its role in immunogenicity
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19. Differential dependence on target site tissue for gene gun and i.m. DNA immunizations
20. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles
21. Direct gene transfer into mouse muscle in vivo
22. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines
23. Heterologous protection against influenza by injection of DNA encoding a viral protein
24. DNA vaccines