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Volumn 53, Issue 6, 1998, Pages 1512-1518

The Wilms' tumor suppressor WT1: Approaches to gene function

Author keywords

Cancer; Childhood tumor; Chromosomes; Development

Indexed keywords

CARCINOGENESIS; CHILDHOOD CANCER; CONFERENCE PAPER; GENE EXPRESSION; GENE FUNCTION; NEPHROBLASTOMA; PRIORITY JOURNAL; PROMOTER REGION; TUMOR SUPPRESSOR GENE;

EID: 0031779074     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1998.00935.x     Document Type: Conference Paper
Times cited : (38)

References (63)
  • 1
    • 0027205529 scopus 로고
    • Large scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor
    • COLES HSR, BURNE JF, RAFF MC: Large scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 118:777-784, 1993
    • (1993) Development , vol.118 , pp. 777-784
    • Coles, H.S.R.1    Burne, J.F.2    Raff, M.C.3
  • 5
    • 0026588871 scopus 로고
    • The genomic organization and expression of the WT1 gene
    • GESSLER M, KONIG A, BRUNS GA: The genomic organization and expression of the WT1 gene. Genomics 12:807-813, 1992
    • (1992) Genomics , vol.12 , pp. 807-813
    • Gessler, M.1    Konig, A.2    Bruns, G.A.3
  • 9
    • 0029991989 scopus 로고    scopus 로고
    • A non-AUG translation initiation event generates novel WT1 isoforms
    • BRUENING W, PELLETIER J: A non-AUG translation initiation event generates novel WT1 isoforms. J Biol Chem 271:8646-8654, 1996
    • (1996) J Biol Chem , vol.271 , pp. 8646-8654
    • Bruening, W.1    Pelletier, J.2
  • 10
    • 0031033340 scopus 로고    scopus 로고
    • Differential regulation of the Wilms' Tumor gene, WT1 during differentiation of embryonal carcinoma and embryonic stem cells
    • SCHARNHORST V, KRANENBURG O, VAN DER EB AJ, JOCHEMSEN AG: Differential regulation of the Wilms' Tumor gene, WT1 during differentiation of embryonal carcinoma and embryonic stem cells. Cell Growth Differ 8:133-143, 1997
    • (1997) Cell Growth Differ , vol.8 , pp. 133-143
    • Scharnhorst, V.1    Kranenburg, O.2    Van Der Eb, A.J.3    Jochemsen, A.G.4
  • 12
    • 0025605969 scopus 로고
    • Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence
    • RAUSCHER FJ, MORRIS JF, TOURNAY OE, COOK DM, CURRAN T: Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence. Science 250:1259-1262, 1990
    • (1990) Science , vol.250 , pp. 1259-1262
    • Rauscher, F.J.1    Morris, J.F.2    Tournay, O.E.3    Cook, D.M.4    Curran, T.5
  • 13
    • 0028799701 scopus 로고
    • Sequence and structural requirements for high-affinity DNA-binding by the WT1 gene product
    • NAKAGAMA H, HEINRICH G, PELLETIER J, HOUSMAN DE: Sequence and structural requirements for high-affinity DNA-binding by the WT1 gene product. Mol Cell Biol 15:1489-1498, 1995
    • (1995) Mol Cell Biol , vol.15 , pp. 1489-1498
    • Nakagama, H.1    Heinrich, G.2    Pelletier, J.3    Housman, D.E.4
  • 14
    • 0028919256 scopus 로고
    • High affinity binding sites for the Wilms' tumour suppressor protein WT1
    • HAMILTON TB, BARILLA KC, ROMANIUK PJ: High affinity binding sites for the Wilms' tumour suppressor protein WT1. Nucl Acids Res 23:277-284, 1995
    • (1995) Nucl Acids Res , vol.23 , pp. 277-284
    • Hamilton, T.B.1    Barilla, K.C.2    Romaniuk, P.J.3
  • 15
    • 0027368523 scopus 로고
    • A second transcriptionally active DNA-binding site for Wilms tumor gene product, WT1
    • WANG Z-Y, QIU Q-Q, ENGER KT, DEUEL T: A second transcriptionally active DNA-binding site for Wilms tumor gene product, WT1. Proc Natl Acad Sci USA 90:8896-8900, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8896-8900
    • Wang, Z.-Y.1    Qiu, Q.-Q.2    Enger, K.T.3    Deuel, T.4
  • 17
    • 0026720732 scopus 로고
    • Modulation of DNA binding specificity by alternative splicing of the Wilms tumor WT1 gene transcript
    • BICKMORE WA, OGHENE K, LITTLE MH, SEAWRIGHT A, VAN HEYNINGEN V, HASTIE ND: Modulation of DNA binding specificity by alternative splicing of the Wilms tumor WT1 gene transcript. Science 257:235-237, 1992
    • (1992) Science , vol.257 , pp. 235-237
    • Bickmore, W.A.1    Oghene, K.2    Little, M.H.3    Seawright, A.4    Van Heyningen, V.5    Hastie, N.D.6
  • 19
    • 0028897181 scopus 로고
    • Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, WT1, have altered DNA binding specificity and regulate transcription in different ways
    • WANG Z, QIU Q, HUANG J, GURRIERI M, DEUEL TF: Products of alternatively spliced transcripts of the Wilms' tumor suppressor gene, WT1, have altered DNA binding specificity and regulate transcription in different ways. Oncogene 10:415-422, 1995
    • (1995) Oncogene , vol.10 , pp. 415-422
    • Wang, Z.1    Qiu, Q.2    Huang, J.3    Gurrieri, M.4    Deuel, T.F.5
  • 22
    • 0027202558 scopus 로고
    • A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein
    • MADDEN SL, COOK DM, RAUSCHER FJ III: A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein. Oncogene 8:1713-1720, 1993
    • (1993) Oncogene , vol.8 , pp. 1713-1720
    • Madden, S.L.1    Cook, D.M.2    Rauscher III, F.J.3
  • 25
    • 0029560249 scopus 로고
    • The transcriptional effect of WT1 is modulated by choice of expression vector
    • REDDY JC, HOSONO S, LICHT JD: The transcriptional effect of WT1 is modulated by choice of expression vector. J Biol Chem 270:29976-29982, 1995b
    • (1995) J Biol Chem , vol.270 , pp. 29976-29982
    • Reddy, J.C.1    Hosono, S.2    Licht, J.D.3
  • 27
    • 0030010389 scopus 로고    scopus 로고
    • An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling
    • KENNEDY D, RAMSDALE T, MATTICK J, LITTLE M: An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling. Nature Genet 12:329-332, 1996
    • (1996) Nature Genet , vol.12 , pp. 329-332
    • Kennedy, D.1    Ramsdale, T.2    Mattick, J.3    Little, M.4
  • 31
    • 0030978224 scopus 로고    scopus 로고
    • Wilms' tumor 1-Kts isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor
    • MENKE AL, SHVARTS A, RITECO N, VAN HAM RCA, VAN DER EB AJ, JOCHEMSEN AG: Wilms' tumor 1-Kts isoforms induce p53-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptor or the insulin receptor. Cancer Res 57:1353-1363, 1997
    • (1997) Cancer Res , vol.57 , pp. 1353-1363
    • Menke, A.L.1    Shvarts, A.2    Riteco, N.3    Van Ham, R.C.A.4    Van Der Eb, A.J.5    Jochemsen, A.G.6
  • 32
    • 0029880547 scopus 로고    scopus 로고
    • WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines
    • ALGAR EM, KHROMYKH T, SMITH SI, BLACKBURN DM, BRYSON GJ, SMITH PJA: WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines. Oncogene 12:1005-1014, 1996
    • (1996) Oncogene , vol.12 , pp. 1005-1014
    • Algar, E.M.1    Khromykh, T.2    Smith, S.I.3    Blackburn, D.M.4    Bryson, G.J.5    Smith, P.J.A.6
  • 35
    • 0028990227 scopus 로고
    • G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/cdk complexes
    • KUDOH T, ISHIDATE T, MORIYAMA M, TOYOSHIMA K, AKIYAMA T: G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/cdk complexes. Proc Natl Acad Sci USA 92:4517-4521, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4517-4521
    • Kudoh, T.1    Ishidate, T.2    Moriyama, M.3    Toyoshima, K.4    Akiyama, T.5
  • 37
    • 0026458229 scopus 로고
    • Molecular cloning of rat Wilms' tumor complementary DNA and study of of messenger RNA expression in the urogenital system and the brain
    • SHARMA PM, YANG X, BOWMAN M, ROBERTS V, SUKUMAR S: Molecular cloning of rat Wilms' tumor complementary DNA and study of of messenger RNA expression in the urogenital system and the brain. Cancer Res 52:6407-6412, 1992
    • (1992) Cancer Res , vol.52 , pp. 6407-6412
    • Sharma, P.M.1    Yang, X.2    Bowman, M.3    Roberts, V.4    Sukumar, S.5
  • 38
    • 0026749126 scopus 로고
    • RNA polymerase chain reaction detects different levels of four alternatively spliced WT1 transcripts in Wilms' tumors
    • BRENNER B, WILDHARDT G, SCHNEIDER S, ROYER-POKORA B: RNA polymerase chain reaction detects different levels of four alternatively spliced WT1 transcripts in Wilms' tumors. Oncogene 7:1431-1433, 1992
    • (1992) Oncogene , vol.7 , pp. 1431-1433
    • Brenner, B.1    Wildhardt, G.2    Schneider, S.3    Royer-Pokora, B.4
  • 39
    • 0028292477 scopus 로고
    • Wilms' Tumor suppressor gene expression in rat and human mesothelioma
    • WALKER C, RUTTEN F, YUAN X, PASS H, MEW DM, EVERITT J: Wilms' Tumor suppressor gene expression in rat and human mesothelioma. Canc Res 54:3101-3106, 1994
    • (1994) Canc Res , vol.54 , pp. 3101-3106
    • Walker, C.1    Rutten, F.2    Yuan, X.3    Pass, H.4    Mew, D.M.5    Everitt, J.6
  • 41
    • 0028587166 scopus 로고
    • The genetics of Wilms' tumor-A case of disrupted development
    • HASTIE, ND: The genetics of Wilms' tumor-A case of disrupted development. (Review) Annu Rev Genet 28:523-558, 1994
    • (1994) Annu Rev Genet , vol.28 , pp. 523-558
    • Hastie, N.D.1
  • 43
    • 0027384740 scopus 로고
    • Characterization of the transcriptional regulatory region of the human WT1 gene
    • HOFMANN W, ROYER H-D, DRECHSLER M, SCHNEIDER S, ROYER-POKORA B: Characterization of the transcriptional regulatory region of the human WT1 gene. Oncogene 8:3123-3132, 1993
    • (1993) Oncogene , vol.8 , pp. 3123-3132
    • Hofmann, W.1    Royer, H.-D.2    Drechsler, M.3    Schneider, S.4    Royer-Pokora, B.5
  • 45
    • 0029866180 scopus 로고    scopus 로고
    • Differential function of the Wilms' tumor gene WT1 splice isoforms in transcriptional regulation
    • HEWITT SM, FRAIZER GC, WU YJ, RAUSCHER FJ III, SAUNDERS GF: Differential function of the Wilms' tumor gene WT1 splice isoforms in transcriptional regulation. J Biol Chem 271:8588-8592, 1996
    • (1996) J Biol Chem , vol.271 , pp. 8588-8592
    • Hewitt, S.M.1    Fraizer, G.C.2    Wu, Y.J.3    Rauscher III, F.J.4    Saunders, G.F.5
  • 46
    • 0028805671 scopus 로고
    • WT1 induces expression of insulin-like growth factor 2 in Wilms' tumor cells
    • NICHOLS KE, RE GG, YAN YX, GARVIN AJ, HABER DA: WT1 induces expression of insulin-like growth factor 2 in Wilms' tumor cells. Cancer Res 55:4540-4543, 1995
    • (1995) Cancer Res , vol.55 , pp. 4540-4543
    • Nichols, K.E.1    Re, G.G.2    Yan, Y.X.3    Garvin, A.J.4    Haber, D.A.5
  • 47
    • 0028318393 scopus 로고
    • Transcriptional represion of the insulin-like growth factor 1 receptor (IGF-I-R) gene by the tumor suppresor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site
    • WERNER H, RAUSCHER FJ III, SUKHATME VP, DRUMMOND IA, ROBERTS CT JR, LEROITH D: Transcriptional represion of the insulin-like growth factor 1 receptor (IGF-I-R) gene by the tumor suppresor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site. J Biol Chem 269:12577-12582, 1994
    • (1994) J Biol Chem , vol.269 , pp. 12577-12582
    • Werner, H.1    Rauscher III, F.J.2    Sukhatme, V.P.3    Drummond, I.A.4    Roberts Jr., C.T.5    Leroith, D.6
  • 48
    • 0027278677 scopus 로고
    • Increased expression of the insulin-like growth factor 1 receptor gene, IGFIR, in Wilms tumor is correlated with modulation of IGFIR promoter activity by the WT1 Wilms tumor gene product
    • WERNER H, RE GG, DRUMMOND IA, SUKHATME VP, RAUSCHER FJ III, SENS DA, GARVIN AJ, LEROITH D, ROBERTS CT JR: Increased expression of the insulin-like growth factor 1 receptor gene, IGFIR, in Wilms tumor is correlated with modulation of IGFIR promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci USA 90:5828-5832, 1993
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5828-5832
    • Werner, H.1    Re, G.G.2    Drummond, I.A.3    Sukhatme, V.P.4    Rauscher III, F.J.5    Sens, D.A.6    Garvin, A.J.7    Leroith, D.8    Roberts Jr., C.T.9
  • 49
    • 0026526495 scopus 로고
    • The Wilms' Tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene
    • WANG, ZY, MADDEN SL, DEUEL TF, RAUSCHER FJ III: The Wilms' Tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene. J Biol Chem 267:21999-22002, 1992
    • (1992) J Biol Chem , vol.267 , pp. 21999-22002
    • Wang, Z.Y.1    Madden, S.L.2    Deuel, T.F.3    Rauscher III, F.J.4
  • 50
    • 0027286309 scopus 로고
    • The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains
    • WANG Z-Y, QIU Q-O, DEUEL TF: The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains. J Biol Chem 268:9172-91715, 1993
    • (1993) J Biol Chem , vol.268 , pp. 9172-91715
    • Wang, Z.-Y.1    Qiu, Q.-O.2    Deuel, T.F.3
  • 51
    • 0028904247 scopus 로고
    • WT1, the Wilms' tumor suppressor gene product, represses transcription through an interactive nuclear protein
    • WANG Z, QIU Q, GURRIERI M, HUANG, J, DEUEL TF: WT1, the Wilms' tumor suppressor gene product, represses transcription through an interactive nuclear protein. Oncogene 10:1243-1247, 1995b
    • (1995) Oncogene , vol.10 , pp. 1243-1247
    • Wang, Z.1    Qiu, Q.2    Gurrieri, M.3    Huang, J.4    Deuel, T.F.5
  • 53
    • 0027384536 scopus 로고
    • Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus
    • HARRINGTON MA, KONICEK H, SONG A, XIA X-L, FREDERICKS WJ, RAUSCHER FJ III: Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus. J Biol Chem 268:21271-21275, 1993
    • (1993) J Biol Chem , vol.268 , pp. 21271-21275
    • Harrington, M.A.1    Konicek, H.2    Song, A.3    Xia, X.-L.4    Fredericks, W.J.5    Rauscher III, F.J.6
  • 55
    • 0029925705 scopus 로고    scopus 로고
    • Regulation of nov by WT1: A potential role for nov in nephrogenesis
    • MARTINERIE C, CHEVALIER G, RAUSCHER FJ III, PERBAL B: Regulation of nov by WT1: A potential role for nov in nephrogenesis. Oncogene 12:1479-1492, 1996
    • (1996) Oncogene , vol.12 , pp. 1479-1492
    • Martinerie, C.1    Chevalier, G.2    Rauscher III, F.J.3    Perbal, B.4
  • 56
    • 0028967215 scopus 로고
    • Repression of the retinoic acid receptor-a gene by the Wilms' tumor suppressor gene product, WT1
    • GOODYER P, DEHBI M, TORBAN E, BRUENING W, PELLETIER J: Repression of the retinoic acid receptor-a gene by the Wilms' tumor suppressor gene product, WT1. Oncogene 10:1125-1129, 1995
    • (1995) Oncogene , vol.10 , pp. 1125-1129
    • Goodyer, P.1    Dehbi, M.2    Torban, E.3    Bruening, W.4    Pelletier, J.5
  • 57
    • 0029102967 scopus 로고
    • Wilms' tumor protein WT1 as an ovarian transcription factor: Decreases in expression during follicle development and repression of inhihin-a gene promoter
    • HSU SY, KUBO M, CHUN S-Y, HALUSKA FG, HOUSMAN DE, HSUEH AJW: Wilms' tumor protein WT1 as an ovarian transcription factor: Decreases in expression during follicle development and repression of inhihin-a gene promoter. Mol Endocrinol 9:1356-1366, 1995
    • (1995) Mol Endocrinol , vol.9 , pp. 1356-1366
    • Hsu, S.Y.1    Kubo, M.2    Chun, S.-Y.3    Haluska, F.G.4    Housman, D.E.5    Hsueh, A.J.W.6
  • 58
    • 0028815650 scopus 로고
    • Repression of the c-myb gene by WT1 protein in T and B cell lines
    • MCCANN S, SULLIVAN J, GUERRA J, ARCINAS M, BONER LM: Repression of the c-myb gene by WT1 protein in T and B cell lines. J Biol Chem 270:23785-23789, 1995
    • (1995) J Biol Chem , vol.270 , pp. 23785-23789
    • Mccann, S.1    Sullivan, J.2    Guerra, J.3    Arcinas, M.4    Boner, L.M.5
  • 61
    • 0028844582 scopus 로고
    • Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' Tumor suppressor gene WT1
    • HEWITT SM, HAMADA S, MCDONNELI TJ, RAUSCHER FJ III, SAUNDERS GF: Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' Tumor suppressor gene WT1. Cancer Res 55:5386-5389, 1995
    • (1995) Cancer Res , vol.55 , pp. 5386-5389
    • Hewitt, S.M.1    Hamada, S.2    Mcdonneli, T.J.3    Rauscher III, F.J.4    Saunders, G.F.5
  • 62
    • 0029973558 scopus 로고    scopus 로고
    • Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1
    • COOK DM, HINKES MT, BERNFIELD M, RAUSCHER FJ III: Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1. Oncogene 13:1789-1799, 1996
    • (1996) Oncogene , vol.13 , pp. 1789-1799
    • Cook, D.M.1    Hinkes, M.T.2    Bernfield, M.3    Rauscher III, F.J.4


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