Concussion in athletics: Ongoing clinical and brain imaging research controversies

Brain Imaging and Behavior

Volumn 6, Issue 2, 2012, Pages 224-243

  Slobounov, Semyon ^a,b   Gay, Michael ^a   Johnson, Brian ^a   Zhang, Kai ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Clinical outcome; Mild TBI; Neuroimaging

Indexed keywords

ARTICLE; BOLD SIGNAL; BRAIN FUNCTION; CLINICAL ASSESSMENT TOOL; CLINICAL EFFECTIVENESS; DEFAULT MODE NETWORK; DIFFUSION TENSOR IMAGING; ELECTROENCEPHALOGRAM; EVENT RELATED POTENTIAL; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEALTH PRACTITIONER; HUMAN; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POSTERIOR CINGULATE; PRIORITY JOURNAL; SPORT CONCUSSION ASSESSMENT TOOL; SPORT INJURY; TRAUMATIC BRAIN INJURY; WORKING MEMORY;

ATHLETIC INJURIES; BRAIN; BRAIN CONCUSSION; HUMANS; NEUROIMAGING;

EID: 84863334730     PISSN: 19317557     EISSN: 19317565     Source Type: Journal    
DOI: 10.1007/s11682-012-9167-2     Document Type: Article

References (173)

1. Alves, W. M., Rimel, R. W., & Nelson, W. E. (1987). University-of-virginia prospective-study of football-induced minor head-injury-status-report. Clinics in Sports Medicine, 6, 211-218.
2. Anderson, T., Heitger, M., & Macleod, A. D. (2006). Concussion and mild head injury. Practical Neurology, 6, 342-357.
3. Arciniegas, D. B. (2011). Clinical electrophysiologic assessments and mild traumatic brain injury: state-of-the-science and implications for clinical practice. International Journal of Psychophysiology, 82, 41-52.
4. Asato, M. R. (2010). White matter development in adolescence: A DTI study. New York, NY: Cerebral cortex (1991) 20: 2122-2131.
5. Aubry, M., Cantu, R., Dvorak, J., Graf-Baumann, T., Johnston, K., Kelly, J., Lovell, M., McCrory, P., Meeuwisse, W., & Schamasch, P. (2002). Summary and agreement statement of the first international conference on concussion in sport, Vienna 2001. Recommendations for the improvement of safety and health of athletes who may suffer concussive injuries. British Journal of Sports Medicine, 36, 6-10.
6. Audoin, B., Ibarrola, D., Ranjeva, J. P., Confort-Gouny, S., Malikova, I., Ali-Cherif, A., Pelletier, J., & Cozzone, P. (2003). Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of MS. Human Brain Mapping, 20, 51-58.
7. Babikian, T. (2010). Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI. Journal of Neurotrauma, 27, 473-481.
8. Barkhoudarian, G., Hovda, D. A., Giza, C. C. (2011). The molecular pathophysiology of concussive brain injury. Clinics in Sports Medicine, 30, 33-48, vii-iii.
9. Barnes, S. M., Walter, K. H., & Chard, K. M. (2012). Does a history of mild traumatic brain injury increase suicide risk in veterans with PTSD? Rehabilitation Psychology, 57, 18-26.
10. Barr, W. B., Prichep, L. S., Chabot, R., Powell, M. R., & McCrea, M. (2012). Measuring brain electrical activity to track recovery from sport-related concussion. Brain Injury, 26, 58-66.
11. Barth. J., Alves, W., Ryan, T., Macciocchi, S., Rimel, R., Jane, J., Nelson, W. (1989). Chapter 17: Mild head injury in sport: Neuropsychological sequelae and recovery of function. In: H. Levin, H. Eisenberg and A. Benton (Eds.), Mild head injury. Oxford Press.
12. Barwick, F., Arnett, P., & Slobounov, S. (2012). EEG correlates of fatigue during administration of a neuropsychological test battery. Clinical Neurophysiology, 123, 278-284.
13. Bazarian, J. J., Veenema, T., Brayer, A. F., & Lee, E. (2001). Knowledge of concussion guidelines among practitioners caring for children. Clinical Pediatrics, 40, 207-212.
14. Bazarian, J. J., Zhu, T., Blyth, B., Borrino, A., & Zhong, J. (2012). Subject-specific changes in brain white matter on diffusion tensor imaging after sports-related concussion. Magnetism Resonance Imaging, 30, 171-180.
15. Bazarian, J. J., Zhong, J., Blyth, B., Zhu, T., Kavcic, V., & Peterson, D. (2007). Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study. Journal of Neurotrauma, 24, 1447-1459.
16. Beckmann, C. F., DeLuca, M., Devlin, J. T., & Smith, S. M. (2005). Investigations into resting-state connectivity using independent component analysis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 360, 1001-1013.
17. Belanger, H. G. (2007). Recent neuroimaging techniques in mild traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 19, 5-20.
18. Belanger, H. G., Spiegel, E., & Vanderploeg, R. D. (2010). Neuropsychological performance following a history of multiple self-reported concussions: a meta-analysis. Journal of the International Neuropsychological Society, 16, 262-267.
19. Bigler, E. D., & Maxwell, W. L. (2012). Neuropathology of mild traumatic brain injury: Relationship to neuroimaging findings. Brain Imaging Behaviour.
20. Biswal, B., Yetkin, F. Z., Haughton, V. M., & Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine, 34, 537-541.
21. Blaylock, R. L., & Maroon, J. (2011). Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-a unifying hypothesis. Surgical Neurology International, 2, 107.
22. Braver, T. S., Cohen, J. D., Nystrom, L. E., Jonides, J., Smith, E. E., & Noll, D. C. (1997). A parametric study of prefrontal cortex involvement in human working memory. NeuroImage, 5, 49-62.
23. Broglio, S. P., Pontifex, M. B., O'Connor, P., & Hillman, C. H. (2009). The Persistent Effects of Concussion on Neuroelectric Indices of Attention. Journal of Neurotrauma, 26, 1463-1470.
24. Browne, K. D., Chen, X. H., Meaney, D. F., & Smith, D. H. (2011). Mild traumatic brain injury and diffuse axonal injury in swine. Journal of Neurotrauma, 28, 1747-1755.
25. Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. (2009). Default-mode brain dysfunction in mental disorders: a systematic review. Neuroscience and Biobehavioral Reviews, 33, 279-296.
26. Bruce, J. M., & Echemendia, R. J. (2009). History of multiple self-reported concussions is not associated with reduced cognitive abilities. Neurosurgery, 64, 100-106. discussion 106.
27. Bryant, R. A. (1999). Postconcussive symptoms and posttraumatic stress disorder after mild traumatic brain injury. The Journal of Nervous and Mental Disease, 187, 302.
28. Cantu, R. C., Aubry, M., Dvorak, J., Graf-Baumann, T., Johnston, K., Kelly, J., Lovell, M., McCrory, P., Meeuwisse, W., Schamasch, P., Kevin, M., Bruce, S. L., Ferrara, M. S., Kelly, J. P., McCrea, M., Putukian, M., & McLeod, T. C. (2006). Overview of concussion consensus statements since 2000. Neurosurgical Focus, 21, E3.
29. Cao, C., & Slobounov, S. (2010). Alteration of cortical functional connectivity as a result of traumatic brain injury revealed by graph theory, ICA, and sLORETA analyses of EEG signals. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 18, 11-19.
30. Cao, C., & Slobounov, S. (2011). Application of a novel measure of EEG non-stationarity as 'Shannon- entropy of the peak frequency shifting' for detecting residual abnormalities in concussed individuals. Clinical Neurophysiology, 122, 1314-1321.
31. Cao, C., Tutwiler, R. L., & Slobounov, S. (2008). Automatic classification of athletes with residual functional deficits following concussion by means of EEG signal using support vector machine. IEEE transactions on neural systems and rehabilitation engineering, 16, 327-335.
32. CAoSMC C. (2000). CASM Guidelines for assessment and management of sport-related concussion. Clinical Journal of Sports Medicine, 10, 209-211.
33. Cecil, K. M. (1998). Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients. Journal of Neurosurgery, 88, 795-801.
34. Chang, L., Tomasi, D., Yakupov, R., Lozar, C., Arnold, S., Caparelli, E., & Ernst, T. (2004). Adaptation of the attention network in human immunodeficiency virus brain injury. Annals of Neurology, 56, 259-272.
35. Chason, J. L., Hardy, W. G., Webster, J. E., & Gurdjian, E. S. (1958). Alterations in cell structure of the brain associated with experimental concussion. Journal of Neurosurgery, 15, 135-139.
36. Chen, J. K., Johnston, K. M., Collie, A., McCrory, P., & Ptito, A. (2007). A validation of the post concussion symptom scale in the assessment of complex concussion using cognitive testing and functional MRI. Journal of Neurology, Neurosurgery, and Psychiatry, 78, 1231-1238.
37. Chen, J. K., Johnston, K. M., Frey, S., Petrides, M., Worsley, K., & Ptito, A. (2004). Functional abnormalities in symptomatic concussed athletes: an fMRI study. NeuroImage, 22, 68-82.
38. Chen, J. K., Johnston, K. M., Petrides, M., & Ptito, A. (2008). Neural substrates of symptoms of depression following concussion in male athletes with persisting postconcussion symptoms. Archives of General Psychiatry, 65, 81-89.
39. Chiaravalloti, N., Hillary, F., Ricker, J., Christodoulou, C., Kalnin, A., Liu, W. C., Steffener, J., & DeLuca, J. (2005). Cerebral activation patterns during working memory performance in multiple sclerosis using FMRI. ournal of Clinical and Experimental Neuropsychology, 27, 33-54.
40. Chrisman, S. P., Schiff, M. A., & Rivara, F. P. (2011). Physician concussion knowledge and the effect of mailing the CDC's "Heads up" toolkit. Clinical Pediatrics, 50, 1031-1039.
41. Chu, Z., Wilde, E. A., Hunter, J. V., McCauley, S. R., Bigler, E. D., Troyanskaya, M., Yallampalli, R., Chia, J. M., & Levin, H. S. (2009). Voxel-based analysis of diffusion tensor imaging in mild traumatic brain injury in adolescents. American Journal of Neuroradiology, 31, 340-346.
42. Courtney, S. (2004). Attention and cognitive control as emergent properties of information representation in working memory. Cognitive, Affective, & Behavioral Neuroscience, 4, 501-516.
43. Covassin, T., Elbin, R., Kontos, A., & Larson, E. (2010). Investigating baseline neurocognitive performance between male and female athletes with a history of multiple concussion. Journal of Neurology, Neurosurgery & Psychiatry, 81, 597-601.
44. Creed, J. A., DiLeonardi, A. M., Fox, D. P., Tessler, A. R., & Raghupathi, R. (2011). Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function. Journal of Neurotrauma, 28, 547-563.
45. Cubon, V. A. (2011). A diffusion tensor imaging study on the white matter skeleton in individuals with sports-related concussion. Journal of Neurotrauma, 28, 189-201.
46. Cubon, V. A., Putukian, M., Boyer, C., & Dettwiler, A. (2011). A diffusion tensor imaging study on the white matter skeleton in individuals with sports-related concussion. Journal of Neurotrauma, 28, 189-201.
47. Damoiseaux, J. S., Rombouts, S. A., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006). Consistent resting-state networks across healthy subjects. Proceedings of the National Academy of Sciences of the United States of America, 103, 13848-13853.
48. Daniel, J. C., Olesniewicz, M. H., Reeves, D. L., Tam, D., Bleiberg, J., Thatcher, R., & Salazar, A. (1999). Repeated measures of cognitive processing efficiency in adolescent athletes: implications for monitoring recovery from concussion. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 12, 167-169.
49. Dasilva, F. L. (1991). Neural mechanisms underlying brain waves-from neural membranes to networks. Electroencephalography and Clinical Neurophysiology, 79, 81-93.
50. Davis, G. A., Iverson, G. L., Guskiewicz, K. M., Ptito, A., & Johnston, K. M. (2009). Contributions of neuroimaging, balance testing, electrophysiology and blood markers to the assessment of sport-related concussion. British Journal of Sports Medicine, 43, I36-I45.
51. de la Plata, C. D. M., Garces, J., Kojori, E. S., Grinnan, J., Krishnan, K., Pidikiti, R., Spence, J., Devous, M. D., Moore, C., McColl, R., Madden, C., & Diaz-Arrastia, R. (2011). Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury. Archives of Neurology, 68, 74-84.
52. De Luca, M., Beckmann, C. F., De Stefano, N., Matthews, P. M., & Smith, S. M. (2006). fMRI resting state networks define distinct modes of long-distance interactions in the human brain. NeuroImage, 29, 1359-1367.
53. Duff, J. (2004). The usefulness of quantitative EEG (QEEG) and neurotherapy in the assessment and treatment of post-concussion syndrome. Clinical EEG and Neuroscience, 35, 198-209.
54. Faas, F. H., & Ommaya, A. K. (1968). Brain tissue electrolytes and water content in experimental concussion in the monkey. Journal of Neurosurgery, 28, 137-144.
55. Flamm, E. S., Ommaya, A. K., Coe, J., Krueger, T. P., & Faas, F. H. (1966). Cardiovascular effects of experimental head injury in the monkey. Surgical Forum, 17, 414-416.
56. Forn, C., Barros-Loscertales, A., Escudero, J., Belloch, V., Campos, S., Parcet, M. A., & Avila, C. (2006). Cortical reorganization during PASAT task in MS patients with preserved working memory functions. NeuroImage, 31, 686-691.
57. Fox, M. D., & Greicius, M. (2010). Clinical applications of resting state functional connectivity. Frontiers in Systems Neuroscience, 4, 19.
58. Fox, M. D., & Raichle, M. E. (2007). Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nature Reviews Neuroscience, 8, 700-711.
59. Gardner, A., Shores, E. A., & Batchelor, J. (2010). Reduced processing speed in rugby union players reporting three or more previous concussions. Archives of Clinical Neuropsychology, 25, 174-181.
60. Gasparovic, C., Yeo, R., Mannell, M., Ling, J., Elgie, R., Phillips, J., Doezema, D., Mayer, A. (2009). Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: A 1H-magnetic resonance spectroscopy study. Journal of Neurotrauma, 110306202455053.
61. Gavett, B., Stern, R., Cantu, R., Nowinski, C., & McKee, A. (2010). Mild traumatic brain injury: a risk factor for neurodegeneration. Alzheimer's Research & Therapy, 2, 1-3.
62. Geets, W., & Louette, N. (1985). Early EEG in 300 cerebral concussions. Revue d'Électroencéphalographie et de Neurophysiologie Clinique, 14, 333-338.
63. Giza, C. C., & Hovda, D. A. (2001). The neurometabolic cascade of concussion. Journal of Athletic Training, 36, 228-235.
64. Glaser, M. A., & Sjaardema, H. (1940). The value of the electroencephalograph in cranio-cerebral injuries. West Surgery, 48, 6989-6996.
65. Goetz, P., Blamire, A., Rajagopalan, B., Cadoux-Hudson, T., Young, D., & Styles, P. (2004). Increase in apparent diffusion coefficient in normal appearing white matter following human traumatic brain injury correlates with injury severity. Journal of Neurotrauma, 21, 645-654.
66. Gosselin, N., Theriault, M., Leclerc, S., Montplaisir, J., & Lassonde, M. (2006). Neurophysiological anomalies in symptomatic and asymptomatic concussed athletes. Neurosurgery, 58, 1151-1160.
67. Govind, V. (2010). Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits. Journal of Neurotrauma, 27, 483-496.
68. Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences of the United States of America, 100, 253-258.
69. Grundl, P. D., Biagas, K. V., Kochanek, P. M., Schiding, J. K., Barmada, M. A., & Nemoto, E. M. (1994). Early cerebrovascular response to head injury in immature and mature rats. Journal of Neurotrauma, 11, 135-148.
70. Harch, P. G., Andrews, S. R., Fogarty, E. F., Amen, D., Pezzullo, J. C., Lucarini, J., Aubrey, C., Taylor, D. V., Staab, P. K., & van Meter, K. W. (2012). A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder. Journal of Neurotrauma, 29, 168-185.
71. Helgeson, S. R. (2011). Identifying brain injury in state juvenile justice, corrections, and homeless populations. Brain Injury Professional, 7.
72. Henry, L. C., Tremblay, J., Tremblay, S., Lepore, N., Theoret, H., Ellemberg, D., & Lassonde, M. (2011). Acute and chronic changes in diffusivity measures after sports concussion. Journal of Neurotrauma, 110824121127008.
73. Henry, L. C., Tremblay, S., Boulanger, Y., Ellemberg, D., & Lassonde, M. (2010). Neurometabolic changes in the acute phase after sports concussions correlate with symptom severity. Journal of Neurotrauma, 27, 65-76.
74. Hillary, F. G. (2008). Neuroimaging of working memory dysfunction and the dilemma with brain reorganization hypotheses. Journal of the International Neuropsychological Society: JINS, 14, 526-534.
75. Hillary, F. G., Genova, H. M., Medaglia, J. D., Fitzpatrick, N. M., Chiou, K. S., Wardecker, B. M., Franklin, R. G., Jr., Wang, J., & DeLuca, J. (2010). The nature of processing speed deficits in traumatic brain injury: is less brain more? Brain Imaging and Behavior, 4, 141-154.
76. Hillary, F. G., Schultheis, M. T., Challis, B. H., Millis, S. R., Carnevale, G. J., Galshi, T., & DeLuca, J. (2003). Spacing of repetitions improves learning and memory after moderate and severe TBI. Journal of Clinical and Experimental Neuropsychology, 25, 49-58.
77. Hillary, F. G., Steffener, J., Biswal, B. B., Lange, G., DeLuca, J., & Ashburner, J. (2002). Functional magnetic resonance imaging technology and traumatic brain injury rehabilitation: guidelines for methodological and conceptual pitfalls. The Journal of Head Trauma Rehabilitation, 17, 411-430.
78. Hoge, C. W., McGurk, D., Thomas, J. L., Cox, A. L., Engel, C. C., & Castro, C. A. (2008). Mild traumatic brain injury in U. S. soldiers returning from Iraq. The New England Journal of Medicine, 358, 453-463.
79. Horowitz, A. L. (1995). MRI physics for radiologists: A visual approach. New York: Springer.
80. Hugenholtz, H., & Richard, M. T. (1982). Return to athletic competition following concussion. Canadian Medical Association Journal, 127, 827-829.
81. Jaeggi, S. M., Seewer, R., Nirkko, A. C., Eckstein, D., Schroth, G., Groner, R., & Gutbrod, K. (2003). Does excessive memory load attenuate activation in the prefrontal cortex? Load-dependent processing in single and dual tasks: functional magnetic resonance imaging study. NeuroImage, 19, 210-225.
82. Jantzen, K. J. (2010). Functional magnetic resonance imaging of mild traumatic brain injury. Journal of Head Trauma Rehabilitation, 25, 256-266.
83. Jasper, H. H., Kershman, J., & Elvidge, A. R. (1940). Electroencephalographic study in clinical cases of injury of the head. Archives of Neurology and Psychiatry, 44, 328-350.
84. Johnson, B. (2012). Metabolic alterations in corpus callosum may compromise brain functional connectivity in MTBI patients: An 1H-MRS study. Neuroscience Letters, 509, 5-8.
85. Johnson, B., Zhang, K., Gay, M., Horovitz, S., Hallett, M., Sebastianelli, W., & Slobounov, S. (2012). Alteration of brain default network in subacute phase of injury in concussed individuals: resting-state fMRI study. NeuroImage, 59, 511-518.
86. Jueptner, M., & Weiller, C. (1995). Review: does measurement of regional cerebral blood flow reflect synaptic activity?-implications for PET and fMRI. NeuroImage, 2, 148-156.
87. Kan, E. M., Ling, E.-A., & Lu, J. (2012). Microenvironment changes in mild traumatic brain injury. Brain Research Bulletin, 87, 359-372.
88. Kirov, I. (2007). Characterizing 'mild' in traumatic brain injury with proton MR spectroscopy in the thalamus: initial findings. Brain Injury, 21, 1147-1154.
89. Landau, S. M., Schumacher, E. H., Garavan, H., Druzgal, T. J., & D'Esposito, M. (2004). A functional MRI study of the influence of practice on component processes of working memory. NeuroImage, 22, 211-221.
90. Langlois, J. A., Rutland-Brown, W., & Wald, M. M. (2006). The epidemiology and impact of traumatic brain injury: a brief overview. The Journal of Head Trauma Rehabilitation, 21, 375-378.
91. Le Bihan, D. (2001). Diffusion tensor imaging: concepts and applications. Journal of Magnetic Resonance Imaging, 13, 534-546.
92. Levin, H. S. (2003). Neuroplasticity following non-penetrating traumatic brain injury. Brain Injury, 17, 665-674.
93. Lewine, J. D., Davis, J. T., Bigler, E. D., Thoma, R., Hill, D., Funke, M., Sloan, J. H., Hall, S., & Orrison, W. W. (2007). Objective documentation of traumatic brain injury subsequent to mild head trauma: multimodal brain imaging with MEG, SPECT, and MRI. The Journal of Head Trauma Rehabilitation, 22, 141-155.
94. Lincoln, A. E., Caswell, S. V., Almquist, J. L., Dunn, R. E., Norris, J. B., & Hinton, R. Y. (2011). Trends in concussion incidence in high school sports a prospective 11-year study. The American Journal of Sports Medicine, 39, 958-963.
95. Logothetis, N. K. (2008). What we can do and what we cannot do with fMRI. Nature, 453(7197), 869-878.
96. Lutzenberger, W., Elbert, T., & Rockstroh, B. (1987). A brief tutorial on the implications of volume conduction for the interpretation of the EEG. Journal of Psychophysiology, 1, 81-89.
97. Mainero, C., Pantano, P., Caramia, F., & Pozzilli, C. (2006). Brain reorganization during attention and memory tasks in multiple sclerosis: insights from functional MRI studies. Journal of Neurological Sciences, 245, 93-98.
98. Maruishi, M., Miyatani, M., Nakao, T., & Muranaka, H. (2007). Compensatory cortical activation during performance of an attention task by patients with diffuse axonal injury: a functional magnetic resonance imaging study. Journal of Neurology, Neurosurgery, and Psychiatry, 78, 168-173.
99. Maruta, J., Lee, S. W., Jacobs, E. F., & Ghajar, J. (2010). A unified science of concussion. Annals of the New York Academy of Sciences, 1208, 58-66.
100. Maugans, T. A., Farley, C., Altaye, M., Leach, J., & Cecil, K. M. (2012). Pediatric sportsrelated concussion produces cerebral blood flow alterations. Pediatrics, 129, 28-37.
101. Max, J. E., Keatley, E., Wilde, E. A., Bigler, E. D., Levin, H. S., Schachar, R. J., Saunders, A., Ewing-Cobbs, L., Chapman, S. B., Dennis, M., & Yang, T. T. (2011) Anxiety disorders in children and adolescents in the first six months after traumatic brain injury. The Journal of Neuropsychiatry and Clinical Neurosciences, 23, 29-39.
102. Mayer, A. R., Mannell, M. V., Ling, J., Gasparovic, C., & Yeo, R. A. (2011). Functional connectivity in mild traumatic brain injury. Human Brain Mapping, 32, 1825-1835.
103. Mayer, A. R., Mannell, M. V., Ling, J., Elgie, R., Gasparovic, C., Phillips, J. P., Doezema, D., & Yeo, R. A. (2009). Auditory orienting and inhibition of return in mild traumatic brain injury: a FMRI study. Human Brain Mapping, 30, 4152-4166.
104. McAllister, T. W., Flashman, L. A., McDonald, B. C., & Saykin, A. J. (2006). Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Journal of Neurotrauma, 23, 1450-1467.
105. McAllister, T. W., Saykin, A. J., Flashman, L. A., Sparling, M. B., Johnson, S. C., Guerin, S. J., Mamourian, A. C., Weaver, J. B., & Yanofsky, N. (1999). Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study. Neurology, 53, 1300-1308.
106. McAllister, T. W., Sparling, M. B., Flashman, L. A., Guerin, S. J., Mamourian, A. C., & Saykin, A. J. (2001). Differential working memory load effects after mild traumatic brain injury. NeuroImage, 14, 1004-1012.
107. McClelland, R. J., Fenton, G. W., & Rutherford, W. (1994). The postconcussional-syndrome revisited. Journal of the Royal Society of Medicine, 87, 508-510.
108. McCrea, M., Kelly, J. P., Kluge, J., Ackley, B., & Randolph, C. (1997). Standardized assessment of concussion in football players. Neurology, 48, 586-588.
109. McCrea, M., Prichep, L., Powell, M. R., Chabot, R., & Barr, W. B. (2010). Acute effects and recovery after sport-related concussion: a neurocognitive and quantitative brain electrical activity study. Journal of Head Trauma Rehabilitation, 25, 283-292.
110. McCrory, P., Johnston, K., Meeuwisse, W., Aubry, M., Cantu, R., Dvorak, J., Graf-Baumann, T., Kelly, J., Lovell, M., & Schamasch, P. (2005). Summary and agreement statement of the 2nd international conference on concussion in sport, prague 2004. Clinical Journal of Sport Medicine, 15, 48-55.
111. McCrory, P., Meeuwisse, W., Johnston, K., Dvorak, J., Aubry, M., Molloy, M., & Cantu, R. (2009). Consensus statement on concussion in sport 3(rd) international conference on concussion in sport held in Zurich, November 2008. Clinical Journal of Sport Medicine, 19, 185-200.
112. Montgomery, E. A., Fenton, G. W., McClelland, R. J., Macflynn, G., & Rutherford, W. H. (1991). The psychobiology of minor head-injury. Psychological Medicine, 21, 375-384.
113. Moser, R. S., Iverson, G. L., Echemendia, R. J., Lovell, M. R., Schatz, P., Webbe, F. M., Ruff, R. M., Barth, J. T., & Nan Policy Planning, C. (2007). Neuropsychological evaluation in the diagnosis and management of sports-related concussion. Archives of Clinical Neuropsychology, 22, 909-916.
114. Nakamura, T., Hillary, F. G., & Biswal, B. B. (2009). Resting network plasticity following brain injury. PLoS One, 4, e8220.
115. Neil, J., Miller, J., Mukherjee, P., & Hüppi, P. S. (2002). Diffusion tensor imaging of normal and injured developing human brain-a technical review. NMR in Biomedicine, 15, 543-552.
116. Nevin, N. C. (1967). Neuropathological changes in the white matter following head injury. Journal of Neuropathology and Experimental Neurology, 26, 77-84.
117. Nuwer, M. R., Hovda, D. A., Schrader, L. M., & Vespa, P. M. (2005). Routine and quantitative EEG in mild traumatic brain injury. Clinical Neurophysiology, 116, 2001-2025.
118. Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990). Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proceedings of the National Academy of Sciences of the United States of America, 87, 9868-9872.
119. Ogawa, S., Menon, R. S., Tank, D. W., Kim, S. G., Merkle, H., Ellermann, J. M., & Ugurbil, K. (1993). Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophysical Journal, 64(3), 803-812.
120. Olejniczak, P. (2006). Neurophysiologic basis of EEG. Journal of Clinical Neurophysiology, 23, 186-189.
121. Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005). N-back working memory paradigm: a meta-analysis of normative functional neuroimaging. Human Brain Mapping, 25, 46-59.
122. Pantano, P., Mainero, C., & Caramia, F. (2006). Functional brain reorganization in multiple sclerosis: evidence from fMRI studies. Journal of Neuroimaging, 16, 104-114.
123. Perlstein, W. M., Cole, M. A., Demery, J. A., Seignourel, P. J., Dixit, N. K., Larson, M. J., & Briggs, R. W. (2004). Parametric manipulation of working memory load in traumatic brain injury: behavioral and neural correlates. Journal of the International Neuropsychological Society: JINS, 10, 724-741.
124. Pratapchand, R., Sinniah, M., & Salem, F. A. (1988). Cognitive evoked-potential P300-a metric for cerebral concussion. Acta Neurologica Scandinavica, 78, 185-189.
125. Ptito, A., Chen, J. K., & Johnston, K. M. (2007). Contributions of functional magnetic resonance imaging (fMRI) to sport concussion evaluation. NeuroRehabilitation, 22, 217-227.
126. Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001). A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98, 676-682.
127. Raichle, M. E., & Mintun, M. A. (2006). Brain work and brain imaging. Annual Review of Neuroscience, 29, 449-476.
128. Reijneveld, J. C., Ponten, S. C., Berendse, H. W., & Stam, C. J. (2007). The application of graph theoretical analysis to complex networks in the brain. Clinical Neurophysiology, 118, 2317-2331.
129. Ross, B. D. (1998). 1H MRS in acute traumatic brain injury. Journal of Magnetic Resonance Imaging, 8, 829-840.
130. Ruff, R. M. (2011). Mild traumatic brain injury and neural recovery: rethinking the debate. NeuroRehabilitation, 28, 167-180.
131. Rypma, B., & D'Esposito, M. (1999). The roles of prefrontal brain regions in components of working memory: effects of memory load and individual differences. Proceedings of the Academy of Natural Sciences of United States, 96, 6558-6563.
132. Sanchez-Carrion, R., Fernandez-Espejo, D., Junque, C., Falcon, C., Bargallo, N., Roig, T., Bernabeu, M., Tormos, J. M., & Vendrell, P. (2008). A longitudinal fMRI study of working memory in severe TBI patients with diffuse axonal injury. NeuroImage, 43, 421-429.
133. Sanchez-Carrion, R., Gomez, P. V., Junque, C., Fernandez-Espejo, D., Falcon, C., Bargallo, N., Roig-Rovira, T., Ensenat-Cantallops, A., & Bernabeu, M. (2008). Frontal hypoactivation on functional magnetic resonance imaging in working memory after severe diffuse traumatic brain injury. Journal of Neurotrauma, 25, 479-494.
134. Scheibel, R. S., Newsome, M. R., Troyanskaya, M., Steinberg, J. L., Goldstein, F. C., Mao, H., & Levin, H. S. (2009). Effects of severity of traumatic brain injury and brain reserve on cognitive-control related brain activation. Journal of Neurotrauma, 26, 1447-1461.
135. Schwarz, A. (2010). Suicide reveals signs of a disease seen in NFL. In: The New York Times New York City: Arthur Ochs Sulzberger, Jr.
136. Shah, S., Yallampalli, R., Merkley, T. L., McCauley, S. R., Bigler, E. D., Macleod, M., Chu, Z., Li, X., Troyanskaya, M., Hunter, J. V., Levin, H. S., & Wilde, E. A. (2012). Diffusion tensor imaging and volumetric analysis of the ventral striatum in adults with traumatic brain injury. Brain Injury, 26, 201-210.
137. Sharp, D. J. (2011). Investigating white matter injury after mild traumatic brain injury. Current Opinion in Neurology, 24, 558-563.
138. Sharp, D. J., & Ham, T. E. (2011). Investigating white matter injury after mild traumatic brain injury. Current Opinion in Neurology, 24(6), 558-563.
139. Shekdar, K. (2011). Role of magnetic resonance spectroscopy in evaluation of congenital/developmental brain abnormalities. Seminars in Ultrasound, CT, and MRI, 32, 510-538.
140. Signoretti, S., Pietro, V., Vagnozzi, R., Lazzarino, G., Amorini, A. M., Belli, A., D'Urso, S., & Tavazzi, B. (2009). Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the rat. Molecular and Cellular Biochemistry, 333, 269-277.
141. Slobounov, S., Cao, C., & Sebastianelli, W. (2009). Differential effect of first versus second concussive episodes on wavelet information quality of EEG. Clinical Neurophysiology, 120, 862-867.
142. Slobounov, S., Sebastianelli, W., & Hallett, M. (2012). Residual brain dysfunction observed one year post-mild traumatic brain injury: Combined EEG and balance study. Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology.
143. Slobounov, S., Sebastianelli, W., & Moss, R. (2005). Alteration of posture-related cortical potentials in mild traumatic brain injury. Neuroscience Letters, 383, 251-255.
144. Slobounov, S., Sebastianelli, W., & Newell, K. M. (2011a). Incorporating virtual reality graphics with brain imaging for assessment of sport-related concussions. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011, 1383-1386.
145. Slobounov, S., Slobounov, E., & Newell, K. (2006a). Application of virtual reality graphics in assessment of concussion. Cyberpsychology & Behavior, 9, 188-191.
146. Slobounov, S., Tutwiler, R., Sebastianelli, W., & Slobounov, E. (2006b). Alteration of postural responses to visual field motion in mild traumatic brain injury. Neurosurgery, 59, 134-139. discussion 134-139.
147. Slobounov, S. M., Gay, M., Zhang, K., Johnson, B., Pennell, D., Sebastianelli, W., Horovitz, S., & Hallett, M. (2011b). Alteration of brain functional network at rest and in response to YMCA physical stress test in concussed athletes: RsFMRI study. NeuroImage, 55, 1716-1727.
148. Slobounov, S. M., Zhang, K., Pennell, D., Ray, W., Johnson, B., & Sebastianelli, W. (2010). Functional abnormalities in normally appearing athletes following mild traumatic brain injury: a functional MRI study. Experimental Brain Research, 202, 341-354.
149. Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., & Beckmann, C. F. (2009). Correspondence of the brain's functional architecture during activation and rest. Proceedings of the National Academy of Sciences of the United States of America, 106, 13040-13045.
150. Snook, L. (2005). Diffusion tensor imaging of neurodevelopment in children and young adults. NeuroImage (Orlando, Fla), 26, 1164.
151. Sporns, O., Honey, C. J., & Kotter, R. (2007). Identification and classification of hubs in brain networks. PLoS One, 2, e1049.
152. Stulemeijer, M., Vos, P. E., van der Werf, S., van Dijk, G., Rijpkema, M., & Fernandez, G. (2010). How mild traumatic brain injury may affect declarative memory performance in the post-acute stage. Journal of Neurotrauma, 27, 1585-1595.
153. Teasdale, T. W., & Engberg, A. W. (2001). Suicide after traumatic brain injury: a population study. Journal of Neurology, Neurosurgery and Psychiatry, 71, 436-440.
154. Tebano, M. T., Cameroni, M., Gallozzi, G., Loizzo, A., Palazzino, G., Pezzini, G., & Ricci, G. F. (1988). EEG spectral-analysis after minor head-injury in man. Electroencephalography and Clinical Neurophysiology, 70, 185-189.
155. Thatcher, R. W., Walker, R. A., Gerson, I., & Geisler, F. H. (1989). EEG discriminant analyses of mild head trauma. Electroencephalography and Clinical Neurophysiology, 73, 94-106.
156. Theriault, M., De Beaumont, L., Gosselin, N., Filipinni, M., & Lassonde, M. (2009). Electrophysiological abnormalities in well functioning multiple concussed athletes. Brain Injury, 23, 899-906.
157. Theriault, M., De Beaumont, L., Tremblay, S., Lassonde, M., & Jolicoeur, P. (2011). Cumulative effects of concussions in athletes revealed by electrophysiological abnormalities on visual working memory. Journal of Clinical and Experimental Neuropsychology, 33, 30-41.
158. Thornton, K. E. (1999). Exploratory investigation into mild brain injury and discriminant analysis with high frequency bands (32-64 Hz). Brain Injury, 13, 477-488.
159. Turner, G. R., & Levine, B. (2008). Augmented neural activity during executive control processing following diffuse axonal injury. Neurology, 71, 812-818.
160. Uryu, K., Laurer, H., McIntosh, T., Pratico, D., Martinez, D., Leight, S., Lee, V. M. Y., & Trojanowski, J. Q. (2002). Repetitive mild brain trauma accelerates A beta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. Journal of Neuroscience, 22, 446-454.
161. Vagnozzi, R., Signoretti, S., Cristofori, L., Alessandrini, F., Floris, R., Isgro, E., Ria, A., Marziale, S., Zoccatelli, G., Tavazzi, B., Del Bolgia, F., Sorge, R., Broglio, S. P., McIntosh, T. K., & Lazzarino, G. (2010). Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients. Brain, 133, 3232-3242.
162. Varela, F., Lachaux, J. P., Rodriguez, E., & Martinerie, J. (2001). The brainweb: phase synchronization and large-scale integration. Nature Reviews Neuroscience, 2, 229-239.
163. Walz, N. C. (2008). Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes. Journal of Neurotrauma, 25, 94-103.
164. Walz, N. C., Cecil, K. M., Wade, S. L., & Michaud, L. J. (2008). Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes. Journal of Neurotrauma, 25(2), 94-103.
165. Watson, M. R., Fenton, G. W., McClelland, R. J., Lumsden, J., Headley, M., & Rutherford, W. H. (1995). The post-concussional state-neurophysiological aspects. The British Journal of Psychiatry, 167, 514-521.
166. Weissman, D. H., Roberts, K. C., Visscher, K. M., & Woldorff, M. G. (2006). The neural bases of momentary lapses in attention. Nature Neuroscience, 9, 971-978.
167. Wilde, E. A., McCauley, S. R., Hunter, J. V., Bigler, E. D., Chu, Z., Wang, Z. J., Hanten, G. R., Troyanskaya, M., Yallampalli, R., Li, X., Chia, J., & Levin, H. S. (2008). Diffusion tensor imaging of acute mild traumatic brain injury in adolescents. Neurology, 70, 948-955.
168. Wilde, E. A., Merkley, T. L., Bigler, E. D., Max, J. E., Schmidt, A. T., Ayoub, K. W., McCauley, S. R., Hunter, J. V., Hanten, G., Li, X., Chu, Z. D., & Levin, H. S. (2012). Longitudinal changes in cortical thickness in children after traumatic brain injury and their relation to behavioral regulation and emotional control. International Journal of Developmental Neuroscience, 30, 267-276.
169. Williams, D. (1941). The electro-encephalogram in acute head injury. Journal of Neurology and Psychology, 107-30.
170. Yuen, T. J., Browne, K. D., Iwata, A., & Smith, D. H. (2009). Sodium channelopathy induced by mild axonal trauma worsens outcome after a repeat injury. Journal of Neuroscience Research, 87, 3620-3625.
171. Zhang, K., Johnson, B., Gay, M., Horovitz, S. G., Hallett, M., Sebastianelli, W., & Slobounov, S. (2012). Default mode network in concussed individuals in response to the YMCA physical stress test. Journal of Neurotrauma, 29, 756-765.
172. Zhang, K., Johnson, B., Pennell, D., Ray, W., Sebastianelli, W., & Slobounov, S. (2010). Are functional deficits in concussed individuals consistent with white matter structural alterations: combined FMRI & DTI study. Experimental Brain Research, 204, 57-70.
173. Zhu, T., Hu, R., Qiu, X., Taylor, M., Tso, Y., Yiannoutsos, C., Navia, B., Mori, S., Ekholm, S., Schifitto, G., & Zhong, J. (2011). Quantification of accuracy and precision of multi-center DTI measurements: a diffusion phantom and human brain study. NeuroImage, 56, 1398-1411.