Evidence for the efficacy of statins in animal stroke models: A meta-analysis

Journal of Neurochemistry

Volumn 122, Issue 2, 2012, Pages 233-243

  García Bonilla, Lidia ^a   Campos, Mireia ^a   Giralt, Dolors ^a   Salat, David ^a   Chacõn, Pilar ^a   Hernández Guillamon, Mar ^a   Rosell, Anna ^a   Montaner, Joan ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

animal models; ischemic stroke; meta analysis; meta regression; statin; systematic review

Indexed keywords

ACETYLSALICYLIC ACID; ATORVASTATIN; CERIVASTATIN; COMPACTIN; DIPYRIDAMOLE; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PHENOBARBITAL; PITAVASTATIN; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTINUOUS INFUSION; DRUG DOSE COMPARISON; DRUG EFFICACY; META ANALYSIS; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SCORING SYSTEM;

ANIMALS; BRAIN ISCHEMIA; DATA INTERPRETATION, STATISTICAL; DISEASE MODELS, ANIMAL; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; PUBLICATION BIAS; RATS; REGRESSION ANALYSIS; RESEARCH DESIGN; STROKE;

ANIMALIA;

EID: 84863316981     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07773.x     Document Type: Review

References (40)

1. Amarenco P., and, Labreuche J., (2009) Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol. 8, 453-463.
2. Baryan H. K., Allan S. M., Vail A., and, Smith C. J., (2012) Systematic review and meta-analysis of the efficacy of statins in experimental stroke. Int. J. Stroke 7, 150-156.
3. Bellosta S., Paoletti R., and, Corsini A., (2004) Safety of statins: focus on clinical pharmacokinetics and drug interactions. Circulation 109, III50-57. (Pubitemid 38786444)
4. Berger C., Xia F., Maurer M. H., and, Schwab S., (2008) Neuroprotection by pravastatin in acute ischemic stroke in rats. Brain Res. Rev. 58, 48-56. (Pubitemid 351852927)
5. Biffi A., Devan W. J., Anderson C. D., Cortellini L., Furie K. L., Rosand J., and, Rost N. S., (2011) Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis. Stroke 42, 1314-1319.
6. Cui W., Matsuno K., Iwata K., et al., (2009) NADPH oxidase isoforms and anti-hypertensive effects of atorvastatin demonstrated in two animal models. J. Pharmacol. Sci. 111, 260-268.
7. Danton G. H., and, Dietrich W. D., (2004) The search for neuroprotective strategies in stroke. AJNR Am. J. Neuroradiol. 25, 181-194. (Pubitemid 38235294)
8. Endo A., Kuroda M., and, Tanzawa K., (1976) Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett. 72, 323-326. (Pubitemid 8017240)
9. Endres M., and, Laufs U., (2004) Effects of statins on endothelium and signaling mechanisms. Stroke 35, 2708-2711. (Pubitemid 39458376)
10. Endres M., Laufs U., Huang Z., Nakamura T., Huang P., Moskowitz M. A., and, Liao J. K., (1998) Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl Acad. Sci. USA 95, 8880-8885. (Pubitemid 28350583)
11. Frantzias J., Sena E. S., Macleod M. R., and, Al-Shahi Salman R., (2011) Treatment of intracerebral hemorrhage in animal models: meta-analysis. Ann. Neurol. 69, 389-399.
12. George S. J., Dhond A. J., Alderson S. M., and, Ezekowitz M. D., (2002) Neuroprotective effects of statins may not be related to total and low-density lipoprotein cholesterol lowering. Am. J. Cardiol. 90, 1237-1239. (Pubitemid 35346882)
13. Grundy S. M., (1988) HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N Engl. J. Med. 319, 24-33.
14. Hayashi T., Hamakawa K., Nagotani S., et al., (2005) HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons. Brain Res. 1037, 52-58. (Pubitemid 40362381)
15. Hong H., Zeng J. S., Kreulen D. L., Kaufman D. I., and, Chen A. F., (2006) Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke. Am. J. Physiol. Heart Circ. Physiol. 291, H2210-2215.
16. Iadecola C., and, Anrather J., (2011) The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796-808.
17. Kawai H., Deguchi S., Deguchi K., et al., (2011) Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat. Brain Res. 1368, 317-323.
18. Laufs U., Gertz K., Dirnagl U., Bohm M., Nickenig G., and, Endres M., (2002) Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Res. 942, 23-30. (Pubitemid 34597065)
19. Laufs U., Gertz K., Huang P., Nickenig G., Bohm M., Dirnagl U., and, Endres M., (2000) Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke 31, 2442-2449.
20. Macleod M. R., O'Collins T., Howells D. W., and, Donnan G. A., (2004) Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 35, 1203-1208. (Pubitemid 38543544)
21. Maron D. J., Fazio S., and, Linton M. F., (2000) Current perspectives on statins. Circulation 101, 207-213. (Pubitemid 30044262)
22. Mayanagi K., Katakam P. V., Gaspar T., Domoki F., and, Busija D. W., (2008) Acute treatment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia. J. Cereb. Blood Flow Metab. 28, 1927-1935.
23. Montaner J., Chacon P., Krupinski J., Rubio F., Millan M., Molina C. A., Hereu P., Quintana M., and, Alvarez-Sabin J., (2008) Simvastatin in the acute phase of ischemic stroke: a safety and efficacy pilot trial. Eur. J. Neurol. 15, 82-90. (Pubitemid 350265291)
24. Nagahiro S., Uno M., Sato K., Goto S., Morioka M., and, Ushio Y., (1998) Pathophysiology and treatment of cerebral ischemia. J. Med. Invest. 45, 57-70. (Pubitemid 128501267)
25. Nezasa K., Higaki K., Takeuchi M., Nakano M., and, Koike M., (2003) Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin. Xenobiotica 33, 379-388. (Pubitemid 36688114)
26. Prinz V., and, Endres M., (2011) Statins and stroke: prevention and beyond. Curr. Opin. Neurol. 24, 75-80.
27. Pruefer D., Scalia R., and, Lefer A. M., (1999) Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats. Arterioscler Thromb. Vasc. Biol. 19, 2894-2900. (Pubitemid 30029815)
28. Romano M., Diomede L., Sironi M., et al., (2000a) Inhibition of monocyte chemotactic protein-1 synthesis by statins. Lab Invest. 80, 1095-1100. (Pubitemid 30483228)
29. Romano M., Mezzetti A., Marulli C., et al., (2000b) Fluvastatin reduces soluble P-selectin and ICAM-1 levels in hypercholesterolemic patients: role of nitric oxide. J. Investig. Med. 48, 183-189.
30. STAIR (1999) Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30, 2752-2758.
31. Sena E. S., Briscoe C. L., Howells D. W., Donnan G. A., Sandercock P. A., and, Macleod M. R., (2010a) Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. J. Cereb. Blood Flow Metab. 30, 1905-1913.
32. Sena E. S., van der Worp H. B., Bath P. M., Howells D. W., and, Macleod M. R., (2010b) Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol. 8, e1000344.
33. Sironi L., Banfi C., Brioschi M., et al., (2006) Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment. Neurobiol Dis. 22, 445-451.
34. Squizzato A., Romualdi E., Dentali F., and, Ageno W., (2011) Statins for acute ischemic stroke. Cochrane Database Syst. Rev. C00755, 1.
35. Sterne J. A., Egger M., and, Smith G. D., (2001) Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis. BMJ. 323, 101-105. (Pubitemid 32681979)
36. Trinkl A., Vosko M. R., Wunderlich N., Dichgans M., and, Hamann G. F., (2006) Pravastatin reduces microvascular basal lamina damage following focal cerebral ischemia and reperfusion. Eur. J. Neurosci. 24, 520-526. (Pubitemid 44100343)
37. Wald D. S., Law M., and, Morris J., (2003) Serum homocysteine and the severity of coronary artery disease. Thromb Res. 111, 55-57. (Pubitemid 37485927)
38. Waxman D. J., and, Azaroff L., (1992) Phenobarbital induction of cytochrome P-450 gene expression. Biochem. J. 281, 577-592.
39. Wood W. G., Eckert G. P., Igbavboa U., and, Muller W. E., (2010) Statins and neuroprotection: a prescription to move the field forward. Ann. N. Y. Acad Sci. 1199, 69-76.
40. Yamada M., Huang Z., Dalkara T., Endres M., Laufs U., Waeber C., Huang P. L., Liao J. K., and, Moskowitz M. A., (2000) Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J. Cereb. Blood Flow Metab. 20, 709-717. (Pubitemid 30217509)