Activation of NF-kB and ERK1/2 after permanent focal ischemia is abolished by simvastatin treatment

Neurobiology of Disease

Volumn 22, Issue 2, 2006, Pages 445-451

  Sironi, Luigi ^a   Banfi, Cristina ^a,b   Brioschi, Maura ^a,b   Gelosa, Paolo ^a   Guerrini, Uliano ^a   Nobili, Elena ^a   Gianella, Anita ^a   Paoletti, Rodolfo ^a   Tremoli, Elena ^a,b   Cimino, Mauro ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b CENTRO CARDIOLOGICO MONZINO   (Italy)

^c UNIVERSITY OF URBINO   (Italy)

Author keywords

Cerebral ischemia; Inflammation; MAP kinase; Permanent middle cerebral artery occlusion; Rat; Statin; Transcription factor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN INHIBITOR; SIMVASTATIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; INFLAMMATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENCEPHALITIS; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERLEUKIN-1; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; UP-REGULATION;

EID: 33646136668     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.12.004     Document Type: Article

References (29)

1. Amarenco P., Lavallee P., and Touboul P.J. Stroke prevention, blood cholesterol, and statins. Lancet Neurol. 3 (2004) 271-278
2. Amin-Hanjani S., Stagliano N.E., Yamada M., Huang P.L., Liao J.K., and Moskowitz M.A. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke 32 (2001) 980-986
3. Balduini W., De Angelis V., Mazzoni E., and Cimino M. Simvastatin protects against long-lasting behavioural and morphological consequences of neonatal hypoxic/ischemic brain injury. Stroke 32 (2001) 2181-2185
4. Balduini W., Mazzoli E., Carloni S., De Simoni M.G., Perego C., Sironi L., and Cimino M. Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does not affect endothelial nitric oxide synthase expression. Stroke 34 (2003) 2007-2012
5. Barone F.C., and Feuerstein G.Z. Inflammatory mediators and stroke: new opportunities for novel therapeutics. J. Cereb. Blood Flow Metab. 19 (1999) 819-934
6. Berti R., Williams A.J., Moffett J.R., Hale S.L., Velarde L.C., Elliott P.J., Yao C., Dave J.R., and Tortella F.C. Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury. J. Cereb. Blood Flow Metab. 22 (2002) 1068-1079
7. Cercek B., Yamashita M., Dimayuga P., Zhu J., Fishbein M.C., Kaul S., Shah P.K., Nilsson J., and Regnstrom J. Nuclear factor-kappaB activity and arterial response to balloon injury. Atherosclerosis 131 (1997) 59-66
8. Davignon J., and Mabile L. Mechanisms of action of statins and their pleiotropic effects. Ann. Endocrinol. 62 (2001) 101-112
9. Endres M., Laufs U., Huang Z., Nakamura T., Huang P., Moskowitz M.A., and Liao J.K. Stroke protection by 3-hydroxy-3-mehylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 8880-8885
10. Ferrer I., Friguls B., Dalfo E., and Planas A.M. Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia. Acta Neuropathol. 105 (2003) 425-437
11. Guijarro C., Blanco-Colio L.M., Ortego M., Alonso C., Ortiz A., Plaza J.J., Diaz C., Hernandez G., and Egido J. 3-Hydroxy-3-methylglutaryl coenzyme A reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Circ. Res. 83 (1998) 490-500
12. Hilgendorff A., Muth H., Parviz B., Staubitz A., Haberbosch W., Tillmanns H., and Holschermann H. Statins differ in their ability to block NF-kappaB activation in human blood monocytes. Int. J. Clin. Pharmacol. Ther. 41 (2003) 397-401
13. Iadecola C., and Alexander M. Cerebral ischemia and inflammation. Curr. Opin. Neurol. 14 (2001) 89-94
14. Irving E.A., and Bamford M. Role of mitogen- and stress-activated kinases in ischemic injury. J. Cereb. Blood Flow Metab. 22 (2002) 631-647
15. Joussen A.M., Poulaki V., Mitsiades N., Kirchhof B., Koizumi K., Dohmen S., and Adamis A.P. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J. 16 (2002) 438-440
16. Kim J.S., Gautam S.C., Chopp M., Zaloga C., Jones M.L., Ward P.A., and Welch K.M. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat. J. Neuroimmunol. 56 (1995) 127-134
17. Kretz-Remy C., Munsch B., and Arrigo A.P. NFkappa B-dependent transcriptional activation during heat shock recovery. Thermolability of the NF-kappaB/Ikappa B complex. J. Biol. Chem. 276 (2001) 43723-43733
18. Laufs U., Gertz K., Huang P., Nickenig G., Bohm M., Dirnagl U., and Endres M. Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice. Stroke 31 (2000) 2442-2449
19. Liu Z.X., Nickel C.H., and Cantley L.G. HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. Am. J. Physiol.: Renal Physiol. 281 (2001) F62-F70
20. Mattson M.P., and Camandola S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107 (2001) 247-254
21. Namura S., Iihara K., Takami S., Nagata I., Kikuchi H., Matsushita K., Moskowitz M.A., Bonventre J.V., and Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 11569-11574
22. Nurmi A., Lindsberg P.J., Koistinaho M., Zhang W., Juettler E., Karjalainen-Lindsberg M.L., Weih F., Frank N., Schwaninger M., and Koistinaho J. Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke 35 (2004) 987-991
23. Schneider A., Martin-Villalba A., Weih F., Wirth T., and Schwaninger M. NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat. Med. 5 (1999) 554-559
24. Sironi L., Cimino M., Guerrini U., Calvio A.M., Lodetti B., Asdente M., Balduini W., Paoletti R., and Tremoli E. Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 322-327
25. Stephenson D., Yin T., Smalstig E.B., Hsu M.A., Panetta J., Little S., and Clemens J. Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 20 (2000) 592-603
26. Takemoto M., and Liao J.K. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler. Thromb. Vasc. Biol. 21 (2001) 1712-1719
27. Tamura A., Graham D.I., McCullogh J., and Teasdale M.G. Focal cerebral ischemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 1 (1981) 53-60
28. Wang Z.Q., Wu D.C., Huang F.P., and Yang G.Y. Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia. Brain Res. 996 (2004) 55-66
29. Wu D.C., Ye W., Che X.M., and Yang G.Y. Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain. J. Cereb. Blood Flow Metab. 20 (2000) 1320-1330