Topological and mutational analysis of Saccharomyces cerevisiae Fks1

Eukaryotic Cell

Volumn 11, Issue 7, 2012, Pages 952-960

  Johnson, Michael E ^a   Edlind, Thomas D ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECHINOCANDIN; FKS1 PROTEIN, S CEREVISIAE; GLUCOSYLTRANSFERASE; MEMBRANE PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; DNA MUTATIONAL ANALYSIS; ECHINOCANDINS; GLUCOSYLTRANSFERASES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

FUNGI; PROTISTA; SACCHAROMYCES CEREVISIAE;

EID: 84863300556     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.00082-12     Document Type: Article

References (48)

1. Baltz R. 2009. Daptomycin: mechanisms of action and resistance, and biosynthetic engineering. Curr. Opin. Chem. Biol. 13:144-151.
2. Boeck LD, Fukuda DS, Abbott BJ, Debono M. 1989. Deacylation of echinocandin B by Actinoplanes utahensis. J. Antibiot. 42:382-388.
3. Breton C, Bettler E, Joziasse DH, Geremia RA, Imberty A. 1998. Sequence-function relationships of prokaryotic and eukaryotic galactosyltransferases. J. Biochem. 123:1000-1009.
4. Charnock SJ, Davies GJ. 1999. Structure of the nucleotide-diphosphosugar transferase, SpsA from Bacillus subtilis, in native and nucleotidecomplexed forms. Biochemistry 38:6380-6385.
5. Chen CP, Kernytsky A, Rost B. 2002. Transmembrane helix predictions revisited. Protein Sci. 11:2774-2791.
6. Chen SCA, Sorrell TC. 2007. Antifungal agents. Med. J. Aust. 187:404-409.
7. Denning DW. 2003. Echinocandin antifungal drugs. Lancet 362:1142-1151.
8. Doering TL. 2009. How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in Cryptococcus neoformans. Annu. Rev. Microbiol. 63:223-247.
9. Douglas CM. 2001. Fungal beta(1,3)-D-glucan synthesis. Med. Mycol. 39(Suppl 1):55-66.
10. Douglas CM, et al. 1997. Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors. Antimicrob. Agents Chemother. 41:2471-2479.
11. Douglas CM, et al. 1994. The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-Dglucan synthase. Proc. Natl. Acad. Sci. U. S. A. 91:12907-12911.
12. Drummond RA, Brown GD. 2011. The role of dectin-1 in the host defence against fungal infections. Curr. Opin. Microbiol. 14:392-399.
13. Edlind TD, Katiyar SK. 2004. The echinocandin "target" identified by cross-linking is a homolog of Pil1 and Lsp1, sphingolipid-dependent regulators of cell wall integrity signaling. Antimicrob. Agents Chemother. 48:4491.
14. Fulton Z, et al. 2008. Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species. J. Biol. Chem. 283:27881-27890.
15. Ha Y-S, Covert SF, Momany M. 2006. FsFKS1, the 1,3-_-glucan synthase from the caspofungin-resistant fungus Fusarium solani. Eukaryot. Cell 5:1036-1042.
16. Hector RF, Bierer DE. 2011. New _-glucan inhibitors as antifungal drugs. Expert Opin. Ther. Pat. 21:1597-1610.
17. Hildebrand A, Remmert M, Biegert A, Söding J. 2009. Fast and accurate automatic structure prediction with HHpred. Protein Struct. Func. Bioinform. 77:128-132.
18. Johnson ME, Katiyar SK, Edlind TD. 2011. New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium species. Antimicrob. Agents Chemother. 55:3774-3781.
19. Katiyar SK, Edlind TD. 2009. Role for Fks1 in the intrinsic echinocandin resistance of Fusarium solani as evidenced by hybrid expression in Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 53:1772-1778.
20. Kikuchi N, Kwon Y-D, Gotoh M, Narimatsu H. 2003. Comparison of glycosyltransferase families using the profile hidden Markov model. Biochem. Biophys. Res. Commun. 310:574-579.
21. Kim H, Melén K, von Heijne G. 2003. Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions. J. Biol. Chem. 278:10208-10213.
22. Kim H, von Heijne G, Nilsson I. 2005. Membrane topology of the STT3 subunit of the oligosaccharyl transferase complex. J. Biol. Chem. 280: 20261-20267.
23. Krogh A, Larsson B, von Heijne G, Sonnhammer ELL. 2001. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305:567-580.
24. Kurtz MB, Douglas CM. 1997. Lipopeptide inhibitors of fungal glucan synthase. J. Med. Vet. Mycol. 35:79-86.
25. Latgé J-P. 2007. The cell wall: a carbohydrate armour for the fungal cell. Mol. Microbiol. 66:279-290.
26. Lesage G, Bussey H. 2006. Cell wall assembly in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 70:317-343.
27. Loibl M, et al. 2010. C terminus of Nce102 determines the structure and function of microdomains in the Saccharomyces cerevisiae plasma membrane. Eukaryot. Cell 9:1184-1192.
28. Mazur P, et al. 1995. Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase. Mol. Cell. Biol. 15: 5671-5681.
29. Melén K, Krogh A, von Heijne G. 2003. Reliability measures for membrane protein topology prediction algorithms. J. Mol. Biol. 327:735-744.
30. Mio T, et al. 1997. Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in beta-1,3-glucan synthesis. J. Bacteriol. 179:4096-4105.
31. Möller S, Croning MDR, Apweiler R. 2001. Evaluation of methods for the prediction of membrane spanning regions. Bioinformatics 17:646-653.
32. Nett JE, Crawford K, Marchillo K, Andes DR. 2010. Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyene. Antimicrob. Agents Chemother. 54:3505-3508.
33. Okada H, et al. 2010. Multiple functional domains of the yeast 1,3-_-glucan synthase subunit Fks1p revealed by quantitative phenotypic analysis of temperature-sensitive mutants. Genetics 184:1013-1024.
34. Onishi J, et al. 2000. Discovery of novel antifungal (1,3)-_-D-glucan synthase inhibitors. Antimicrob. Agents Chemother. 44:368-377.
35. Ostrosky-Zeichner L. 2012. Invasive mycoses: diagnostic challenges. Am. J. Med. 125:S14-S24.
36. Perlin DS. 2007. Resistance to echinocandin-class antifungal drugs. Drug Resist. Updat. 10:121-130.
37. Pfaller MA, Diekema DJ. 2004. Twelve years of fluconazole in clinical practice: global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida. Clin. Microbiol. Infect. 10:11-23.
38. Qadota H, et al. 1996. Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-_-glucan synthase. Science 272:279-281.
39. Radding JA, Heidler SA, Turner WW. 1998. Photoaffinity analog of the semisynthetic echinocandin LY303366: identification of echinocandin targets in Candida albicans. Antimicrob. Agents Chemother. 42:1187-1194.
40. Saxena IM, Brown RM, Jr, Dandekar T. 2001. Structure-function characterization of cellulose synthase: relationship to other glycosyltransferases. Phytochemistry 57:1135-1148.
41. Schimoler-O'Rourke R, Renault S, Mo W, Selitrennikoff CP. 2003. Neurospora crassa FKS protein binds to the (1,3)-_-glucan synthase substrate, UDP-glucose. Curr. Microbiol. 46:408-412.
42. Sengstag C, Stirling C, Schekman R, Rine J. 1990. Genetic and biochemical evaluation of eukaryotic membrane protein topology: multiple transmembrane domains of Saccharomyces cerevisiae 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mol. Cell. Biol. 10:672-680.
43. Strahl-Bolsinger S, Scheinost A. 1999. Transmembrane topology of Pmt1p, a member of an evolutionarily conserved family of protein Omannosyltransferases. J. Biol. Chem. 274:9068-9075.
44. Thompson JR, et al. 1999. A glucan synthase FKS1 homolog in Cryptococcus neoformans is single copy and encodes an essential function. J. Bacteriol. 181:444-453.
45. Utsugi T, et al. 2002. Movement of yeast 1,3-_-glucan synthase is essential for uniform cell wall synthesis. Genes Cells 7:1-9.
46. Viklund H, Elofsson A. 2004. Best _-helical transmembrane protein topology predictions are achieved using hidden Markov models and evolutionary information. Protein Sci. 13:1908-1917.
47. Villasmil ML, Nickels JJT. 2011. Determination of the membrane topology of Arv1 and the requirement of the ER luminal region for Arv1 function in Saccharomyces cerevisiae. FEMS Yeast Res. 11:524-527.
48. Walker SS, et al. 2011. Discovery of a novel class of orally active antifungal _-1,3-D-glucan synthase inhibitors. Antimicrob. Agents Chemother. 55: 5099-5106.