Invasive mycoses: Diagnostic challenges

American Journal of Medicine

Volumn 125, Issue 1 SUPPL., 2012, Pages

  Ostrosky Zeichner, Luis ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b MEMORIAL HERMANN HOSPITAL   (United States)

Author keywords

Glucan; d arabinitol; Galactomannan; Mannan; Nonculture based diagnostics; PCR assays

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; ARABINITOL; BETA GLUCAN; FLUCONAZOLE; GALACTOMANNAN; IMMUNOGLOBULIN G; MANNAN; NUCLEIC ACID;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIBIOTIC PROPHYLAXIS; ARTICLE; ASPERGILLOSIS; ASPERGILLUS; AUTOPSY; CANCER PATIENT; CANDIDA; CANDIDA GLABRATA; CANDIDIASIS; CELL WALL; CRYPTOCOCCOSIS; DELAYED DIAGNOSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DISEASE MARKER; EARLY DIAGNOSIS; ENZYME IMMUNOASSAY; FEVER; FUNGAL CELL; FUNGAL DETECTION; FUNGUS CULTURE; FUNGUS ISOLATION; FUSARIOSIS; HIGH RISK PATIENT; HISTOPATHOLOGY; HUMAN; INFECTION RISK; INVASIVE ASPERGILLOSIS; INVASIVE CANDIDIASIS; META ANALYSIS (TOPIC); MYCOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; SYSTEMIC MYCOSIS; THERAPY DELAY; UNSPECIFIED SIDE EFFECT;

ADULT; AMPHOTERICIN B; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; BETA-GLUCANS; BIOLOGICAL MARKERS; FEMALE; FUSARIOSIS; HUMANS; IMMUNOCOMPROMISED HOST; LEUKEMIA, MYELOID, ACUTE; META-ANALYSIS AS TOPIC; MYCOSES; OPPORTUNISTIC INFECTIONS; POLYMERASE CHAIN REACTION;

EID: 84055193579     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2011.10.008     Document Type: Article

References (110)

1. M.A. Pfaller, D.J. Diekema Epidemiology of invasive mycoses in North America Crit Rev Microbiol 36 2010 1 53
2. A.N. Ellepola, C.J. Morrison Laboratory diagnosis of invasive candidiasis J Microbiol 43 spec no 2005 65 84 (Pubitemid 40431503)
3. W.W. Hope, T.J. Walsh, D.W. Denning Laboratory diagnosis of invasive aspergillosis Lancet Infect Dis 5 2005 609 622 (Pubitemid 41383906)
4. S. Preuner, T. Lion Towards molecular diagnostics of invasive fungal infections Expert Rev Mol Diagn 9 2009 397 401
5. M. Bassetti, E.M. Trecarichi, E. Righi Incidence, risk factors, and predictors of outcome of candidemia: survey in 2 Italian university hospitals Diagn Microbiol Infect Dis 58 2007 325 331 (Pubitemid 47017636)
6. K.W. Garey, M. Rege, M.P. Pai Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study Clin Infect Dis 43 2006 25 31 (Pubitemid 43939072)
7. Y. Golan, M.P. Wolf, S.G. Pauker, J.B. Wong, S. Hadley Empirical anti-Candida therapy among selected patients in the intensive care unit: a cost-effectiveness analysis Ann Intern Med 143 2005 857 869 (Pubitemid 46202221)
8. M. von Eiff, N. Roos, R. Schulten, M. Hesse, M. Zuhlsdorf, J. van de Loo Pulmonary aspergillosis: early diagnosis improves survival Respiration 62 1995 341 347
9. N.L. Wengenack, M.J. Binnicker Fungal molecular diagnostics Clin Chest Med 30 2009 391 408 viii
10. B.D. Alexander Diagnosis of fungal infection: new technologies for the mycology laboratory Transpl Infect Dis 4 suppl 3 2002 32 37 (Pubitemid 34832434)
11. J.J. Vehreschild, M.J. Ruping, A. Steinbach, O.A. Cornely Diagnosis and treatment of fungal infections in allogeneic stem cell and solid organ transplant recipients Expert Opin Pharmacother 11 2010 95 113
12. M.T. Montagna, G. Caggiano, E. Borghi, G. Morace The role of the laboratory in the diagnosis of invasive candidiasis Drugs 69 suppl 1 2009 59 63
13. J. Peman, R. Zaragoza Current diagnostic approaches to invasive candidiasis in critical care settings Mycoses 53 2010 424 433
14. J. Berenguer, M. Buck, F. Witebsky, F. Stock, P.A. Pizzo, T.J. Walsh Lysis-centrifugation blood cultures in the detection of tissue-proven invasive candidiasis: disseminated versus single-organ infection Diagn Microbiol Infect Dis 17 1993 103 109 (Pubitemid 23294544)
15. P.D. Barnes, K.A. Marr Aspergillosis: spectrum of disease, diagnosis, and treatment Infect Dis Clin North Am 20 2006 545 561 vi (Pubitemid 44375112)
16. P.D. Barnes, K.A. Marr Risks, diagnosis and outcomes of invasive fungal infections in haematopoietic stem cell transplant recipients Br J Haematol 139 2007 519 531 (Pubitemid 350043811)
17. J.A. Horvath, S. Dummer The use of respiratory-tract cultures in the diagnosis of invasive pulmonary aspergillosis Am J Med 100 1996 171 178 (Pubitemid 26062511)
18. P. Sales Mda Chapter 5Aspergillosis: from diagnosis to treatment J Bras Pneumol 35 2009 1238 1244
19. R.A. Barnes Early diagnosis of fungal infection in immunocompromised patients J Antimicrob Chemother 61 suppl 1 2008 i3 i6
20. S.P. Georgiadou, N.V. Sipsas, E.M. Marom, D.P. Kontoyiannis The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts Clin Infect Dis 52 2011 1144 1155
21. M.B. Gotway, S.K. Dawn, E.M. Caoili, G.P. Reddy, P.A. Araoz, W.R. Webb The radiologic spectrum of pulmonary Aspergillus infections J Comput Assist Tomogr 26 2002 159 173 (Pubitemid 34233359)
22. A. Cornillet, C. Camus, S. Nimubona Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey Clin Infect Dis 43 2006 577 584 (Pubitemid 44267116)
23. R. Sherif, B.H. Segal Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications Curr Opin Pulm Med 16 2010 242 250
24. J.R. Perfect, G.M. Cox, J.Y. Lee The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis Clin Infect Dis 33 2001 1824 1833 (Pubitemid 33105120)
25. R. Duthie, D.W. Denning Aspergillus fungemia: report of two cases and review Clin Infect Dis 20 1995 598 605
26. J.L. Hsu, S.J. Ruoss, N.D. Bower, M. Lin, M. Holodniy, D.A. Stevens Diagnosing invasive fungal disease in critically ill patients Crit Rev Microbiol 37 2011 277 312
27. M. Morrell, V.J. Fraser, M.H. Kollef Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality Antimicrob Agents Chemother 49 2005 3640 3645 (Pubitemid 41233011)
28. J. Nolla-Salas, A. Sitges-Serra, C. Leon-Gil Study Group of Fungal Infection in the ICU Candidemia in non-neutropenic critically ill patients: analysis of prognostic factors and assessment of systemic antifungal therapy Intensive Care Med 23 1997 23 30 (Pubitemid 27067892)
29. G.P. Patel, D. Simon, M. Scheetz, C.W. Crank, T. Lodise, N. Patel The effect of time to antifungal therapy on mortality in candidemia-associated septic shock Am J Ther 16 2009 508 511
30. M. Tumbarello, B. Posteraro, E.M. Trecarichi Biofilm production by Candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemia J Clin Microbiol 45 2007 1843 1850 (Pubitemid 46933916)
31. M.D. Zilberberg, M.H. Kollef, H. Arnold Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study BMC Infect Dis 10 2010 150
32. D. Caillot, O. Casasnovas, A. Bernard Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery J Clin Oncol 15 1997 139 147 (Pubitemid 27020567)
33. S.C. Chen, D.P. Kontoyiannis New molecular and surrogate biomarker-based tests in the diagnosis of bacterial and fungal infection in febrile neutropenic patients Curr Opin Infect Dis 23 2010 567 577
34. H. Einsele, J. Loeffler Contribution of new diagnostic approaches to antifungal treatment plans in high-risk haematology patients Clin Microbiol Infect 14 suppl 4 2008 37 45 (Pubitemid 351593915)
35. B.P. Guery, M.C. Arendrup, G. Auzinger Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: part I Epidemiology and diagnosis Intensive Care Med 35 2009 55 62
36. A. Lain, N. Elguezabal, M.D. Moragues, J.C. Garcia-Ruiz, A. del Palacio, J. Ponton Contribution of serum biomarkers to the diagnosis of invasive candidiasis Expert Rev Mol Diagn 8 2008 315 325 (Pubitemid 351724710)
37. N. Akamatsu, Y. Sugawara, J. Kaneko, S. Tamura, M. Makuuchi Preemptive treatment of fungal infection based on plasma (1 → 3)β-d-glucan levels after liver transplantation Infection 35 2007 346 351 (Pubitemid 47502349)
38. A. Mikolajewska, S. Schwartz, M. Ruhnke Antifungal treatment strategies in patients with haematological diseases or cancer: from prophylaxis to empirical, pre-emptive and targeted therapy Mycoses 2011 Epub ahead of print
39. M.J. Ruping, J.J. Vehreschild, O.A. Cornely Patients at high risk of invasive fungal infections: when and how to treat Drugs 68 2008 1941 1962
40. G. Morace, E. Borghi Fungal infections in ICU patients: epidemiology and the role of diagnostics Minerva Anestesiol 76 2010 950 956
41. R. Herbrecht, A. Berceanu β-d-glucan detection test: a step toward preemptive therapy for fungal infections in leukemic patients? Clin Infect Dis 46 2008 886 889 (Pubitemid 351417191)
42. C. Cordonnier, C. Pautas, S. Maury Empirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial Clin Infect Dis 48 2009 1042 1051
43. J. Maertens, K. Theunissen, G. Verhoef Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study Clin Infect Dis 41 2005 1242 1250 (Pubitemid 41534660)
44. J. Hsu, C. Abad, M. Dinh, N. Safdar Prevention of endemic healthcare-associated Clostridium difficile infection: reviewing the evidence Am J Gastroenterol 105 2010 2327 2329
45. S.F. Yeo, B. Wong Current status of nonculture methods for diagnosis of invasive fungal infections Clin Microbiol Rev 15 2002 465 484 (Pubitemid 34761353)
46. T. Obayashi, M. Yoshida, T. Mori Plasma (1→3)-β-d-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes Lancet 345 1995 17 20
47. J.A. Van Burik, D. Myerson, R.W. Schreckhise, R.A. Bowden Panfungal PCR assay for detection of fungal infection in human blood specimens J Clin Microbiol 36 1998 1169 1175 (Pubitemid 28207992)
48. F. Persat, R. Topenot, M.A. Piens, A. Thiebaut, E. Dannaoui, S. Picot Evaluation of different commercial ELISA methods for the serodiagnosis of systemic candidosis Mycoses 45 2002 455 460 (Pubitemid 35471999)
49. Philip A., Odabasi Z., Mattiuzzi G., Paetznick V.L., Rex J.H., Ostrosky-Zeichner L. SysCan3 for the Detection of Anti-Candida Antibodies for the Diagnosis of Invasive Candidiasis (IC) 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, 2003 Sep 14-17; 43: Abstract M-2060.
50. A. Philip, Z. Odabasi, G. Matiuzzi SysCan3, a kit for detection of anti-Candida antibodies for diagnosis of invasive candidiasis J Clin Microbiol 43 2005 4834 4835 (Pubitemid 41298288)
51. F.M. Klis Review: Cell wall assembly in yeast Yeast 10 1994 851 869 (Pubitemid 24235063)
52. M. Ellis, B. Al-Ramadi, R. Bernsen, J. Kristensen, H. Alizadeh, U. Hedstrom Prospective evaluation of mannan and anti-mannan antibodies for diagnosis of invasive Candida infections in patients with neutropenic fever J Med Microbiol 58 2009 606 615
53. M. Mikulska, T. Calandra, M. Sanguinetti, D. Poulain, C. Viscoli The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia Crit Care 14 2010 R222
54. S. Tokunaga, M. Ohkawa, M. Takashima Diagnostic value of determination of serum mannan concentrations in patients with candiduria Eur J Clin Microbiol Infect Dis 12 1993 542 545 (Pubitemid 23241805)
55. F.M. Verduyn Lunel, J.P. Donnelly, H.A. van der Lee, N.M. Blijlevens, P.E. Verweij Circulating Candida-specific anti-mannan antibodies precede invasive candidiasis in patients undergoing myelo-ablative chemotherapy Clin Microbiol Infect 15 2009 380 386
56. M.H. Weiner, M. Coats-Stephen Immunodiagnosis of systemic candidiasis: mannan antigenemia detected by radioimmunoassay in experimental and human infections J Infect Dis 140 1979 989 993 (Pubitemid 10165142)
57. M.C. Arendrup, O.J. Bergmann, L. Larsson, H.V. Nielsen, J.O. Jarlov, B. Christensson Detection of candidaemia in patients with and without underlying haematological disease Clin Microbiol Infect 16 2010 855 862
58. B. Sendid, J.L. Poirot, M. Tabouret Combined detection of mannanaemia and antimannan antibodies as a strategy for the diagnosis of systemic infection caused by pathogenic Candida species J Med Microbiol 51 2002 433 442 (Pubitemid 34450601)
59. B. Sendid, M. Tabouret, J.L. Poirot, D. Mathieu, J. Fruit, D. Poulain New enzyme immunoassays for sensitive detection of circulating Candida albicans mannan and antimannan antibodies: useful combined test for diagnosis of systemic candidiasis J Clin Microbiol 37 1999 1510 1517 (Pubitemid 29187827)
60. E.M. Bernard, K.J. Christiansen, S.F. Tsang, T.E. Kiehn, D. Armstrong Rate of arabinitol production by pathogenic yeast species J Clin Microbiol 14 1981 189 194 (Pubitemid 11095521)
61. S.F. Yeo, S. Huie, A.N. Sofair, S. Campbell, A. Durante, B. Wong Measurement of serum d-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia J Clin Microbiol 44 2006 3894 3899 (Pubitemid 44737225)
62. E.M. Bernard, B. Wong, D. Armstrong Stereoisomeric configuration of arabinitol in serum, urine, and tissues in invasive candidiasis J Infect Dis 151 1985 711 715 (Pubitemid 15102170)
63. E.J. Holak, J. Wu, S.L. Spruance Value of serum arabinitol for the management of Candida infections in clinical practice Mycopathologia 93 1986 99 104 (Pubitemid 16137291)
64. T.E. Kiehn, E.M. Bernard, J.W. Gold, D. Armstrong Candidiasis: detection by gas-liquid chromatography of d-arabinitol, a fungal metabolite, in human serum Science 206 1979 577 580 (Pubitemid 10192166)
65. L. Lehtonen, A. Rantala, P. Oksman, E. Eerola, O.P. Lehtonen Determination of serum arabinitol levels by mass spectrometry in patients with postoperative candidiasis Eur J Clin Microbiol Infect Dis 12 1993 330 335 (Pubitemid 23184845)
66. J. Roboz, R. Suzuki, J.F. Holland Quantification of arabinitol in serum by selected ion monitoring as a diagnostic technique in invasive candidiasis J Clin Microbiol 12 1980 594 601
67. S.F. Yeo, Y. Zhang, D. Schafer, S. Campbell, B. Wong A rapid, automated enzymatic fluorometric assay for determination of D-arabinitol in serum J Clin Microbiol 38 2000 1439 1443 (Pubitemid 30216668)
68. B. Christensson, G. Sigmundsdottir, L. Larsson D-arabinitola marker for invasive candidiasis Med Mycol 37 1999 391 396
69. J.W. Gold, B. Wong, E.M. Bernard, T.E. Kiehn, D. Armstrong Serum arabinitol concentrations and arabinitol/creatinine ratios in invasive candidiasis J Infect Dis 147 1983 504 513 (Pubitemid 13163191)
70. B. Wong, E.M. Bernard, J.W. Gold, D. Fong, D. Armstrong The arabinitol appearance rate in laboratory animals and humans: estimation from the arabinitol/creatine ratio and relevance to the diagnosis of candidiasis J Infect Dis 146 1982 353 359 (Pubitemid 12031212)
71. T.J. Walsh, W.G. Merz, J.W. Lee Diagnosis and therapeutic monitoring of invasive candidiasis by rapid enzymatic detection of serum d-arabinitol Am J Med 99 1995 164 172
72. A.C. Switchenko, C.G. Miyada, T.C. Goodman An automated enzymatic method for measurement of d-arabinitol, a metabolite of pathogenic Candida species J Clin Microbiol 32 1994 92 97 (Pubitemid 24016789)
73. L. Lehtonen, V.J. Anttila, T. Ruutu Diagnosis of disseminated candidiasis by measurement of urine d-arabinitol/l-arabinitol ratio J Clin Microbiol 34 1996 2175 2179 (Pubitemid 26272199)
74. B. Wong, K.L. Brauer Enantioselective measurement of fungal d-arabinitol in the sera of normal adults and patients with candidiasis J Clin Microbiol 26 1988 1670 1674
75. J. Roboz, R.N. Katz Diagnosis of disseminated candidiasis based on serum d-/l-arabinitol ratios using negative chemical ionization mass spectrometry J Chromatogr 575 1992 281 286
76. K.A. Marr, S.A. Balajee, L. McLaughlin, M. Tabouret, C. Bentsen, T.J. Walsh Detection of galactomannan antigenemia by enzyme immunoassay for the diagnosis of invasive aspergillosis: variables that affect performance J Infect Dis 190 2004 641 649 (Pubitemid 38982107)
77. R. Petraitiene, V. Petraitis, A.H. Groll Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in treatment and prevention of experimental invasive pulmonary aspergillosis: correlation with galactomannan antigenemia Antimicrob Agents Chemother 45 2001 857 869 (Pubitemid 32182037)
78. V. Verdaguer, T.J. Walsh, W. Hope, K.J. Cortez Galactomannan antigen detection in the diagnosis of invasive aspergillosis Expert Rev Mol Diagn 7 2007 21 32 (Pubitemid 46114704)
79. C.D. Pfeiffer, J.P. Fine, N. Safdar Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis Clin Infect Dis 42 2006 1417 1427
80. T.J. Walsh, E.J. Anaissie, D.W. Denning Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America Clin Infect Dis 46 2008 327 360 (Pubitemid 351265310)
81. F. Boutboul, C. Alberti, T. Leblanc Invasive aspergillosis in allogeneic stem cell transplant recipients: increasing antigenemia is associated with progressive disease Clin Infect Dis 34 2002 939 943 (Pubitemid 34229762)
82. M.H. Miceli, M.L. Grazziutti, G. Woods Strong correlation between serum aspergillus galactomannan index and outcome of aspergillosis in patients with hematological cancer: clinical and research implications Clin Infect Dis 46 2008 1412 1422 (Pubitemid 351589942)
83. G. Woods, M.H. Miceli, M.L. Grazziutti, W. Zhao, B. Barlogie, E. Anaissie Serum aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer Cancer 110 2007 830 834 (Pubitemid 47257661)
84. Y.L. Guo, Y.Q. Chen, K. Wang, S.M. Qin, C. Wu, J.L. Kong Accuracy of BAL galactomannan in diagnosing invasive aspergillosis: a bivariate metaanalysis and systematic review Chest 138 2010 817 824
85. C.A. Hage, K.S. Knox, T.E. Davis, L.J. Wheat Antigen detection in bronchoalveolar lavage fluid for diagnosis of fungal pneumonia Curr Opin Pulm Med 17 2011 167 171
86. J. Maertens, V. Maertens, K. Theunissen Bronchoalveolar lavage fluid galactomannan for the diagnosis of invasive pulmonary aspergillosis in patients with hematologic diseases Clin Infect Dis 49 2009 1688 1693
87. W. Meersseman, K. Lagrou, J. Maertens Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients Am J Respir Crit Care Med 177 2008 27 34
88. R.R. Klont, M.A. Mennink-Kersten, P.E. Verweij Utility of Aspergillus antigen detection in specimens other than serum specimens Clin Infect Dis 39 2004 1467 1474 (Pubitemid 39518210)
89. Fungitell Assay Product Information Sheet http://www.acciusa.com/ clinical/fungitell/index.html Accessed August 28, 2011
90. P.G. Pappas, C.A. Kauffman, D. Andes Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America Clin Infect Dis 48 2009 503 535
91. B. De Pauw, T.J. Walsh, J.P. Donnelly et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group Clin Infect Dis 46 2008 1813 1821
92. L.J. Wheat Approach to the diagnosis of invasive aspergillosis and candidiasis Clin Chest Med 30 2009 367 377 viii
93. D.E. Karageorgopoulos, E.K. Vouloumanou, F. Ntziora, A. Michalopoulos, P.I. Rafailidis, M.E. Falagas β-d-glucan assay for the diagnosis of invasive fungal infections: a meta-analysis Clin Infect Dis 52 2011 750 770
94. T. Obayashi, K. Negishi, T. Suzuki, N. Funata Reappraisal of the serum (1→3)-β-d-glucan assay for the diagnosis of invasive fungal infectionsa study based on autopsy cases from 6 years Clin Infect Dis 46 2008 1864 1870
95. Z. Odabasi, G. Mattiuzzi, E. Estey Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome Clin Infect Dis 39 2004 199 205 (Pubitemid 38971490)
96. L. Ostrosky-Zeichner, B.D. Alexander, D.H. Kett Multicenter clinical evaluation of the (1→3) β-d-glucan assay as an aid to diagnosis of fungal infections in humans Clin Infect Dis 41 2005 654 659 (Pubitemid 41170353)
97. S. Koo, J.M. Bryar, J.H. Page, L.R. Baden, F.M. Marty Diagnostic performance of the (1→3)-β-d-glucan assay for invasive fungal disease Clin Infect Dis 49 2009 1650 1659
98. R.Y. Hachem, D.P. Kontoyiannis, R.F. Chemaly, Y. Jiang, R. Reitzel, I. Raad Utility of galactomannan enzyme immunoassay and (1,3) β-d-glucan in diagnosis of invasive fungal infections: low sensitivity for Aspergillus fumigatus infection in hematologic malignancy patients J Clin Microbiol 47 2009 129 133
99. C. Pazos, J. Ponton, A. Del Palacio Contribution of (1->3)-β-d- glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients: a comparison with serial screening for circulating galactomannan J Clin Microbiol 43 2005 299 305 (Pubitemid 40096315)
100. C. Pazos, M.D. Moragues, G. Quindos, J. Ponton, A. del Palacio Diagnostic potential of (1,3)-β-d-glucan and anti-Candida albicans germ tube antibodies for the diagnosis and therapeutic monitoring of invasive candidiasis in neutropenic adult patients Rev Iberoam Micol 23 2006 209 215 (Pubitemid 44735884)
101. D.S. Perlin Antifungal drug resistance: do molecular methods provide a way forward? Curr Opin Infect Dis 22 2009 568 573
102. G. Garcia-Effron, A. Dilger, L. Alcazar-Fuoli, S. Park, E. Mellado, D.S. Perlin Rapid detection of triazole antifungal resistance in Aspergillus fumigatus J Clin Microbiol 46 2008 1200 1206 (Pubitemid 351563556)
103. G. Jannes, D. De Vos A review of current and future molecular diagnostic tests for use in the microbiology laboratory Methods Mol Biol 345 2006 1 21
104. G. Kofla, M. Ruhnke Development of a new real-time TaqMan PCR assay for quantitative analyses of Candida albicans resistance genes expression J Microbiol Methods 68 2007 178 183 (Pubitemid 46054330)
105. C. Mengoli, M. Cruciani, R.A. Barnes, J. Loeffler, J.P. Donnelly Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis Lancet Infect Dis 9 2009 89 96
106. L. Metwally, G. Hogg, P.V. Coyle Rapid differentiation between fluconazole-sensitive and -resistant species of Candida directly from positive blood-culture bottles by real-time PCR J Med Microbiol 56 2007 964 970 (Pubitemid 47047491)
107. Y. Zhao, S. Park, B.N. Kreiswirth Rapid real-time nucleic acid sequence-based amplification-molecular beacon platform to detect fungal and bacterial bloodstream infections J Clin Microbiol 47 2009 2067 2078
108. T. Avni, L. Leibovici, M. Paul PCR diagnosis of invasive candidiasis: systematic review and meta-analysis J Clin Microbiol 49 2011 665 670
109. S. Ascioglu, J.H. Rex, B. de Pauw Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus Clin Infect Dis 34 2002 7 14 (Pubitemid 33152659)
110. M. Cuenca-Estrella, Y. Meije, C. Diaz-Pedroche Value of serial quantification of fungal DNA by a real-time PCR-based technique for early diagnosis of invasive aspergillosis in patients with febrile neutropenia J Clin Microbiol 47 2009 379 384